MX2017013896A - Pharmaceutical composition for oral administration. - Google Patents

Pharmaceutical composition for oral administration.

Info

Publication number
MX2017013896A
MX2017013896A MX2017013896A MX2017013896A MX2017013896A MX 2017013896 A MX2017013896 A MX 2017013896A MX 2017013896 A MX2017013896 A MX 2017013896A MX 2017013896 A MX2017013896 A MX 2017013896A MX 2017013896 A MX2017013896 A MX 2017013896A
Authority
MX
Mexico
Prior art keywords
pharmaceutical composition
oral administration
solubility
ethylpyrrolidin
pyrazin
Prior art date
Application number
MX2017013896A
Other languages
Spanish (es)
Inventor
Sakai Toshiro
Nishimura Koji
Suda Yumiko
Kojima Ryo
Oyama Dai
Naiki Kumi
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2017013896A publication Critical patent/MX2017013896A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4- methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2- yl)carbamoyl]pyrazin-2-yl}piperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the medicinal substance are improved.
MX2017013896A 2015-04-28 2016-04-27 Pharmaceutical composition for oral administration. MX2017013896A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015092005 2015-04-28
PCT/JP2016/063151 WO2016175230A1 (en) 2015-04-28 2016-04-27 Pharmaceutical composition for oral administration

Publications (1)

Publication Number Publication Date
MX2017013896A true MX2017013896A (en) 2018-03-15

Family

ID=57198463

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017013896A MX2017013896A (en) 2015-04-28 2016-04-27 Pharmaceutical composition for oral administration.

Country Status (9)

Country Link
US (1) US10583087B2 (en)
EP (1) EP3290037A4 (en)
JP (1) JP6680297B2 (en)
CN (1) CN107530342A (en)
HK (1) HK1245646A1 (en)
MX (1) MX2017013896A (en)
PH (1) PH12017501831A1 (en)
TW (1) TW201713343A (en)
WO (1) WO2016175230A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA47106A (en) 2016-12-21 2019-10-30 Amgen Inc ANTI-TNF ALPHA ANTIBODY FORMULATIONS
WO2019172420A1 (en) * 2018-03-09 2019-09-12 協和発酵キリン株式会社 Pharmaceutical composition
HUE068695T2 (en) 2018-05-08 2025-01-28 Nippon Shinyaku Co Ltd Azabenzimidazole compounds and pharmaceutical
EA202191372A1 (en) * 2018-12-14 2021-09-16 Фуджифилм Корпорэйшн TABLET AND METHOD FOR OBTAINING TABLETS
WO2022004859A1 (en) * 2020-07-02 2022-01-06 ＡＲＴｈａｍ Ｔｈｅｒａｐｅｕｔｉｃｓ株式会社 Oral pharmaceutical composition and method for producing same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW486370B (en) * 1996-12-25 2002-05-11 Yamanouchi Pharma Co Ltd Rapidly disintegrable pharmaceutical composition
CA2552766C (en) 2004-11-23 2010-08-17 Dong Wha Pharmaceutical Ind. Co., Ltd. N-hydroxy-4- {5- [4- (5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy} benzamidine bis(methanesulfonate)
CN101299993A (en) 2005-11-04 2008-11-05 伊士曼化工公司 Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents
AR068986A1 (en) * 2007-10-12 2009-12-23 Novartis Ag COMPOSITIONS THAT INCLUDE MODULATORS OF THE SPHINGOSINE-1 PHOSPHATE RECEIVER (S1P)
DK2593081T3 (en) * 2010-07-15 2014-06-10 Tedec Meiji Farma S A Ferrimannitol ovalbumin tablet formulation
TWI564008B (en) 2010-09-30 2017-01-01 鹽野義製藥股份有限公司 Formulation for solubility enhancement of poorly soluble drugs
TWI647227B (en) 2013-02-28 2019-01-11 日商安斯泰來製藥股份有限公司 2-guanamine thiazole derivative or a salt thereof

Also Published As

Publication number Publication date
US10583087B2 (en) 2020-03-10
TW201713343A (en) 2017-04-16
US20180116965A1 (en) 2018-05-03
PH12017501831A1 (en) 2018-04-23
EP3290037A1 (en) 2018-03-07
JP6680297B2 (en) 2020-04-15
JPWO2016175230A1 (en) 2018-02-22
CN107530342A (en) 2018-01-02
WO2016175230A1 (en) 2016-11-03
EP3290037A4 (en) 2019-01-23
HK1245646A1 (en) 2018-08-31

Similar Documents

Publication Publication Date Title
PH12017501831A1 (en) Pharmaceutical compositions for oral administration
PH12016501310A1 (en) Pharmaceutical compositions comprising azd9291
SG194756A1 (en) Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids
MX2021004110A (en) Pharmaceutical compositions comprising n-(3,5-dimethoxyphenyl)-n' -(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl] ethane-1,2-diamine.
EP4516353A3 (en) Pharmaceutical compositions comprising (2s)-{(1s)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide
EA201792592A1 (en) PHARMACEUTICAL PREPARATIONS CONTAINING TENOFOVIR AND EMTRICITABIN
JP2015510916A5 (en)
PE20170773A1 (en) PHARMACEUTICAL FORMULATIONS, PROCESSES FOR THE PREPARATION, AND METHODS OF USE
MY206893A (en) Formulation having improved ph-dependent drug-release characteristics, containing esomeprazole or pharmaceutically acceptable salt thereof
PH12017502252B1 (en) Stable pharmaceutical composition for oral administration
MX387639B (en) PHARMACEUTICAL FORMULATIONS OF PYRIDINIUM COMPOUND AND A PERMEABILITY ENHANCER OR A BASE.
MX2020002432A (en) Pharmaceutical composition.
WO2013188465A3 (en) Treating drug addiction and preventing drug relapse
MX2016017402A (en) Pharmaceutical composition for oral administration.
MD20170094A2 (en) Process for manufacturing dry powder blends
MY182781A (en) Stabilized desmopressin
TN2013000440A1 (en) Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids
TH177974A (en) Pharmaceutical components for oral administration
RU2764750C3 (en) STABLE PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION
EA201791798A1 (en) PHARMACEUTICAL COMPOSITIONS INCLUDING N- (3,5-DIMETOXIPHENYL) -N '- (1-METHYLETHYL) -N- [3- (1-METHYL-1H-PYRAZOL-4-IL) CHINOXALIN-6-IL] ETAN-1 , 2-DIAMOND
TH167761A (en) Pharmaceutical components for oral administration
HK1257509A1 (en) Pulsatile release pharmaceutical composition comprising naftazone or one of its salts
UA97982U (en) DRESSING MEDICINE FOR TABLETS