CN201299646Y - System of non-invasive fixed micro device inside human esophagus - Google Patents

Abstract

Disclosed is a system of a non-invasive fixed micro device inside a human esophagus, which is characterized in that the system comprises an external magnetic field locating device and a micro device arranged inside the human body. The external magnetic field locating device comprises a permanent magnet and a locating carrier thereof; and the locating carrier is used to fix the permanent magnet and to carry and position the permanent magnet at a special part of the human body. The micro device inside the human body comprises a shell, a functional module and a permanent magnet. The external magnetic field locating device generates magnetic force through the permanent magnet thereof to attract the permanent magnet embedded in the micro device inside the human body to locate the micro device inside the human body. The shell of the micro device takes the shape of a flat capsule, a relatively flat crust is adhered at the side face of the shell, which is parallel to the embedded permanent magnet, and the other parts of the crust is streamline. The micro device is equipped with a sensor or an actuator inside to satisfy the requirements of physiological parameter monitoring and treatment inside the esophagus. The micro device is pain-free and non-invasive, and convenient to operate, and a patient can endure the micro device with little pain.

Description

The system of non-invasive in vivo minitype device fixed in esophagus

Technical field

This utility model relates to medical apparatus and instruments, relates in particular to esophagus disease diagnosis and treatment medical apparatus and instruments, particularly a kind of system of non-invasive in vivo minitype device fixed in esophagus.

Background technology

Along with people's the rhythm of life quickening and the continuous change of dietary structure, the sickness rate of digestive tract function disease is elevated to first day by day, wherein common esophagus disease has anti-fluidity esophagitis, esophageal carcinoma, esophageal stricture, esophageal varix, dyspepsia, functional dysphagia or the like, has brought misery for people's body and mind.In medical diagnosis and the therapeutic process, often need specific solid space in the esophagus is carried out continuous monitoring or treatment, such as: to the discriminating of anti-fluidity esophagitis, whether have the anti-stream of acid or alkali is counter flows, the degree of anti-stream is how; At esophagus disease, treatment such as the electricity irritation that continues, release etc.; Especially after the esophagus operation, need to understand surgical effect, whether have rejection, whether organ dysfunction recovers normally more to need to carry out secular monitoring.

Diagnosis and treatment technology that a lot of esophaguses have been arranged now, such as pusher upper digestive tract such as fibergastroscope, electronic gastroscope, ultrasonic endoscope endoscope, can enter in the esophagus, observe the image situation of lesion region, can sample, treatment such as excision, because toleration is poor, is not suitable for operating for a long time.Prior art also comprises the physiological parameter monitor of catheter type, and such as monitoring meanss such as catheter type pH meter, catheter type manometer, catheter type bilirubinometers, these technology all need catheter retaining, makes the people feel painful, embarrassed, can't take food, and also is difficult to long-time use.

Recently, various radiotelemetries have been created and have been used.The interior micro device of body of several capsule shape has been described among patent ZL200410021933.5, ZL02137054.0, the US2003191430, after swallowing, move with peristalsis of the digest tract, can finish image, acid-base value, pressure and other parameters in the monitoring digestive tract, data utilize radio frequency transmission to arrive external small-sized receptor, but,, can't carry out long term monitoring to specific solid space equally because the micro device position can't be fixed in the body of these capsule shape.

Patent US6285897 has described the method for physiological parameter in a kind of telemonitoring body cavities, to comprise the physiological parameter sensors monitor and be fixed to the tract wall, wherein said monitor is fixed to the fixing means that adopts on the described wall and is made up of one or more following article: nail, pin, hook, barb, clip or other probe into article in the mucosa of described tract wall to small part.Mention a kind of method of fixing a device at the human body surface tissue among the patent US6689056, individual cavity and contact pin are arranged on the housing of this device, transport this by a guiding device and install a certain position, make cavity close on the surface texture of fixed position, tissue is extracted in the cavity, promote the contact pin penetrate tissue, device is fixed on this position.Above-described fixed form all has wound, and patient's toleration is poor, and is easy to generate infection risk.

