MX2012002711A - Antimicrobial compositions and products. - Google Patents

Antimicrobial compositions and products.

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Publication number
MX2012002711A
MX2012002711A MX2012002711A MX2012002711A MX2012002711A MX 2012002711 A MX2012002711 A MX 2012002711A MX 2012002711 A MX2012002711 A MX 2012002711A MX 2012002711 A MX2012002711 A MX 2012002711A MX 2012002711 A MX2012002711 A MX 2012002711A
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MX
Mexico
Prior art keywords
solution
weight
antimicrobial
textiles
around
Prior art date
Application number
MX2012002711A
Other languages
Spanish (es)
Inventor
Howard S Rosing
Yu-Te Lin
Chieh-Fu Huang
Ronald I Pass
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Biomed Protect Llc
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Publication date
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Publication of MX2012002711A publication Critical patent/MX2012002711A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/21—Acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Abstract

The present disclosure provides antimicrobial compositions for use in textiles, as well as methods of preparing these compositions and treating textiles with these compositions.

Description

COMPOSITIONS AND ANTIMICROBIAL PRODUCTS FIELD OF THE INVENTION Antimicrobial compositions are provided for use in textiles, as well as methods for preparing these compositions and treating textiles with these compositions.
BACKGROUND OF THE INVENTION There are many reasons to want to incorporate antimicrobial agents in textiles. For example, antimicrobial activity can enhance the durability of textiles by inhibiting the growth of bacteria and fungi that live in textiles and cause damage to their components. Textiles with antimicrobial activity. they also prevent the creation of odor by preventing or reducing microbes that feed on organic materials in the textile. Additionally, antimicrobial treated textiles can kill pathogenic microbes thereby protecting the carrier from being exposed to disease causing agents.
Other uses of antimicrobial treated textiles include wound care. For example, a medical bandage that has been treated with antimicrobial agents offers the wound a favorable environment for healing and also prevents bacterial organisms from growing on the site. Additionally, antimicrobial cleaning fabrics can prevent the microorganisms that cause the disease from surviving or even proliferate in the internal cracks of the fabric when the fabric absorbs the contaminated fluid.
Antimicrobial white bedding offers an enhanced level of hygiene and safety in hospital or hotel rooms. Its use may limit the transmission of bacterial disease in hospitals and lower rates in such hospitalized patients who acquire nosocomial infections, which have increased in frequency in recent years.
Although textiles with antimicrobial characteristics have been introduced in recent years, most of these textiles are prepared by adding antimicrobial agents for textiles. Specifically, the antimicrobial agents are impregnated in or coated on the fibers of the textile. The antimicrobial agents, however, do not bind permanently to the textile fibers and thus are prone to leaching, so that these agents are absorbed by the human skin. In addition to leaching, antimicrobial agents are not able to withstand many washes, so the antimicrobial effect can not last long. Although certain textiles treated with N-halamin are known to be regenerable after exhaustion by the treated textiles, the use of bleach with chlorine is necessary to regenerate the antimicrobial activity.
In this way, there is a need to overcome the disadvantages mentioned above. The current antimicrobial treatment of textiles leaves a need for a means to provide various textiles with minimal leaching, more permanent antimicrobial characteristics, and that do not require the use of chlorine for regenerable antimicrobial properties.
DETAILED DESCRIPTION OF THE INVENTION Although particular embodiments are described herein, those embodiments comprise simple examples of the disclosed inventions and are not intended to limit this description. The terminology used herein serves the purpose of describing those embodiments, and is not intended to be limiting, since the scope of the current description will be limited only by the appended claims.
Where a range of values is provided, each participating value is included within the description, up to one tenth of the lower limit unit unless the context clearly dictates otherwise, between the upper and lower limits of such interval and any other established or intermediate value in such established interval. The upper and lower limits of these smaller intervals can independently be included in the smaller intervals and are also included within the description, subject to. any limit specifically excluded in the established interval. Where the established range includes one or both of the limits, the ranges that exclude either or both of these included limits are also included in the description. The relationships, concentrations, quantities, and other numerical data may be expressed herein in an interval format. Such interval format is used for convenience and brevity, and in this way, it must be interpreted in a flexible manner to include not only the numerical values explicitly. mentioned as the limits of the interval, but also to include all the individual numerical values or sub-intervals encompassed within such interval as if each numerical value and sub-interval is explicitly mentioned. For purposes of illustration only, a concentration range of "from about 0.1% to about 5%" should be construed to include not only the explicitly mentioned concentration of about 0.1% by weight to about 5% by weight, but also includes individual concentrations (eg, 1%, 2%, 3%, and 4%) and sub-ranges (eg, 0.5%, 1.1%, 2.2%, 3.3%, and 4.4%) within the indicated range. The term "around.de" may include ± 1%, ± 2%, ± 3%, + 4%, ± 5%, ± 6%, ± 7%, ± 8%, ± 9%, or + 10%, or more of the numerical values that are modified. The term "about" or "about" may include an error acceptable for a particular value as determined by someone of ordinary skill in the general chemistry, organic chemistry, polymer chemistry, materials science, which depends in part on how the value is measured or determined. In certain modalities, "around" can mean one or more standard deviations.
