MX2012003441A - Metodo para el diagnostico de esteatohepatitis no alcoholica basado en un perfil metabolomico. - Google Patents

Metodo para el diagnostico de esteatohepatitis no alcoholica basado en un perfil metabolomico.

Info

Publication number
MX2012003441A
MX2012003441A MX2012003441A MX2012003441A MX2012003441A MX 2012003441 A MX2012003441 A MX 2012003441A MX 2012003441 A MX2012003441 A MX 2012003441A MX 2012003441 A MX2012003441 A MX 2012003441A MX 2012003441 A MX2012003441 A MX 2012003441A
Authority
MX
Mexico
Prior art keywords
diagnosis
alcoholic steatohepatitis
metabolomic profile
steatohepatitis based
nash
Prior art date
Application number
MX2012003441A
Other languages
English (en)
Inventor
Azucena Castro Espido
Jose Maria Mato De La Paz
Maria Luz Martinez Chantar
Jonathan Barr
Original Assignee
One Way Liver Genomics Sl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by One Way Liver Genomics Sl filed Critical One Way Liver Genomics Sl
Publication of MX2012003441A publication Critical patent/MX2012003441A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

La invención se refiere a métodos para el diagnóstico de esteatosis no alcohólica (EHNA). El método se basa en la determinación de ciertos marcadores metabólicos en una muestra biológica del paciente que aumentan o disminuyen en los pacientes de EHNA frente a los pacientes con hígado graso sencillo (esteatosis).
MX2012003441A 2009-09-22 2010-09-20 Metodo para el diagnostico de esteatohepatitis no alcoholica basado en un perfil metabolomico. MX2012003441A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382174A EP2309276A1 (en) 2009-09-22 2009-09-22 Method for the diagnosis of non-alcoholic steatohepatitis based on a metabolomic profile
PCT/EP2010/063792 WO2011036117A1 (en) 2009-09-22 2010-09-20 Method for the diagnosis of non-alcoholic steatohepatitis based on a metabolomic profile

Publications (1)

Publication Number Publication Date
MX2012003441A true MX2012003441A (es) 2012-05-22

Family

ID=41300407

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012003441A MX2012003441A (es) 2009-09-22 2010-09-20 Metodo para el diagnostico de esteatohepatitis no alcoholica basado en un perfil metabolomico.

Country Status (6)

Country Link
US (1) US8758992B2 (es)
EP (2) EP2309276A1 (es)
AR (1) AR078309A1 (es)
CA (1) CA2775033C (es)
MX (1) MX2012003441A (es)
WO (1) WO2011036117A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2157431A1 (en) * 2008-08-11 2010-02-24 One Way Liver Genomics, S.L. Method for the diagnosis of NASH using metabolic profiles
EP2309276A1 (en) 2009-09-22 2011-04-13 One Way Liver Genomics, S.L. Method for the diagnosis of non-alcoholic steatohepatitis based on a metabolomic profile
WO2012143514A1 (en) * 2011-04-20 2012-10-26 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Method for the diagnosis of liver injury based on a metabolomic profile
CA2917483A1 (en) 2013-07-09 2015-01-15 Stemina Biomarker Discovery, Inc. Biomarkers of autism spectrum disorder
WO2016081534A1 (en) * 2014-11-19 2016-05-26 Metabolon, Inc. Biomarkers for fatty liver disease and methods using the same
WO2017217340A1 (ja) * 2016-06-13 2017-12-21 国立大学法人九州大学 フリーラジカル消費速度情報の取得方法およびｎａｓｈの判定方法
WO2018007422A1 (en) * 2016-07-05 2018-01-11 One Way Liver,S.L. Identification of human non-alcoholic fatty liver disease (nafld) subtypes
CN114502149A (zh) * 2019-07-17 2022-05-13 贝克心脏与糖尿病研究所 用于维持或调节人体组织中醚脂质分子混合物的组合物
RU2744021C1 (ru) * 2020-09-23 2021-03-02 федеральное государственное бюджетное образовательное учреждение высшего образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохранения Российской Федерации Способ дифференциальной диагностики стеатоза и неалкогольного стеатогепатита у женщин

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5397894A (en) 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
ES2226549B1 (es) 2002-12-18 2006-07-16 One Way Liver Genomics, S.L. Metodo para el diagnostico de esteatohepatitis no alcoholica (nash) mediante el empleo de marcadores moleculares.
WO2005109006A1 (ja) 2004-04-23 2005-11-17 Ajinomoto Co., Inc. 非アルコール性脂肪肝炎鑑別方法
EP1619257A1 (en) 2004-07-23 2006-01-25 One Way Liver Genomics, S.L. Method for the in vitro diagnosis of non-alcoholic steatohepatitis
US7860656B2 (en) 2005-02-03 2010-12-28 Assistance Publique-Hopitaux De Paris (Ap-Hp) Diagnosis method of hepatic steatosis using biochemical markers
JP2008538893A (ja) 2005-04-28 2008-11-13 国立大学法人高知大学 脂質代謝不全の検出方法、及びそれに使用する検査薬
US20090304704A1 (en) 2006-05-03 2009-12-10 Geisinger Clinic Methods for diagnosing and predicting non-alcoholic steatohepatitis (nash)
WO2007136822A2 (en) 2006-05-19 2007-11-29 George Mason Intellectual Properties, Inc. Methods to diagnose non-alcoholic steatohepatitis
CA2662987A1 (en) * 2006-08-08 2008-02-21 Tethys Bioscience, Inc. Markers of non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash) and methods of use thereof
ES2324189B1 (es) 2006-10-03 2010-05-13 Consejo Superior Investig. Cientificas Aparato para el diagnostico y monitorizacion de la esteatosis hepatica basado en la medicion de la impedancia electrica.
JP5299960B2 (ja) 2006-11-06 2013-09-25 公立大学法人横浜市立大学 脂肪性肝疾患の診断方法、診断装置、診断プログラム、診断薬及び脂肪性肝疾患用治療薬のスクリーニング方法
EP2157431A1 (en) * 2008-08-11 2010-02-24 One Way Liver Genomics, S.L. Method for the diagnosis of NASH using metabolic profiles
EP2309276A1 (en) 2009-09-22 2011-04-13 One Way Liver Genomics, S.L. Method for the diagnosis of non-alcoholic steatohepatitis based on a metabolomic profile
US8871454B2 (en) 2010-01-26 2014-10-28 Children's Hospital Medical Center Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (NASH)

Also Published As

Publication number Publication date
EP2480895B1 (en) 2018-03-14
AR078309A1 (es) 2011-10-26
CA2775033A1 (en) 2011-03-31
EP2309276A1 (en) 2011-04-13
US8758992B2 (en) 2014-06-24
CA2775033C (en) 2018-03-27
EP2480895A1 (en) 2012-08-01
WO2011036117A1 (en) 2011-03-31
US20120187289A1 (en) 2012-07-26

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