MX2012001846A - Metodos y composiciones para el tratamiento de leucemia. - Google Patents

Metodos y composiciones para el tratamiento de leucemia.

Info

Publication number
MX2012001846A
MX2012001846A MX2012001846A MX2012001846A MX2012001846A MX 2012001846 A MX2012001846 A MX 2012001846A MX 2012001846 A MX2012001846 A MX 2012001846A MX 2012001846 A MX2012001846 A MX 2012001846A MX 2012001846 A MX2012001846 A MX 2012001846A
Authority
MX
Mexico
Prior art keywords
compositions
methods
treating leukemia
leukemia
treating
Prior art date
Application number
MX2012001846A
Other languages
English (en)
Inventor
Paul W Manley
Stefan Peukert
Marion Dorsch
Mhairi Copland
David Irvine
Original Assignee
Univ Glasgow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Glasgow filed Critical Univ Glasgow
Publication of MX2012001846A publication Critical patent/MX2012001846A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una combinación de un inhibidor de BCR-ABL y un inhibidor de la senda de Hedgehog, para el tratamiento de leucemia.
MX2012001846A 2009-08-12 2010-08-11 Metodos y composiciones para el tratamiento de leucemia. MX2012001846A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/539,855 US20110039850A1 (en) 2009-08-12 2009-08-12 Leukemia Treatment
PCT/US2010/045133 WO2011019798A1 (en) 2009-08-12 2010-08-11 Methods and compositions for treating leukemia

Publications (1)

Publication Number Publication Date
MX2012001846A true MX2012001846A (es) 2012-05-22

Family

ID=42727621

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001846A MX2012001846A (es) 2009-08-12 2010-08-11 Metodos y composiciones para el tratamiento de leucemia.

Country Status (19)

Country Link
US (3) US20110039850A1 (es)
EP (1) EP2464423A1 (es)
JP (1) JP2013501798A (es)
KR (1) KR20120089844A (es)
CN (2) CN103736094A (es)
AU (1) AU2010282547A1 (es)
BR (1) BR112012003278A2 (es)
CA (1) CA2769300A1 (es)
CL (1) CL2012000350A1 (es)
IL (1) IL217764A0 (es)
MA (1) MA33555B1 (es)
MX (1) MX2012001846A (es)
NZ (1) NZ597864A (es)
PH (1) PH12014500538A1 (es)
RU (1) RU2012108930A (es)
SG (2) SG10201407435WA (es)
TN (1) TN2012000029A1 (es)
WO (1) WO2011019798A1 (es)
ZA (1) ZA201200434B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104262262B (zh) * 2014-08-29 2016-06-08 西安交通大学 一种N,6二苯基嘧啶-4-胺类Bcr-Abl抑制剂及其制备方法和应用
SI3700902T1 (sl) 2017-10-27 2023-10-30 Boehringer Ingelheim International Gmbh Inhibitorji trpc6

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA93548C2 (uk) * 2006-05-05 2011-02-25 Айерем Елелсі Сполуки та композиції як модулятори хеджхогівського сигнального шляху
MY156814A (en) * 2007-03-15 2016-03-31 Novartis Ag Organic compounds and their uses
ES2569941T3 (es) * 2007-06-07 2016-05-13 Novartis Ag Derivados de bifenilcarboxamida como moduladores de la ruta de hedgehog
BRPI0815330A2 (pt) * 2007-08-16 2017-05-09 Irm Llc métodos e composições para tratar cânceres
WO2010030948A2 (en) * 2008-09-12 2010-03-18 The Board Of Trustees Of The Leland Stanford Junior University Hedgehog signaling and cancer stem cells in hematopoietic cell malignancies

Also Published As

Publication number Publication date
CA2769300A1 (en) 2011-02-17
SG10201407435WA (en) 2014-12-30
SG178082A1 (en) 2012-03-29
AU2010282547A1 (en) 2012-02-16
WO2011019798A1 (en) 2011-02-17
US20120329798A1 (en) 2012-12-27
EP2464423A1 (en) 2012-06-20
IL217764A0 (en) 2012-03-29
RU2012108930A (ru) 2013-09-20
JP2013501798A (ja) 2013-01-17
MA33555B1 (fr) 2012-09-01
TN2012000029A1 (en) 2013-09-19
CL2012000350A1 (es) 2012-10-12
PH12014500538A1 (en) 2015-09-07
BR112012003278A2 (pt) 2016-03-01
CN102695547A (zh) 2012-09-26
US20110039850A1 (en) 2011-02-17
CN103736094A (zh) 2014-04-23
ZA201200434B (en) 2012-10-31
US20150209365A1 (en) 2015-07-30
NZ597864A (en) 2014-01-31
KR20120089844A (ko) 2012-08-14

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal