MX2012013234A - Endoscopy capsule for detecting a metabolic product of a pathogen located in or on the wall of a hollow organ of the human or animal gastrointestinal tract. - Google Patents

Endoscopy capsule for detecting a metabolic product of a pathogen located in or on the wall of a hollow organ of the human or animal gastrointestinal tract.

Info

Publication number
MX2012013234A
MX2012013234A MX2012013234A MX2012013234A MX2012013234A MX 2012013234 A MX2012013234 A MX 2012013234A MX 2012013234 A MX2012013234 A MX 2012013234A MX 2012013234 A MX2012013234 A MX 2012013234A MX 2012013234 A MX2012013234 A MX 2012013234A
Authority
MX
Mexico
Prior art keywords
capsule
gravity
endoscopy
center
sensor
Prior art date
Application number
MX2012013234A
Other languages
Spanish (es)
Inventor
Rainer Kuth
Helmut Neumann
Markus Neurath
Original Assignee
Siemens Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Ag filed Critical Siemens Ag
Publication of MX2012013234A publication Critical patent/MX2012013234A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4216—Diagnosing or evaluating gastrointestinal ulcers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A61B5/073—Intestinal transmitters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6861—Capsules, e.g. for swallowing or implanting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041—Capsule endoscopes for imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70—Manipulators specially adapted for use in surgery
    • A61B34/73—Manipulators for magnetic surgery
    • A61B2034/731—Arrangement of the coils or magnets

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Optics & Photonics (AREA)
  • Endoscopes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

An endoscopy capsule (6) contains, on one side of its housing (10), a sensor (12) for detecting a metabolic product of a bacterium located in or on the wall of a hollow organ (2) of the human or animal gastrointestinal tract, particularly in the stomach wall. The specific weight of the endoscopy capsule (6) is greater than the specific weight of a liquid (4) located in the hollow organ (2), and the mass centre of gravity (14) of the endoscopy capsule (6) is spaced apart from the volume centre of gravity (16) of the displaced liquid (4), wherein mass centre of gravity (14) and volume centre of gravity (16) define a straight connecting line (18) on which the sensor (10) is arranged on that side of the housing (10) adjacent to the mass centre of gravity (14). This ensures that the endoscopy capsule (6) is always in contact with the wall of the hollow organ (2) via the housing side on which the sensor (10) is arranged.

