MX2016003035A - Preparacion de 3-fluoropropil-nor-beta-cit radioyodado. - Google Patents

Preparacion de 3-fluoropropil-nor-beta-cit radioyodado.

Info

Publication number
MX2016003035A
MX2016003035A MX2016003035A MX2016003035A MX2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A MX 2016003035 A MX2016003035 A MX 2016003035A
Authority
MX
Mexico
Prior art keywords
fluoropropyl
radioiodinated
cit
preparation
beta
Prior art date
Application number
MX2016003035A
Other languages
English (en)
Inventor
Edmund C Hudson
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of MX2016003035A publication Critical patent/MX2016003035A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona generalmente procesos para la preparación de 3-fluoropropil-nor-ß-CIT radioyodado. En particular, el proceso usa un intermediario de arilsilano, evitando así el uso de hexametildiestaño y reduciendo la cantidad de pasos previamente necesarios para la preparación de 3-fluoropropil-nor-ß-CIT radioyodado a partir de anhidroecgonina metiléster. La invención también se refiere a la alquilación de un nortropano al análogo de N-(3-fluoropropil) correspondiente usando 3-fluoropropanal.
MX2016003035A 2013-09-25 2014-09-25 Preparacion de 3-fluoropropil-nor-beta-cit radioyodado. MX2016003035A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361882039P 2013-09-25 2013-09-25
PCT/US2014/057404 WO2015048250A1 (en) 2013-09-25 2014-09-25 Preparation of radioiodinated 3-fluoropropyl-nor-beta-cit

Publications (1)

Publication Number Publication Date
MX2016003035A true MX2016003035A (es) 2016-06-10

Family

ID=52691501

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016003035A MX2016003035A (es) 2013-09-25 2014-09-25 Preparacion de 3-fluoropropil-nor-beta-cit radioyodado.

Country Status (11)

Country Link
US (1) US9339565B2 (es)
EP (1) EP3049378B1 (es)
JP (2) JP6224256B2 (es)
AU (1) AU2014326601B2 (es)
BR (1) BR112016006129A2 (es)
CA (1) CA2922723C (es)
ES (1) ES2711122T3 (es)
MX (1) MX2016003035A (es)
PL (1) PL3049378T3 (es)
TR (1) TR201901758T4 (es)
WO (1) WO2015048250A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939253B (zh) 2010-05-12 2015-10-07 雀巢产品技术援助有限公司 用于通过离心法制备饮料的载体和胶囊以及用于通过离心法制备饮料的系统和方法
US9513907B2 (en) * 2013-08-06 2016-12-06 Intel Corporation Methods, apparatus, instructions and logic to provide vector population count functionality
JP7028765B2 (ja) 2015-05-22 2022-03-02 トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー ベンズアミドおよび活性化合物組成物および使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190601A (en) 1978-05-31 1980-02-26 Union Carbide Corporation Production of tertiary amines by reductive alkylation
US6123917A (en) * 1990-08-09 2000-09-26 Research Triangle Institute Method for making cocaine receptor binding ligands and intermediates therefor
US5698179A (en) * 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
CA2270242A1 (en) * 1996-10-29 1998-05-07 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
FI104048B (fi) * 1997-06-16 1999-11-15 Map Medical Technologies Oy Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön
CA2285516C (en) 1999-05-12 2010-12-07 President And Fellows Of Harvard College Dopamine transporter imaging agents
JP2001213881A (ja) * 2000-02-02 2001-08-07 Nihon Medi Physics Co Ltd アンヒドロエクゴニン誘導体の合成法
RS20060198A (en) * 2003-10-03 2008-09-29 Pfizer Limited, Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activ ity for the treatment of hiv and inflammation
KR100789847B1 (ko) * 2004-12-15 2007-12-28 (주)퓨쳐켐 알코올 용매하에서 유기플루오로 화합물의 제조방법
KR20100077189A (ko) * 2007-11-07 2010-07-07 지이 헬쓰케어 비브이 방사성약제의 안정화
US8431701B2 (en) * 2009-02-17 2013-04-30 Mallinckrodt Llc Process for the reductive alkylation of normorphinans
GB0922023D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Preparation of n-monofluoroalkyl compounds

Also Published As

Publication number Publication date
TR201901758T4 (tr) 2019-03-21
US9339565B2 (en) 2016-05-17
CA2922723A1 (en) 2015-04-02
WO2015048250A1 (en) 2015-04-02
EP3049378A1 (en) 2016-08-03
US20150087838A1 (en) 2015-03-26
JP6423936B2 (ja) 2018-11-14
AU2014326601A1 (en) 2016-03-17
EP3049378A4 (en) 2017-04-19
PL3049378T3 (pl) 2019-06-28
JP6224256B2 (ja) 2017-11-01
AU2014326601B2 (en) 2018-01-18
BR112016006129A2 (pt) 2017-08-01
ES2711122T3 (es) 2019-04-30
EP3049378B1 (en) 2018-12-05
CA2922723C (en) 2022-04-19
JP2016533390A (ja) 2016-10-27
JP2017218460A (ja) 2017-12-14

Similar Documents

Publication Publication Date Title
IL241046A0 (en) Fertilizer composition and method for its preparation
MA40386A (fr) Procédé de préparation de cabozantinib marqué au fluor-18 et d'analogues de celui-ci
PH12016501414A1 (en) Long-acting insulin and use thereof
MX365494B (es) Procedimiento de compuesto antifungico.
MX2015002487A (es) Proceso para la preparacion de teneligliptina.
MX369357B (es) Procedimiento de compuesto antifungico.
IN2015KN00323A (es)
PL3334805T3 (pl) Proces formulacji paliwa
MX2021007245A (es) Microorganismos para la produccion de putrescina u ornitina y procedimiento para la produccion de putrescina u ornitina usando los mismos.
MX2014010433A (es) Nueva forma cristalina de sulfato de sitagliptina.
IN2013MU00646A (es)
IN2014DN03464A (es)
GEP201706626B (en) Synthesis of (s)-nifuratel
PH12020550871A1 (en) Process for the preparation of opicapone and intermediates thereof
IN2013MU03070A (es)
IN2013CH04906A (es)
MX2016003035A (es) Preparacion de 3-fluoropropil-nor-beta-cit radioyodado.
ZA202109307B (en) Methods relating to tuberculosis
MX369174B (es) Proceso para la preparación de un compuesto.
GB201905004D0 (en) Improvements relating to fasteners for clothing
MX2015011881A (es) Proceso para la preparacion de 3,7-dimetilnonan-1-ol.
IN2013CH05865A (es)
IN2013MU01501A (es)
IN2014DN06536A (es)
PH12016501994B1 (en) Novel crystal of doripenem, and preparation method therefor