As will be apparent to those of skill in the art during the reading of this disclosure, each of the individual embodiments described and illustrated herein have discrete components and characteristics that can be easily separated from or combined with the characteristics of any of the various other modalities without departing from the scope or spirit of the current description. Any method mentioned can be carried out in the order of events mentioned or in any other order that is logically possible.
The modalities of the current description will employ, unless otherwise indicated, general chemistry, organic chemistry, polymer chemistry, materials science, and the like, which are within the skill of the art. Such techniques are fully explained in the literature.
Before describing the various modalities, the following definitions are provided and should be used unless otherwise indicated.
I. Definitions Unless defined otherwise, all technical and scientific terms used in the present have the same meaning as. It is commonly understood by someone with experience in the general chemistry, organic chemistry, polymer chemistry, and materials science. Although methods and materials similar or equivalent to those described herein can be used in practice or proven from the current description, suitable methods and materials are described herein.
As used in the specification and the appended claims, the singular forms "a," "an," and "the" may include plural referents unless the context clearly dictates otherwise. Thus, for example, with reference to "a support" includes a plurality of supports. In this specification and in the claims that follow, reference will be made to a number of terms that will be defined to have the following meanings unless a contrary intention is apparent.
As used herein, "D DMH", or "DMDM hydantoin" refers to 1,3-dimethylol-5,5-dimethylhydantoin, [ie, 1,3-bis (hydroxymethyl) -5,5-dimethylhydantoin], having the CAS Number 6440-58-0.
As used herein, "MDMH" or "MDM hydantoin" refers to l-methylol-5,5-dimethylhydantoin, [that is, 1- (hydroxymethyl) -5,5-dimethylhydantoin] having the CAS number 116-25-6.
As used herein, "chitosan" refers to , where n is around 3 to about 6000 As used herein, "textile" refers to a material that contains natural and / or artificial fibers.
In some cases, the textile comprises about 5% to about 90% cellulose. The antimicrobial compositions of the present disclosure may be applied during or after processing to textiles such as clothing, including uniforms, socks, underwear; medical textiles, including patient curtains, gauze, surgeon suits, caps, and masks; and home textiles, including carpet, bedding, and curtains.
As used herein, "antimicrobial" or "antimicrobial composition" refers to a substance capable of killing or inhibiting the growth of microorganisms, such as bacteria (e.g., Streptococcus, Enterococcus, Bacteroidaceae, Enterobacteriaceae, Vibrionaceae, Pasteurellae, Pseudomonadaceae, Escherichia coli, Staphylococcus aureus, Shigalla sonnei, Salmonella enteritidis, Salmonella choterse-suis, Pseudomonas aeruginosa, VRE, MRSA, Proteus mirabilis, Campylobacter jejuni, and Brevibacterium), virus (eg, MS-2 Bacteriophage, Canduda albicans, strain of influenza A, strain of influenza B, and Swine Influenza), fungi (for example, alassezia fúrfur and Trichophyton mentagrophytes), and protozoans.
II. Modalities of the current description The embodiments of the present disclosure include antimicrobial compositions, methods for preparing these antimicrobial compositions, and textiles including these compositions. Consequently, the modalities of the current description. they include textiles treated with the antimicrobial compositions described below and methods for applying these antimicrobial compositions to textiles. Examples of textiles that can be treated with the antimicrobial compositions described below include medical textiles, housing textiles, and clothing-related textiles.
