MX2014008763A - Compuestos y metodos para tratar infecciones por candidosis y aspergillus. - Google Patents
Compuestos y metodos para tratar infecciones por candidosis y aspergillus.Info
- Publication number
- MX2014008763A MX2014008763A MX2014008763A MX2014008763A MX2014008763A MX 2014008763 A MX2014008763 A MX 2014008763A MX 2014008763 A MX2014008763 A MX 2014008763A MX 2014008763 A MX2014008763 A MX 2014008763A MX 2014008763 A MX2014008763 A MX 2014008763A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- methods
- aspergillus
- candida
- mammal
- Prior art date
Links
- 201000002909 Aspergillosis Diseases 0.000 title abstract 2
- 208000036641 Aspergillus infections Diseases 0.000 title abstract 2
- 201000003984 candidiasis Diseases 0.000 title abstract 2
- 241000222122 Candida albicans Species 0.000 title 1
- 206010007134 Candida infections Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 241000228212 Aspergillus Species 0.000 abstract 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000007027 Oral Candidiasis Diseases 0.000 abstract 1
- 206010042938 Systemic candida Diseases 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 208000019164 disseminated candidiasis Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
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- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
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- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
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- C—CHEMISTRY; METALLURGY
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- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
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- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
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- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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Abstract
La presente descripción proporciona oligómeros antimicrobianos facialmente anfifílicos, sales farmacéuticamente aceptables de estos o una composición farmacéutica de estos útiles para destruir o inhibir el crecimiento de una especie Candida o Aspergillus así como también prevenir o tratar un mamífero con candidosis (oral y/o diseminada) o una infección por Aspergillus. El(Los) método(s) empleado(s) comprende(n) poner en contacto la especie Candida o Aspergillus con o administrar al mamífero que lo necesita una cantidad eficaz del oligómero antimicrobiano, sales farmacéuticamente aceptables de este o una composición farmacéutica de este.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261587865P | 2012-01-18 | 2012-01-18 | |
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EP2061490B1 (en) * | 2006-08-25 | 2017-11-08 | Agency for Science, Technology and Research | Modulators of candida hyphal morphogenesis and uses thereof |
US20090092574A1 (en) | 2006-12-29 | 2009-04-09 | Scott Richard W | Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof |
DK2709619T3 (en) | 2011-05-16 | 2018-01-15 | Cellceutix Corp | RELATIONSHIPS FOR USING THE TREATMENT OF MUCOSITIS |
US11531020B2 (en) | 2017-01-18 | 2022-12-20 | Youhealth Biotech, Limited | Methods and compositions for nanopore sequencing |
CN115745910A (zh) * | 2017-07-21 | 2023-03-07 | 安塔比奥公司 | 化学化合物 |
WO2019185586A1 (en) * | 2018-03-26 | 2019-10-03 | Universidad Complutense De Madrid | Ligands for enhanced imaging and drug delivery to neuroblastoma cells |
US11771694B2 (en) | 2020-06-05 | 2023-10-03 | Innovation Pharmaceuticals Inc. | Arylamide compounds for treatment and prevention of viral infections |
WO2022192162A1 (en) * | 2021-03-09 | 2022-09-15 | Fox Chase Chemical Diversity Center, Inc. | Novel heteroaromatic compounds exhibiting antifungal activity and their method of use |
CN114890982A (zh) * | 2022-05-16 | 2022-08-12 | 内蒙古大学 | 一种季铵盐修饰的二苯并噻吩亚砜衍生物的制备方法 |
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EP2471524A3 (en) * | 2003-03-17 | 2012-12-12 | The Trustees Of The University Of Pennsylvania | Facially amphiphllic polymers and oligomers and uses thereof |
EP2433627A1 (en) * | 2005-02-25 | 2012-03-28 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer |
US20090092574A1 (en) * | 2006-12-29 | 2009-04-09 | Scott Richard W | Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof |
AU2011276349A1 (en) * | 2010-07-07 | 2013-02-28 | Polymedix, Inc. | Methods of immune modulation |
US20150094294A1 (en) * | 2012-02-29 | 2015-04-02 | Cellceutix Corporation | Compounds and methods for treating malaria |
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JP2015505325A (ja) | 2015-02-19 |
IL233605A0 (en) | 2014-08-31 |
CN104486945B (zh) | 2016-03-16 |
WO2013109827A1 (en) | 2013-07-25 |
AU2013209622A1 (en) | 2014-09-11 |
US20130252964A1 (en) | 2013-09-26 |
CL2014001883A1 (es) | 2015-02-27 |
BR112014017642A2 (pt) | 2019-09-24 |
US20160287586A1 (en) | 2016-10-06 |
US8895561B2 (en) | 2014-11-25 |
EP2804476A1 (en) | 2014-11-26 |
NZ628927A (en) | 2015-10-30 |
SG11201404165RA (en) | 2014-10-30 |
CA2862170A1 (en) | 2013-07-25 |
HK1203763A1 (en) | 2015-11-06 |
KR20140129030A (ko) | 2014-11-06 |
RU2014133744A (ru) | 2016-03-10 |
CN104486945A (zh) | 2015-04-01 |
EP2804476A4 (en) | 2016-01-06 |
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