Those skilled in the art as can be known, esophagus is the flesh pipeline that connects pharyngeal stomach function regulating, esophageal wall is made of mucosa, tela submucosa, flesh layer and adventitia four layer tissues, and more mucus is arranged on the esophageal wall, so smooth surface.In swallowing saliva or food process, the dividing a word with a hyphen at the end of a line property wave motion that esophagus is relaxed and contracted by the smooth muscle layer order, peristalsis produces certain contractility, therefore will be in esophagus internal fixation one be individual micro device, the thrust that must can overcome the gravity of self and swallow generation, and consider the needs of long period of operation, and the preferably painless noinvasive of this technology, not influencing daily life, existing technology all is difficult to realize.

Summary of the invention

At the deficiencies in the prior art, the purpose of this utility model be to provide a kind of in esophagus the system of ad-hoc location non-invasive in vivo minitype device fixed, according to clinical needs, micro device is used for monitoring intraesophageal physiological parameter in this body, perhaps also can carry out electricity irritation or release in the esophagus, the location is accurate, handling safety.

For realizing that the technical scheme that this utility model purpose adopts is such, promptly a kind of system of non-invasive in vivo minitype device fixed in esophagus comprises micro device in external magnetic field positioner and the body; Described external magnetic field positioner comprises permanent magnet and location carrier thereof, and described location carrier comprises fixing to permanent magnet, and carries the location of permanent magnet on the human body specific part; Micro device comprises shell, functional module and permanent magnet in the described body, and wherein: functional module and permanent magnet are by body seal; The external magnetic field positioner is finished location miniature in the body by the magnetic attraction of permanent magnet generation to the permanent magnet in the micro device in the body.

The described external magnetic field positioner of esophagus specific part can produce stable gradient magnetic to the solid space of esophagus appointed area, and the magnetic field intensity of external magnetic field positioner outside is no more than 100 Gausses; The material of its permanent magnet can be a kind of in the permanent magnet material of neodymium iron boron, aluminum nickel cobalt or other high energy product parameters, and magnetic energy product is greater than 20MGOe; Described location carrier adopt permanent magnet can be fixed on the trunk first half, rubber-like vest shape fixing band, or elastic cross-like bundling belt.

The material of the shell of micro device is and the medical high polymer plastics of inside of human body tissue compatible in the described body, has hydrophobic property, is not easy to adhere to solution and food debris; The shell external diameter is flat capsule shape structure less than the internal diameter of esophagus, has the opposed flattened housing that contacts with esophageal wall and adheres to the side, and this shell side is parallel with embedded permanent magnet, and other housing parts adopt streamlined appearance; The material of its permanent magnet is the magnetic material of neodymium iron boron, aluminum nickel cobalt or other high energy product parameters, and magnetic energy product is greater than 20MGOe; Permanent magnet is a laminated structure, and magnetizing direction is a thickness direction.

In order to prevent that micro device is shed to gastric immediately in the body after swallowing, also be convenient to accurate location, in described body, have on the shell of micro device with housing in disconnected perforation, be convenient to micro device in the described body is through in the backguy, determine that according to the length of backguy it enters in the body, as intraesophageal position, behind the location, remove or swallow backguy.

In order to realize the clinical practice needs, described functional module contains at least a physiological parameter sensors or executor.Such as, in order to realize the physiological parameter monitoring function, described functional module planted agent is contained at least a pick off, and the parameter of monitoring comprises and is not limited to following kind: image, temperature, pressure, pH value, impedance, enzyme, glucose, bilirubin, creatinine, blood urea nitrogen, urinary nitrogen, feritin, angiotensin, specific ion (as sodium, potassium, calcium, carbonate, phosphate etc.) or the like; In order to realize therapeutic use, micro device should be able to be finished predetermined actions or according to the command execution corresponding operating of external controller in the body, such as electricity irritation, ultrasonic diagnosis, electromagnetic wave, perhaps carries out tissues sampled, discharges function such as medicine.

