MX2020003591A - Constructos del virus recombinante no patogenico de la enfermedad de marek que codifica multiples antigenos heterologos. - Google Patents
Constructos del virus recombinante no patogenico de la enfermedad de marek que codifica multiples antigenos heterologos.Info
- Publication number
- MX2020003591A MX2020003591A MX2020003591A MX2020003591A MX2020003591A MX 2020003591 A MX2020003591 A MX 2020003591A MX 2020003591 A MX2020003591 A MX 2020003591A MX 2020003591 A MX2020003591 A MX 2020003591A MX 2020003591 A MX2020003591 A MX 2020003591A
- Authority
- MX
- Mexico
- Prior art keywords
- disease virus
- constructs encoding
- heterologous antigens
- encoding multiple
- recombinant non
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
- A61K39/255—Marek's disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/17—Newcastle disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/869—Herpesviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16341—Use of virus, viral particle or viral elements as a vector
- C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/10011—Birnaviridae
- C12N2720/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Abstract
La presente invención describe constructos del virus no patogénico multivalente recombinante de la enfermedad de Marek que codifica y expresa los antígenos extraños de tres o más virus aviares, junto con los métodos de uso de las vacunas de virus multivalente de las aves de corral.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762571524P | 2017-10-12 | 2017-10-12 | |
US201862729673P | 2018-09-11 | 2018-09-11 | |
PCT/EP2018/077725 WO2019072964A1 (en) | 2017-10-12 | 2018-10-11 | RECOMBINANT NON-PATHOGENIC MAREK DISEASE VIRUS CONSTRUCTS ENCODING MULTIPLE HETEROLOGOUS ANTIGENS |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020003591A true MX2020003591A (es) | 2020-07-22 |
Family
ID=63878656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020003591A MX2020003591A (es) | 2017-10-12 | 2018-10-11 | Constructos del virus recombinante no patogenico de la enfermedad de marek que codifica multiples antigenos heterologos. |
Country Status (7)
Country | Link |
---|---|
US (2) | US11229698B2 (es) |
EP (1) | EP3694987A1 (es) |
JP (1) | JP2021500876A (es) |
CN (1) | CN111542599A (es) |
BR (1) | BR112020007213A2 (es) |
MX (1) | MX2020003591A (es) |
WO (1) | WO2019072964A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE061405T2 (hu) * | 2016-06-17 | 2023-06-28 | Intervet Int Bv | Nem patogén Marek-betegség vírus konstruktok, amelyek fertõzõ laryngotracheitis vírus és fertõzõ bursitis vírus antigéneket kódolnak |
JP2023506919A (ja) | 2019-12-20 | 2023-02-20 | インターベット インターナショナル ベー. フェー. | 多価hvtベクターワクチン |
CN112206317B (zh) * | 2020-10-12 | 2023-09-22 | 浙江省淡水水产研究所 | 一种草鱼出血病二价核酸菌蜕疫苗的制备方法 |
WO2022136623A1 (en) | 2020-12-24 | 2022-06-30 | Intervet International B.V. | Multivalent hvt vector vaccine |
WO2023213946A1 (en) | 2022-05-05 | 2023-11-09 | Intervet International B.V. | New multivalent hvt vector vaccine |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965138A (en) | 1985-09-06 | 1999-10-12 | Syntro Corporation | Recombinant chimeric virus and uses thereof |
US5834305A (en) | 1985-09-06 | 1998-11-10 | Syntro Corporation | Attenuated herpesvirus, herpesvirus which include foreign DNA encoding an amino acid sequence and vaccines containing same |
US6121043A (en) | 1985-09-06 | 2000-09-19 | Syntro Corporation | Recombinant herpesvirus of turkeys comprising a foreign DNA inserted into a non-essential region of the herpesvirus of turkeys genome |
US5961982A (en) | 1985-09-06 | 1999-10-05 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
