MX2010006867A - Acidos grasos de longitud de cadena media, sales y trigliceridos en combinacion con gemcitabina para el tratamiento de cancer pancreatico. - Google Patents
Acidos grasos de longitud de cadena media, sales y trigliceridos en combinacion con gemcitabina para el tratamiento de cancer pancreatico.Info
- Publication number
- MX2010006867A MX2010006867A MX2010006867A MX2010006867A MX2010006867A MX 2010006867 A MX2010006867 A MX 2010006867A MX 2010006867 A MX2010006867 A MX 2010006867A MX 2010006867 A MX2010006867 A MX 2010006867A MX 2010006867 A MX2010006867 A MX 2010006867A
- Authority
- MX
- Mexico
- Prior art keywords
- chain length
- medium
- gemcitabine
- triglycerides
- salts
- Prior art date
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 3
- 229930195729 fatty acid Natural products 0.000 title abstract 3
- 239000000194 fatty acid Substances 0.000 title abstract 3
- 150000004665 fatty acids Chemical class 0.000 title abstract 3
- 150000003626 triacylglycerols Chemical class 0.000 title abstract 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 title abstract 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 title abstract 2
- 229960005277 gemcitabine Drugs 0.000 title abstract 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title abstract 2
- 201000002528 pancreatic cancer Diseases 0.000 title abstract 2
- 208000008443 pancreatic carcinoma Diseases 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 abstract 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 abstract 2
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N trilaurin Chemical compound CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 abstract 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 abstract 1
- 239000005639 Lauric acid Substances 0.000 abstract 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 abstract 1
- 229960001433 erlotinib Drugs 0.000 abstract 1
- 229940033355 lauric acid Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 abstract 1
- 229940082004 sodium laurate Drugs 0.000 abstract 1
- FIWQZURFGYXCEO-UHFFFAOYSA-M sodium;decanoate Chemical compound [Na+].CCCCCCCCCC([O-])=O FIWQZURFGYXCEO-UHFFFAOYSA-M 0.000 abstract 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 abstract 1
- 229940093633 tricaprin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US812907P | 2007-12-19 | 2007-12-19 | |
| PCT/CA2008/002190 WO2009076761A1 (en) | 2007-12-19 | 2008-12-18 | Medium-chain length fatty acids, salts and triglycerides in combination with gemcitabine for treatment of pancreatic cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010006867A true MX2010006867A (es) | 2010-08-31 |
Family
ID=40795145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010006867A MX2010006867A (es) | 2007-12-19 | 2008-12-18 | Acidos grasos de longitud de cadena media, sales y trigliceridos en combinacion con gemcitabina para el tratamiento de cancer pancreatico. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8946190B2 (https=) |
| EP (1) | EP2231166B1 (https=) |
| JP (1) | JP5473937B2 (https=) |
| KR (1) | KR101603351B1 (https=) |
| CN (1) | CN101903028B (https=) |
| AU (1) | AU2008338204B2 (https=) |
| BR (1) | BRPI0821395A2 (https=) |
| CA (1) | CA2708679C (https=) |
| DK (1) | DK2231166T3 (https=) |
| ES (1) | ES2414617T3 (https=) |
| MX (1) | MX2010006867A (https=) |
| NZ (1) | NZ586249A (https=) |
| PT (1) | PT2231166E (https=) |
| TW (1) | TWI448290B (https=) |
| WO (1) | WO2009076761A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA022445B1 (ru) | 2009-05-04 | 2016-01-29 | Прометик Байосайенсиз Инк. | Замещенные ароматические соединения, композиции на их основе и их фармацевтические применения |
| CN105997967B (zh) * | 2010-10-27 | 2019-08-23 | 普罗米蒂克医药Smt有限公司 | 用于治疗癌症的化合物和组合物 |
| CN102617679B (zh) * | 2012-03-13 | 2014-11-26 | 北京大学 | 一种共轭亚油酸与吉西他滨连接的前体药物制备方法及其应用 |