Description

CAPSULE FOR ENDOSCOPY TO DETECT A METABOLIC PRODUCT OF A PATHOGEN LODGED IN OR ON THE WALL OF A HOLLOW ORGAN OF THE HUMAN OR ANIMAL GASTROINTESTINAL TRACT FIELD OF THE INVENTION Capsule for endoscopy to detect a metabolic product of a pathogen housed in or on the wall of a hollow organ of the human or animal gastrointestinal tract.
BACKGROUND OF THE INVENTION The invention relates to an endoscopy capsule with a sensor positioned on one side of its housing to detect a metabolic product of a pathogen housed in or on the wall of a hollow organ of the human or animal gastrointestinal tract, such as is known from example by WO 2009/127528 Al.
To detect the presence of a pathogen in a hollow organ of the human or animal intestinal tract, especially the stomach, as is known from WO2009 / 127528 Al, in which an endoscopy capsule is inserted into the body organ, the which contains a sensor, which detects bacteria with the help of the metabolic products that it excretes. Such a pathogen can be, for example, Helicobacter pylori, which can be located in the mucosa of the stomach and is responsible for a series of stomach diseases. It has been determined that in the world approximately 50% of all people over 40 years old are infected with this bacterium. The infection can in the least of the cases lead to stomach pains, in the most severe cases to stomach ulcers that bleed heavily and that can produce hemorrhages, and are also carcinogenic.
Since in the case of chronic diseases of the upper gastrointestinal tract is considered as the cause of this type of bacteria, and in the case of an infection with a bacteria there is a possibility to eliminate the cause of diseases by killing the bacteria in question , due to the plurality of this type of diseases, it is desirable to present a diagnosis possibility that can be tolerated by the patient, whose performance is simple and economical, so that as regards the frequency of the diseases, the greatest number of diseases can be examined. patients about the presence of a bacterial infection.
SUMMARY OF THE INVENTION The invention therefore proposes the task of producing an endoscopy capsule with a sensor placed on one side of the housing to detect the metabolic product of a pathogen that is found in the wall of a hollow organ of the gastrointestinal tract, especially in or on the wall of the stomach, which can be used with a small technical deployment and devices.
The aforementioned task is solved according to the invention with the aid of an endoscopy capsule with the features of claim 1. According to this characteristic, the specific weight of the endoscopy capsule is greater than the specific weight of the liquid found. in a hollow organ in which the mass center of gravity of the capsule for endoscopy is different from the volumetric center of gravity of the liquid displaced by the capsule and the center of gravity of masses and the center of gravity volume produce a straight line of connection in which the sensor is placed on the side of the housing adjacent to the center of mass gravity.
By means of these measurements, the endoscopy capsule is immersed in a hollow organ filled with a liquid, usually water, thanks to the force of gravity until it reaches an area of the wall of the hollow organ below.
Since the mass center of gravity of the endoscopy capsule and the volumetric center of gravity of the displaced fluid are different from each other, and the sensor located on a side adjacent to the mass center of gravity of the housing in the straight line of connection determined by the mass center of gravity and the volumetric center of gravity, it is ensured that the endoscopy capsule on the side of the housing comes in contact with the wall in which the sensor is located.
With a capsule for endoscopy produced in this way a reduced technical deployment is ensured, in such a way that the sensor placed in the capsule for endoscopy is placed in the direct vicinity of the wall and therefore is in a region in which it is greater the concentration of metabolic products eventually present.
In another embodiment of the invention, the housing of the capsule for endoscopy at least in the area of the sensor has a curve shape symmetrical to the rotation, for example the shape of a spherical dome or an oval shape for example the dome is a rotation ellipsoid , where the center of gravity of masses and the center of gravity volume are in the axis of symmetry of rotation. The weight of the capsule for endoscopy as well as the distance between the mass center of gravity and the volumetric center of gravity are measured in such a way that the rotational symmetry axis of the housing resting on the wall extends parallel to the vertical. In other words, the endoscopy capsule is shaped in such a way that it lifts on its own. In this way it is ensured that the sensor, which in this case is located at the narrow end of the housing, thanks to this conformation that rises by itself, then remains in contact with the mucosa of the hollow organ, when the capsule for endoscopy has reached Wall.
Other advantageous embodiments of the invention are given in the other dependent claims.
BRIEF DESCRIPTION OF THE FIGURES To further describe the invention, reference is made to an exemplary embodiment represented in the single figure, in which a schematic diagram of an endoscopy capsule according to the invention is shown in an end position in the wall of a hollow organ.
DETAILED DESCRIPTION OF THE INVENTION According to the figure a hollow organ 2 of the gastrointestinal tract, in the example a stomach, is filled with a liquid 4, for example water. In the hollow organ 2, an ingestable endoscopy capsule 6 has been placed, which has the shape of a rotating ellipsoid, to enable its transport and elimination without problems. The capsule for endoscopy 6 has a specific weight, which is greater than the specific weight of the liquid 4, so that it automatically sinks downwards, that is, in the direction of the force of gravity in the liquid 4, until it reaches the wall 8 of the hollow organ 2.
On one side of the housing 10 of the endoscopy capsule 6 there is shown a sensor 12 which in the figure is only shown schematically, with which it is possible to detect a metabolic product for example of a bacterium found in the wall 8 of the hollow organ 2, for example Helicobacter pylori. The mass center of gravity 14 of the endoscopy capsule 6 as well as the volumetric center of gravity 16 of the liquid 4 ejected by the endoscopy capsule 6 are separated from each other by a distance a. The center of gravity of mass 14 and the center of gravity volumetric 16 form a straight line of connection 18 in which the side of the housing 10 of the sensor 12 is placed, adjacent to the center of gravity of mass 14, in such a way that the capsule for endoscopy 6 it is immersed first with that side and reaches the wall 8.
In the illustrated embodiment, the straight line of connection 18 corresponds to the axis of rotational symmetry of the housing 10, which in the example has the form of a rotational ellipsoid.
The weight of the endoscopy capsule 6 and the distance a between the center of gravity of mass 14 and the center of gravity volume 16 in an advantageous embodiment are measured in such a way that the capsule for endoscopy 6 is automatically lifted and the straight line of connection 18 or the axis of symmetry of rotation is directed in the direction of the force of gravity, this is parallel to the vertical. In this way it is ensured that the sensor 12 is placed in the immediate vicinity of the wall 8 of the hollow member 2.
The capsule for endoscopy 6 has a transmitter 20, which transmits the data detected by the sensor 12 to an external receiver 22, which for example is fixed in the belt of a patient.
An energy supply device 24, for example an external energy store, for example a battery, or an externally rechargeable energy store, serves to supply power to the transmitter 20.
The start of the measurement, that is, the activation of the sensor 12 is carried out by an external signal, for example with the aid of a radio signal, with the help of an external magnet or by means of a mechanical shock.
In case of need to make a long-term measurement possible, it may be necessary to fix the capsule for endoscopy 6 for at least a longer period of time with a fixation device in the final or resting position, since otherwise due to natural peristaltic movements, after a short stay time the capsule would be eliminated along with the liquid. To this end, a permanent magnet 26 can be placed in the endoscopy capsule 6, so that the endoscopy capsule 6 is supported in the rest position with the aid of an external magnetic system 28.
Alternatively, it is also possible for the endoscopy capsule 6 as the holding system to have a holding device 30 that can be expanded in the hollow member 2 or anchored in the wall, which in the figure is only shown schematically in a shaded manner. This fastening device 30 may consist of a material that after a predetermined dwell time of self-release of the hollow organ 2, such that the capsule for endoscopy 6 is released and can be expelled.

