MX2019007891A - Sales de oxalato de tianeptina y polimorfos. - Google Patents
Sales de oxalato de tianeptina y polimorfos.Info
- Publication number
- MX2019007891A MX2019007891A MX2019007891A MX2019007891A MX2019007891A MX 2019007891 A MX2019007891 A MX 2019007891A MX 2019007891 A MX2019007891 A MX 2019007891A MX 2019007891 A MX2019007891 A MX 2019007891A MX 2019007891 A MX2019007891 A MX 2019007891A
- Authority
- MX
- Mexico
- Prior art keywords
- polymorphs
- tianeptine
- oxalate salts
- tianeptine oxalate
- oxalate
- Prior art date
Links
- 229960005138 tianeptine Drugs 0.000 title abstract 3
- -1 Tianeptine oxalate salts Chemical class 0.000 title 1
- JICJBGPOMZQUBB-UHFFFAOYSA-N 7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid Chemical compound O=S1(=O)N(C)C2=CC=CC=C2C(NCCCCCCC(O)=O)C2=CC=C(Cl)C=C21 JICJBGPOMZQUBB-UHFFFAOYSA-N 0.000 abstract 2
- ZTHVLZXTYSAELD-UHFFFAOYSA-N 7-[(3-chloro-6-methyl-11h-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid Chemical compound CN1SC2=CC(Cl)=CC=C2C(NCCCCCCC(O)=O)C2=CC=CC=C12 ZTHVLZXTYSAELD-UHFFFAOYSA-N 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 150000003891 oxalate salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662439533P | 2016-12-28 | 2016-12-28 | |
| PCT/IB2017/001709 WO2018122606A1 (en) | 2016-12-28 | 2017-12-28 | Tianeptine oxalate salts and polymorphs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019007891A true MX2019007891A (es) | 2019-12-16 |
Family
ID=61283255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019007891A MX2019007891A (es) | 2016-12-28 | 2017-12-28 | Sales de oxalato de tianeptina y polimorfos. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10449203B2 (https=) |
| EP (1) | EP3562812A1 (https=) |
| JP (2) | JP2020503330A (https=) |
| CN (1) | CN110418785A (https=) |
| AU (1) | AU2017385958B2 (https=) |
| BR (1) | BR112019013244A2 (https=) |
| CA (1) | CA3048324A1 (https=) |
| IL (1) | IL267708A (https=) |
| MX (1) | MX2019007891A (https=) |
| MY (1) | MY199385A (https=) |
| NZ (1) | NZ754797A (https=) |
| WO (1) | WO2018122606A1 (https=) |
| ZA (1) | ZA201904185B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10449203B2 (en) * | 2016-12-28 | 2019-10-22 | Tonix Pharma Holdings Limited | Tianeptine oxalate salts and polymorphs |
| US20240165126A1 (en) | 2021-03-15 | 2024-05-23 | Tonix Pharmaceuticals Holding Corp. | Tianeptine oxalate and naloxone combination for the treatment of major depressive disorder |
| EP4337638A1 (en) * | 2021-05-11 | 2024-03-20 | Astex Pharmaceuticals, Inc. | Solid forms of salts of 4-[5-[(3s)-3-aminopyrrolidine-1-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-ethylpropyl)phenyl]phenyl]-2-fluoro-benzonitrile |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3758528A (en) * | 1970-03-13 | 1973-09-11 | Science Union & Cie | Tricyclic compounds |
| FR2635461B1 (fr) * | 1988-08-18 | 1992-01-17 | Adir | Utilisation de derives tricycliques pour l'obtention de medicaments destines au traitement du stress |
| US5405842A (en) | 1994-01-28 | 1995-04-11 | Silverman; Bernard A. | Treatment of steroid dependent asthmatics |
| FR2791891A1 (fr) | 1999-04-07 | 2000-10-13 | Adir | Utilisation de la tianeptine pour l'obtention de medicaments destines au traitement des pathologies de la neurodegenerescence |
| TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| US9314469B2 (en) | 2008-05-05 | 2016-04-19 | Tonix Pharma Holdings Limited | Method for treating neurocognitive dysfunction |
| US8198268B2 (en) * | 2008-10-31 | 2012-06-12 | Janssen Biotech, Inc. | Tianeptine sulfate salt forms and methods of making and using the same |
| US10449203B2 (en) * | 2016-12-28 | 2019-10-22 | Tonix Pharma Holdings Limited | Tianeptine oxalate salts and polymorphs |
-
2017
- 2017-12-28 US US15/856,818 patent/US10449203B2/en active Active
- 2017-12-28 EP EP17844642.3A patent/EP3562812A1/en not_active Withdrawn
- 2017-12-28 CA CA3048324A patent/CA3048324A1/en active Pending