| WO2014126969A1 (en) | 2013-02-12 | 2014-08-21 | Bend Research, Inc. | Solid dispersions of low-water solubility actives |
| US9737538B2 (en) | 2013-02-12 | 2017-08-22 | Bend Research, Inc. | Solid dispersions of low-water solubility actives |
| MX377728B (es) | 2013-02-28 | 2025-03-11 | Pronova Biopharma Norge As | Composición que comprende un compuesto lípido, un triglicerido y un tensioactivo, y métodos de uso de la misma. |
| WO2015116782A1 (en) | 2014-01-29 | 2015-08-06 | Board Of Regents, The University Of Texas System | Nucleobase analogue derivatives and their applications |
| SG11202103011YA (en) | 2018-10-11 | 2021-04-29 | Basf As | Aromatic compounds and pharmaceutical uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE168557T1 (de) * | 1989-03-13 | 1998-08-15 | Cellegy Pharma Inc | Topische zubereitungen enthaltend aliphatische amine zur behandlung von hautkrankheiten |
| US6340705B1 (en) * | 1999-09-10 | 2002-01-22 | Monsanto Technology, Llc | Use of α-linolenic acid metabolites for treatment or prevention of cancer |
| JP5026655B2 (ja) * | 2001-04-18 | 2012-09-12 | プロメティック、バイオサイエンシーズ、インコーポレーテッド | 好中球の生存及び活性化因子としての中鎖脂肪酸、グリセリド及び類似体 |
| EP1427366A2 (en) * | 2001-08-29 | 2004-06-16 | UMD, Inc. | Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy |
| US20060012880A1 (en) * | 2002-05-02 | 2006-01-19 | Law Benjamin P | Optical device with refractive and diffractive properties |
| ATE419846T1 (de) * | 2003-02-07 | 2009-01-15 | Prometic Biosciences Inc | Fettsäuren mittlerer kettenlänge, glyceride und analoga als stimulatoren der erythropoiese |
| ES2264886B1 (es) * | 2005-05-12 | 2008-02-01 | Proyecto Empresarial Brudy, S.L. | Utilizacion de acido docosahexaenoico para el tratamiento de enfermedades tumorales. |
-
2008
- 2008-12-18 CN CN2008801221273A patent/CN101903028B/zh not_active Expired - Fee Related
- 2008-12-18 DK DK08862479.6T patent/DK2231166T3/da active
- 2008-12-18 NZ NZ586249A patent/NZ586249A/en not_active IP Right Cessation
- 2008-12-18 JP JP2010538291A patent/JP5473937B2/ja not_active Expired - Fee Related
- 2008-12-18 KR KR1020107015015A patent/KR101603351B1/ko not_active Expired - Fee Related
- 2008-12-18 AU AU2008338204A patent/AU2008338204B2/en not_active Ceased
- 2008-12-18 BR BRPI0821395-0A patent/BRPI0821395A2/pt not_active IP Right Cessation
- 2008-12-18 MX MX2010006867A patent/MX2010006867A/es active IP Right Grant
- 2008-12-18 TW TW097149396A patent/TWI448290B/zh not_active IP Right Cessation
- 2008-12-18 EP EP08862479A patent/EP2231166B1/en not_active Not-in-force
- 2008-12-18 CA CA2708679A patent/CA2708679C/en active Active
- 2008-12-18 ES ES08862479T patent/ES2414617T3/es active Active
- 2008-12-18 PT PT88624796T patent/PT2231166E/pt unknown
- 2008-12-18 WO PCT/CA2008/002190 patent/WO2009076761A1/en not_active Ceased
- 2008-12-18 US US12/809,380 patent/US8946190B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW200934494A (en) | 2009-08-16 |
| DK2231166T3 (da) | 2013-06-24 |
| WO2009076761A1 (en) | 2009-06-25 |
| CN101903028A (zh) | 2010-12-01 |
| KR101603351B1 (ko) | 2016-03-14 |
| TWI448290B (zh) | 2014-08-11 |
| CA2708679A1 (en) | 2009-06-25 |
| US8946190B2 (en) | 2015-02-03 |
| EP2231166A4 (en) | 2012-02-22 |
| JP5473937B2 (ja) | 2014-04-16 |
| KR20100101134A (ko) | 2010-09-16 |
| HK1151244A1 (en) | 2012-01-27 |
| AU2008338204B2 (en) | 2015-03-05 |
| EP2231166A1 (en) | 2010-09-29 |
| US20100273731A1 (en) | 2010-10-28 |
| EP2231166B1 (en) | 2013-03-20 |
| ES2414617T3 (es) | 2013-07-22 |
| PT2231166E (pt) | 2013-06-17 |
| CN101903028B (zh) | 2013-06-05 |
| AU2008338204A1 (en) | 2009-06-25 |
| NZ586249A (en) | 2012-05-25 |
| BRPI0821395A2 (pt) | 2015-06-16 |
| CA2708679C (en) | 2016-11-15 |
| JP2011506492A (ja) | 2011-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |