CN209392567U - Alimentary canal device for administration of drugs and its application capsule - Google Patents
Alimentary canal device for administration of drugs and its application capsule Download PDFInfo
- Publication number
- CN209392567U CN209392567U CN201820071266.9U CN201820071266U CN209392567U CN 209392567 U CN209392567 U CN 209392567U CN 201820071266 U CN201820071266 U CN 201820071266U CN 209392567 U CN209392567 U CN 209392567U
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- capsule
- shell body
- inner housing
- magnetic pole
- application
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- 239000002775 capsule Substances 0.000 title claims abstract description 342
- 229940079593 drug Drugs 0.000 title claims abstract description 143
- 239000003814 drug Substances 0.000 title claims abstract description 140
- 239000000843 powder Substances 0.000 claims description 32
- 238000001514 detection method Methods 0.000 claims description 24
- 238000004891 communication Methods 0.000 claims description 15
- 238000007789 sealing Methods 0.000 claims description 13
- 238000006073 displacement reaction Methods 0.000 claims description 12
- 102000004190 Enzymes Human genes 0.000 claims description 9
- 108090000790 Enzymes Proteins 0.000 claims description 9
- 230000005540 biological transmission Effects 0.000 claims description 6
- 210000001072 colon Anatomy 0.000 claims description 6
- 239000003292 glue Substances 0.000 claims description 4
- 230000008901 benefit Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 238000001139 pH measurement Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 abstract description 10
- 210000000214 mouth Anatomy 0.000 description 103
- 238000010586 diagram Methods 0.000 description 13
- 210000001035 gastrointestinal tract Anatomy 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 230000003902 lesion Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 238000009434 installation Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000004880 explosion Methods 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 125000006850 spacer group Chemical group 0.000 description 4
- 230000001079 digestive effect Effects 0.000 description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000112 colonic effect Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 101000803709 Homo sapiens Vitronectin Proteins 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000006247 magnetic powder Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- 238000002626 targeted therapy Methods 0.000 description 1
- 208000016752 upper digestive tract disease Diseases 0.000 description 1
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- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The utility model provides a kind of alimentary canal device for administration of drugs and its application capsule.In the assembled state, due to the constraint for the position limiting structure that the rotary stopper slot on the rotary stopper pin and capsule shell body on capsule inner housing collectively constitutes, and it is fixed on the first magnetic pole of capsule inner housing and is fixed between the magnetic pole of the second magnetic pole of capsule shell body that there are angles, rotary torsion is caused, so that the application capsule is in intimate-association state always.When applying external magnetic field, at least one of both first magnetic pole and the second magnetic pole or both all turn in external magnetic field backspin.Rotation between magnetic pole, the rotation for driving the capsule inner housing, capsule shell body mutual, drug release mouth thereon is caused to eliminate dislocation, to which the mouth that releases the drug is in the open state when applying external magnetic field, inside and outside shell drug release mouth is in dislocation closed state when cancelling external magnetic field, thus to realize the purpose for pinpointing targeting application.The utility model is administered easy to operate, capsule capacity boost, and targeting application treatment may be implemented.
Description
Technical field
The utility model relates to the field of medical instrument technology, more particularly to a kind of alimentary canal device for administration of drugs that can be swallowed, tools
For body, it is related to the capsule type digestive tract device for administration of drugs and its application capsule of a kind of external magnetic field control.
Background technique
Modern causes the disease incidence of disease of digestive tract to increase increasingly, alimentary canal since work rhythm quickening, diet are uneven
Disease becomes the common disease for influencing modern's health.And human body all-digestive tract overall length is more than 9 meters, and belongs to slender pipeline, point
It is distributed between each organ of trunk, the irregular closure of all-digestive tract structure, to the fixed point of clinical disease of upper digestive tract
Administration and treatment zone carry out very big challenge.
In view of gastral particularity, the micromation of alimentary canal capsule is the target that industry is pursued.Also, to realize fixed point
Target administration, existing alimentary canal capsule integrated driving generally in application capsule, controls capsule as core component
In administering position in the digestive tract.The micromation degree of capsule is largely determined by the driving method of driving mechanism.And show
Some driving methods specifically include that motor drive mode, electromagnetic drive mode, compressed spring driving method etc., or use these
Mode opens capsule hole.Due to being integrated in application capsule with upper drive mechanism, and the alimentary canal application capsule for being suitble to people to swallow
Finite volume system, driving mechanism volume for occupying in application capsule is bigger, and the capacity for loading drug is then fewer.Therefore, micro-
After the capsule of type loads a driving mechanism, it is bound to cause the problem that capsule structure is complicated, capacity is small.
Therefore, it is necessary to propose a kind of alimentary canal device for administration of drugs and its application capsule, simplify capsule structure, while one
Capsule capacity is promoted under fixed capsule volumetric constraint, moreover it is possible to realize fixed point targeted therapy purpose.
Utility model content
In view of this, the present invention provides a kind of application capsules comprising capsule inner housing, capsule shell body,
One magnetic pole, the second magnetic pole and medicinal powder, the size of the capsule shell body are greater than the size of the capsule inner housing, and the capsule shell
Body and the capsule inner housing match each other and are rotary dynamic seal；First magnetic pole is fixed in the capsule inner housing, outer diameter
Match with the internal diameter of the capsule inner housing；Second magnetic pole is fixed in the capsule shell body, outer diameter and the capsule shell
The internal diameter of body matches；First magnetic pole and second magnetic pole are radial polarised, and in the application capsule, first magnetic pole with
It is in be greater than 0 ° of angle less than 90 ° that second magnetic pole, which is arranged to pole direction,；The medicinal powder be located at first magnetic pole and this second
Between magnetic pole.
One embodiment according to the present utility model, when not applying external magnetic field, first magnetic pole and second magnetic pole
Pole direction is in be greater than 0 ° of angle less than 90 °, and attract one another；When applying external magnetic field, first magnetic pole and second magnetic
At least one of both columns are deflected along the central axes of the application capsule, drive the capsule inner housing and the capsule shell body one
Play deflection.
Embodiment according to the present utility model is provided at least one drug release mouth, the capsule inner casing on the capsule shell body
Drug release mouth identical with quantity on the capsule shell body is provided on body, and the drug release mouth on the capsule inner housing and the glue
The drug release mouth on capsule outer housing is organized pair two-by-two, and miss one another sealing when not applying external magnetic field, outside when applying external magnetic field
It is overlapped by the capsule shell body with the relative rotation of the capsule inner housing under magnetic fields, so that the drug release of the application capsule
Mouth is in the open state.