Based on said structure, this utility model discloses a kind of method at non-invasive in vivo minitype device fixed in esophagus, as shown in Figure 1, fix an external magnetic field positioner on trunk, described external magnetic field positioner can produce the stable magnetostatic field with certain magnetic field gradient at the esophagus assigned address; Micro device 2 external structures are according to airflow design in the capsule shape body of embedded permanent magnet, the patient swallows voluntarily, and micro device enters esophagus in the described body, when arriving the described gradient magnetic scope of esophagus, micro device is under the action of a magnetic field in the body, and micro device can be adjacent to esophageal wall in the body; In swallowing saliva or food process, mucus or spoon meat can impact to micro device in the body, and fairshaped enclosure designs can realize minimum impulsive force; After micro device is impacted in the body, can depart from equilibrium point, direction to stomach glides, because gradient magnetic is on the direction that moves to stomach, magnetic field intensity can increase gradually, and direction is all pointed to equilibrium point, captivation to micro device in the body strengthens, can offset the impact that spoon meat or mucus cause, and after swallowing act finishes, get back to the equilbrium position gradually, realize purpose at non-invasive in vivo minitype device fixed in esophagus.If do not need to continue micro device in the fixed body, as long as the external magnetic field positioner is taken away, micro device will be discharged through digestive tract naturally from the esophageal wall landing in the body.This apparatus structure is simple, easy to operate, and is harmless to human body, and micro device is disposable use in the body, avoids the risk of cross infection.

By dissecting knowledge and radioscopy as can be known, esophagus is in the middle part of going up of trunk basically, same individual on an empty stomach, under different feed states such as be satiated with food, stand, walk, doss, different figures' the situation, esophagus can produce certain relative displacement by relative trunk, and external magnetic field positioner and trunk relative position are fixed, therefore, the relative position of micro device meeting and esophagus also has certain relative displacement in the body, should consider this factor in the process of clinical application.For safety, reliability, the comfortableness that the assurance system uses, need to solve following key issue:

1. micro device designing requirement in the body: the shell size is suitable, avoids incarceration, adopts medical material and secure seal, acid-alkali-corrosive-resisting; When swallowing saliva or food, the smaller the better to the impulsive force of micro device in the body; With the contact area of esophageal wall can not be too little, reduce pressure to esophagus.

2. embedded little permanent magnet: overall structure, the weight limits of micro device in the receptor, need select the material of high energy product parameter for use, and appropriate design magnet shape and magnetizing direction allow the active force between the Magnet reach maximum, and then reduce the target of overall system weight.

3. external magnetic field positioner: select the permanent magnet material of high energy product parameter, appropriate design magnet structure and magnetic circuit be in the solid space at center with " fixing point " in the esophagus, along esophagus direction structure gradient magnetic; At the people of different builds, take different external magnetic field positioners, reduce the intensity and the weight of external magnetic field positioner as far as possible, improve comfortableness and safety; The external magnetic field positioner should be fixed with the trunk relative position, and is comfortable and easy to wear, do not influence sleep and basic living needs; Magnetic field beyond the target area needs to weaken, and avoids attracting ferruginous article, meets accident.

Description of drawings

Fig. 1 is a functional schematic of the present utility model.

Fig. 2 is that micro device is subjected to liquid hydraulic shock power effect sketch map in the body.

Fig. 3 is the interior micro device functional schematic of the pH body of embodiment.

Fig. 4 is the functional schematic of the data logger of embodiment.

Fig. 5 is that the interior micro device of the pH body of embodiment is at three kinds of position force analysis figure.

In the accompanying drawing: 1, external magnetic field positioner; 2, micro device in the body; 3, esophagus; 11, permanent magnet; 21, capsule housing; 22, functional module; 23, permanent magnet; 221, pH pick off, 222, battery; Data 223, processor; 224, memorizer; 225, A/D sample circuit; 226, radiofrequency emitting module; 4, data logger; 41 batteries; 42, signal receiving module; 43, memorizer; 44, data processor; 45, button; 46, display lamp, 47, buzzer; 48, data-interface; 49, monitor shell.

The specific embodiment

Below in conjunction with drawings and Examples the technical solution of the utility model is further elaborated.

Fig. 1 is a functional schematic of the present utility model, fixes an external magnetic field positioner 1 on trunk, and micro device 2 produces captivation in the body in the esophagus 3 to swallowing, and the interior micro device 2 of body can be fixed on the esophageal wall.

