MX2018016417A - Proteinas de fusion tatk-cdkl5, composiciones, formulaciones y uso de las mismas. - Google Patents
Proteinas de fusion tatk-cdkl5, composiciones, formulaciones y uso de las mismas.Info
- Publication number
- MX2018016417A MX2018016417A MX2018016417A MX2018016417A MX2018016417A MX 2018016417 A MX2018016417 A MX 2018016417A MX 2018016417 A MX2018016417 A MX 2018016417A MX 2018016417 A MX2018016417 A MX 2018016417A MX 2018016417 A MX2018016417 A MX 2018016417A
- Authority
- MX
- Mexico
- Prior art keywords
- tatä
- cdkl5
- fusion proteins
- compositions
- formulations
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11022—Cyclin-dependent kinase (2.7.11.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11023—[RNA-polymerase-subunit] kinase (2.7.11.23)
Abstract
En el presente documento se describen composiciones y formulaciones que contienen una proteína de fusión TATK-CDKL5. También se desvelan métodos de producción de una proteína de fusión TATK-CDKL5 de vectores que contienen un ADNc de TATK-CDKL5 y métodos de transducción de células con los vectores que contienen un ADNc de TATK-CDKL5 y la proteína de fusión TATK-CDKL5. También se desvelan los usos de las proteínas de fusión TATK-CDKL5 para tratar deficiencias en CDKL5 por administración sistémica o intravenosa de las proteínas de fusión.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662355579P | 2016-06-28 | 2016-06-28 | |
US201662381886P | 2016-08-31 | 2016-08-31 | |
PCT/US2017/039692 WO2018005617A2 (en) | 2016-06-28 | 2017-06-28 | TATĸ-CDKL5 FUSION PROTEINS, COMPOSITIONS, FORMULATIONS, AND USE THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018016417A true MX2018016417A (es) | 2019-09-09 |
Family
ID=60787683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018016417A MX2018016417A (es) | 2016-06-28 | 2017-06-28 | Proteinas de fusion tatk-cdkl5, composiciones, formulaciones y uso de las mismas. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20210268072A1 (es) |
EP (1) | EP3475418A4 (es) |
JP (1) | JP2019522989A (es) |
KR (1) | KR20190034546A (es) |
CN (1) | CN109844109A (es) |
AU (1) | AU2017290047A1 (es) |
BR (1) | BR112018077225A2 (es) |
CA (1) | CA3029473A1 (es) |
IL (1) | IL263842A (es) |
MX (1) | MX2018016417A (es) |
TW (1) | TW201803893A (es) |
WO (1) | WO2018005617A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2020345943A1 (en) | 2019-09-10 | 2022-03-31 | Obsidian Therapeutics, Inc. | CA2-IL15 fusion proteins for tunable regulation |
CN114901802A (zh) * | 2019-10-30 | 2022-08-12 | 阿米库斯治疗学公司 | 重组cdkl5蛋白、基因疗法和生产方法 |
IL303239A (en) | 2020-12-01 | 2023-07-01 | Univ Pennsylvania | Compositions and their uses for the treatment of Engelmann syndrome |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100489101C (zh) * | 2006-12-19 | 2009-05-20 | 浙江大学 | G-eGFP蛋白及其制备方法与应用 |
CN101704893A (zh) * | 2009-11-02 | 2010-05-12 | 江苏大学 | 带穿膜序列的人Scurfin蛋白全长及片段以及制备方法 |
AU2015221860B2 (en) * | 2014-02-28 | 2019-09-12 | Alma Mater Studiorum-Universita Di Bologna | TATk-CDKL5 fusion proteins, compositions, formulations, and use thereof |
WO2017153834A1 (en) * | 2016-03-10 | 2017-09-14 | Alma Mater Studiorum - Universitá Di Bologna | TREATMENT OF CDKL5 DISORDERS WITH GSK3β INHIBITOR TIDEGLUSIB |
-
2017
- 2017-06-28 CA CA3029473A patent/CA3029473A1/en active Pending
- 2017-06-28 EP EP17821132.2A patent/EP3475418A4/en active Pending
- 2017-06-28 BR BR112018077225-9A patent/BR112018077225A2/pt not_active Application Discontinuation
- 2017-06-28 KR KR1020197002667A patent/KR20190034546A/ko unknown
- 2017-06-28 WO PCT/US2017/039692 patent/WO2018005617A2/en unknown
- 2017-06-28 TW TW106121604A patent/TW201803893A/zh unknown
- 2017-06-28 US US16/314,145 patent/US20210268072A1/en active Pending
- 2017-06-28 MX MX2018016417A patent/MX2018016417A/es unknown
- 2017-06-28 AU AU2017290047A patent/AU2017290047A1/en not_active Abandoned
- 2017-06-28 CN CN201780040913.8A patent/CN109844109A/zh active Pending
- 2017-06-28 JP JP2018568751A patent/JP2019522989A/ja active Pending
-
2018
- 2018-12-19 IL IL263842A patent/IL263842A/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW201803893A (zh) | 2018-02-01 |
AU2017290047A1 (en) | 2019-01-17 |
EP3475418A4 (en) | 2020-03-04 |
JP2019522989A (ja) | 2019-08-22 |
CN109844109A (zh) | 2019-06-04 |
US20210268072A1 (en) | 2021-09-02 |
WO2018005617A2 (en) | 2018-01-04 |
WO2018005617A3 (en) | 2018-02-08 |
KR20190034546A (ko) | 2019-04-02 |
IL263842A (en) | 2019-01-31 |
BR112018077225A2 (pt) | 2019-04-09 |
EP3475418A2 (en) | 2019-05-01 |
CA3029473A1 (en) | 2018-01-04 |
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