MX2016003035A - Preparacion de 3-fluoropropil-nor-beta-cit radioyodado. - Google Patents

Preparacion de 3-fluoropropil-nor-beta-cit radioyodado.

Info

Publication number
MX2016003035A
MX2016003035A MX2016003035A MX2016003035A MX2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A
Authority
MX
Mexico
Prior art keywords
fluoropropyl
radioiodinated
cit
preparation
beta
Prior art date
Application number
MX2016003035A
Other languages
English (en)
Inventor
Edmund C Hudson
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of MX2016003035A publication Critical patent/MX2016003035A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona generalmente procesos para la preparación de 3-fluoropropil-nor-ß-CIT radioyodado. En particular, el proceso usa un intermediario de arilsilano, evitando así el uso de hexametildiestaño y reduciendo la cantidad de pasos previamente necesarios para la preparación de 3-fluoropropil-nor-ß-CIT radioyodado a partir de anhidroecgonina metiléster. La invención también se refiere a la alquilación de un nortropano al análogo de N-(3-fluoropropil) correspondiente usando 3-fluoropropanal.
MX2016003035A 2013-09-25 2014-09-25 Preparacion de 3-fluoropropil-nor-beta-cit radioyodado. MX2016003035A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361882039P 2013-09-25 2013-09-25
PCT/US2014/057404 WO2015048250A1 (en) 2013-09-25 2014-09-25 Preparation of radioiodinated 3-fluoropropyl-nor-beta-cit

Publications (1)

Publication Number Publication Date
MX2016003035A true MX2016003035A (es) 2016-06-10

Family

ID=52691501

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016003035A MX2016003035A (es) 2013-09-25 2014-09-25 Preparacion de 3-fluoropropil-nor-beta-cit radioyodado.

Country Status (11)

Country Link
US (1) US9339565B2 (es)
EP (1) EP3049378B1 (es)
JP (2) JP6224256B2 (es)
AU (1) AU2014326601B2 (es)
BR (1) BR112016006129A2 (es)
CA (1) CA2922723C (es)
ES (1) ES2711122T3 (es)
MX (1) MX2016003035A (es)
PL (1) PL3049378T3 (es)
TR (1) TR201901758T4 (es)
WO (1) WO2015048250A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2578588C2 (ru) 2010-05-12 2016-03-27 Нестек С.А. Подложка, капсула для приготовления напитков центрифугированием, система и способ приготовления напитка центрифугированием
US9513907B2 (en) * 2013-08-06 2016-12-06 Intel Corporation Methods, apparatus, instructions and logic to provide vector population count functionality
AU2016267059B2 (en) 2015-05-22 2020-08-13 Translational Drug Development Llc Benzamide and active compound compositions and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190601A (en) * 1978-05-31 1980-02-26 Union Carbide Corporation Production of tertiary amines by reductive alkylation
US6123917A (en) 1990-08-09 2000-09-26 Research Triangle Institute Method for making cocaine receptor binding ligands and intermediates therefor
US5698179A (en) * 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
EP0946204A1 (en) * 1996-10-29 1999-10-06 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
FI104048B (fi) * 1997-06-16 1999-11-15 Map Medical Technologies Oy Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön
CA2721484A1 (en) 1999-05-12 2000-11-12 President And Fellows Of Harvard College Dopamine transporter imaging agents
JP2001213881A (ja) 2000-02-02 2001-08-07 Nihon Medi Physics Co Ltd アンヒドロエクゴニン誘導体の合成法
AU2004278158B2 (en) * 2003-10-03 2009-08-13 Pfizer Inc. Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflammation
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
EP2214722A1 (en) * 2007-11-07 2010-08-11 GE Healthcare BV Stabilization of radiopharmaceuticals
AU2010216150B2 (en) * 2009-02-17 2015-05-14 Mallinckrodt Llc Process for the reductive alkylation of normorphinans
GB0922023D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Preparation of n-monofluoroalkyl compounds

Also Published As

Publication number Publication date
BR112016006129A2 (pt) 2017-08-01
EP3049378A4 (en) 2017-04-19
US9339565B2 (en) 2016-05-17
PL3049378T3 (pl) 2019-06-28
CA2922723C (en) 2022-04-19
AU2014326601A1 (en) 2016-03-17
CA2922723A1 (en) 2015-04-02
WO2015048250A1 (en) 2015-04-02
ES2711122T3 (es) 2019-04-30
JP2016533390A (ja) 2016-10-27
AU2014326601B2 (en) 2018-01-18
TR201901758T4 (tr) 2019-03-21
EP3049378A1 (en) 2016-08-03
EP3049378B1 (en) 2018-12-05
JP6224256B2 (ja) 2017-11-01
JP6423936B2 (ja) 2018-11-14
US20150087838A1 (en) 2015-03-26
JP2017218460A (ja) 2017-12-14

Similar Documents

Publication Publication Date Title
IL241046A0 (en) Fertilizer composition and method for its preparation
MA40386A (fr) Procédé de préparation de cabozantinib marqué au fluor-18 et d'analogues de celui-ci
PH12016501414A1 (en) Long-acting insulin and use thereof
MX365494B (es) Procedimiento de compuesto antifungico.
MX370649B (es) Proceso para la preparacion de teneligliptina.
MX369357B (es) Procedimiento de compuesto antifungico.
IN2015KN00323A (es)
MX2021007245A (es) Microorganismos para la produccion de putrescina u ornitina y procedimiento para la produccion de putrescina u ornitina usando los mismos.
PL3334805T3 (pl) Proces formulacji paliwa
MX2014010433A (es) Nueva forma cristalina de sulfato de sitagliptina.
IN2013MU00646A (es)
PH12020550871A1 (en) Process for the preparation of opicapone and intermediates thereof
GEP201706626B (en) Synthesis of (s)-nifuratel
IN2013MU03070A (es)
IN2013CH04906A (es)
MX2016003035A (es) Preparacion de 3-fluoropropil-nor-beta-cit radioyodado.
ZA202109307B (en) Methods relating to tuberculosis
MX369174B (es) Proceso para la preparación de un compuesto.
GB201905004D0 (en) Improvements relating to fasteners for clothing
MX2015011881A (es) Proceso para la preparacion de 3,7-dimetilnonan-1-ol.
IN2013CH05865A (es)
IN2013MU01501A (es)
IN2014DN06536A (es)
IN2014MN01941A (es)
PH12016501994A1 (en) Novel crystal of doripenem, and preparation method therefor