Be subjected to shown in the liquid hydraulic shock power effect sketch map as micro device in Fig. 2 is body, the people is when swallowing saliva and food spoon meat, unavoidably can be to micro device in the body 2 power that impacts, can have a strong impact on fixed effect, therefore, the external shape of shell is carried out airflow design, all is streamlined as automobile, aircraft, bridge pier, is usually expressed as level and smooth and regular surface, does not have big fluctuating and sharp-pointed corner angle.Fluid mainly shows as laminar flow in the streamliner surface, does not have or seldom have turbulent flow, and this has guaranteed that object is subjected to less resistance.Reduce the probability that this type of impact causes the interior micro device 2 of body in the esophagus 3 to come off as far as possible.

For this utility model better is described, now introduce an embodiment " pH value of esophagus wireless monitor capsule system ", the pH value that is used for 5cm place, LES (following sphincter) top in the long term monitoring esophagus comprises micro device 2 and vitro data monitor 4 three parts in external magnetic field positioner 1, the pH body.Micro device 2 enters esophagus through swallowing in the pH of capsule shape body, be subjected to the captivation of external magnetic field positioner 1, micro device 2 is adjacent to esophageal wall in the pH body, pH value in the long term monitoring esophagus, and data are sent to external data sink by radiofrequency signal, this inventive embodiment is used for realizing pH value in the wireless monitor esophagus, can be used for the diagnosis of anti-fluidity esophagitis, also can be used for the auxiliary diagnosis of esophagus relevant disease.

The permanent magnet 11 of present embodiment adopts Nd-Fe-Bo permanent magnet material, trade mark N50, magnetic energy product is 50MGOe, cotton, nylon, rubber band elastomeric material are made the location carrier 12 of short vest pattern, be through on the trunk, wherein, the magnetic field that abnormally-structured permanent magnet produces guarantees to form a stable gradient magnetic near the specific solid space scope of the 2cm radius of esophagus LES top 5cm.

From life security, the magnetic field intensity of this utility model external magnetic field positioner 1 outside is no more than 100 Gausses, in order to achieve this end, be designed to the permanent magnet in the external magnetic field positioner 1 11 abnormally-structured, such as: part is taked U type structure, perhaps adopt the combination magnet of multiple magnetizing direction, trunk magnetic field in addition all is in the closed magnetic circuit, only the torso portion of target area is in open magnetic circuit.For the shielding of magnetostatic field, can certainly adopt magnetic shielding materials such as soft iron, silicon steel, permalloy auxiliary, the pcrmeability of magnetic shielding material is higher, and barrel is thicker, and shield effectiveness is just significantly; Simultaneously also can be by increasing the method for elastomeric material thickness, protection people's life security in the process of implementing, is answered the factors such as weight, human comfort degree, safety of analysis of magnetic shielding material, designs on application foundation.

Fig. 4 is as micro device 2 functional schematics in the pH body of embodiment.Micro device 2 partly is made up of shell 21, functional module 22 and permanent magnet 23 3 in the pH body, wherein functional module comprises pH pick off 221, battery 222, data processor 223, memorizer 224, A/D sampling 225, radiofrequency emitting module 226, and wherein the transducing part of pH pick off 221 is exposed to the outside of capsule shell; Described pH pick off connects data processor by the A/D sample circuit, under data processor controlled, the pH pick off converts the pH value of gathering to data format by the A/D sample circuit, be temporarily stored in the memorizer in the capsule, by signal emission module data be sent to external data logger 4 again.The material of described permanent magnet 23 is a NdFeB material, and the magnetic direction that embedded permanent magnet produces is perpendicular to the length direction of shell, and the micro device 2 tailing edge esophagus of being swallowed glides in the pH body, and the magnetic direction of embedded permanent magnet is just perpendicular to esophagus.Wherein, corresponding devices can followingly be selected: battery 222 adopts the 3V silver oxide button cell, it is the chip of MSP430f2012 that data processor 223 can adopt model, its inner integrated 2Kflash, the RAM of 128B, the AD of 10Bit, can satisfy the needs of data storage and procedure stores, the pH pick off that pH pick off 221 selects for use medical antimony measurement electrode and Ag/AgCl reference electrode to form, utilize miniature three amplifiers, adopt the A/D sample circuit 225 of constant pressure and flow circuits built pH pick off, built-in A/D carries out data acquisition via data processor, adopt the signal emission module 226 of TH72015 then, the FSK/ASK communication modes, European 433MHz ISM band arrives external data logger with transfer of data.

