MX2020004588A - Inhibidor de proteasa de doble cabeza. - Google Patents

Inhibidor de proteasa de doble cabeza.

Info

Publication number
MX2020004588A
MX2020004588A MX2020004588A MX2020004588A MX2020004588A MX 2020004588 A MX2020004588 A MX 2020004588A MX 2020004588 A MX2020004588 A MX 2020004588A MX 2020004588 A MX2020004588 A MX 2020004588A MX 2020004588 A MX2020004588 A MX 2020004588A
Authority
MX
Mexico
Prior art keywords
compound
headed
double
protease inhibitor
enteropeptidase
Prior art date
Application number
MX2020004588A
Other languages
English (en)
Inventor
Koji Ito
Tomoko Kanda
Satoshi Umezaki
Yusuke Shiraishi
Tomio Kimura
Ken-Ichi Komori
Yasunori Tokunaga
Haruka Yamada
Naoya Kinoshita
Kenji Yoneda
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of MX2020004588A publication Critical patent/MX2020004588A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención proporciona un compuesto que es altamente seguro y útil en la prevención, alivio y/o tratamiento de varias enfermedades que implican la inhibición de la enteropeptidasa y/o la inhibición de la tripsina, una composición farmacéutica que contiene el compuesto, un método para producir el compuesto y similar; específicamente, la presente invención proporciona un compuesto representado por la siguiente fórmula general (I): en donde: A1 y A2 cada uno representa independientemente un residuo inhibidor que tiene por lo menos una actividad seleccionada de una actividad inhibidora de enteropeptidasa y una actividad inhibidora de tripsina; y Z representa un separador que une A1 a A2 o una sal farmacéuticamente aceptable del mismo.
MX2020004588A 2017-11-02 2018-11-02 Inhibidor de proteasa de doble cabeza. MX2020004588A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017213163 2017-11-02
PCT/JP2018/040915 WO2019088270A1 (ja) 2017-11-02 2018-11-02 蛋白分解酵素の双頭型阻害剤

Publications (1)

Publication Number Publication Date
MX2020004588A true MX2020004588A (es) 2020-12-03

Family

ID=66332029

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004588A MX2020004588A (es) 2017-11-02 2018-11-02 Inhibidor de proteasa de doble cabeza.

Country Status (10)

Country Link
US (1) US11465965B2 (es)
EP (1) EP3705471A4 (es)
JP (1) JPWO2019088270A1 (es)
KR (1) KR20200075867A (es)
CN (1) CN111542511A (es)
AU (1) AU2018361589A1 (es)
BR (1) BR112020008676A2 (es)
CA (1) CA3081564A1 (es)
MX (1) MX2020004588A (es)
WO (1) WO2019088270A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3650440A4 (en) * 2018-08-27 2020-11-25 Scohia Pharma, Inc. BENZOIC ESTER COMPOUND
WO2021166899A1 (ja) * 2020-02-17 2021-08-26 宇部興産株式会社 インクレチン様物質と組み合わせて使用するための消化管プロテアーゼ阻害剤を含む薬剤
US20230271983A1 (en) * 2020-07-29 2023-08-31 Universidade De Santiago De Compostela Functionalized isonitriles and products, preparation and uses thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5289640A (en) 1976-01-21 1977-07-27 Ono Pharmaceut Co Ltd Guanidinobenzoic acid derivatives, and antiplasmin agents and remedies for pancreas diseases containing the said guanidinobensolc acid deriv atives
GB8430253D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
CA2588087A1 (en) 2004-11-15 2006-05-18 Obe Therapy Biotechnology S.A.S. Methods of reducing body fat
PT1813614E (pt) 2006-01-25 2012-01-09 Sanofi Sa Agentes citotóxicos compreendendo novos derivados de tomaimicina
CA2642273C (en) * 2006-02-14 2016-09-20 President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
HUE028064T2 (en) 2007-12-03 2016-11-28 Obe Therapy Biotechnology Inhibitors of enteropeptidase boropeptide and their use in the treatment of diseases associated with obesity, overweight and / or abnormal fat metabolism
MX2010010783A (es) * 2008-04-04 2010-11-12 Univ California Conjugados del compuesto hidrazida divalente para inhibir el regulador de conductancia de transmembrana de fibrosis quistica.
KR101766619B1 (ko) 2008-12-31 2017-08-08 알데릭스, 인코포레이티드 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 ｎｈｅ-매개된 역수송을 억제하는 화합물 및 방법
ES2532201T3 (es) 2009-12-07 2015-03-25 Ajinomoto Co., Inc. Derivado de éster de ácido heteroarilcarboxílico
ES2618024T3 (es) 2011-06-07 2017-06-20 Ea Pharma Co., Ltd. Derivado de éster de ácido carboxílico heterocíclico
IN2014CN01930A (es) 2011-09-15 2015-09-04 Astellas Pharma Inc
US9024044B2 (en) 2012-06-14 2015-05-05 Ajinomoto Co., Inc. Heteroarylcarboxylic acid ester derivative
SG10201707504VA (en) 2013-03-13 2017-10-30 Takeda Pharmaceuticals Co Guanidinobenzoic acid ester compound
CN105518000B (zh) * 2013-07-02 2018-09-14 加州生物医学研究所 用于治疗囊性纤维化的化合物
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9975903B2 (en) 2014-12-26 2018-05-22 Takeda Pharmaceutical Company Limited Condensed heterocyclic compound
US10017487B2 (en) 2015-03-27 2018-07-10 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
EP3650440A4 (en) 2018-08-27 2020-11-25 Scohia Pharma, Inc. BENZOIC ESTER COMPOUND

Also Published As

Publication number Publication date
CA3081564A1 (en) 2019-05-09
AU2018361589A1 (en) 2020-06-04
CN111542511A (zh) 2020-08-14
KR20200075867A (ko) 2020-06-26
US11465965B2 (en) 2022-10-11
US20200347011A1 (en) 2020-11-05
RU2020117612A3 (es) 2022-03-02
EP3705471A4 (en) 2021-08-11
WO2019088270A1 (ja) 2019-05-09
JPWO2019088270A1 (ja) 2020-12-03
RU2020117612A (ru) 2021-12-03
EP3705471A1 (en) 2020-09-09
BR112020008676A2 (pt) 2020-10-27

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