MX2012003212A - Papel del acido n-2-hidroxi-etil-piperazina-n´-2-etano sulfonico (hepes) en el control del dolor y reversion de lesiones por desmielinizacion. - Google Patents

Papel del acido n-2-hidroxi-etil-piperazina-n´-2-etano sulfonico (hepes) en el control del dolor y reversion de lesiones por desmielinizacion.

Info

Publication number
MX2012003212A
MX2012003212A MX2012003212A MX2012003212A MX2012003212A MX 2012003212 A MX2012003212 A MX 2012003212A MX 2012003212 A MX2012003212 A MX 2012003212A MX 2012003212 A MX2012003212 A MX 2012003212A MX 2012003212 A MX2012003212 A MX 2012003212A
Authority
MX
Mexico
Prior art keywords
cancer
hepes
disease
composition
diseases
Prior art date
Application number
MX2012003212A
Other languages
English (en)
Spanish (es)
Inventor
Ivan E Danhof
Original Assignee
North Texas Medical Ass
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by North Texas Medical Ass filed Critical North Texas Medical Ass
Publication of MX2012003212A publication Critical patent/MX2012003212A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX2012003212A 2009-09-17 2010-09-17 Papel del acido n-2-hidroxi-etil-piperazina-n´-2-etano sulfonico (hepes) en el control del dolor y reversion de lesiones por desmielinizacion. MX2012003212A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24346409P 2009-09-17 2009-09-17
PCT/US2010/049405 WO2011035212A2 (en) 2009-09-17 2010-09-17 Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Publications (1)

Publication Number Publication Date
MX2012003212A true MX2012003212A (es) 2012-09-07

Family

ID=43757159

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012003212A MX2012003212A (es) 2009-09-17 2010-09-17 Papel del acido n-2-hidroxi-etil-piperazina-n´-2-etano sulfonico (hepes) en el control del dolor y reversion de lesiones por desmielinizacion.
MX2015008916A MX360190B (es) 2009-09-17 2010-09-17 Papel del acido n-2-hidroxi-etil-piperazina-n' -2-etano sulfonico (hepes) en el tratamiento de sintomas de abstinencia, efectos colaterales o ambos despues del tratamiento con anti-depresivos o inhibidores de serotonina selectiva (ssri).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2015008916A MX360190B (es) 2009-09-17 2010-09-17 Papel del acido n-2-hidroxi-etil-piperazina-n' -2-etano sulfonico (hepes) en el tratamiento de sintomas de abstinencia, efectos colaterales o ambos despues del tratamiento con anti-depresivos o inhibidores de serotonina selectiva (ssri).

Country Status (18)

Country Link
US (4) US8883855B2 (https=)
EP (3) EP2477626A4 (https=)
JP (4) JP2013505264A (https=)
KR (1) KR101737775B1 (https=)
CN (4) CN109224077A (https=)
AR (1) AR078290A1 (https=)
AU (1) AU2010295445B2 (https=)
BR (1) BR112012006155A2 (https=)
CA (3) CA2774375C (https=)
HK (1) HK1199621A1 (https=)
IL (2) IL264055B2 (https=)
IN (1) IN2012DN02499A (https=)
MX (2) MX2012003212A (https=)
MY (2) MY159626A (https=)
NZ (1) NZ598861A (https=)
SG (3) SG10201500510YA (https=)
TW (2) TWI562777B (https=)
WO (1) WO2011035212A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY159626A (en) 2009-09-17 2017-01-13 Bespoke Bioscience Llc Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury
EP3171872B1 (en) 2014-07-21 2020-11-11 Glia, LLC Method for treating radiotherapy-and-chemotherapy associated cognitive or emotional impairment with cannabinoids
CA2984379C (en) * 2015-04-28 2024-06-11 Newsouth Innovations Pty Limited Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies, and inactivity