Fig. 5 is the functional schematic of embodiment data logger 4.Data logger 4 is by battery 41, signal receiving module-42, and memorizer-43, data processor-44, button 45, display lamp-46, buzzer-47, data-interface-48, monitor shell-49 is formed.Wherein: the data of described signal receiving module 42 receiving modules 22 transmission under data processor 44 controls, are temporary in data in the memorizer 43, or send once more by data-interface 48.Described data logger shell 49 is by nontoxic, the harmless material of human body is made; The patient utilizes the button 45 on the data logger to write down incidents such as feed in the operating process, sleep, acid regurgitation; Memorizer 43 in the data logger 4 is used for storing the pH data, and described pH data can transmit by carrying out data between the data handling equipment such as data-interface 48 and computer PC; Computer PC can be finished monitor time check and correction, instructs the doctor to carry out initialization operations such as pH value calibration, also can the data of test be shown, operations such as statistics, analysis.Wherein, described battery 41 can adopt 7#1.5 volt alkaline battery, utilize the LDO boost module to provide 3V voltage for system applies, data processor 44 adopts MSP430F1232,22 I/O, 10 AD, program storage is no less than 8K, be with 1 serial ports, the 8MHZ clock, signal receiving module 22 adopts TH71101 FSK/FM/ASK 433MHz receptor, and memorizer 43 adopts the FALSH memorizer AT45DB642D of the 64M BIT of atmel corp, and data-interface 48 adopts RS232 MAX3221 and PC to carry out two-way transfer of data.

Analyze for stressed object with micro device in the pH body 2, mainly comprise the downward thrust of gravity, the elastic force of esophagus, food itself, magnetic attraction, with frictional force of esophagus or the like, except gravity, the size and Orientation of each power is along with factor such as micro device 2 gliding speeds in people's attitude, peristalsis of the digest tract, the pH body and change.Analyze for stressed object with micro device in the pH body 2, mainly comprise gravity G, magnetic attraction F, with downward thrust T of the elastic force N of the frictional force f of esophagus, esophagus and food or the like, except gravity, the size and Orientation of each power is along with factors such as people's attitude, peristalsis of the digest tract, pH capsule gliding speeds and change.As shown in Figure 5, left figure is that micro device is in three kinds of positions of esophagus in the pH body, and right figure is corresponding force analysis figure.Micro device 2 embedded permanent magnets 23 are close to the flat sides of shell 21 in the pH body, at the diverse location of gradient magnetic.State 1., micro device 2 has just been swallowed and has been entered esophagus in the pH body, micro device 2 mainly is subjected to gravity G and swallows the thrust T1 of generation in the pH body, quickens to descend.Along with the carrying out that swallows, the frictional force of esophagus makes speed slack-off, under the active force in magnetic field, be adjacent to esophageal wall, enter the 2. state, micro device 2 is at captivation F1, esophagus elastic force N1 and the esophageal wall frictional force f1 stress balance in gravity G, magnetic field in the pH body, and the interior micro device (2) of pH body is the esophageal wall transfixion relatively.When swallowing saliva or food, micro device 2 is subjected to instantaneous impact in the pH body, be offset to stomach, it is big that magnetic attraction becomes rapidly, direction is pointed to equilibrium point, and impulsive force T2 reduces rapidly, and magnetic attraction F2, frictional force f2, impulsive force T2, gravity G make a concerted effort upwards, and micro device 2 will be got back to equilibrium point in the pH body.

By clinical trial as can be known, the motive force that in the feed spoon meat process micromodule is produced is about 0.05N.Analyze according to limit stressing conditions, captivation in external magnetic field positioner 1 and the pH body between the micro device 2 is greater than gravity and the downward thrust of esophagus, the fixedly needs that just can satisfy micro device 2 in the pH body are with height 170cm, the artificial example of body weight 60Kg, the shirtfront is 16cm to the distance of back, suppose that esophagus is positioned at the trunk middle, two block permanent magnets are 8cm at interval, the weight of micro device 2 is 3g in the pH body of capsule shape, the Nd-Fe-B permanent magnet of micro device 2 embedded trade mark N50 in the pH body, the standard value of magnetic energy product is 50MGOe, be of a size of 8mm * 20mm * 2mm, magnetizing direction is a thickness 2mm direction, at the external neodymium iron boron magnetic body that the trade mark N50 of a 50mm * 50mm * 25mm is set, magnetizing direction is the direction of thickness 25mm, both captivations can reach 0.2N, are far longer than the 0.07N that makes a concerted effort of the thrust of capsular gravity and spoon meat, just can satisfy fixedly requirement.In the actual application,, in the process that meets clinical needs, adopt few permanent magnet of trying one's best, reduce patient's burden, improve the level of comfort that uses in order to reduce system weight.