The embodiments of the antimicrobial compositions of the present disclosure can be added to a variety of textiles. Textiles that have been treated with the antimicrobial compositions or antimicrobial compositions treated of the present disclosure demonstrate antimicrobial activity. Therefore, the antimicrobial effect demonstrated by these treated textiles is highly durable, so that these textiles can be washed numerous times with little until without loss of antimicrobial activity. In certain embodiments, the antimicrobial aspect of the textile is renewable or regenerable without the addition of chlorine bleach. Additionally, textiles treated with the antimicrobial compositions of the present disclosure show negligible leaching and thus are unlikely to affect health issues for those in contact with these treated textiles.
One embodiment of the present disclosure includes antimicrobial compositions in the form of an aqueous solution consisting of water, an organic acid present at about 0.1% up to about 10% by weight of solution, chitosan present at about 0.1% up to about 10% by weight of solution, as well as one or more heterocyclic N-halamine compounds present in about 5% to about 90% by weight of solution. Examples of suitable organic acids for use in the antimicrobial compositions of the present disclosure include, but are not limited to, citric acid, acetic acid, lactic acid, formic acid, and oxalic acid. Examples of heterocyclic N-halamine compounds suitable for use in the antimicrobial compositions of the present disclosure include, but are not limited to MDMH, DMDMH; monomethylated and dimethylated derivatives of 2, 2, 5, 5-tetramethyl-l, 3-imidazolidin-4-one, 6,6-dimethyl-1,3,5-triazin-2,4-dione, 4, 4, 5, 5-tetramethyl-l, 3-imidazolidin-2-one, cyanuric acid, and 5,5-dimethylhydantoin; and monomethoxylated and dimethoxylated derivatives of monomethylated and dimethylated derivatives of 2,2,5,5-tetramethyl-l, 3-imidazolidin-4-one, 6,6-dimethyl-1,3,5-triazine-2,4-dione, 4,4,5,5-tetramethyl- 1, 3-imidazolidin-2-one, cyanuric acid, 5, 5-dimethylhydantoin. Examples of the monomethoxylated and dimethoxylated compounds are monomethoxymethyl-5,5-dimethylhydantoin and 1,3-dimethoxymethyl-5,5-dimethylhydantoin, respectively.
One embodiment of the present disclosure includes an aqueous solution consisting of water, citric acid, chitosan, and DMDMH, for example, an aqueous solution consisting of water, from about 0.2% to about 1.0% citric acid by weight of water. solution, about 0.2% up to about 1.0% chitosan by weight of solution, and about 30% up to about 35% DMDMH by weight of solution.
One embodiment of the present disclosure includes an aqueous solution consisting of water, citric acid, chitosan, and MDMH, per. example, an aqueous solution consisting of water, about 0.2% to about 1.0% citric acid by weight of solution, about 0.2% to about 1.0% chitosan by weight of solution, and about 30% up to about 35% MDMH by weight of solution.
One embodiment of the present disclosure includes an aqueous solution consisting of water, citric acid, chitosan, DMDMH, and MDMH, for example, an aqueous solution consisting of water, from about 0.2% to about 1.0% citric acid in water. solution weight, about 0.2% to about 1.0% chitosan by weight of solution, about 20% up to about 25% DMDMH by weight of solution, and about 20% up to about 25% MDMH by weight of solution.
In addition to the aforementioned embodiments, embodiments of the present disclosure may also include compositions comprising the antimicrobial compositions of the current disclosure. For example, embodiments of the current disclosure may include each of the ingredients of the antimicrobial compositions as described and further include additives used to prepare the antimicrobial composition of the current description for application to textiles. Examples of additives that can be used in conjunction with the antimicrobial compositions of the present disclosure include, but are not limited to, an ionic halide salt, an organic acid, and water. Examples of ionic halide salts suitable for use as treatment solutions for use in conjunction with the antimicrobial compositions of the present disclosure include, but are not limited to, magnesium chloride, magnesium bromide, calcium chloride, calcium bromide, potassium chloride, and combinations thereof.
One embodiment of the present disclosure includes an aqueous solution comprising water, an organic acid present in about 0.1% up to about 10% by weight of solution, chitosan present in about 0.1% up to about 10% by weight of solution, and one or more N-halamin compounds (for example MD H and / or DMDMH) present in about 5% to about 90% by weight solution. The solution may be diluted with water, pH adjusted to about 1.0 to about 5.0 using an organic acid (eg, citric acid, acetic acid, and / or lactic acid), and may further comprise an ionic halide salt (e.g. , magnesium chloride, magnesium bromide, and / or calcium chloride) present in about 1% to about 10% by weight of solution.
