CN113197783A - Subacid hypochlorous acid disinfection wet tissue and preparation method thereof - Google Patents
Subacid hypochlorous acid disinfection wet tissue and preparation method thereof Download PDFInfo
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- CN113197783A CN113197783A CN202110505496.8A CN202110505496A CN113197783A CN 113197783 A CN113197783 A CN 113197783A CN 202110505496 A CN202110505496 A CN 202110505496A CN 113197783 A CN113197783 A CN 113197783A
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- disinfectant
- hypochlorous acid
- acid
- slightly acidic
- acidic hypochlorous
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- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 title claims abstract description 75
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title description 8
- 239000000645 desinfectant Substances 0.000 claims abstract description 95
- 230000002378 acidificating effect Effects 0.000 claims abstract description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 55
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 16
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 10
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 10
- 239000002253 acid Substances 0.000 claims abstract description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 63
- 235000015165 citric acid Nutrition 0.000 claims description 21
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 14
- 238000002791 soaking Methods 0.000 claims description 12
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 11
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 11
- 239000001630 malic acid Substances 0.000 claims description 11
- 235000011090 malic acid Nutrition 0.000 claims description 11
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 8
- 239000001354 calcium citrate Substances 0.000 claims description 8
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 8
- 239000004310 lactic acid Substances 0.000 claims description 7
- 235000014655 lactic acid Nutrition 0.000 claims description 7
- 239000004745 nonwoven fabric Substances 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 7
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 claims description 5
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 5
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 5
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 5
- 239000001527 calcium lactate Substances 0.000 claims description 5
- 229960002401 calcium lactate Drugs 0.000 claims description 5
- 235000011086 calcium lactate Nutrition 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 229960002713 calcium chloride Drugs 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 13
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 230000009257 reactivity Effects 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
- 210000004243 sweat Anatomy 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 40
- 206010070834 Sensitisation Diseases 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 15
- 230000008313 sensitization Effects 0.000 description 15
- 230000008569 process Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 201000004624 Dermatitis Diseases 0.000 description 5
- 206010015150 Erythema Diseases 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 238000010171 animal model Methods 0.000 description 5
- 238000011109 contamination Methods 0.000 description 5
- 231100000321 erythema Toxicity 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 5
- 238000010181 skin prick test Methods 0.000 description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 230000007794 irritation Effects 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002906 medical waste Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
Abstract
The invention discloses a subacid hypochlorous acid disinfection wet tissue, and disinfectant used by the disinfection wet tissue is prepared by mixing subacid hypochlorous acid water, carbonic acid, fruit acid and soluble calcium salt; the pH value of the disinfectant is 5-5.6, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 50-60 ppm. Based on the extremely high reactivity and instability of hypochlorous acid, the stability of slightly acidic hypochlorous acid water is greatly improved by adding carbonic acid, fruit acid and soluble calcium salt into the disinfectant prepared after mixing, the pH of the disinfectant is controlled to be 5-5.6, the initial concentration of the slightly acidic hypochlorous acid water in the disinfectant is 50-60ppm, and after the disinfectant is placed at 25 ℃ for 6 months, the concentration of the slightly acidic hypochlorous acid water is still about 40ppm, which shows that the stability is better, the disinfectant can be ensured to have better disinfection and sterilization effects, the sterilization rate of the disinfectant reaches more than 99.99 percent, the slightly acidic disinfectant is close to the pH value of sweat on the surface of skin, and therefore, the disinfectant has no stimulation to the skin; no harmful residue after the action, and is more environment-friendly.
Description
Technical Field
The invention relates to the technical field of disinfection wet tissues, and particularly relates to a subacid hypochlorous acid disinfection wet tissue and a preparation method thereof.
Background
The sanitary requirements of chlorine-containing disinfectants indicate that the general chlorine-containing disinfectants are used for disinfecting surfaces of general objects, medical instruments, medical wastes, food and cooking utensils, fabrics, fruits, vegetables, water and the like in medical and health institutions, public places and families, and are also suitable for treating various pollutants in epidemic areas. Is not suitable for sterilizing indoor air, hands, skin and mucous membrane. At the same time. Hypochlorous acid is also clearly distinguished from common chlorine-containing disinfectants. According to the latest national standard, hypochlorous acid in the chlorine-containing disinfectant is the only one suitable for indoor air disinfection, and can also be used for disinfecting hands, skin and mucous membranes.
Hypochlorous acid (HClO) is used as an oxidant with very active chemical properties and has a strong sterilization effect. The dilute hypochlorous acid solution has very high-efficiency capability of killing microorganisms, is safe in use process and free of pollution, and is widely applied to disinfection, cleaning, nursing and the like of various industries such as individuals, families, medical treatment, agriculture, livestock breeding and the like. However, due to the extremely high reactivity and instability of hypochlorous acid, the disinfectant wet tissue prepared by using the disinfectant wet tissue in the prior art has poor disinfection effect due to poor stability of active ingredients, and the irritation to skin is increased by increasing the content of hypochlorous acid for improving the disinfection effect, so that the safety is reduced.
