MX2020002882A - Fosforamiditas de nucleósido modificado. - Google Patents

Fosforamiditas de nucleósido modificado.

Info

Publication number
MX2020002882A
MX2020002882A MX2020002882A MX2020002882A MX2020002882A MX 2020002882 A MX2020002882 A MX 2020002882A MX 2020002882 A MX2020002882 A MX 2020002882A MX 2020002882 A MX2020002882 A MX 2020002882A MX 2020002882 A MX2020002882 A MX 2020002882A
Authority
MX
Mexico
Prior art keywords
modified nucleoside
nucleoside phosphoramidites
phosphoramidites
formulae
substituents
Prior art date
Application number
MX2020002882A
Other languages
English (en)
Inventor
Sergei Gryaznov
Jin Hong
Vivek Kumar Rajwanshi
Original Assignee
Janssen Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biopharma Inc filed Critical Janssen Biopharma Inc
Publication of MX2020002882A publication Critical patent/MX2020002882A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente descripción se relaciona con compuestos y composiciones que contienen monómeros de nucleósidos de 5'-fosforamidita de las Fórmulas (I) y (II), y métodos para elaborarlos y usarlos, en donde los sustituyentes son como se definen en las reivindicaciones anexas.
MX2020002882A 2017-09-14 2018-09-14 Fosforamiditas de nucleósido modificado. MX2020002882A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762558763P 2017-09-14 2017-09-14
PCT/IB2018/057077 WO2019053659A1 (en) 2017-09-14 2018-09-14 PHOSPHORAMIDITES OF MODIFIED NUCLEOSIDES

Publications (1)

Publication Number Publication Date
MX2020002882A true MX2020002882A (es) 2020-10-05

Family

ID=63713969

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002882A MX2020002882A (es) 2017-09-14 2018-09-14 Fosforamiditas de nucleósido modificado.

Country Status (16)

Country Link
US (1) US11180524B2 (es)
EP (1) EP3681894A1 (es)
JP (2) JP7478660B2 (es)
KR (1) KR20200100033A (es)
CN (1) CN111465610A (es)
AU (1) AU2018332214B2 (es)
BR (1) BR112020005067A2 (es)
CA (1) CA3075718A1 (es)
CL (2) CL2020000657A1 (es)
EA (1) EA202090719A1 (es)
IL (2) IL303486A (es)
MX (1) MX2020002882A (es)
PH (1) PH12020550127A1 (es)
SG (1) SG11202002294VA (es)
UA (1) UA127737C2 (es)
WO (1) WO2019053659A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114685560B (zh) * 2020-12-31 2024-05-14 沈阳药科大学 含哌啶骨架亚磷酰胺单体及寡聚核苷酸的合成和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001018015A1 (en) * 1999-09-10 2001-03-15 Geron Corporation Oligonucleotide n3'→p5' thiophosphoramidates: their synthesis and use
US20020127598A1 (en) * 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
JP4255227B2 (ja) * 2000-11-21 2009-04-15 武 今西 Ｎ３’−ｐ５’結合を有する２’，４’−ｂｎａオリゴヌクレオチド
US9133233B2 (en) * 2003-11-04 2015-09-15 Geron Corporation RNA amidates and thioamidates for RNAi
US8138330B2 (en) * 2006-09-11 2012-03-20 Sigma-Aldrich Co. Llc Process for the synthesis of oligonucleotides
WO2010027512A2 (en) * 2008-09-06 2010-03-11 Chemgenes Corporation Rna synthesis - phosphoramidites for synthetic rna in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic rna at the 3' - end
US8541569B2 (en) 2008-09-06 2013-09-24 Chemgenes Corporation Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
US9725479B2 (en) * 2010-04-22 2017-08-08 Ionis Pharmaceuticals, Inc. 5′-end derivatives
MY194058A (en) 2016-01-11 2022-11-10 Innate Tumor Immunity Inc Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
BR112019004911A2 (pt) * 2016-09-14 2019-06-25 Janssen Biopharma Inc oligonucleotídeos modificados e métodos de uso

Also Published As

Publication number Publication date
IL303486A (en) 2023-08-01
CL2021000381A1 (es) 2021-07-02
JP2024054157A (ja) 2024-04-16
JP7478660B2 (ja) 2024-05-07
AU2018332214A8 (en) 2021-10-07
AU2018332214B2 (en) 2023-11-02
WO2019053659A1 (en) 2019-03-21
PH12020550127A1 (en) 2021-02-08
EP3681894A1 (en) 2020-07-22
US20200255468A1 (en) 2020-08-13
IL273274A (en) 2020-04-30
CN111465610A (zh) 2020-07-28
US11180524B2 (en) 2021-11-23
IL273274B1 (en) 2023-08-01
BR112020005067A2 (pt) 2020-09-15
IL273274B2 (en) 2023-12-01
SG11202002294VA (en) 2020-04-29
US20220048941A1 (en) 2022-02-17
CL2020000657A1 (es) 2020-10-23
AU2018332214A1 (en) 2020-04-02
KR20200100033A (ko) 2020-08-25
UA127737C2 (uk) 2023-12-20
EA202090719A1 (ru) 2020-07-01
CA3075718A1 (en) 2019-03-21
JP2020533387A (ja) 2020-11-19

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