One embodiment of the present disclosure includes an aqueous solution comprising water, citric acid, chitosan, and DMDMH, for example, an aqueous solution of water, from about 0.2% to about 1.0% citric acid by weight of solution, about 0.2% up to about 1.0% chitosan by weight of solution, and about 30% up to about 35% DMDMH by weight of solution. The solution can be diluted with water, pH adjusted to about 3.0 to about 3.5 using citric acid, and can further comprise magnesium chloride present at about 4.0% to about 7.0% by weight of solution.
One embodiment of the present disclosure includes an aqueous solution comprising water, citric acid, chitosan, and MDMH, for example, an aqueous solution consisting of water, about 0.2% to about 1.0% citric acid by weight of solution, about 0.2% up to about 1.0% chitosan by weight of solution, and about 30% up to about 35% MDMH by weight of solution. The solution can be diluted with water, pH adjusted to about 3.0 to about 3.5 using citric acid, and can further comprise magnesium chloride present at about 4.0% to about 7.0% by weight of solution.
One embodiment of the present disclosure includes an aqueous solution comprising water, citric acid, chitosan, DMDMH, and MDMH, for example, an aqueous solution consisting of water, from about 0.2% to about 1.0% citric acid by weight of water. solution, about 0.2% up to about 1.0% chitosan by weight of solution, about 20% up to about 25% DMDMH by weight of solution, and about 20% up to about 25% MDMH by weight of solution. The solution can be diluted with water, pH adjusted to about 3.0 to about 3.5 using citric acid, and. it may further comprise magnesium chloride present at about 4.0% to about 7.0% by weight of solution.
One embodiment of the present disclosure includes a method for treating textiles with the ancrobial compositions of the present disclosure. The textiles can be treated either by applying the ancrobial composition to the textile, or by immersing the textile in the ancrobial composition. For example, textiles can be sprayed with the ancrobial compositions of the current description. Alternatively, the textiles can be put into baths of the ancrobial compositions of the current description. In spite of everything, the treatment results in a textile that is composed of an ancrobial composition. The addition of the ancrobial compositions of the present disclosure to such textiles results in the heterocyclic N-halamin compound covalently bonded to cellulose: CELLULOSA QUITOSANO DMDMH EXAMPLES The following synthetic and biological examples are offered to illustrate modalities of the current description, and are not to be constructed in any way as to limit the scope of the description. In the examples below, abbreviations have their meanings generally accepted.
Example 1 10g of chitosan, of citric acid, H0 HÓ oh, dissolve in 980g of H20. The resulting solution is combined with 1500g of a solution containing 55% DMDMH, by weight of solution to produce approximately 2500g of an ancrobial composition which is approximately: 0.4% by weight citric acid solution, Chitosan at 0.4% by weight of solution, DMDMH at 33% by weight of solution, and H20 at 66.2% by weight of solution.
Example 2 lOg of chitosan,, and lOg of citric acid, dissolve in 980g of H20. The resulting solution is combined with 1500g of a solution that It contains 55% MDMH, by weight of solution to produce approximately 2500g. of an ancrobial composition that is approximately: 0.4% citric acid solution, Chitosan at 0.4% by weight of solution, MDMH at 33% by weight of solution, and H20 at 66.2% by weight of solution.
Example 3 lOg of chitosan, and 10g of citric acid, are dissolved in 780g of H20.
The resulting solution is combined with 1700g of a solution which contains 33.2% by weight DMDMH, and MDMH at 31. 5%, an ancrobial composition that is approximately: ' 0.4% by weight citric acid solution, Chitosan at 0.4% by weight of solution, DMDMH at 22.6% by weight of solution, and MDMH at 21.4% by weight of solution.
H2O at 55.2% by weight of solution.
Example 4 The composition of Example 1, made of citric acid, chitosan, DMDMH, and water, can be placed in a convenient form for textile treatment. Approximately 2500g of an ancrobial composition that is approximately: 0.4% by weight citric acid solution, Chitosan at 0.4% by weight of solution, DMDMH at 33% by weight of solution, and H20 at 66.2% by weight of solution is diluted by 39.16kg of H20 to form a diluted antimicrobial composition of 41.66kg. - The pH of the resulting diluted antimicrobial composition is maintained in the range of about 3.0 to about 3.5 using citric acid. Finally, 250g of magnesium chloride is added to the solution to produce an antimicrobial composition treated for use in textile processing.