Therefore, a disinfectant wet wipe with good disinfection effect, high stability and no irritation to skin is urgently needed by consumers.
Disclosure of Invention
The invention aims to provide the slightly acidic hypochlorous acid disinfectant wet tissue which is good in disinfection effect, high in stability and free of irritation to skin.
The invention also aims to provide a method for preparing the slightly acidic hypochlorous acid disinfectant wet tissue.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a slightly acidic hypochlorous acid disinfection wet tissue, the disinfectant used for disinfection wet tissue is prepared by mixing slightly acidic hypochlorous acid water, carbonic acid, fruit acid and soluble calcium salt; the pH value of the disinfectant is 5-5.6, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 50-60 ppm.
Preferably, the initial concentration of the slightly acidic hypochlorous acid water in the disinfectant is 50-55 ppm.
Preferably, the fruit acid is one or a combination of more of glycolic acid, lactic acid, malic acid, tartaric acid or citric acid.
Preferably, the soluble calcium salt is one or a combination of calcium hypochlorite, calcium chloride, calcium lactate, calcium bicarbonate and calcium citrate.
Preferably, the pH value of the disinfectant is 5.2-5.6.
Preferably, the slightly acidic hypochlorous acid water, the fruit acid and the soluble calcium salt are uniformly mixed to be used as a disinfectant for standby; and then soaking the sterilized non-woven fabric in the disinfectant, and sealing and aseptically packaging to obtain the disinfectant.
The invention has the beneficial effects that:
(1) based on the extremely high reactivity and instability of hypochlorous acid, the stability of slightly acidic hypochlorous acid water is greatly improved by adding the disinfectant prepared by mixing carbonic acid, fruit acid and soluble calcium salt, the decomposition of the slightly acidic hypochlorous acid water is effectively delayed, the concentration of the slightly acidic hypochlorous acid water is still about 40ppm after the disinfectant is placed at 25 ℃ for 6 months under the conditions that the pH of the disinfectant is controlled to be 5-5.6 and the initial concentration of the slightly acidic hypochlorous acid water in the disinfectant is 50-60ppm, so that the stability of the disinfectant is better, and the disinfectant has better disinfection and sterilization effects.
(2) The invention has high disinfection and sterilization efficiency, the germ killing rate reaches more than 99.99 percent, and the sterilization range is wide; the subacidity is similar to the pH value of sweat on the surface of the skin, so that the skin is not irritated; no harmful residue after the action, and is more environment-friendly.
(3) The raw materials are widely available, and the reagents are cheap, so that the whole manufacturing cost is low, and the method is suitable for large-scale production.
(4) The slightly acidic hypochlorous acid water stabilizer which is formed by combining carbonic acid, fruit acid and soluble calcium salt is necessary, and unexpected technical effects on improving the stability of slightly acidic hypochlorous acid water are achieved.
Detailed Description
The following examples further illustrate embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
A slightly acidic hypochlorous acid disinfection wet tissue, the disinfectant used for disinfection wet tissue is prepared by mixing slightly acidic hypochlorous acid water, carbonic acid, citric acid and calcium lactate; the pH value of the disinfectant is 5.6, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 58 ppm.
The preparation method of the disinfection wet tissue comprises the following steps: the slightly acidic hypochlorous acid water, carbonic acid, citric acid and calcium lactate are uniformly mixed to prepare a disinfectant, the pH of the disinfectant is adjusted by the carbonic acid and/or the citric acid in the mixing process, and the mass ratio of the carbonic acid to the citric acid to the calcium lactate is 1: 2: 1; the pH of the mixed disinfectant is 5.6, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 60 ppm.
And then soaking the sterilized non-woven fabric in the disinfectant, and sealing and aseptically packaging to obtain the disinfectant.
The concentration of slightly acidic hypochlorous acid water of the disinfectant prepared in the embodiment is tested and placed in a constant temperature water bath kettle at 25 ℃ for 10 days, 30 days, 60 days, 90 days, 120 days and 180 days, and the experimental result shows that the concentration of slightly acidic hypochlorous acid water is 58ppm, 55ppm, 50ppm, 46ppm, 45ppm and 44ppm respectively.
The prepared wet disinfection tissue is used for carrying out microbial contamination test, bacteria are directly contaminated on the wet disinfection tissue, the soaking effect is 5min, and the average killing rate of staphylococcus aureus and escherichia coli reaches 100%.
Meanwhile, the prepared wet disinfection tissue is used for performing a skin allergy test: the skin of the experimental animal has no erythema reaction or edema reaction, the sensitization rate is 0%, and the sensitization intensity of the disinfection wet tissue is evaluated according to the sensitization intensity grading standard that no skin allergy reaction is seen.
