MX2016003035A - Preparacion de 3-fluoropropil-nor-beta-cit radioyodado. - Google Patents
Preparacion de 3-fluoropropil-nor-beta-cit radioyodado.Info
- Publication number
- MX2016003035A MX2016003035A MX2016003035A MX2016003035A MX2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A
- Authority
- MX
- Mexico
- Prior art keywords
- fluoropropyl
- radioiodinated
- cit
- preparation
- beta
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención proporciona generalmente procesos para la preparación de 3-fluoropropil-nor-ß-CIT radioyodado. En particular, el proceso usa un intermediario de arilsilano, evitando así el uso de hexametildiestaño y reduciendo la cantidad de pasos previamente necesarios para la preparación de 3-fluoropropil-nor-ß-CIT radioyodado a partir de anhidroecgonina metiléster. La invención también se refiere a la alquilación de un nortropano al análogo de N-(3-fluoropropil) correspondiente usando 3-fluoropropanal.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361882039P | 2013-09-25 | 2013-09-25 | |
PCT/US2014/057404 WO2015048250A1 (en) | 2013-09-25 | 2014-09-25 | Preparation of radioiodinated 3-fluoropropyl-nor-beta-cit |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016003035A true MX2016003035A (es) | 2016-06-10 |
Family
ID=52691501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016003035A MX2016003035A (es) | 2013-09-25 | 2014-09-25 | Preparacion de 3-fluoropropil-nor-beta-cit radioyodado. |
Country Status (11)
Country | Link |
---|---|
US (1) | US9339565B2 (es) |
EP (1) | EP3049378B1 (es) |
JP (2) | JP6224256B2 (es) |
AU (1) | AU2014326601B2 (es) |
BR (1) | BR112016006129A2 (es) |
CA (1) | CA2922723C (es) |
ES (1) | ES2711122T3 (es) |
MX (1) | MX2016003035A (es) |
PL (1) | PL3049378T3 (es) |
TR (1) | TR201901758T4 (es) |
WO (1) | WO2015048250A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102939253B (zh) | 2010-05-12 | 2015-10-07 | 雀巢产品技术援助有限公司 | 用于通过离心法制备饮料的载体和胶囊以及用于通过离心法制备饮料的系统和方法 |
US9513907B2 (en) * | 2013-08-06 | 2016-12-06 | Intel Corporation | Methods, apparatus, instructions and logic to provide vector population count functionality |
JP7028765B2 (ja) | 2015-05-22 | 2022-03-02 | トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー | ベンズアミドおよび活性化合物組成物および使用方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4190601A (en) | 1978-05-31 | 1980-02-26 | Union Carbide Corporation | Production of tertiary amines by reductive alkylation |
US6123917A (en) * | 1990-08-09 | 2000-09-26 | Research Triangle Institute | Method for making cocaine receptor binding ligands and intermediates therefor |
US5698179A (en) * | 1992-02-25 | 1997-12-16 | Neuro Imaging Technologies, Llc | Iodinated neuroprobe for mapping monoamine reuptake sites |
CA2270242A1 (en) * | 1996-10-29 | 1998-05-07 | Guilford Pharmaceuticals Inc. | Process for the preparation of radiopharmaceuticals |
FI104048B (fi) * | 1997-06-16 | 1999-11-15 | Map Medical Technologies Oy | Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön |
CA2285516C (en) | 1999-05-12 | 2010-12-07 | President And Fellows Of Harvard College | Dopamine transporter imaging agents |
JP2001213881A (ja) * | 2000-02-02 | 2001-08-07 | Nihon Medi Physics Co Ltd | アンヒドロエクゴニン誘導体の合成法 |
RS20060198A (en) * | 2003-10-03 | 2008-09-29 | Pfizer Limited, | Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activ ity for the treatment of hiv and inflammation |
KR100789847B1 (ko) * | 2004-12-15 | 2007-12-28 | (주)퓨쳐켐 | 알코올 용매하에서 유기플루오로 화합물의 제조방법 |
KR20100077189A (ko) * | 2007-11-07 | 2010-07-07 | 지이 헬쓰케어 비브이 | 방사성약제의 안정화 |
US8431701B2 (en) * | 2009-02-17 | 2013-04-30 | Mallinckrodt Llc | Process for the reductive alkylation of normorphinans |
GB0922023D0 (en) * | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Preparation of n-monofluoroalkyl compounds |
-
2014
- 2014-09-25 BR BR112016006129A patent/BR112016006129A2/pt not_active Application Discontinuation
- 2014-09-25 US US14/496,376 patent/US9339565B2/en active Active
- 2014-09-25 AU AU2014326601A patent/AU2014326601B2/en active Active
- 2014-09-25 WO PCT/US2014/057404 patent/WO2015048250A1/en active Application Filing
- 2014-09-25 CA CA2922723A patent/CA2922723C/en active Active
- 2014-09-25 PL PL14849233T patent/PL3049378T3/pl unknown
- 2014-09-25 EP EP14849233.3A patent/EP3049378B1/en active Active
- 2014-09-25 JP JP2016545225A patent/JP6224256B2/ja active Active
- 2014-09-25 MX MX2016003035A patent/MX2016003035A/es unknown
- 2014-09-25 ES ES14849233T patent/ES2711122T3/es active Active
- 2014-09-25 TR TR2019/01758T patent/TR201901758T4/tr unknown
-
2017
- 2017-09-22 JP JP2017182197A patent/JP6423936B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
TR201901758T4 (tr) | 2019-03-21 |
US9339565B2 (en) | 2016-05-17 |
CA2922723A1 (en) | 2015-04-02 |
WO2015048250A1 (en) | 2015-04-02 |
EP3049378A1 (en) | 2016-08-03 |
US20150087838A1 (en) | 2015-03-26 |
JP6423936B2 (ja) | 2018-11-14 |
AU2014326601A1 (en) | 2016-03-17 |
EP3049378A4 (en) | 2017-04-19 |
PL3049378T3 (pl) | 2019-06-28 |
JP6224256B2 (ja) | 2017-11-01 |
AU2014326601B2 (en) | 2018-01-18 |
BR112016006129A2 (pt) | 2017-08-01 |
ES2711122T3 (es) | 2019-04-30 |
EP3049378B1 (en) | 2018-12-05 |
CA2922723C (en) | 2022-04-19 |
JP2016533390A (ja) | 2016-10-27 |
JP2017218460A (ja) | 2017-12-14 |
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