One embodiment according to the present utility model, the capsule shell body are round cup-like structure, including bottom of a cup, by the cup
Bottom is extended and the annular mouth with the vertical annular wall of the bottom of a cup and positioned at the side opposite with the bottom of a cup of the annular wall；
Rotary stopper slot is equipped at the close annular mouth of the annular wall；The capsule inner housing is lid-like, including caping and vertical
In the annular wall of the caping, the rotation to match with the rotary stopper slot is provided near the caping and the annular wall joint
Spacer pin.The rotary stopper slot include the entrance at an angle of plane where with annular mouth and with where the annular mouth
The parallel displacement portion of plane, the entrance connect with the displacement portion.
One embodiment according to the present utility model is provided with a drug release mouth in the annular wall of the capsule shell body, should
Be provided with a drug release mouth in the annular wall of capsule inner housing, this two drug release mouths are organized pair each other, when not applying external magnetic field that
This dislocation sealing passes through the opposite rotation of the capsule shell body and the capsule inner housing when applying external magnetic field under external magnetic field
Then it is opened.Drug release mouth on the capsule shell body is located at the entrance close beneath of the rotary stopper slot, the capsule inner casing
Drug release mouth on body is located at the close beneath of the rotary stopper pin.
Another embodiment according to the present utility model, in the annular wall of the capsule shell body setting there are two the mouth that releases the drug,
Release the drug mouth there are two setting in the annular wall of the capsule inner housing, and two drug release mouths of the capsule shell body and the capsule inner casing
Between two drug release mouths of body respectively two-by-two group pair, miss one another sealing when not applying external magnetic field, when applying external magnetic field
It is opened under external magnetic field by the capsule shell body and the relative rotation of the capsule inner housing.On the capsule shell body
Two drug release mouths are divided into the rotary stopper slot two sides；Two drug release mouths on the capsule inner housing, one of them is located at the rotation
The close beneath for turning spacer pin, the central axes with another drug release mouth relative to the application capsule are symmetrical arranged.
Further embodiment according to the present utility model, there are three above to release for setting in the annular wall of the capsule shell body
Medicine mouth, setting drug release mouth identical with the capsule shell body quantity in the annular wall of the capsule inner housing, and the capsule shell body,
Drug release mouth on capsule inner housing distinguishes group pair two-by-two, and miss one another sealing when not applying external magnetic field, when applying external magnetic field
It is opened under external magnetic field by the capsule shell body and the relative rotation of the capsule inner housing.
The annular mouth inside of one embodiment according to the present utility model, the capsule shell body is provided with internal screw thread；The glue
External screw thread is arranged in the caping of intracapsular shell and annular wall joint, which matches with the internal screw thread.
The utility model also provides a kind of alimentary canal device for administration of drugs comprising external magnetic field magnet and above-mentioned application capsule, it should
Application capsule is microstructure, and when use enters alimentary canal, and human external is located at when which uses.
Embodiment according to the present utility model, the alimentary canal device for administration of drugs further include that position detection unit and wireless communication are single
Member, the two signal communication；The position detection unit is arranged in the application capsule, for detecting the current location of the application capsule
Information；And the wireless communication unit is used to receive the location information of the position detection unit, and sends the location information to outside
Portion's equipment.
Compared with prior art, in alimentary canal device for administration of drugs provided by the utility model, firstly, since first magnetic pole is solid
Be scheduled in the capsule inner housing, which is fixed in the capsule shell body, in no external magnetic field, the first magnetic pole with
Second magnetic pole be also set to it is in a certain angle so that there is rotary torsion always between two magnetic poles, so that the application
The internal bond strength of capsule is strong.When applying external magnetic field, which is further increased, thus drive the capsule inner housing,
Capsule shell body relative rotation.Existing rotary torsion is in no externally-applied magnetic field always for first magnetic pole and second magnetic pole
It is generated by the constraint position-limiting action of rotary stopper slot and rotary stopper pin.Applying external magnetic field or revocation external magnetic field process
In, the relative rotation of the two is similarly constrained by rotary stopper slot and rotary stopper pin.Secondly, the rotation between two magnetic poles,
The rotation for driving the capsule inner housing, capsule shell body mutual causes the gradually coincidence of drug release mouth thereon, so that
The mouth that releases the drug is in the open state when applying external magnetic field, in dislocation closed state when cancelling external magnetic field.Finally, the first magnetic pole with
There is also mutual attractive force in itself between second magnetic pole, it can be ensured that the capsule inner housing and the capsule shell body be not along the application
The central axes of capsule are to separation, so that it is guaranteed that safety in use.
The position limiting structure that the rotary stopper pin is formed with the rotary stopper slot matches each other, and effect has three: first is that this
Capsule inner housing or the capsule shell body relative rotation play guiding role；Second is that playing position-limiting action, make to be administered capsule combination
Together, it is unlikely to scatter in use；Third is that act on the detent of first magnetic pole and second magnetic pole, due to this
One magnetic pole is fixed in the capsule inner housing, which is fixed in the capsule shell body, by the rotary stopper pin with
The detent of the rotary stopper slot acts on, it is therefore an objective to make the pole direction of both first magnetic pole and second magnetic pole in assembling
(it is greater than 0 ° less than 90 °) at an angle, to there is rotary torsion always, enhances the capsule inner housing and the capsule shell body
The power that be combined with each other.
In short, in the assembled state, due to the rotation on the rotary stopper pin and the capsule shell body on the capsule inner housing
Turn the constraint for the position limiting structure that limiting slot collectively constitutes, there are angles between the first magnetic pole or the magnetic pole of the second magnetic pole, to deposit
In rotary torsion, so that the application capsule itself is in inner tight bonding state always.When applying external magnetic field, the first magnetic pole
All turn in external magnetic field backspin at least one of both the second magnetic pole or both.Rotation between two magnetic poles, band
The mutual rotation of the capsule inner housing, capsule shell body is moved, drug release mouth thereon is caused to eliminate dislocation and be gradually overlapped, from
And making drug release mouth in the open state when applying external magnetic field, inside and outside shell drug release mouth is in dislocation closed when cancelling external magnetic field
State, to realize the purpose that medicinal powder releases.The utility model structure simplifies, and application is easy to operate, and highly-safe, capsule capacity obtains
To promotion, but also it is able to achieve fixed point targeting application.
By designing above, the structure for being administered capsule is simplified, while in the case where being administered the given volume of capsule,
Volume shared by medicinal powder can be larger, so that the dose out when being administered is more, to improve capsule capacity.Also, it is administered capsule
Fixed point target application, therapeutic effect can be provided, medicinal powder cost is saved.
The above description is merely an outline of the technical solution of the present invention, in order to better understand the skill of the utility model
Art means, and being implemented in accordance with the contents of the specification, and in order to allow the above and other purpose, feature of the utility model
It can be more clearly understood with advantage, it is special below to lift preferred embodiment, and cooperate attached drawing, detailed description are as follows.