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641529B2 (en) * 1990-07-30 1993-09-23 Bloomfield D.A. Zwitterionic compounds and their N-halo derivatives for use in the treatment of clinical conditions
US5643562A (en) * 1993-03-29 1997-07-01 Queen's University Of Kingston Method for treating amyloidosis
US5840294A (en) * 1993-03-29 1998-11-24 Queen's University At Kingston Method for treating amyloidosis
DK0779890T3 (da) 1995-07-06 2001-11-26 Fraunhofer Ges Forschung Thiosilaner, fremgangsmåde til fremstilling deraf og anvendelse deraf
US5716959A (en) * 1996-02-13 1998-02-10 T. Ronald Theodore Method of treating disease with piperazine zwitterion compounds
WO1999040909A1 (en) * 1998-02-11 1999-08-19 Neurochem, Inc. Method for modulating macrophage activation
ATE524181T1 (de) 2004-11-10 2011-09-15 Inst Nat Sante Rech Med Verwendung von 1,4-bis (3-aminoalkyl) piperazin- derivaten bei der behandlung von neurodegenerativen erkrankungen
JP2010532331A (ja) * 2007-07-05 2010-10-07 アンセルム(アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル) 抗痙攣医薬組成物
EP2011491A1 (en) 2007-07-05 2009-01-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Anticonvulsive pharmaceutical compositions
EP2163246A1 (en) * 2008-09-12 2010-03-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Taurine or taurine-like substances for the prevention of the irreversible visual effects of vigabatrin
JP2013504151A (ja) 2009-09-04 2013-02-04 ビーエーエスエフ ソシエタス・ヨーロピア 色素増感太陽電池
AU2014206220B2 (en) 2009-09-17 2016-09-29 Bespoke Bioscience, Llc Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury
MY159626A (en) 2009-09-17 2017-01-13 Bespoke Bioscience Llc Role of n-2-hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury

Also Published As

Publication number Publication date
IL218677B (en) 2019-01-31
TW201117813A (en) 2011-06-01
EP2477626A2 (en) 2012-07-25
KR101737775B1 (ko) 2017-05-19
HK1199621A1 (en) 2015-07-10
US10213425B2 (en) 2019-02-26
EP2477626A4 (en) 2013-05-22
JP2013505264A (ja) 2013-02-14
MX360190B (es) 2018-10-24
MY159626A (en) 2017-01-13
TW201440769A (zh) 2014-11-01
CA2774375A1 (en) 2011-03-24
TWI562777B (en) 2016-12-21
TWI494106B (zh) 2015-08-01
US20140378467A1 (en) 2014-12-25
JP2015129150A (ja) 2015-07-16
CA2774375C (en) 2018-02-13
US20190142825A1 (en) 2019-05-16
IL264055A (en) 2019-01-31
AR078290A1 (es) 2011-10-26
SG10201500510YA (en) 2015-03-30
CA2977918C (en) 2021-08-10
CN103977405A (zh) 2014-08-13
SG179191A1 (en) 2012-04-27
CA3122553A1 (en) 2011-03-24
NZ598861A (en) 2013-01-25
KR20120081151A (ko) 2012-07-18
EP2835133A1 (en) 2015-02-11
US20110071157A1 (en) 2011-03-24
BR112012006155A2 (pt) 2016-06-28
MY174012A (en) 2020-03-03
SG10202100421XA (en) 2021-02-25
CN102612366A (zh) 2012-07-25
EP3520794A2 (en) 2019-08-07
US20180028530A1 (en) 2018-02-01
WO2011035212A2 (en) 2011-03-24
IL264055B1 (en) 2024-05-01
CA2977918A1 (en) 2011-03-24
IL218677A0 (en) 2012-05-31
CN107260740A (zh) 2017-10-20
JP6347807B2 (ja) 2018-06-27
US8883855B2 (en) 2014-11-11
JP5974062B2 (ja) 2016-08-23
EP3520794A3 (en) 2019-11-20
EP2835133B1 (en) 2019-04-24
US9867820B2 (en) 2018-01-16
JP2015052006A (ja) 2015-03-19
WO2011035212A3 (en) 2011-07-14
JP2016216493A (ja) 2016-12-22
CN109224077A (zh) 2019-01-18
IL264055B2 (en) 2024-09-01
AU2010295445B2 (en) 2014-09-25
AU2010295445A1 (en) 2012-04-12
IN2012DN02499A (https=) 2015-08-28

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