MX2010009999A - Derivados de amidas del acido 3-trifluorometil-pirazina-2-carboxil ico como agentes para aumentar el colesterol de lipoproteinas de alta densidad. - Google Patents
Derivados de amidas del acido 3-trifluorometil-pirazina-2-carboxil ico como agentes para aumentar el colesterol de lipoproteinas de alta densidad.Info
- Publication number
- MX2010009999A MX2010009999A MX2010009999A MX2010009999A MX2010009999A MX 2010009999 A MX2010009999 A MX 2010009999A MX 2010009999 A MX2010009999 A MX 2010009999A MX 2010009999 A MX2010009999 A MX 2010009999A MX 2010009999 A MX2010009999 A MX 2010009999A
- Authority
- MX
- Mexico
- Prior art keywords
- hdl
- pyrazine
- trifluoromethyl
- carboxylic acid
- acid amide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente invención se refiere a derivados de pirazina de la fórmula (I) en donde R1 a R8 son tal y como se definen en la descripción y las reivindicaciones, para la preparación de medicamentos para el tratamiento y/o profilaxis de enfermedades que pueden tratarse con agentes para aumentar el colesterol HDL, tal como preferiblemente dislipemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08153802 | 2008-03-31 | ||
PCT/EP2009/053344 WO2009121741A1 (en) | 2008-03-31 | 2009-03-23 | 3-trifluoromethyl-pyrazine-2-carboxylic acid amide derivatives as hdl-cholesterol raising agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010009999A true MX2010009999A (es) | 2010-09-30 |
Family
ID=40585575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010009999A MX2010009999A (es) | 2008-03-31 | 2009-03-23 | Derivados de amidas del acido 3-trifluorometil-pirazina-2-carboxil ico como agentes para aumentar el colesterol de lipoproteinas de alta densidad. |
Country Status (14)
Country | Link |
---|---|
US (1) | US8088920B2 (es) |
EP (1) | EP2271632B1 (es) |
JP (1) | JP5243596B2 (es) |
KR (1) | KR101307066B1 (es) |
CN (1) | CN101981015B (es) |
AR (1) | AR071111A1 (es) |
AU (1) | AU2009231376A1 (es) |
CA (1) | CA2718645A1 (es) |
ES (1) | ES2408961T3 (es) |
IL (1) | IL208022A0 (es) |
MX (1) | MX2010009999A (es) |
PE (1) | PE20091711A1 (es) |
TW (1) | TW200944514A (es) |
WO (1) | WO2009121741A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101107896B1 (ko) * | 2006-10-04 | 2012-01-25 | 에프. 호프만-라 로슈 아게 | 고 밀도 지단백질(hdl)-콜레스테롤 상승제로서 3-피리딘카복스아마이드 및 2-피라진카복스아마이드 유도체 |
WO2012031817A1 (en) * | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Determination of abca1 protein levels in cells |
US8410107B2 (en) | 2010-10-15 | 2013-04-02 | Hoffmann-La Roche Inc. | N-pyridin-3-yl or N-pyrazin-2-yl carboxamides |
US8669254B2 (en) | 2010-12-15 | 2014-03-11 | Hoffman-La Roche Inc. | Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9403808B2 (en) * | 2011-10-28 | 2016-08-02 | Hoffmann-La Roche Inc. | Pyrazine derivatives |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4293552A (en) * | 1978-02-27 | 1981-10-06 | Eli Lilly And Company | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas |
IL159897A0 (en) * | 2001-07-19 | 2004-06-20 | Cv Therapeutics Inc | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
MX2007012213A (es) | 2005-04-06 | 2007-12-10 | Hoffmann La Roche | Derivados de piridin-3-carboxamida como agonistas inversos de canabinoides. |
US7629346B2 (en) | 2006-06-19 | 2009-12-08 | Hoffmann-La Roche Inc. | Pyrazinecarboxamide derivatives as CB1 antagonists |
US7781593B2 (en) * | 2006-09-14 | 2010-08-24 | Hoffmann-La Roche Inc. | 5-phenyl-nicotinamide derivatives |
KR101107896B1 (ko) * | 2006-10-04 | 2012-01-25 | 에프. 호프만-라 로슈 아게 | 고 밀도 지단백질(hdl)-콜레스테롤 상승제로서 3-피리딘카복스아마이드 및 2-피라진카복스아마이드 유도체 |
DE602007006531D1 (de) * | 2006-10-04 | 2010-06-24 | Hoffmann La Roche | Pyrazin-2-carboxamid-derivate als cb2-rezeptormodulatoren |
-
2009
- 2009-03-16 US US12/404,365 patent/US8088920B2/en not_active Expired - Fee Related
- 2009-03-23 CA CA2718645A patent/CA2718645A1/en not_active Abandoned
- 2009-03-23 CN CN200980110553XA patent/CN101981015B/zh not_active Expired - Fee Related
- 2009-03-23 MX MX2010009999A patent/MX2010009999A/es active IP Right Grant
- 2009-03-23 KR KR1020107021710A patent/KR101307066B1/ko not_active IP Right Cessation
- 2009-03-23 EP EP09728270.1A patent/EP2271632B1/en not_active Not-in-force
- 2009-03-23 JP JP2011502335A patent/JP5243596B2/ja not_active Expired - Fee Related
- 2009-03-23 WO PCT/EP2009/053344 patent/WO2009121741A1/en active Application Filing
- 2009-03-23 AU AU2009231376A patent/AU2009231376A1/en not_active Abandoned
- 2009-03-23 ES ES09728270T patent/ES2408961T3/es active Active
- 2009-03-30 PE PE2009000467A patent/PE20091711A1/es not_active Application Discontinuation
- 2009-03-30 TW TW098110492A patent/TW200944514A/zh unknown
- 2009-03-30 AR ARP090101125A patent/AR071111A1/es unknown
-
2010
- 2010-09-06 IL IL208022A patent/IL208022A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US8088920B2 (en) | 2012-01-03 |
TW200944514A (en) | 2009-11-01 |
EP2271632A1 (en) | 2011-01-12 |
CN101981015B (zh) | 2013-08-21 |
CN101981015A (zh) | 2011-02-23 |
JP5243596B2 (ja) | 2013-07-24 |
KR20100119819A (ko) | 2010-11-10 |
CA2718645A1 (en) | 2009-10-08 |
US20090247550A1 (en) | 2009-10-01 |
AU2009231376A1 (en) | 2009-10-08 |
JP2011516445A (ja) | 2011-05-26 |
PE20091711A1 (es) | 2009-11-13 |
WO2009121741A1 (en) | 2009-10-08 |
ES2408961T3 (es) | 2013-06-24 |
AR071111A1 (es) | 2010-05-26 |
EP2271632B1 (en) | 2013-04-17 |
KR101307066B1 (ko) | 2013-09-11 |
IL208022A0 (en) | 2010-12-30 |
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Legal Events
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FG | Grant or registration |