Detailed description of the invention
Fig. 1 is alimentary canal device for administration of drugs schematic diagram provided by the utility model.
Fig. 2 is the perspective view of the explosion of application capsule shown in FIG. 1.
Fig. 3 is state signal of two magnetic poles of the application capsule of the utility model in the nature of no external force
Figure.
Fig. 4 is that the state when pole line of two magnetic poles of the application capsule of the utility model forms angle is illustrated
Figure.
Fig. 5 is magnetic pole deflection principle schematic diagram when applying external magnetic field.
Fig. 6 is the capsule shell body structural schematic diagram of the utility model.
Fig. 7 is the capsule inner shell structure schematic diagram of the utility model.
Fig. 8 is perspective view of the explosion of the application capsule of the utility model when applying external magnetic field.
Fig. 9 is the application capsule assembling schematic diagram of the utility model.
Figure 10 is the use schematic diagram of the alimentary canal device for administration of drugs of the utility model.
Figure 11 is the overall structure diagram of the alimentary canal device for administration of drugs of the utility model.
Specific embodiment
Further to illustrate that the utility model is the technical means and efficacy reaching predetermined purpose of utility model and being taken,
Below in conjunction with attached drawing and preferred embodiment, to the utility model, detailed description are as follows.
Referring to Fig. 1, the alimentary canal device for administration of drugs 100 of the utility model is the capsule type digestive tract application of external magnetic field control
Device comprising external magnetic field magnet 110 and application capsule 120, wherein the application capsule 120 is microstructure, when in use
Enter human body alimentary canal by oral cavity, in human vitronectin when which uses.
It is illustrated in figure 2 the perspective view of the explosion of the application capsule 120.As seen from the figure, which includes in capsule
Shell 121, capsule shell body 122, the first magnetic pole 123, the second magnetic pole 124 and medicinal powder 125, wherein capsule shell body 122
Size is greater than the size of the capsule inner housing 121, and is between the two rotary dynamic seal, matches each other, collectively forms the application
The shell of capsule 120.First magnetic pole 123 is fixed in the capsule inner housing 121, outer diameter and the capsule inner housing 121
Internal diameter matches.Second magnetic pole 124 is fixed in the capsule shell body 122, the internal diameter of outer diameter and the capsule shell body 122
Matching.First magnetic pole 123 and the second magnetic pole 124 are radial polarised magnetic pole.The medicinal powder 125 is located at first magnetic pole 123 and should
Between second magnetic pole 124.In assembling, which is seated between first magnetic pole 123 and second magnetic pole 124, to medicine
The shape of powder 125 does not require.First the first magnetic pole 123 can be packed into capsule inner housing 121, then again fill medicinal powder 125
The space above the first magnetic pole 123 in the capsule inner housing 121 is filled out, finally again and outside the capsule equipped with the second magnetic pole 124
Shell 122 is assembled into application capsule 120；Medicinal powder can also be pressed into and 124 shape phase of first magnetic pole 123 and the second magnetic pole
It is matched cylindric, then application capsule 120 is assembled into other component.
It is illustrated in figure 3 the nature of the first magnetic pole 123 and the second magnetic pole 124 of application capsule 120 in no external force
Under status diagram.As shown, without any external force under natural conditions, first magnetic pole 123 and the second magnetic pole
124 are spaced a distance, which is the thickness for the medicinal powder 125 being clipped in the middle, and indicate the spacing with L in Fig. 3.Moreover,
First magnetic pole 123 and the second magnetic pole 124 are radial polarised.So-called radial polarised refers to that the two poles of the earth N, S of magnetic pole are diametrically square
To.In one embodiment of the utility model, as shown in figure 3, without any external force (including additional magnetic described below
Field or mechanical limit structure) under natural conditions, first magnetic pole 123 is contrary with the pole of the second magnetic pole 124, puts down
Row and coaxial, radial constraint, rotation is freely.When no externally-applied magnetic field, the limitation rotated to it without mechanical limit structure, between end face
Certain distance (thickness that the distance is medicinal powder 125), pole from each other are kept in the case where certain, between two magnetic poles
It is contrary, by magnetic force attract.For example, the pole N of first magnetic pole 123 is in left side, and the pole S is on right side in Fig. 3；Second magnetic
The pole N of column 124 is on right side, and the pole S is in left side.It should be noted that pole is contrary herein, as shown in figure 3, referring to two
The NS extreme direction of magnetic pole is on the contrary, in not outer plus external force, and in the same side, a magnetic pole is the pole N, another magnetic pole is the pole S, on the contrary
?.
In the utility model, the radial polarised of first magnetic pole 123 and the second magnetic pole 124 is to realize in the following way
: it is first required shape with magnetic powder machine-shaping, is sintered later, finally with electromagnetic field along radial magnetizing.Generally making
When making magnet, added magnetic field is added in which both ends of magnet, and pole orientation determines that.
As shown in figure 4, schematic diagram when forming angle for the pole line of first magnetic pole 123 and the second magnetic pole 124.It needs
It should be noted that the pole line of two magnetic poles at this time forms angle, it is by limit described below when no external magnetic field applies
Structure detent and formed；When there is external magnetic field application, external magnetic field and the position limiting structure detent can cause such state.Also,
Due to the presence of position limiting structure described below, use state after assembling, the pole line of two magnetic poles has been in always
The state of angle.The angle α is any angle, as long as making two magnetic pole deflections.In an implementation of the utility model
In example, which is greater than 0 ° less than 90 °.At this point, wherein at least one magnetic pole deflects relative to another magnetic pole, or
Both deflect.Due to one of magnetic pole the pole N and the pole S of another magnetic pole or the pole S of a magnetic pole with it is another
The pole N of a magnetic pole is attracted each other respectively, when there are angle α, deflection torsion can be generated between two magnetic poles, in the deflection torsion
Under the action of, the combination of two magnetic poles is closer.