Example 5 The composition of Example 2, made of citric acid, chitosan, MD H, and water, can be placed in a convenient form for textile treatment. Approximately 2500g of an antimicrobial composition that is: 0.4% by weight citric acid solution, Chitosan at 0.4% by weight of solution, MDMH at 33% by weight of solution, and H20 at 66.2% by weight of solution it is diluted by 39.16kg of H20 forming a diluted antimicrobial composition of 41.66kg. The pH of the resulting diluted antimicrobial composition is maintained in the range of about 3.0 to about 3.5 using citric acid. Finally, 250g of magnesium chloride is added to the solution to produce an antimicrobial composition treated for use in textile processing.
Example 6 The composition of Example 3, made of citric acid, chitosan, DMDMH, MDMH, and water, can be placed in a convenient form for textile treatment. Approximately 2500g of an antimicrobial composition. What is it: 0.4% by weight citric acid solution, Chitosan at 0.4% by weight of solution, DMDMH at 22.6% by weight of solution, and MDMH at 21.4% by weight of solution.
H20 at 55.2% by weight of solution it is diluted by 39.16kg of H20 forming 41.66kg of a diluted antimicrobial composition. The pH of the resulting diluted antimicrobial composition is maintained in the range of about 3.0 to about 3.5 using citric acid. Finally, 250g of magnesium chloride is added to the solution to produce an antimicrobial composition treated for use in textile processing.
Example 7 lOg de quito y lOg of citric acid, of H20.
The resulting solution is combined with 2000g of a solution that contain in weight of solution and 7. 5% MDMH, solution to produce approximately 2500g of an antimicrobial composition which is: 0.4% by weight citric acid solution, Chitosan at 0.4% by weight of solution, D DMH at 25.6% by weight of solution, MDMH at 5.6% by weight of solution, and H20 at 68% by weight of solution.

Claims (16)

NOVELTY OF THE INVENTION Having described the present invention, it is considered as novelty, and therefore the content of the following is claimed as property: CLAIMS
1. An aqueous solution characterized because it consists of: an additional compound selected from a group consisting of: , and a combination thereof, where n is around 3 to about 6000.
2. The solution in accordance with the claim characterized because the additional compound is
3. The solution according to claim 1, characterized in that the additional compound is
4. The solution according to claim characterized in that the additional compounds are
5. The solution according to claim characterized in that it consists of: H20, around 0.2% up to around 1.0% in weight of solution; around 0.2% up to around 1. I heard from in weight of solution; Y around 30% up to around 35% of in weight of solution.
6. The solution according to claim 3 characterized in that it consists of: H20, about 0.2% to about 1.0% by weight of solution; around 0.2% to around 1.0% of solution weight; about 30% up to about 35% by weight of solution.
7. The solution according to claim characterized in that it consists of: H20, around 0.2% up to around 1.0% solution weight; around 0.2% to around 1.0% of in weight of solution; Y about 20 to about 25% by weight of solution; Y about 20 to about 25% by weight of solution.
8. An aqueous solution characterized in that it comprises: an additional compound selected from a group consisting of: , and a combination thereof, where n is around 3 to about 6000.
9. The aqueous solution according to claim 8, characterized in that it also comprises MgCl 2.
10. The aqueous solution in accordance with claim 9, characterized is present in about 0.2% up to about 1.0% by weight of solution; is present at around 0.2% up to about 1.0% by weight of solution; and the additional compound is and is present in about 30% to about 35% by weight of solution.
11. The aqueous solution in accordance with claim 9, characterized is present at about 0.2% up to about 1.0% by weight from solution; is present in about 0.2% up to about 1.0% by weight solution; and the additional compound is and is present in about 30% to about 35% by weight of solution.
12. The aqueous solution according to claim 9, characterized in that it is present in about 0.2% up to about 1.0% by weight from solution; is present in about 0.2% up to about 1.0% by weight solution; and the additional compounds are and is present in about 20% up to about 25% by weight of solution and present in about 20% up to about 25% by weight of solution.
13. A textile characterized in that it comprises the aqueous solution according to claim 1.
14. A textile characterized in that it comprises the aqueous solution according to claim 9.
15. A method for adding the aqueous solution according to claim 1 for a textile, characterized in that it comprises contacting the textile with the aqueous solution in accordance with the claim
16. A method to add the aqueous solution in accordance with the. claim 9 to a textile, characterized in that it comprises contacting the textile with the aqueous solution in accordance with the claim
MX2012002711A 2009-09-03 2009-09-04 Antimicrobial compositions and products. MX2012002711A (en)

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