MX2010004453A - Procedimiento sintetico de alta pureza para la preparacion de intermediarios de ester de acido dodecahidro-nafto-furanil-carbami co. - Google Patents

Procedimiento sintetico de alta pureza para la preparacion de intermediarios de ester de acido dodecahidro-nafto-furanil-carbami co.

Info

Publication number
MX2010004453A
MX2010004453A MX2010004453A MX2010004453A MX2010004453A MX 2010004453 A MX2010004453 A MX 2010004453A MX 2010004453 A MX2010004453 A MX 2010004453A MX 2010004453 A MX2010004453 A MX 2010004453A MX 2010004453 A MX2010004453 A MX 2010004453A
Authority
MX
Mexico
Prior art keywords
naptho
dodecahydro
furanyl
preparation
acid ester
Prior art date
Application number
MX2010004453A
Other languages
English (en)
Inventor
Tao Wang
Jing Liao
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2010004453A publication Critical patent/MX2010004453A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta solicitud describe un procedimiento novedoso para sintetizar compuestos análogos de himbacina, e intermediarios de fórmula (I) útiles en la síntesis de los mismos; los compuestos en cuestión son útiles como antagonistas del receptor de trombina con propiedades farmacéuticas útiles.
MX2010004453A 2007-10-24 2008-10-22 Procedimiento sintetico de alta pureza para la preparacion de intermediarios de ester de acido dodecahidro-nafto-furanil-carbami co. MX2010004453A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16407P 2007-10-24 2007-10-24
PCT/US2008/080699 WO2009055416A1 (en) 2007-10-24 2008-10-22 High purity synthetic process for the preparation of dodecahydro-naptho-furanyl-carbamic acid ester intermediates

Publications (1)

Publication Number Publication Date
MX2010004453A true MX2010004453A (es) 2010-07-28

Family

ID=40251794

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004453A MX2010004453A (es) 2007-10-24 2008-10-22 Procedimiento sintetico de alta pureza para la preparacion de intermediarios de ester de acido dodecahidro-nafto-furanil-carbami co.

Country Status (9)

Country Link
EP (1) EP2212307B1 (es)
JP (2) JP5432910B2 (es)
CN (1) CN101910148B (es)
AR (1) AR068996A1 (es)
CA (1) CA2703487A1 (es)
ES (1) ES2398502T3 (es)
HK (1) HK1146271A1 (es)
MX (1) MX2010004453A (es)
WO (1) WO2009055416A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772276B2 (en) 2005-01-14 2010-08-10 Schering Corporation Exo-selective synthesis of himbacine analogs
PT1848705E (pt) * 2005-01-14 2010-05-10 Schering Corp Sínteses exo- e diastereo-selectivas de análogos da himbacina

Also Published As

Publication number Publication date
JP5432910B2 (ja) 2014-03-05
CN101910148A (zh) 2010-12-08
JP2013224334A (ja) 2013-10-31
EP2212307A1 (en) 2010-08-04
CN101910148B (zh) 2014-06-04
WO2009055416A1 (en) 2009-04-30
HK1146271A1 (en) 2011-05-20
JP2011500822A (ja) 2011-01-06
ES2398502T3 (es) 2013-03-19
CA2703487A1 (en) 2009-04-30
EP2212307B1 (en) 2012-11-28
AR068996A1 (es) 2009-12-23

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Legal Events

Date Code Title Description
HC Change of company name or juridical status
FG Grant or registration