When applying external magnetic field, in extreme circumstances, the effect meeting of external magnetic field so that the pole direction of two magnetic poles is consistent,
That is, external magnetic field makes N, S of two magnetic poles extremely in the same direction, rotary torsion at this time between the two is maximum.It is illustrated in figure 5
One embodiment of the utility model, wherein first magnetic pole 123 and the second magnetic pole 124 are horizontal positioned, and the left figure of Fig. 5 is just to open
Begin to apply state when external magnetic field, first magnetic pole 123 and second magnetic pole 124 are in initial angle α in figure, and the angle is under
Position limiting structure described in text is limited.When the N of external magnetic field extremely close to first magnetic pole 123 and the second magnetic pole 124 when, first magnetic
Column 123 and second magnetic pole 124 will not be generated in vertical direction away from or approaching this because being assemblied in the application capsule 120
The displacement of external magnetic field, but have at least one magnetic pole and deflect.First magnetic pole 123 is moved closer to the pole N of external magnetic field
When with the second magnetic pole 124, the pole N of external magnetic field can generate attraction with the pole S of first magnetic pole 123, at the same with second magnetic pole
124 pole N generates repulsive interaction.At this point, second magnetic pole 124 is because can not be in vertical direction far from the external magnetic field, then it can be automatic
It deflects, so that its pole N moves closer to the N of the external magnetic field by deflection by deflecting away from the pole N of the external magnetic field, the pole S
Pole.In this way, external magnetic field becomes larger first magnetic pole 123 and the attraction of second magnetic pole 124, while first magnetic pole
Angle α between 123 and second magnetic pole 124 also becomes larger, and the rotary torsion of generation also becomes larger.In this way, be fixed on this
The capsule shell body 122 outside two magnetic poles 124 is fixed on outside first magnetic pole 123 in the case where the rotation of second magnetic pole 124 drives
Capsule inner housing 121 in the case where the rotation of first magnetic pole 123 drives, at least one or two of two magnetic poles can produce simultaneously
The raw deflection relative to another magnetic pole.It, should when the external magnetic field continues infinitely close to first magnetic pole 123 and the second magnetic pole 124
The pole N of second magnetic pole 124 deflects into opposite side, and the first magnetic pole 123 and the second magnetic pole 124 in the same direction, generate between the two at this time
Rotary torsion is maximum.
One with ordinary skill in the art would appreciate that in another embodiment, when the pole S of external magnetic field move closer to this
When one magnetic pole 123 and second magnetic pole 124, the pole S of first magnetic pole 123 can repel with it, so that first magnetic pole 123 is opposite
It is deflected in second magnetic pole 124, because first magnetic pole 123 is fixed on the capsule inner housing 121, first magnetic pole
123 deflection can drive the deflection of the capsule inner housing 121 relative to the capsule shell body 122 simultaneously.Since external magnetic field is close
Direction it is different, may be such that a rotation in two magnetic poles, it is also possible to so that two magnetic poles rotate.For example,
In one embodiment of the utility model, when external magnetic field close to when, among first magnetic pole 123 and 124 the two of the second magnetic pole
At least one meeting identical with the external magnetic field polarity deflect relative to another；In another of the utility model
In embodiment, when external magnetic field close to when, first magnetic pole 123 and second magnetic pole 124 both deflect.No matter which kind of feelings
Condition, result are all that first magnetic pole 123 occurs to deflect relatively with second magnetic pole 124, drive the capsule inner housing 121 and are somebody's turn to do
Opposite deflect occurs for capsule shell body 122.
As shown in fig. 6, being the structural schematic diagram of the capsule shell body 122.The capsule shell body 122 is round cup-shaped knot
Structure comprising bottom of a cup 1222, extended by the bottom of a cup 1222 and the annular wall 1224 vertical with the bottom of a cup 1222 and be located at should
The annular mouth 1226 with 1222 opposite side of bottom of a cup of annular wall 1224.In the capsule shell body 122 close to the annular mouth
In annular wall 1224 at 1226, it is provided with rotary stopper slot 1228, the rotary stopper slot 1228 and rotation described below limit
Position pin cooperation, provides displacement rails for the rotary stopper pin.The rotary stopper slot 1228 includes and 1226 place plane of annular mouth
Entrance 1281 and the displacement portion 1282 parallel with the 1226 place plane of annular mouth at an angle, the entrance 1281
It is connect with the displacement portion 1282, constitutes the slot of a substantially l-shaped.In one embodiment of the utility model, the entrance
1281 perpendicular to the displacement portion 1282.In another embodiment of the utility model, the entrance 1281 and the displacement portion
1282 in obtuse angle.In the further embodiment of the utility model, the entrance 1281 and the displacement portion 1282 are at an acute angle.It is preferred that
Ground is round and smooth curved surface in the entrance 1281 and 1282 joint of displacement portion.
As shown in fig. 7, being the structural schematic diagram of the capsule inner housing 121.The capsule inner housing 121 is round cover shape knot
Structure comprising caping 1212 and the annular wall 1214 perpendicular to the caping 1212.In the caping 1212 and the annular wall 1214
Joint is provided with rotary stopper pin 1218, the rotary stopper slot 1228 of the rotary stopper pin 1218 and the capsule shell body 122
It matches, engages for rotating the capsule inner housing 121 with the capsule shell body 122.
In assembling, need to be measured the pole direction of first magnetic pole 123, the second magnetic pole 124 with instrument, and according to finding out
Pole direction first magnetic pole 123 is mounted in the capsule inner housing 121, which is mounted on the capsule
In outer housing 122.The angle of installation needs to consider the position of the rotary stopper slot 1228 and the rotary stopper pin 1218, without outer
Under the normal operating condition for adding magnetic field, the position limiting structure that the rotary stopper slot 1228 and the rotary stopper pin 1218 collectively form,
Detent effect to first magnetic pole 123 and second magnetic pole 124, so that between first magnetic pole 123 and second magnetic pole 124
Pole direction make an angle alpha, the range of the angle α is greater than 0 ° less than 90 °.The presence of the angle α, so that first magnetic pole
There is rotary torsion always between 123 and second magnetic pole 124, so that total is in tightening state always.Meanwhile
There is attraction always between first magnetic pole 123 and second magnetic pole 124.In this way, being unlikely to digesting in use
It falls off in road, therefore meets security requirement.
To further enhance safety, in an embodiment of the utility model, in the ring of the capsule shell body 122
The inside of shape mouth 1226 is provided with internal screw thread 1227.The caping 1212 of the capsule inner housing 121 connects with the annular wall 1214
Place is provided with external screw thread 1217, and the internal screw thread 1227 of the external screw thread 1217 and the capsule shell body 122 matches and screw thread connects
It connects.In this way, even if in extreme circumstances, the rotary stopper pin 1218 of the capsule inner housing 121 rotates to the entrance 1281
Position has due to peristalsis of the digest tract or external force when falling off risk, due to the external screw thread 1217 and the internal screw thread 1227 it
Between threaded connection, still be able to ensure the capsule apparatus 100 using safe.