Claims (8)

NOVELTY OF THE INVENTION Having described the present invention as above, it is considered as a novelty and therefore the content of the following is claimed as property: CLAIMS
1. An endoscopy capsule (6) with a sensor (12) positioned on one side of its housing (10) to detect a metabolic product of a pathogen housed in or on the wall of a hollow organ (2) of the human or animal gastrointestinal tract , characterized in that its specific weight is greater than the specific weight of the liquid (4) found in a hollow organ (2) in which the mass center of gravity (14) of the endoscopy capsule is different from the center of gravity volumetric (16) of the liquid (4) displaced by the capsule and the mass center of gravity (14) and the volumetric center of gravity (16) produce a straight connection line (18) in which the sensor is placed (10). ) on the side of the housing (10) adjacent to the center of mass gravity (14).
2. The capsule for endoscopy according to claim 1, characterized in that its housing (10) at least in the area of the sensor (12) has a curve shape symmetrical to the rotation and wherein the center of gravity of masses (14) and the Volumetric center of gravity (16) are located on the axis of rotational symmetry, the weight of the capsule for endoscopy as well as the distance (a) between the center of mass gravity (14) and the center of gravity volumetric (16) they are measured in such a way that the axis of rotational symmetry of the housing (10) supported on the wall (8) extends parallel to the vertical.
3. The capsule for endoscopy according to claim 1 or 2, characterized in that it has a transmitter (20) for the wireless transmission of the measured values with the sensor (12).
4. The capsule for endoscopy according to claim 1, 2 or 3, characterized in that the sensor (12) can be activated by an external signal.
5. The capsule for endoscopy according to one of claims 1 to 4, characterized in that it has an internal or externally rechargeable energy store.
6. The capsule for endoscopy according to one of claims 1 to 5, characterized in that it has a fastening system for fixing the capsule for endoscopy in a final position.
7. The endoscopy capsule according to claim 6, characterized in that the fastening system is a permanent magnet (26).
8. The capsule for endoscopy according to claim 6, characterized in that as fastening system has a clamping device (30) that can expand in the hollow organ (2) or anchor in the wall.
MX2012013234A 2010-05-14 2011-05-06 Endoscopy capsule for detecting a metabolic product of a pathogen located in or on the wall of a hollow organ of the human or animal gastrointestinal tract. MX2012013234A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010020614A DE102010020614A1 (en) 2010-05-14 2010-05-14 Endoscopy capsule for detecting a metabolic product of an exciter located in or on the wall of a hollow organ of the human or animal gastrointestinal tract
PCT/EP2011/057300 WO2011141372A1 (en) 2010-05-14 2011-05-06 Endoscopy capsule for detecting a metabolic product of a pathogen located in or on the wall of a hollow organ of the human or animal gastrointestinal tract

Publications (1)

Publication Number Publication Date
MX2012013234A true MX2012013234A (en) 2013-01-24

Family

ID=44350622

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013234A MX2012013234A (en) 2010-05-14 2011-05-06 Endoscopy capsule for detecting a metabolic product of a pathogen located in or on the wall of a hollow organ of the human or animal gastrointestinal tract.

Country Status (5)

Country Link
CN (1) CN102985006A (en)
BR (1) BR112012029056A2 (en)
DE (1) DE102010020614A1 (en)
MX (1) MX2012013234A (en)
WO (1) WO2011141372A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102961111B (en) * 2012-11-07 2016-02-24 深圳市资福技术有限公司 A kind of upright capsule endoscope
DE102013202257A1 (en) * 2013-02-12 2013-08-22 Siemens Aktiengesellschaft Endoscopic capsule and method of making an endoscopy capsule
CN103259728B (en) 2013-05-24 2016-03-30 华为技术有限公司 A kind of OFS in-band communications method and OFS
CA3063928A1 (en) 2017-05-17 2018-11-22 Massachusetts Institute Of Technology Self-righting systems and related components and methods
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US11202903B2 (en) 2018-05-17 2021-12-21 Massachusetts Institute Of Technology Systems for electrical stimulation
US11771829B2 (en) 2019-02-01 2023-10-03 Massachusetts Institute Of Technology Systems and methods for liquid injection
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003278576A1 (en) * 2002-10-31 2004-05-25 Given Imaging Ltd. System and method for in vivo detection of h. pylori
DE10336734A1 (en) * 2003-08-11 2005-03-10 Siemens Ag Tissue anchor for endorobots
DE102005032290A1 (en) * 2005-07-11 2007-01-18 Siemens Ag Capsule and method to be used for magnetic wireless diagnosis and treatment of gastrointestinal tract, comprises substance releasing facility and anchor
WO2007077768A1 (en) * 2005-12-28 2007-07-12 Olympus Medical Systems Corp. System for observing inside of subject and method of observing inside of subject
AU2007322906B2 (en) * 2006-11-24 2011-01-20 Olympus Medical Systems Corp. Encapsulated endoscope
US8702591B2 (en) * 2007-01-12 2014-04-22 Olympus Medical Systems Corp. Capsule medical apparatus
US8870767B2 (en) 2008-04-18 2014-10-28 Siemens Aktiengesellschaft Endocapsule

Also Published As

Publication number Publication date
CN102985006A (en) 2013-03-20
WO2011141372A1 (en) 2011-11-17
BR112012029056A2 (en) 2016-08-09
DE102010020614A1 (en) 2011-11-17

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