MX2015009432A - Procesos para la preparacion de derivados de beta-aminoácido quiral mediante catalizadores de hidrogenacion asimetrica. - Google Patents

Procesos para la preparacion de derivados de beta-aminoácido quiral mediante catalizadores de hidrogenacion asimetrica.

Info

Publication number
MX2015009432A
MX2015009432A MX2015009432A MX2015009432A MX2015009432A MX 2015009432 A MX2015009432 A MX 2015009432A MX 2015009432 A MX2015009432 A MX 2015009432A MX 2015009432 A MX2015009432 A MX 2015009432A MX 2015009432 A MX2015009432 A MX 2015009432A
Authority
MX
Mexico
Prior art keywords
processes
preparation
amino acid
acid derivatives
hydrogenation catalysts
Prior art date
Application number
MX2015009432A
Other languages
English (en)
Inventor
Kamaluddin Abdur-Rashid
Rongwei Guo
Xuanhua Chen
Stephen E Horne
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Publication of MX2015009432A publication Critical patent/MX2015009432A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Esta invención proporciona procesos para la preparación de Sitaglitina y sales farmacéuticamente aceptables de la misma; dichos procesos comprenden la hidrogenación enantioselectiva de una enamina proquiral con un catalizador quiral de Rutenio.
MX2015009432A 2013-01-22 2014-01-14 Procesos para la preparacion de derivados de beta-aminoácido quiral mediante catalizadores de hidrogenacion asimetrica. MX2015009432A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361755290P 2013-01-22 2013-01-22
PCT/CA2014/000013 WO2014113869A1 (en) 2013-01-22 2014-01-14 Processes for the preparation of chiral beta amino acid derivatives using asymmetric hydrogenation catalysts

Publications (1)

Publication Number Publication Date
MX2015009432A true MX2015009432A (es) 2016-02-09

Family

ID=51226774

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015009432A MX2015009432A (es) 2013-01-22 2014-01-14 Procesos para la preparacion de derivados de beta-aminoácido quiral mediante catalizadores de hidrogenacion asimetrica.

Country Status (4)

Country Link
US (1) US20150353564A1 (es)
CA (1) CA2898259A1 (es)
MX (1) MX2015009432A (es)
WO (1) WO2014113869A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10462211B2 (en) 2015-03-09 2019-10-29 International Business Machines Corporation System and method for providing more appropriate question/answer responses based upon profiles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ303113B6 (cs) * 2010-03-16 2012-04-11 Zentiva, K.S. Zpusob prípravy sitagliptinu
WO2012031358A1 (en) * 2010-09-10 2012-03-15 Kanata Chemical Technologies Inc. Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis

Also Published As

Publication number Publication date
WO2014113869A1 (en) 2014-07-31
US20150353564A1 (en) 2015-12-10
CA2898259A1 (en) 2014-07-31

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