Please also refer to Fig. 6 and Fig. 7, in one embodiment of the utility model, the annular wall of the capsule shell body 122
A drug release mouth 1225 is provided on 1224,1281 lower section of entrance which is located at the rotary stopper slot 1228 is attached
Closely.A drug release mouth 1215 is provided in the annular wall 1214 of the capsule inner housing 121, which is located at the rotation
The close beneath of spacer pin 1218.This two 1225,1215 groups pairs of drug release mouths, when not reaching fixed point targeting lesions position, nothing
External magnetic field need to be applied, two drug release mouths miss one another closing at this time, are in close state, and reduce the waste of medicinal powder 125.Work as arrival
When fixed point targeting lesions position, by applying external magnetic field, under the action of external magnetic field, in the capsule shell body 122 and the capsule
121 relative rotation of shell, drug release mouth are gradually overlapped until fully opening, and the medicinal powder 125 in the application capsule 120 can be released at this time
Out, meanwhile, digestive juice in the digestive tract can also be contacted by the drug release mouth with medicinal powder 125, accelerate releasing for medicinal powder 125.
At this point, when the capsule inner housing 121, capsule shell body 122 only exist a drug release mouth, two drug release mouths with apply
Direction where the central axes of Drug Capsule 120 are formed by face is vertical, and two drug release mouths are adjacent, in non-externally-applied magnetic field because mutually
It mutually covers and application capsule 120 is made to be in closed state；When applying external magnetic field, because of rotation, two drug release mouths are opened.
In another embodiment of the utility model, it is relatively set in the annular wall 1224 of the capsule shell body 122
Two drug release mouths 1225, the two drug release mouths 1225 are divided into the two sides of the rotary stopper slot 1228.Preferably, two drug release mouths
1225 are located on the same axial plane of the annular wall 1224.There are two release for setting in the annular wall 1214 of the capsule inner housing 121
Medicine mouth 1215, it is preferable that one of drug release mouth is located at the close beneath of the rotary stopper pin 1218, and with another drug release mouth
Central axes relative to the application capsule 120 are symmetrical arranged；It is highly preferred that two drug release mouths 1215 are located at the annular wall 1214
On same axial plane.In the present embodiment, there is the case where two drug release mouths in capsule inner housing 121, capsule shell body 122
Under, when not applying external magnetic field, the first direction at two 1215 places of drug release mouths of the capsule inner housing 121, outside the capsule
Second direction where two of shell 122 drug release mouths 1225 at an angle, as long as ensuring that this is applied when not applying external magnetic field
The drug release mouth of Drug Capsule 120 is completely in closed state.And when applying external magnetic field, under magnetic fields, in the capsule
Shell 121 and the capsule shell body 122 occur it is opposite deflect, outside two drug release mouths 1215 of the capsule inner housing 121, the capsule
Two drug release mouths 1225 of shell 122 are in the open state with deflection.In this way, when reaching fixed point targeting lesions position,
Drug release mouth to be opened, the medicinal powder 125 in the application capsule 120 can release, meanwhile, digestive juice in the digestive tract can also be released by this
Medicine mouth is contacted with medicinal powder 125, accelerates releasing for medicinal powder 125.When not reaching fixed point targeting lesions position, drug release mouth is closed,
Reduce the waste of medicinal powder 125.Thus, it is possible to realize fixed point target administration treatment purpose, improve therapeutic effect, save medicinal powder at
This.
It will appreciated by the skilled person that according to the invention essence of the utility model, the capsule shell body 122
Can be set in annular wall there are three above drug release mouth 1225, can be set in the annular wall of the capsule inner housing 121 with should
The drug release mouth 1215 of identical quantity on capsule shell body 122, and the drug release mouth on the capsule shell body 122, capsule inner housing 121
1225,1215 distinguish group pair two-by-two, when not applying external magnetic field due to the limit knot of the rotary stopper slot and the rotary stopper pin
The effect of structure, so that the drug release mouth 1225,1215 of group pair misses one another sealing two-by-two；When applying external magnetic field, this is organized pair two-by-two
Drug release mouth 1225,1215 passes through the relative rotation of the capsule shell body 122 and the capsule inner housing 121 under external magnetic field
It is opened, to complete application purpose.
According to the of different sizes of the size of the drug release mouth and the capsule, the number of the drug release mouth can be different, theoretically
Can for 1 or more in other words at least one.On drug release mouth 1225 and the capsule inner housing 121 on the capsule shell body 122
1215 quantity of drug release mouth it is identical, and two-by-two group pair, can be arranged at equal intervals, be also possible to unequal interval arrangement, if
The drug release mouth 1225,1215 organized two-by-two pair dislocation sealing when not applying external magnetic field, when applying external magnetic field under external magnetic field
Due to the capsule shell body 122 and 121 relative rotation of capsule inner housing, which weighs each other
It closes and opens.Preferably, the drug release mouth 1225 on the capsule shell body 122, the drug release mouth on the capsule inner housing 121
1215 quantity is respectively 1-10.
Therefore, the position of above-mentioned rotary stopper slot 1228, rotary stopper pin 1218 and drug release mouth is arranged, and it is practical to be conducive to this
The realization of novel application purpose.In this way, in non-externally-applied magnetic field, positioned at the rotary stopper pin 1218 of the capsule inner housing 121
Neighbouring drug release mouth 1215, the face formed with the central axes of the application capsule 120 are on first direction；And it is located at outside the capsule
The face that the central axes of drug release mouth 1225 and the application capsule 120 near the rotary stopper slot 1228 of shell 122 are formed is in
Second direction, the first direction and the second direction are at an angle.
To reach above-mentioned technical effect, in one embodiment, during installation, the pole direction of first magnetic pole 123 (N,
S polarization direction) it is identical in the axial direction as 1215 institute of drug release mouth of the capsule inner housing 121, it that is to say first magnetic pole 123
Pole direction passes through the drug release mouth 1215 of the capsule inner housing 121.The pole direction of second magnetic pole 124 then needs and the capsule
1225 institute of drug release mouth of outer housing 122 is vertical in the axial direction.In another embodiment, when installation, first magnetic pole 123
Pole direction and 1215 institute of drug release mouth of the capsule inner housing 121 are vertical in the axial direction, and the pole side of second magnetic pole 124
It is identical in the axial direction to 1225 institute of drug release mouth with the capsule shell body 122.That is, when not applying external magnetic field,
One magnetic pole 123, the second magnetic pole 124 pole direction at an angle, but all in an axial direction；And the capsule inner housing
Axial direction of the axial direction of two of 121 drug release mouths 1215 then with two drug release mouths 1225 of the capsule shell body 122 be in
Certain angle, preferably vertically.In this way, after assembling, two drug release mouths of the capsule inner housing 121 when not applying external magnetic field
1215 cover each other because of axial even vertical at an angle in shell with two drug release mouths 1225 of the capsule shell body 122
In the wall of body, and entirely to be administered capsule 120 and be in closed state, achievees the effect that dislocation sealing.
