MX2012005165A - Proceso para la preparacion de inhibidor de pirazinona trombina y sus intermediarios. - Google Patents

Proceso para la preparacion de inhibidor de pirazinona trombina y sus intermediarios.

Info

Publication number
MX2012005165A
MX2012005165A MX2012005165A MX2012005165A MX2012005165A MX 2012005165 A MX2012005165 A MX 2012005165A MX 2012005165 A MX2012005165 A MX 2012005165A MX 2012005165 A MX2012005165 A MX 2012005165A MX 2012005165 A MX2012005165 A MX 2012005165A
Authority
MX
Mexico
Prior art keywords
intermediates
preparation
thrombin inhibitor
pyrazinone
pyrazinone thrombin
Prior art date
Application number
MX2012005165A
Other languages
English (en)
Spanish (es)
Inventor
Regury Buchi Reddy
Upparapalli Sampathkumar
Nilam Sahu
Javvaji Karunakara Rao
Reddy Gade Brahma
Original Assignee
Diakron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diakron Pharmaceuticals Inc filed Critical Diakron Pharmaceuticals Inc
Publication of MX2012005165A publication Critical patent/MX2012005165A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MX2012005165A 2009-11-03 2010-11-02 Proceso para la preparacion de inhibidor de pirazinona trombina y sus intermediarios. MX2012005165A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2663CH2009 2009-11-03
PCT/US2010/055176 WO2011056806A1 (en) 2009-11-03 2010-11-02 Process for the preparation of pyrazinone thrombin inhibitor and its intermediates

Publications (1)

Publication Number Publication Date
MX2012005165A true MX2012005165A (es) 2012-08-08

Family

ID=43926105

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012005165A MX2012005165A (es) 2009-11-03 2010-11-02 Proceso para la preparacion de inhibidor de pirazinona trombina y sus intermediarios.

Country Status (10)

Country Link
US (1) US8541580B2 (enExample)
EP (1) EP2496087A4 (enExample)
JP (1) JP2013510159A (enExample)
KR (1) KR20120106727A (enExample)
CN (1) CN102711481A (enExample)
AU (1) AU2010315338A1 (enExample)
CA (1) CA2778922A1 (enExample)
MX (1) MX2012005165A (enExample)
RU (1) RU2012118499A (enExample)
WO (1) WO2011056806A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140090663A (ko) 2011-11-07 2014-07-17 디아크론 파마슈티칼스, 인코포레이티드 직접 트롬빈 억제제의 연장 방출성 제형
RU2018119344A (ru) 2015-10-26 2019-11-28 Байер Кропсайенс Акциенгезельшафт Конденсированные бициклические гетероциклические производные в качестве средства для борьбы с вредителями
CN113710669A (zh) 2019-02-26 2021-11-26 拜耳公司 作为农药的稠合双环杂环衍生物
MX2021010217A (es) 2019-02-26 2021-09-21 Bayer Ag Derivados heterociclos biciclicos condensados como plaguicida.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147078A (en) * 1998-05-19 2000-11-14 Merck & Co., Inc. Pyrazinone thrombin inhibitors
UA58636C2 (uk) * 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
EP1341784A2 (en) * 2000-12-06 2003-09-10 Merck & Co., Inc. Process for making a thrombin inhibitor
EP1422221A1 (en) * 2002-11-20 2004-05-26 Bayer CropScience SA Novel process for the preparation of 2-aminomethylpyridine derivative

Also Published As

Publication number Publication date
US8541580B2 (en) 2013-09-24
RU2012118499A (ru) 2013-12-10
EP2496087A1 (en) 2012-09-12
WO2011056806A1 (en) 2011-05-12
JP2013510159A (ja) 2013-03-21
AU2010315338A1 (en) 2012-05-24
US20110105753A1 (en) 2011-05-05
CA2778922A1 (en) 2011-05-12
KR20120106727A (ko) 2012-09-26
CN102711481A (zh) 2012-10-03
EP2496087A4 (en) 2013-06-19

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