Example 2
A slightly acidic hypochlorous acid disinfection wet tissue is prepared by mixing slightly acidic hypochlorous acid water, carbonic acid, citric acid, malic acid and calcium bicarbonate; the pH value of the disinfectant is 5.0, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 55 ppm.
The preparation method of the disinfection wet tissue comprises the following steps: the slightly acidic hypochlorous acid water, carbonic acid, malic acid and calcium bicarbonate are uniformly mixed to prepare the disinfectant, the pH of the disinfectant is adjusted by the carbonic acid and/or the citric acid and/or the malic acid in the mixing process, and the mass ratio of the carbonic acid to the citric acid to the malic acid to the calcium bicarbonate is 1: 2: 2: 1; the pH of the mixed disinfectant is 5.0, and the initial concentration of the slightly acidic hypochlorous acid water in the disinfectant is 55 ppm.
And then soaking the sterilized non-woven fabric in the disinfectant, and sealing and aseptically packaging to obtain the disinfectant.
The concentration of slightly acidic hypochlorous acid water of the disinfectant prepared in the embodiment is tested and placed in a constant temperature water bath kettle at 25 ℃ for 10 days, 30 days, 60 days, 90 days, 120 days and 180 days, and the experimental result shows that the concentration of slightly acidic hypochlorous acid water is 55ppm, 52ppm, 46ppm, 43ppm and 42ppm respectively.
The prepared wet disinfection tissue is used for carrying out microbial contamination test, bacteria are directly contaminated on the wet disinfection tissue, the soaking effect is 5min, and the average killing rate of staphylococcus aureus and escherichia coli reaches 100%.
Meanwhile, the prepared wet disinfection tissue is used for performing a skin allergy test: the skin of the experimental animal has no erythema reaction or edema reaction, the sensitization rate is 0%, and the sensitization intensity of the disinfection wet tissue is evaluated according to the sensitization intensity grading standard that no skin allergy reaction is seen.
Example 3
A slightly acidic hypochlorous acid disinfection wet tissue is prepared by mixing slightly acidic hypochlorous acid water, carbonic acid, lactic acid, malic acid, citric acid and calcium citrate; the pH value of the disinfectant is 5.2, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 50 ppm.
The preparation method of the disinfection wet tissue comprises the following steps: the slightly acidic hypochlorous acid water, carbonic acid, lactic acid, malic acid, citric acid and calcium citrate are uniformly mixed to prepare the disinfectant, the pH of the disinfectant is adjusted by the carbonic acid, the citric acid, the malic acid or the lactic acid in the mixing process, and the mass ratio of the carbonic acid to the lactic acid to the malic acid to the citric acid to the calcium citrate is 2: 1: 2: 1: 1; the pH of the mixed disinfectant is 5.2, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 50 ppm.
And then soaking the sterilized non-woven fabric in the disinfectant, and sealing and aseptically packaging to obtain the disinfectant.
The concentration of slightly acidic hypochlorous acid water of the disinfectant prepared in the embodiment is tested and placed in a constant temperature water bath kettle at 25 ℃ for 10 days, 30 days, 60 days, 90 days, 120 days and 180 days, and the experimental result shows that the concentration of slightly acidic hypochlorous acid water is 50ppm, 47ppm, 44ppm, 43ppm, 42ppm and 39ppm respectively.
The prepared disinfectant wet tissue is used for carrying out microbial contamination detection, bacteria are directly contaminated on the disinfectant wet tissue, the soaking effect is 5min, and the average killing rate of staphylococcus aureus and escherichia coli reaches 99.999%.
Meanwhile, the prepared wet disinfection tissue is used for performing a skin allergy test: the skin of the experimental animal has no erythema reaction or edema reaction, the sensitization rate is 0%, and the sensitization intensity of the disinfection wet tissue is evaluated according to the sensitization intensity grading standard that no skin allergy reaction is seen.
Example 4
A slightly acidic hypochlorous acid disinfection wet tissue is prepared by mixing slightly acidic hypochlorous acid water, carbonic acid, citric acid and calcium citrate; the pH value of the disinfectant is 5.6, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 58 ppm.
The preparation method of the disinfection wet tissue comprises the following steps: the subacid hypochlorous acid water, carbonic acid, citric acid and calcium citrate are uniformly mixed to prepare the disinfectant, the pH of the disinfectant is adjusted by citric acid in the mixing process, and the mass ratio of the carbonic acid to the lactic acid to the malic acid to the citric acid to the calcium citrate is 1.5: 1: 2: 1: 1; the pH of the mixed disinfectant is 5.2, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 50 ppm.