People at different builds, different esophagus diseases, in esophagus, adopt micro device in this utility model fixed body, need the analysis-by-synthesis esophagus apart from factors such as the distance of body surface, esophagus smooth surface degree, mucus sliminess, esophagus diameter, esophagus movements, the precision of fixed position also also has relation with weight, the material of shell, the shape of micro device in the distribution of gradient magnetic, the body.

In this utility model, if the excessive velocities that micro device 2 is swallowed in the body, and the gradient magnetic sphere of action is too narrow, may have influence on the effect that external magnetic field positioner 1 attracts, and can take some auxiliary technological means or operational approach to improve the reliability of operation.In described body, have on the shell 21 of micro device 2 with housing in disconnected perforation, be convenient to micro device 2 in the described body is through in the backguy, determine that according to the length of backguy it enters in the body, as intraesophageal position, behind the location, remove backguy, this method can avoid micro device 2 to drop to gastric very soon after swallowing, and also is convenient to accurate location.But recalling of backguy can cause certain discomfort to pharyngeal, also can select the medical lead that can delay time and dissolve for use, such as medical protein line, medical PVA water-soluble material or the like, after guaranteeing that the location is finished, to remain backguy and continue to swallow, behind certain hour, backguy is dissolved automatically.

Simultaneously, in the operating process, can limit the movement velocity of micro device in the body earlier with external magnetic field positioner 1 close trunnion, slowly the interior micro device of traction body arrives assigned address then.Perhaps, patient takes the prone position micro device 2 in the body of swallowing, weaken of the influence of the gravity of micro device 2 in the body to acceleration, perhaps add lead that a time-delay dissolves or the like in vivo on the micro device 2, can both reach in the short time in the restriction body micro device and swallow speed, improve the fixedly purpose of reliability.

Except above-mentioned embodiment " pH value of esophagus wireless monitor capsule system ", in order to realize the clinical practice needs, this utility model can produce the embodiment of number of different types " esophagus physiological parameter wireless monitor capsule system ": with the pH pick off 221 in the functional module 22 of micro device 2 in described embodiment " the pH value of esophagus wireless monitor capsule system " body, be changed to other biosensor, get final product with relevant change-over circuit.Such as: the image capturing system that adopts transparent optical protecgulum+miniature wide-angle lens+CMOS integration imaging chip to constitute; Adopt the temperature acquisition system of platinum electrode; Adopt the pressure acquisition system of MEMS silicon pressure sensor+pressure sensing thin film; The impedance collection system that voltage collection circuit in the outer conductive electrode+shell of testing impedance circuit+shell constitutes; Development along with ion sensing fet ISFET technology, according to the difference of sensitive membrane, can detect multiple parameter, such as: inorganic ions FET, its sensitive membrane is generally inorganic grid, solid film or organic polymer PVC film, is used to detect sodium ion, calcium ion, ammonium ion isoconcentration; Enzyme FET at the surperficial fixedly one deck enzyme membrane of sensitive grid, causes that by the reaction product between substrate to be measured and the enzyme the local pH value variation of enzyme membrane is measured; Test the concentration of glucose with dissolved oxygen electrode; And other pick offs can be used for testing the intraesophageal physiological parameter of bilirubin, creatinine, blood urea nitrogen, urinary nitrogen, feritin, angiotensin or the like, enumerate no longer one by one here.