As shown in figure 8, being the perspective view of the explosion of the application capsule 120 when applying external magnetic field.As shown, the first magnetic pole
123 are integrated with the capsule inner housing 121 installation, which is integrated with the capsule shell body 122 installation, medicinal powder
125 are clipped between first magnetic pole 123 and second magnetic pole 124.Due to the rotary stopper slot 1228 and the rotary stopper pin
1218 cooperation, it is in a certain angle always between first magnetic pole 123 and second magnetic pole 124 when no external magnetic field applies, from
And the drug release mouth 1215,1225 is covered in the wall of shell, realize dislocation sealing.When there is external magnetic field application, such as
In embodiment shown in Fig. 8, which is rotated because of magneticaction along the central axes of application capsule 120, band
Move the capsule shell body 122 rotation.In this way, covering 1215,1225, drug release mouth in the wall of shell originally due to shell
121,122 relative rotation and be gradually overlapped so that entirely application capsule 120 drug release mouth it is in the open state.
In one embodiment of the utility model, which can be a variety of shapes and sizes, such as
It can be ellipse, rectangle, square, trapezoidal, star, triangle etc., width is positively correlated with the rotation angle [alpha], as long as
It is practical new to ensure that the shape of the drug release mouth 1215,1225 in rotary course can be realized dislocation sealing, opening can meet this
The requirement of type.In addition, the shape of the drug release mouth 1215,1225 of group pair is preferably identical two-by-two in the same scheme.
In the embodiments of the present invention, which can be magnetic ball, magnetic pole, be not limited only to column.
As shown in figure 9, for the assembling schematic diagram of application capsule 120.After assembling, the rotary stopper pin 1218 and the rotation are limited
The position limiting structure that position slot 1228 forms matches each other, and effect includes: first is that the capsule inner housing 121 or the capsule shell body
122 relative rotation play guiding role；Second is that the position limiting structure plays position-limiting action, it is combined together application capsule 120, no
As for scattering in use；Third is that act on the detent of first magnetic pole 123 and second magnetic pole 124, due to this first
Magnetic pole 123 is fixed in the capsule inner housing 121, which is fixed in the capsule shell body 122, passes through the rotation
The detent for turning spacer pin 1218 and the rotary stopper slot 1228 acts on, it is therefore an objective to make first magnetic pole 123 in assembling and be somebody's turn to do
The pole direction of both second magnetic poles 124 at an angle, to there is rotary torsion always, enhances the capsule inner housing 121
And the power that be combined with each other of the capsule shell body 122.
The rotary stopper pin 1218 and the rotary stopper slot 1228 collectively form position limiting structure as a result, in the capsule
Play the role of guiding, limit and detent in the relative rotation of inner housing 121 and the capsule shell body 122.Those skilled in the art
It is appreciated that the position limiting structure is not limited to the rotary stopper slot, rotary stopper pin, it can also be other forms.For example, in this reality
With in novel one embodiment, which is the cooperation of convex block and sliding rail.
As shown in Figure 10, the schematic diagram in use for the alimentary canal device for administration of drugs 100.As shown, non-externally-applied magnetic field
When, the drug release mouth of the application capsule 120, which misplaces, to be closed；During the application capsule 120, external magnetic field starts pair external magnetic field
The magnetic pole generation effect being administered in capsule 120, continuous close with external magnetic field, drug release mouth starts gradually to beat because of being overlapped
It opens, until being completely coincident, drug release mouth is fully open, and the mouth that releases the drug at this time goes out dose maximum.When external magnetic field is left, drug release mouth is extensive
Multiple dislocation closing, the application capsule 120 restore closed state.
To release by applying external magnetic field when being administered the arrival fixed point targeting lesions position of capsule 120 by this structure
Medicine mouth open, release the medicinal powder 125 in the application capsule 120, meanwhile, digestive juice in the digestive tract also can by the drug release mouth with
Medicinal powder 125 contacts, and accelerates releasing for medicinal powder 125.When application capsule 120 does not reach fixed point targeting lesions position, due to aforementioned
Angle requirement when assembled, so that not applying external magnetic field, drug release mouth is in close state automatically, and no medicinal powder 125 releases.By
This, may be implemented the purpose of fixed point target administration treatment, improve therapeutic effect, save medicinal powder cost.
In actual use, it needs first to detect and determines that the application capsule 120 reaches the intracorporal predetermined position of people, then just apply
Add external magnetic field, is administered under external magnetic field control.In order to detect the capsule type digestive tract device for administration of drugs 100 of external magnetic field control
Position in alimentary canal (gastrointestinal tract), as shown in figure 11, the capsule type digestive tract application of the external magnetic field control of the utility model
Device 100 further includes position detection unit 130, wireless communication unit 140, the wireless communication unit 140 and the position testing unit
First 130 signal communications.The position detection unit 130 is arranged in the application capsule 120, for detecting the application capsule 120
Current location information.The wireless communication unit 140 is used to receive the location information of the position detection unit 130 transmission, and should
Location information is sent to external equipment 150, which has image display function, operator or external control device
The application capsule 120 can be obtained from the external equipment 150 in the position of human body, to decide whether to apply external magnetic field.In this reality
With in novel one embodiment, which is the computer with image display function.At one of the utility model
In embodiment, the external control device can intelligently set for that can issue computer, tablet computer, mobile phone of control instruction etc.
It is standby.
The detection method of the current location information of the application capsule 120 includes but is not limited to following several:
In one embodiment of the utility model, which includes a timer and a data
Transmitting and receiving unit.The time span of the default application of the timer, the time span can be medical institutions' summary
Average data, be also possible to the data that the previous application of patient obtains, or according to multiple spraying time length before patient
And the average length of time summarized.Predict whether the application capsule 120 has arrived at desired position according to the time span.Institute
Data transmission and reception unit is stated for carrying out the transmission of data with wireless communication unit 140.In the preferred embodiment, described
Timer calculates runing time of the application capsule 120 in alimentary canal, and by the runing time and the predetermined time period into
Row compares, when the runing time reaches described predetermined time period (that is, runing time=predetermined time period), then
Determine that application capsule 120 has arrived at desired position；The data transmission and reception unit will have arrived at the letter of desired position
Unit 140 is sent to external equipment 150 to breath by wireless communication, then operator or external control device can decide whether to apply outer
Magnetic field.
In another embodiment of the utility model, which is a pH sensor.The pH is passed
Sensor can select it to detect the range of pH value according to required detection position, for example, the pH sensor can accurately detect pH
The range of value is that perhaps its range for detecting pH value is 4-8 to 2-12 or its range for detecting pH value is 7.6-8.According to existing
Medical experience, human stomach then may determine that at the application capsule 120 according to pH value in acidity into duodenum in alkalinity
In stomach or intestines.According to the pH value of colon site 7.8 or so, the pH that the detection range using pH value is 7.6-8 is sensed
Device then can effectively detect colon site.
