MX2018009406A - Conjugados de glucosa de triptolido, analogos y usos de los mismos. - Google Patents

Conjugados de glucosa de triptolido, analogos y usos de los mismos.

Info

Publication number
MX2018009406A
MX2018009406A MX2018009406A MX2018009406A MX2018009406A MX 2018009406 A MX2018009406 A MX 2018009406A MX 2018009406 A MX2018009406 A MX 2018009406A MX 2018009406 A MX2018009406 A MX 2018009406A MX 2018009406 A MX2018009406 A MX 2018009406A
Authority
MX
Mexico
Prior art keywords
triptolide
analogs
glucose
compounds
glucose conjugates
Prior art date
Application number
MX2018009406A
Other languages
English (en)
Spanish (es)
Inventor
Liu Jun
He Qingli
G Pomper Martin
MINN Li
Yu Biao
Wang Qiaoling
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of MX2018009406A publication Critical patent/MX2018009406A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J73/00Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
MX2018009406A 2016-02-04 2017-02-03 Conjugados de glucosa de triptolido, analogos y usos de los mismos. MX2018009406A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662291416P 2016-02-04 2016-02-04
PCT/US2017/016527 WO2017136739A1 (en) 2016-02-04 2017-02-03 Glucose conjugates of triptolide, analogs and uses thereof

Publications (1)

Publication Number Publication Date
MX2018009406A true MX2018009406A (es) 2018-11-09

Family

ID=59500284

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018009406A MX2018009406A (es) 2016-02-04 2017-02-03 Conjugados de glucosa de triptolido, analogos y usos de los mismos.

Country Status (8)

Country Link
US (2) US10695319B2 (enExample)
EP (1) EP3411121B1 (enExample)
JP (1) JP7042744B2 (enExample)
CN (1) CN108601952B (enExample)
AU (1) AU2017214572A1 (enExample)
CA (1) CA3013619A1 (enExample)
MX (1) MX2018009406A (enExample)
WO (1) WO2017136739A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109942665B (zh) * 2018-04-02 2021-04-06 欣凯医药化工中间体(上海)有限公司 雷公藤内酯醇衍生物及其制备方法和应用
CN109897053B (zh) * 2019-03-28 2020-05-29 中国医学科学院医药生物技术研究所 雷斯吲哚甲及其制备方法和抗丙型肝炎病毒用途
CN111040018A (zh) * 2019-12-30 2020-04-21 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 丙烯酸雷公藤甲素酯、其制备方法及其应用
EP4086271B1 (en) 2019-12-30 2023-12-13 Guangdong Provincial Hospital of TCM Triptolide acrylate, preparation method therefor and use thereof
EP4114468A4 (en) * 2020-03-02 2025-04-09 The Johns Hopkins University GLUCOSETRIPTOLIDE CONJUGATES AND USES THEREOF
JP2023538424A (ja) * 2020-08-21 2023-09-07 ルヤン コーポレイション トリプトリドコンジュゲートおよびその使用
CN115286684A (zh) * 2022-05-20 2022-11-04 福建医科大学 一种糖与雷公藤内酯醇或其衍生物的缀合物及其制备方法与应用
ES3035530T3 (en) 2023-03-09 2025-09-04 Minneamrita Therapeutics Llc Drug combination for the treatment of stomach cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218367B1 (en) * 1998-09-15 2001-04-17 Organomed Corporation Paclitaxel-carbohydrate conjugates: design, synthesis and biological evaluations
US6620843B2 (en) 2001-01-19 2003-09-16 Pharmagenesis Anticancer treatment using triptolide prodrugs
CA2448795A1 (en) 2001-03-15 2002-09-26 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agent
US9150600B2 (en) * 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs

Also Published As

Publication number Publication date
JP2019509986A (ja) 2019-04-11
US20200297693A1 (en) 2020-09-24
EP3411121A1 (en) 2018-12-12
CA3013619A1 (en) 2017-08-10
CN108601952A (zh) 2018-09-28
CN108601952B (zh) 2022-03-04
EP3411121A4 (en) 2019-12-18
EP3411121B1 (en) 2024-09-11
US10695319B2 (en) 2020-06-30
AU2017214572A1 (en) 2018-08-16
JP7042744B2 (ja) 2022-03-28
WO2017136739A1 (en) 2017-08-10
US20190038596A1 (en) 2019-02-07

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