And then soaking the sterilized non-woven fabric in the disinfectant, and sealing and aseptically packaging to obtain the disinfectant.
The concentration of slightly acidic hypochlorous acid water of the disinfectant prepared in the embodiment is tested and placed in a constant temperature water bath kettle at 25 ℃ for 10 days, 30 days, 60 days, 90 days, 120 days and 180 days, and the experimental result shows that the concentration of the slightly acidic hypochlorous acid water is 49ppm, 47ppm, 45ppm, 43ppm and 40ppm respectively.
The prepared wet disinfection tissue is used for carrying out microbial contamination test, bacteria are directly contaminated on the wet disinfection tissue, the soaking effect is 5min, and the average killing rate of staphylococcus aureus and escherichia coli reaches 100%.
Meanwhile, the prepared wet disinfection tissue is used for performing a skin allergy test: the skin of the experimental animal has no erythema reaction or edema reaction, the sensitization rate is 0%, and the sensitization intensity of the disinfection wet tissue is evaluated according to the sensitization intensity grading standard that no skin allergy reaction is seen.
Example 5
A slightly acidic hypochlorous acid disinfection wet tissue is prepared by mixing slightly acidic hypochlorous acid water, carbonic acid, glycolic acid, citric acid and calcium hypochlorite; the pH value of the disinfectant is 5.0, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 59 ppm.
The preparation method of the disinfection wet tissue comprises the following steps: subacidity hypochlorous acid water, carbonic acid, glycolic acid, citric acid and calcium hypochlorite are evenly mixed to prepare a disinfectant, the pH of the disinfectant is adjusted through citric acid in the mixing process, and the mass ratio of the carbonic acid to the glycolic acid to the citric acid to the calcium hypochlorite is 1: 2: 1: 2; the pH of the mixed disinfectant is 5.0, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 59 ppm.
And then soaking the sterilized non-woven fabric in the disinfectant, and sealing and aseptically packaging to obtain the disinfectant.
The concentration of slightly acidic hypochlorous acid water of the disinfectant prepared in the embodiment is tested and placed in a constant temperature water bath kettle at 25 ℃ for 10 days, 30 days, 60 days, 90 days, 120 days and 180 days, and the experimental result shows that the concentration of slightly acidic hypochlorous acid water is 58ppm, 54ppm, 50ppm, 46ppm, 44ppm and 42ppm respectively.
The prepared wet disinfection tissue is used for carrying out microbial contamination test, bacteria are directly contaminated on the wet disinfection tissue, the soaking effect is 5min, and the average killing rate of staphylococcus aureus and escherichia coli reaches 100%.
Meanwhile, the prepared wet disinfection tissue is used for performing a skin allergy test: the skin of the experimental animal has no erythema reaction or edema reaction, the sensitization rate is 0%, and the sensitization intensity of the disinfection wet tissue is evaluated according to the sensitization intensity grading standard that no skin allergy reaction is seen.
The embodiments of the present invention have been described in detail with reference to the examples, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, and the scope of protection is still within the scope of the invention.
Claims (6)
1. A subacid hypochlorous acid disinfection wet tissue is characterized in that: the disinfectant used for the disinfectant wet tissue is prepared by mixing subacid hypochlorous acid water, carbonic acid, tartaric acid and soluble calcium salt; the pH value of the disinfectant is 5-5.6, and the initial concentration of slightly acidic hypochlorous acid water in the disinfectant is 50-60 ppm.
2. The slightly acidic hypochlorous acid disinfectant wet wipe as set forth in claim 1, wherein: the initial concentration of the slightly acidic hypochlorous acid water in the disinfectant is 50-55 ppm.
3. The slightly acidic hypochlorous acid disinfectant wet wipe as set forth in claim 1, wherein: the fruit acid is one or more of glycolic acid, lactic acid, malic acid, tartaric acid or citric acid.
4. The slightly acidic hypochlorous acid disinfectant wet wipe as set forth in claim 3, wherein: the soluble calcium salt is one or a combination of calcium hypochlorite, calcium chloride, calcium lactate, calcium bicarbonate and calcium citrate.
5. The slightly acidic hypochlorous acid disinfectant wet wipe as set forth in claim 1, wherein: the pH value of the disinfectant is 5.2-5.6.
6. The method for preparing a sterilized wet wipe of claim 1, wherein: mixing slightly acidic hypochlorous acid water, fruit acid and soluble calcium salt uniformly to obtain disinfectant; and then soaking the sterilized non-woven fabric in the disinfectant, and sealing and aseptically packaging to obtain the disinfectant.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022266698A1 (en) * | 2021-06-25 | 2022-12-29 | Ttd Global Pty Ltd | Stabilised hypohalous acid solutions |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022266698A1 (en) * | 2021-06-25 | 2022-12-29 | Ttd Global Pty Ltd | Stabilised hypohalous acid solutions |
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