US5928648A (en) | 1985-09-06 | 1999-07-27 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
US4963481A (en) | 1985-12-18 | 1990-10-16 | Genetics Institute Inc | Promoter system |
WO1987004463A1 (en) | 1986-01-27 | 1987-07-30 | Syntro Corporation | Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same |
US5273876A (en) | 1987-06-26 | 1993-12-28 | Syntro Corporation | Recombinant human cytomegalovirus containing foreign gene |
ES2070997T3 (es) | 1989-12-04 | 1995-06-16 | Akzo Nobel Nv | Virus de herpes recombinante de pavos y vacunas vector vivas derivadas de los mismos. |
WO1992003554A1 (en) | 1990-08-24 | 1992-03-05 | Arthur Webster Pty. Ltd. | Infectious laryngotracheitis virus vaccine |
US6183753B1 (en) | 1994-08-09 | 2001-02-06 | Schering-Plough Veterinary Corp. | Recombinant chimeric virus and uses thereof |
US6913751B2 (en) | 1992-06-12 | 2005-07-05 | Schering-Plough Veterinary Corporation | Recombinant avian herpesvirus useful in vaccine production |
US5853733A (en) | 1993-02-26 | 1998-12-29 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
US6875856B2 (en) | 1993-09-24 | 2005-04-05 | Syntro Corporation | Recombinant infectious laryngotracheitis virus and uses thereof |
FR2728795B1 (fr) | 1994-12-30 | 1997-03-21 | Rhone Merieux | Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire |
FR2728794B1 (fr) | 1994-12-30 | 1997-03-21 | Rhone Merieux | Vaccin recombinant aviaire a base de virus herpes aviaire, notamment contre la maladie de gumboro |
US6299882B1 (en) | 1999-04-09 | 2001-10-09 | Schering Corporation | UL54.5 of Marek's disease virus (MDV) |
US6764684B2 (en) | 2001-09-28 | 2004-07-20 | Zeon Corporation | Avian herpesvirus-based recombinant infectious bursal disease vaccine |
CN101210248A (zh) * | 2006-12-30 | 2008-07-02 | 河南农业大学 | 一种ILTV gD糖蛋白核苷酸序列和氨基酸序列及其重组的病毒疫苗以及该疫苗的应用 |
JP2008228658A (ja) | 2007-03-20 | 2008-10-02 | Nippon Zeon Co Ltd | 新規なプロモーター、これを有する組み換え七面鳥ヘルペスウイルス、及びこれを利用した家禽用ワクチン |
TWI468157B (zh) | 2009-04-29 | 2015-01-11 | Intervet Int Bv | 形成錠劑的方法,進行該方法的系統及包含該錠劑的包裝物 |
US8932604B2 (en) | 2011-10-21 | 2015-01-13 | Intervet Inc. | Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and newcastle disease virus antigens |
WO2013057235A1 (en) | 2011-10-21 | 2013-04-25 | Intervet International B.V. | Recombinant nonpathogenic mdv vector providing multivalent immunity |
US9101598B2 (en) | 2011-11-30 | 2015-08-11 | Merial, Inc. | Recombinant Gallid herpesvirus 3 (MDV serotype 2) vectors expressing antigens of avian pathogens and uses thereof |
US9114108B2 (en) | 2011-11-30 | 2015-08-25 | Merial, Inc. | Recombinant HVT vectors expressing antigens of avian pathogens and uses thereof |
PL2785373T3 (pl) * | 2011-11-30 | 2020-06-01 | Boehringer Ingelheim Animal Health USA Inc. | Rekombinowane wektory HVT wyrażające antygeny ptasich patogenów i ich zastosowania |
EP2644702A1 (en) * | 2012-03-30 | 2013-10-02 | Ceva Sante Animale | Multivalent recombinant avian herpes virus and vaccine for immunizing avian species |
US9555016B2 (en) | 2013-06-10 | 2017-01-31 | Covidien Lp | Lytic agents for use in treating intravascular clots |
EP2845904A1 (en) | 2013-09-06 | 2015-03-11 | Ceva Sante Animale | Recombinant Marek's disease viruses and uses thereof |
AR103245A1 (es) * | 2014-12-24 | 2017-04-26 | Intervet Int Bv | Vacuna vectorial basada en hvt (herpes virus de los pavos) frente a nd (enfermedad de newcastle) - ibd (enfermedad de gumboro) mejorada |
HUE061405T2 (hu) * | 2016-06-17 | 2023-06-28 | Intervet Int Bv | Nem patogén Marek-betegség vírus konstruktok, amelyek fertõzõ laryngotracheitis vírus és fertõzõ bursitis vírus antigéneket kódolnak |
