MX2016002747A - Metodos para estudios de asociacion genetica, basados en estimulo-respuesta, geneticamente diversificados. - Google Patents

Metodos para estudios de asociacion genetica, basados en estimulo-respuesta, geneticamente diversificados.

Info

Publication number
MX2016002747A
MX2016002747A MX2016002747A MX2016002747A MX2016002747A MX 2016002747 A MX2016002747 A MX 2016002747A MX 2016002747 A MX2016002747 A MX 2016002747A MX 2016002747 A MX2016002747 A MX 2016002747A MX 2016002747 A MX2016002747 A MX 2016002747A
Authority
MX
Mexico
Prior art keywords
methods
biological samples
studies
gdsrga
subpopulations
Prior art date
Application number
MX2016002747A
Other languages
English (en)
Inventor
Shawn T Coyne
Kevin P Coyne
Original Assignee
Coyne Ip Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coyne Ip Holdings Llc filed Critical Coyne Ip Holdings Llc
Publication of MX2016002747A publication Critical patent/MX2016002747A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Evolutionary Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se proporcionan métodos para mejorar el impacto de los estudios de asociación genética de estímulo-respuesta genéticamente diversificados (GDSRGA). Los métodos pueden implicar desarrollar subpoblaciones que se contrastan en los estudios GDSRGA al obtener una muestra biológica de cada donador de una población de donadores; seleccionar un cohorte común de las muestras biológicas al obtener al menos una secuencia genómica parcial de cada muestra biológica, alinear las secuencias de la muestras biológicas, y remover las muestras biológicas que no se pueden secuenciar con precisión o no logran alinearse; aplicar una molécula de prueba o condición a las muestras biológicas para inducir respuestas fenotípicamente distintas entre los miembros de cohorte; y segregar las muestras biológicas en las subpoblaciones basadas en las respuestas fenotípicamente distintas. Estas subpoblaciones se pueden usar en estudios GDSRGA.
MX2016002747A 2013-09-03 2014-09-03 Metodos para estudios de asociacion genetica, basados en estimulo-respuesta, geneticamente diversificados. MX2016002747A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361873161P 2013-09-03 2013-09-03
PCT/US2014/053819 WO2015034878A2 (en) 2013-09-03 2014-09-03 Methods for genetically diversified stimulus-response based gene association studies

Publications (1)

Publication Number Publication Date
MX2016002747A true MX2016002747A (es) 2016-05-26

Family

ID=52629076

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016002747A MX2016002747A (es) 2013-09-03 2014-09-03 Metodos para estudios de asociacion genetica, basados en estimulo-respuesta, geneticamente diversificados.

Country Status (6)

Country Link
US (1) US20160195514A1 (es)
EP (1) EP3041953A4 (es)
JP (1) JP2016528927A (es)
CA (1) CA2921981A1 (es)
MX (1) MX2016002747A (es)
WO (1) WO2015034878A2 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
EP1248832A4 (en) * 2000-01-21 2004-07-07 Variagenics Inc IDENTIFICATION OF GENETIC COMPONENTS IN DRUG REACTION
US20060257888A1 (en) * 2003-02-27 2006-11-16 Methexis Genomics, N.V. Genetic diagnosis using multiple sequence variant analysis
WO2007123720A2 (en) * 2006-03-30 2007-11-01 Cornell Research Foundation, Inc. System and method for increased cooling rates in rapid cooling of small biological samples
US8170805B2 (en) * 2009-02-06 2012-05-01 Syngenta Participations Ag Method for selecting statistically validated candidate genes

Also Published As

Publication number Publication date
WO2015034878A3 (en) 2015-04-23
JP2016528927A (ja) 2016-09-23
EP3041953A4 (en) 2017-04-26
WO2015034878A2 (en) 2015-03-12
EP3041953A2 (en) 2016-07-13
CA2921981A1 (en) 2015-03-12
US20160195514A1 (en) 2016-07-07

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