In another embodiment of the utility model, which is detected using magnetic field method for tracing
It is administered the position of capsule 120.The position detection unit 130 includes multiple magnetic dipole units, and the magnetic dipole unit is along people
The gastral trend of body is configured.The magnetic dipole unit can be dipole moment (magnetic dipole moment),
The current density of the dipole moment be 0.1A/cm^2 (Amperes per square centimeter) to 1A/cm^2 and its weight be 0.5g (gram) extremely
Between 5g.The movement position for being administered capsule 120 is input to a default alimentary canal and moved towards in figure by the magnetic dipole unit, according to
The movement position, which moves towards present position in figure in default alimentary canal, can determine application capsule 120 position locating in alimentary canal
It sets.
In the further embodiment of the utility model, which includes an external sense unit, should
External sense unit is placed near the ileocaecal sphineter of patient, once the application capsule 120 enters colon, this external sense unit
It can detect a signal, then can determine that application capsule 120 enters the time of colon.The external sense unit can be used with
Lower detection method, but be not limited only to, body surface magnetic field detection method, radio frequency (Radio Freqency, RF) detection method or ultrasonic sensing
Detection method.
In another embodiment of the utility model, which is outside the application capsule 120
Enzyme sensor, for example, being located at the enzyme sensor on the capsule shell body 122.The enzyme sensor is for detecting whether there is alimentary canal
The enzyme of corresponding position exists, such as dedicated for detecting whether the enzyme sensor there are colonic enzyme, should if detecting colonic enzyme
Enzyme sensor will send a signal to external equipment 150 by unit 140 by wireless communication, to confirm arrival colon site.
In another embodiment of the utility model, which includes multiple external sense equipment, should
External sense equipment is configured along the trend of human body alimentary canal.The external sense equipment can be, but be not limited only to, magnetic
Iron, RF unit or ultrasonic sensing unit.When the application capsule 120 is wriggled in human body alimentary canal, apart from the application capsule
120 nearest external sense equipment can sense strongest signal, then can determine application capsule according to the strongest signal
120 position.
By the above method, after position detection unit 130 determines that the application capsule 120 reaches desired position, operator or
External control device applies external magnetic field to the application capsule 120, controls the closing and opening of the drug release mouth of the application capsule 120,
To control the completion of drug release.
In conclusion in the capsule type digestive tract device for administration of drugs of external magnetic field provided by the utility model control, firstly, by
In first magnetic pole 123 in the capsule inner housing 121, which is embedded in the capsule shell body 122, and by
In the requirement of the assembling angle of rotary stopper slot 1228 and rotary stopper pin 1218, even if this first when not applying external magnetic field
There are still the angle αs of polar orientation between magnetic pole 123 and second magnetic pole 124, thus deposit always between two magnetic poles 123,124
In mutual attractive force and rotary torsion, so that the application capsule 120 is in assembled state always, it will not be in use process
In scatter and fall off.When applying external magnetic field, the opposite rotation of caused first magnetic pole 123 or the second magnetic pole 124 under external magnetic field
Turn, the angle of the two increases, and thus the rotary torsion between two magnetic poles 123,124 increases.Secondly, two magnetic poles 123,124
Between rotation, the rotation for driving the capsule inner housing 121, capsule shell body 122 mutual, cause drug release mouth 1215,
1225 dislocation, so that it is guaranteed that drug release mouth 1215,1225 is according to whether the application of external magnetic field and in dislocation closing or open shape
State.In addition, there is also mutual attractive force in itself between the first magnetic pole 123 and the second magnetic pole 124, it can be ensured that the capsule inner housing
121 with the capsule shell body 122 not along the axial separation of the application capsule 120.
Optionally, internal screw thread 1227 is set on the inside of the annular mouth of the capsule shell body 122, in the capsule inner housing 121
Corresponding position external screw thread 1217 is set, threaded connection more ensures the capsule inner housing 121 and the capsule shell body 122 not edge
The axial separation of the application capsule 120.
By designing above, the structure for being administered capsule is simplified, while in the case where being administered the given volume of capsule,
Volume shared by medicinal powder can be larger, and the medicinal powder that can be released in this way is more, to improve capsule capacity.Meanwhile passing through outer magnetic
Fixed point targeting application may be implemented in field control, and treatment is more targeted, which thereby enhances the effect for the treatment of, while reducing need not
The medicinal powder waste wanted.
The above descriptions are merely preferred embodiments of the present invention, not makees in any form to the utility model
Limitation be not intended to limit the utility model although the utility model has been disclosed with preferred embodiment as above, it is any ripe
Professional and technical personnel is known, is not being departed within the scope of technical solutions of the utility model, when in the technology using the disclosure above
Hold the equivalent embodiment made a little change or be modified to equivalent variations, but all without departing from technical solutions of the utility model
Hold, any simple modification, equivalent change and modification made by the above technical examples according to the technical essence of the present invention, still
It is within the scope of the technical solutions of the present invention.
Claims (19)
1. a kind of application capsule, which is characterized in that it include capsule inner housing, capsule shell body, the first magnetic pole, the second magnetic pole with
And medicinal powder,
The size of the capsule shell body is greater than the size of the capsule inner housing, and the capsule shell body and the capsule inner housing are mutual
It matches and is rotary dynamic seal；
First magnetic pole is fixed in the capsule inner housing, and the internal diameter of outer diameter and the capsule inner housing matches；Second magnetic
Column is fixed in the capsule shell body, and the internal diameter of outer diameter and the capsule shell body matches；First magnetic pole and second magnetic
Column is radial polarised, and in the application capsule, and first magnetic pole and second magnetic pole are arranged to pole direction in greater than 0 °
Angle less than 90 °；
The medicinal powder is located between first magnetic pole and second magnetic pole.
2. application capsule according to claim 1, it is characterised in that: when not applying external magnetic field, first magnetic pole with should
The pole direction of second magnetic pole is in be greater than 0 ° of angle less than 90 °, and attract one another；When applying external magnetic field, first magnetic pole
It is deflected at least one of both second magnetic pole along the central axes of the application capsule, drives the capsule inner housing and the glue
Capsule outer housing is deflected together.
3. application capsule according to claim 1 or 2, it is characterised in that: be provided at least one on the capsule shell body
Release the drug mouth, is provided with drug release mouth identical with quantity on the capsule shell body, and the capsule inner housing on the capsule inner housing
On the drug release mouth and the capsule shell body on the drug release mouth organize two-by-two pair, miss one another sealing when not applying external magnetic field,
It is overlapped, is made with the relative rotation of the capsule inner housing by the capsule shell body under external magnetic field when applying external magnetic field
The drug release mouth for obtaining the application capsule is in the open state.