PL3554536T3 (pl) | 2016-12-14 | 2023-03-06 | Boehringer Ingelheim Animal Health USA Inc. | Rekombinowane wektory hvt wyrażające wiele antygenów patogenów ptasich oraz szczepionki je zawierające |
-
2018
- 2018-10-11 EP EP18788715.3A patent/EP3694987A1/en active Pending
- 2018-10-11 MX MX2020003591A patent/MX2020003591A/es unknown
- 2018-10-11 BR BR112020007213-3A patent/BR112020007213A2/pt unknown
- 2018-10-11 CN CN201880065921.2A patent/CN111542599A/zh active Pending
- 2018-10-11 JP JP2020520237A patent/JP2021500876A/ja active Pending
- 2018-10-11 WO PCT/EP2018/077725 patent/WO2019072964A1/en unknown
- 2018-10-11 US US16/753,133 patent/US11229698B2/en active Active
-
2021
- 2021-12-07 US US17/544,044 patent/US20220088187A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11229698B2 (en) | 2022-01-25 |
US20200323978A1 (en) | 2020-10-15 |
JP2021500876A (ja) | 2021-01-14 |
US20220088187A1 (en) | 2022-03-24 |
BR112020007213A2 (pt) | 2020-10-13 |
RU2020115458A (ru) | 2021-11-12 |
EP3694987A1 (en) | 2020-08-19 |
WO2019072964A1 (en) | 2019-04-18 |
RU2020115458A3 (es) | 2022-03-17 |
CN111542599A (zh) | 2020-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2020003591A (es) | Constructos del virus recombinante no patogenico de la enfermedad de marek que codifica multiples antigenos heterologos. | |
MY173856A (en) | Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and newcastle disease virus antigens | |
MX361893B (es) | Vectores recombinantes de herpesvirus 3 galido (mdv serotipo 2) que expresan antigenos de patogenos de aves y sus usos. | |
PH12019501366A1 (en) | Recombinant hvt vectors expressing multiple antigens of avian pathogens, and vaccines comprising them | |
IN2014CH00396A (es) | ||
MX2020003760A (es) | Formulaciones de niraparib. | |
MX344103B (es) | Vacunas de virus herpes vectorizado con virus de enfermedad de newcastle. | |
MX2017005661A (es) | Celulas de mamifero que expresan antigenos de citomegalovirus. | |
WO2015134368A3 (en) | Recombinant herpes simplex virus 2 (hsv-2) vaccine vectors | |
PH12020551716A1 (en) | Anti-ror antibody constructs | |
MX2020004094A (es) | Metodos para administrar inmunoterapia con receptores de antigeno quimerico. | |
JOP20190088A1 (ar) | نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها | |
TN2014000518A1 (en) | Reassortant btv and ahsv vaccines | |
MX2018015756A (es) | Construcciones de virus de la enfermedad de marek recombinantes no patogenicas codificadoras de antigenos del virus de la laringotraqueitis infecciosa y del virus de la enfermedad bursal infecciosa. | |
MX2019004183A (es) | Secuencia de nucleotidos que expresa una proteina de anclaje a exosoma para su uso como vacuna. | |
MA40624A (fr) | Antigènes supérieurs du papillomavirus présentant des propriétés immunologiques supérieures et vaccin les contenant | |
MX2011004219A (es) | Vacuna contra el virus de la peste equina africana. | |
MX2017009889A (es) | Vacuna a base del citomegalovirus, expresando la glicoproteína del virus del ébola. | |
CA3045626A1 (en) | Bovine herpesvirus type 1 (bohv-1) vector against bovine respiratory disease complex | |
MX351642B (es) | Vacuna para virus de leucemia felina recombinante que contiene gen de envoltura del virus de leucemia felina optimizado. | |
IL282465A (en) | Assemble 4/91 IBV with heterologous spike protein | |
PH12018500372A1 (en) | Fcv recombinant vaccines and uses thereof | |
MX2020008779A (es) | Sistemas de vectores virales recombinantes que expresan genes de paramixovirus felino exogenos y vacunas elaboradas a partir de estos. | |
AR113755A1 (es) | Constructos de virus de la enfermedad de marek no patógenos recombinantes que codifican antígenos heterólogos múltiples |