The system of ad-hoc location non-invasive in vivo minitype device fixed in esophagus that this utility model provides, can be according to clinical needs, micro device in the body is used for monitoring various physiological parameters in the esophagus, simultaneously, in order to realize therapeutic use, this utility model can produce the embodiment of number of different types " esophagus is wireless treatment capsule system ": with the pH pick off 221 in the functional module 22 of micro device 2 in the body of described embodiment " pH value of esophagus wireless monitor capsule system ", the executor who is changed to other gets final product with relevant change-over circuit, micro device should be able to be finished predetermined actions or according to the command execution corresponding operating of external controller in the body, such as: by the Digital Logical Circuits driving pressure controlled oscillator output current pulse of data processor, by the outer metal electrode of housing, realize the treatment function of discharging and stimulating; By I/O port, the micro-fluidic integrated chip of D/A output control MEMS of data processor, can be used in the sampling function of esophagus body fluid; By fixing slow releasing pharmaceutical on housing, just can carry out long-term treatment to the mode that the esophagus assigned address carries out slow releasing pharmaceutical; And other be used for ultrasonic diagnosis, electromagnetic wave, tissues sampled or the like treatment function, enumerate no longer one by one here.

In a word, the system of ad-hoc location non-invasive in vivo minitype device fixed in esophagus that this utility model provides, as required, as long as adopt MEMS technology, nanotechnology medical energy converter, executor are carried out microminiaturization, integrated processing, can adopt this utility model to implement, produce the equipment that clinical needs are diagnosed accordingly and treated, handling safety, patient uses no pain.

Claims (10)

1, a kind of system of non-invasive in vivo minitype device fixed in esophagus, it is characterized in that: comprise micro device (2) in external magnetic field positioner (1) and the body, described external magnetic field positioner comprises permanent magnet (11) and location carrier (12) thereof, described location carrier (12) comprises fixing to permanent magnet (11), and carries the location of permanent magnet on the human body specific part; Micro device (2) comprises shell (21), functional module (22) and permanent magnet (23) in the described body, and wherein: functional module (22) and permanent magnet (23) are sealed by shell (21); External magnetic field positioner (1) is finished the location of micro device in the body (2) at the esophagus specific part by the magnetic attraction of permanent magnet (11) generation to the permanent magnet (23) in the micro device in the body (2); The shell (21) of described micro device (2) is the flat capsule shape, and the shell with opposed flattened adheres to the side, and this shell adheres to the parallel permanent magnet (23) that is embedded with of lateral inwall, and other surface of shell is streamlined.

2, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 1 is characterized in that: described permanent magnet (23) is a laminated structure, and magnetizing direction is a thickness direction.

3, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 2 is characterized in that: described shell (21) have with housing in disconnected perforation.

4, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 1, it is characterized in that: the permanent magnet in the described external magnetic field positioner (1) is a kind of in neodymium iron boron, aluminum nickel cobalt or other the high energy product permanent magnet material, and magnetic energy product is greater than 20MGOe; Permanent magnet is a kind of in neodymium iron boron, aluminum nickel cobalt or other high energy product permanent magnet materials in the described micro device (2), and magnetic energy product is greater than 20MGOe.

5, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 1 is characterized in that: described functional module (22) contains at least a physiological parameter sensors or executor.

6, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 5 is characterized in that: described functional module has signal emission module in (22), has the data logger (4) that contains data reception module in the described system.

7, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 5 is characterized in that: described physiological parameter sensors is image, temperature, pressure, pH value, impedance, enzyme, glucose, bilirubin, creatinine, blood urea nitrogen, urinary nitrogen, feritin, angiotensin or ion transducer.

8, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 1, it is characterized in that: described location carrier adopt permanent magnet can be fixed on the trunk first half, rubber-like vest shape fixing band, or elastic cross-like bundling belt.

9, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 6, it is characterized in that: described functional module (22) comprises pH pick off (221), A/D sample circuit (225), data processor (223), memorizer (224) and signal emission module (226), described parts are sealed within the capsule shell (21), and wherein the transducing part of pH pick off (221) is exposed to the outside of capsule shell; Described pH pick off connects data processor by the A/D sample circuit, under data processor controlled, the pH pick off converts the pH value of gathering to data format by the A/D sample circuit, be temporarily stored in the memorizer in the capsule, by signal emission module data be sent to external data logger (4) again.

10, the system of non-invasive in vivo minitype device fixed in esophagus according to claim 6, it is characterized in that: described data logger (4) comprises signal receiving module (42), memorizer (43), data processor (44) and data-interface (48), wherein: the data of described signal receiving module (42) receiving module (22) transmission, under data processor (44) control, data are temporarily stored in the memorizer (43), or send once more by data-interface (48).

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