MX2013008373A - Derivados de diazeniodiolato. - Google Patents

Derivados de diazeniodiolato.

Info

Publication number
MX2013008373A
MX2013008373A MX2013008373A MX2013008373A MX2013008373A MX 2013008373 A MX2013008373 A MX 2013008373A MX 2013008373 A MX2013008373 A MX 2013008373A MX 2013008373 A MX2013008373 A MX 2013008373A MX 2013008373 A MX2013008373 A MX 2013008373A
Authority
MX
Mexico
Prior art keywords
diazeniumdiolate derivatives
diazeniumdiolate
derivatives
eclampsia
nephropathy
Prior art date
Application number
MX2013008373A
Other languages
English (en)
Inventor
Shrenik K Shah
Amjad Ali
Michael Man-Chu Lo
Edward Metzger
James Dellureficio
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2013008373A publication Critical patent/MX2013008373A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/04—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/04—N-nitroso compounds
    • C07C243/06—N-nitroso-amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/08—Azoxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto que tiene la estructura (Ver Formula) útil para tratar hipertensión, hipertensión arterial pulmonar, falla cardiaca congestiva, condiciones que resultan de la retención excesiva de agua, la enfermedad cardiovascular, la diabetes, el estrés oxidativo, la disfunción endotelial, la cirrosis, la pre-eclampsia, la osteoporosis o la nefropatía.
MX2013008373A 2011-01-19 2012-01-12 Derivados de diazeniodiolato. MX2013008373A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161434148P 2011-01-19 2011-01-19
PCT/US2012/021048 WO2012099770A2 (en) 2011-01-19 2012-01-12 Diazeniumdiolate derivatives

Publications (1)

Publication Number Publication Date
MX2013008373A true MX2013008373A (es) 2013-08-12

Family

ID=46516310

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008373A MX2013008373A (es) 2011-01-19 2012-01-12 Derivados de diazeniodiolato.

Country Status (11)

Country Link
US (1) US20130296278A1 (es)
EP (1) EP2665701A2 (es)
JP (1) JP2014508742A (es)
KR (1) KR20140003482A (es)
CN (1) CN103476744A (es)
AU (1) AU2012207528A1 (es)
BR (1) BR112013017517A2 (es)
CA (1) CA2824437A1 (es)
MX (1) MX2013008373A (es)
RU (1) RU2013138391A (es)
WO (1) WO2012099770A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9272987B2 (en) 2011-05-02 2016-03-01 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
WO2005074598A2 (en) * 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
FR2902428B1 (fr) * 2006-06-15 2008-08-15 Servier Lab Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2916757B1 (fr) * 2007-05-30 2009-07-17 Servier Lab Nouveaux derives diazeniumdiolates,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
AU2009206635A1 (en) * 2008-01-24 2009-07-30 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists

Also Published As

Publication number Publication date
EP2665701A2 (en) 2013-11-27
AU2012207528A1 (en) 2013-07-04
BR112013017517A2 (pt) 2016-09-27
CA2824437A1 (en) 2012-07-26
WO2012099770A3 (en) 2012-11-15
CN103476744A (zh) 2013-12-25
RU2013138391A (ru) 2015-02-27
KR20140003482A (ko) 2014-01-09
JP2014508742A (ja) 2014-04-10
WO2012099770A2 (en) 2012-07-26
US20130296278A1 (en) 2013-11-07

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