- 2017-12-28 NZ NZ754797A patent/NZ754797A/en not_active IP Right Cessation
- 2017-12-28 AU AU2017385958A patent/AU2017385958B2/en not_active Ceased
- 2017-12-28 BR BR112019013244A patent/BR112019013244A2/pt not_active IP Right Cessation
- 2017-12-28 WO PCT/IB2017/001709 patent/WO2018122606A1/en not_active Ceased
- 2017-12-28 MY MYPI2019003711A patent/MY199385A/en unknown
- 2017-12-28 CN CN201780085697.9A patent/CN110418785A/zh active Pending
- 2017-12-28 MX MX2019007891A patent/MX2019007891A/es unknown
- 2017-12-28 JP JP2019535330A patent/JP2020503330A/ja active Pending
-
2019
- 2019-06-26 ZA ZA2019/04185A patent/ZA201904185B/en unknown
- 2019-06-27 IL IL267708A patent/IL267708A/en unknown
- 2019-10-09 US US16/597,065 patent/US10946027B2/en active Active
-
2022
- 2022-11-10 JP JP2022180549A patent/JP2023001340A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10449203B2 (en) | 2019-10-22 |
| CN110418785A (zh) | 2019-11-05 |
| CA3048324A1 (en) | 2018-07-05 |
| MY199385A (en) | 2023-10-25 |
| ZA201904185B (en) | 2021-10-27 |
| NZ754797A (en) | 2022-05-27 |
| WO2018122606A1 (en) | 2018-07-05 |
| BR112019013244A2 (pt) | 2019-12-24 |
| AU2017385958B2 (en) | 2021-12-02 |
| JP2020503330A (ja) | 2020-01-30 |
| JP2023001340A (ja) | 2023-01-04 |
| US20200276208A1 (en) | 2020-09-03 |
| US10946027B2 (en) | 2021-03-16 |
| IL267708A (en) | 2019-08-29 |
| AU2017385958A1 (en) | 2019-07-11 |
| EP3562812A1 (en) | 2019-11-06 |
| US20180338984A1 (en) | 2018-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12019501321B1 (en) | Use of pyrazolopyrimidine derivatives for the treatment of pi3k-delta related disorders | |
| UY35683A (es) | Polimorfo de inhibidores de tirosina quinasa de bazo (syk) | |
| GEP20207105B (en) | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors | |
| ZA201804870B (en) | Acid addition salts of piperazine derivatives | |
| PH12017502171B1 (en) | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | |
| MX354021B (es) | Derivados de 5-fluor-4-imino-3- (sustituido) -3,4-dihidropirimidin -2 (1h) ona. | |
| GEP20166474B (en) | Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors | |
| SG10201804791UA (en) | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof | |
| PH12015502018A1 (en) | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh | |
| CL2017002179A1 (es) | Sales de inhibidor de pi3k y procesos de preparación | |
| PH12016501977A1 (en) | 2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES | |
| EA201591804A1 (ru) | Производные 2-((4-амино-3-(3-фтор-5-гидроксифенил)-1h-пиразоло[3,4-d]пиримидин-1-ил)метил)-3-(2-(трифторметил)бензил)хиназолин-4(3h)-она и их применение в качестве ингибиторов фосфоинозитид-3-киназы | |
| NZ711343A (en) | Sodium salt of (2s, 5r)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1 ] octane-2-carboxylic acid and its preparation | |
| MX359673B (es) | Preparacion de intermediarios de pirimidina utiles para la preparacion de maci tentano. | |
| MX2019007891A (es) | Sales de oxalato de tianeptina y polimorfos. | |
| DK3083627T3 (da) | [1,2,4]triazol[1,5-a]pyrimidinderivater som protozoiske proteasominhibitorer til behandling af parasitsygdomme, såsom leishmaniasis | |
| CA2922375C (en) | Alpha-tea salt forms: compositions and uses for treating disease | |
| JOP20170164A1 (ar) | مشتق ترايازولو بيرازينون مفيد كمثبط لـ pde1 بشري | |
| AR092772A1 (es) | Derivado de 7-azaindol | |
| MX2016010564A (es) | Procesos para preparar moduladores del canal ionico heterociclico fusionado. | |
| BR112017007027A2 (pt) | melhorias nos compostos orgânicos ou relativas aos mesmos | |
| BR112017004166A2 (pt) | sal de derivado de cefalosporina, forma sólida cristalina do mesmo e método para produzir o mesmo | |
| BR112015017919A8 (pt) | preparação líquida aquosa e método para clarificar uma preparação líquida aquosa | |
| WO2014167509A3 (en) | Loxoprofen polymorphs and process for preparation of the same | |
| MX2017003415A (es) | Un derivado de tetrahidropirrolo [3,4-d] [1,3]tiazina como inhibidor de bace. |