4. application capsule according to claim 1 or 2, it is characterised in that: the capsule shell body is round cup-like structure, packet
Bottom of a cup is included, is extended by the bottom of a cup and with the vertical annular wall of the bottom of a cup and positioned at the opposite with the bottom of a cup of the annular wall
The annular mouth of side；Rotary stopper slot is equipped at the close annular mouth of the annular wall；The capsule inner housing is lid-like, packet
Caping and the annular wall perpendicular to the caping are included, is provided with and the rotary stopper slot near the caping and the annular wall joint
The rotary stopper pin to match.
5. application capsule according to claim 4, it is characterised in that: the rotary stopper slot include and annular mouth where plane
Entrance and the displacement portion parallel with plane where the annular mouth, the entrance at an angle connects with the displacement portion.
6. application capsule according to claim 4, it is characterised in that: be provided with one in the annular wall of the capsule shell body
Release the drug mouth, is provided with a drug release mouth in the annular wall of the capsule inner housing, this two drug release mouths are organized pair each other, is not applying outside
Miss one another sealing when magnetic field, passes through the capsule shell body and the capsule inner housing under external magnetic field when applying external magnetic field
Relative rotation and be opened.
7. application capsule according to claim 6, it is characterised in that: the drug release mouth on the capsule shell body is located at the rotation
The entrance close beneath of limiting slot, the drug release mouth on the capsule inner housing are located at the close beneath of the rotary stopper pin.
8. application capsule according to claim 4, it is characterised in that: in the annular wall of the capsule shell body there are two settings
Release the drug mouth, sets in the annular wall of the capsule inner housing there are two the mouth that releases the drug, and two drug release mouths of the capsule shell body be somebody's turn to do
Group pair two-by-two is distinguished between two drug release mouths of capsule inner housing, miss one another sealing when not applying external magnetic field, outer when applying
It is opened under external magnetic field by the capsule shell body and the relative rotation of the capsule inner housing when magnetic field.
9. application capsule according to claim 8, it is characterised in that: two drug release mouths on the capsule shell body are divided into
The rotary stopper slot two sides；Two drug release mouths on the capsule inner housing, the lower section that one of them is located at the rotary stopper pin are attached
Closely, the central axes with another drug release mouth relative to the application capsule are symmetrical arranged.
10. application capsule according to claim 4, it is characterised in that: be provided with three in the annular wall of the capsule shell body
A above drug release mouth, setting drug release mouth identical with the capsule shell body quantity in the annular wall of the capsule inner housing, and this
Drug release mouth on capsule shell body, capsule inner housing group pair two-by-two respectively, miss one another sealing when not applying external magnetic field, when applying
Add and is opened under external magnetic field by the capsule shell body and the relative rotation of the capsule inner housing when external magnetic field.
11. application capsule according to claim 4, it is characterised in that: be provided on the inside of the annular mouth of the capsule shell body
Internal screw thread；External screw thread is arranged in the caping of the capsule inner housing and annular wall joint, which matches with the internal screw thread.
12. a kind of alimentary canal device for administration of drugs, which is characterized in that including external magnetic field magnet and application capsule, the application capsule is as weighed
Benefit requires described in any one of 1-11, is microstructure, and when use enters alimentary canal, and people is located at when which uses
Outside body.
13. alimentary canal device for administration of drugs according to claim 12, it is characterised in that: further include position detection unit and wireless
Communication unit, the wireless communication unit and the position detection unit signal communication；The position detection unit is arranged in the application glue
It is intracapsular, for detecting the current location information of the application capsule；And the wireless communication unit is for receiving the position testing unit
The location information of member, and external equipment is sent by the location information.
14. alimentary canal device for administration of drugs according to claim 13, it is characterised in that: the position detection unit includes timer
With data transmission and reception unit, presets in timer and take liquid time span, predict that the application capsule is according to the time span
No arrival desired position, when being administered capsule and reaching desired position, data transmission and reception unit is by the arrival desired position
Information is sent to the wireless communication unit.
15. alimentary canal device for administration of drugs according to claim 13, it is characterised in that: the position detection unit is pH sensing
Device judges the position of the application capsule by the acid-base property of pH value.
16. alimentary canal device for administration of drugs according to claim 13, it is characterised in that: the position detection unit is external sense
Unit, when use, are placed near patient's ileocaecal sphineter, whether to detect the position of the application capsule in colon.
17. alimentary canal device for administration of drugs according to claim 13, it is characterised in that: the position detection unit is to apply positioned at this
Enzyme sensor outside Drug Capsule, for detecting whether there are the enzymes at alimentary canal position.
18. alimentary canal device for administration of drugs according to claim 13, it is characterised in that: the position detection unit includes multiple outer
Portion's sensing equipment, the external sense equipment are configured along the trend of human body alimentary canal；Capsule is administered in human body alimentary canal
When wriggling, the external sense apparatus senses nearest apart from the application capsule to strongest signal are determined according to the strongest signal
It is administered the position of capsule.
19. alimentary canal device for administration of drugs according to claim 13, it is characterised in that: the position detection unit includes multiple magnetic
Doublet unit, the magnetic dipole unit are configured along the trend of human body alimentary canal；The magnetic dipole unit will be administered
The movement position of capsule is input to a default alimentary canal and moves towards in figure, moves towards institute in figure in default alimentary canal according to the movement position
Locating position determines application capsule the location of in alimentary canal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820071266.9U CN209392567U (en) | 2018-01-16 | 2018-01-16 | Alimentary canal device for administration of drugs and its application capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820071266.9U CN209392567U (en) | 2018-01-16 | 2018-01-16 | Alimentary canal device for administration of drugs and its application capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209392567U true CN209392567U (en) | 2019-09-17 |
Family
ID=67876243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820071266.9U Withdrawn - After Issue CN209392567U (en) | 2018-01-16 | 2018-01-16 | Alimentary canal device for administration of drugs and its application capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209392567U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038211A (en) * | 2018-01-16 | 2019-07-23 | 上海安翰医疗技术有限公司 | Alimentary canal device for administration of drugs and its application capsule |
| CN111887788A (en) * | 2020-09-29 | 2020-11-06 | 上海安翰医疗技术有限公司 | Impedance detection method for capsule endoscope and capsule endoscope |
-
2018
- 2018-01-16 CN CN201820071266.9U patent/CN209392567U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038211A (en) * | 2018-01-16 | 2019-07-23 | 上海安翰医疗技术有限公司 | Alimentary canal device for administration of drugs and its application capsule |
| CN110038211B (en) * | 2018-01-16 | 2024-02-27 | 上海安翰医疗技术有限公司 | Digestive tract medicine applying device and medicine applying capsule thereof |
| CN111887788A (en) * | 2020-09-29 | 2020-11-06 | 上海安翰医疗技术有限公司 | Impedance detection method for capsule endoscope and capsule endoscope |
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