MX2010002193A - Metodo de determinacion de actividad pdh y generacion de imagen para su uso en dicho metodo. - Google Patents

Metodo de determinacion de actividad pdh y generacion de imagen para su uso en dicho metodo.

Info

Publication number
MX2010002193A
MX2010002193A MX2010002193A MX2010002193A MX2010002193A MX 2010002193 A MX2010002193 A MX 2010002193A MX 2010002193 A MX2010002193 A MX 2010002193A MX 2010002193 A MX2010002193 A MX 2010002193A MX 2010002193 A MX2010002193 A MX 2010002193A
Authority
MX
Mexico
Prior art keywords
determination
imaging media
pdh activity
imaging
pdh
Prior art date
Application number
MX2010002193A
Other languages
English (en)
Inventor
Marie A Schroeder
Lowri E Cochlin
Helen J Atherton
Lisa C Heather
Kieran Clarke
George K Radda
Damian J Tyler
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of MX2010002193A publication Critical patent/MX2010002193A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90209—Oxidoreductases (1.) acting on NADH or NADPH (1.6), e.g. those with a heme protein as acceptor (1.6.2) (general), Cytochrome-b5 reductase (1.6.2.2) or NADPH-cytochrome P450 reductase (1.6.2.4)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

La presente invención describe un método de determinación de la actividad de PDH por una detección de 13C-MR que utiliza un medio de generación de imagen que comprende 13C-piruvato hiperpolarizado y para el uso del medio de generación de imagen en dicho método.
MX2010002193A 2007-09-07 2008-09-05 Metodo de determinacion de actividad pdh y generacion de imagen para su uso en dicho metodo. MX2010002193A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20074529 2007-09-07
EP08010318 2008-06-06
PCT/EP2008/061725 WO2009030735A1 (en) 2007-09-07 2008-09-05 Method of determination of pdh activity and imaging media for use in said method

Publications (1)

Publication Number Publication Date
MX2010002193A true MX2010002193A (es) 2010-03-18

Family

ID=39829084

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010002193A MX2010002193A (es) 2007-09-07 2008-09-05 Metodo de determinacion de actividad pdh y generacion de imagen para su uso en dicho metodo.

Country Status (11)

Country Link
US (1) US20110033387A1 (es)
EP (1) EP2183591A1 (es)
JP (1) JP2010537657A (es)
KR (1) KR20100068244A (es)
CN (1) CN101796413B (es)
AU (1) AU2008294727B2 (es)
BR (1) BRPI0816484A2 (es)
CA (1) CA2698622A1 (es)
MX (1) MX2010002193A (es)
RU (1) RU2487358C2 (es)
WO (1) WO2009030735A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012027274A2 (en) * 2010-08-23 2012-03-01 The Regents Of The University Of California Compositions and methods for imaging
US8933697B2 (en) * 2011-12-19 2015-01-13 General Electric Company Measurement of chemical equilibrium ratio using a magnetic resonance spectroscopy system
RU2560066C1 (ru) * 2014-05-29 2015-08-20 Федеральное государственное бюджетное учреждение науки Институт катализа им. Г.К. Борескова Сибирского отделения Российской академии наук Способ пробоподготовки биоорганических образцов
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2638820C1 (ru) * 2016-11-03 2017-12-15 Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Способ регистрации малых количеств органических нано- и микрочастиц в биологических тканях
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
BR112021007707A2 (pt) 2018-11-23 2021-07-27 Bayer Aktiengesellschaft formulação de meios de contraste e processo de preparação da mesma

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9811427D0 (en) * 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
WO2006011810A2 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Mr imaging method for the discrimination between healthy and tumour tissue
JP5456256B2 (ja) * 2004-11-19 2014-03-26 ジーイー・ヘルスケア・アクスイェ・セルスカプ 心臓イメージング法
CN100523784C (zh) * 2007-01-17 2009-08-05 华中师范大学 一种测定丙酮酸脱氢酶系活性的分光光度法

Also Published As

Publication number Publication date
BRPI0816484A2 (pt) 2015-03-17
CA2698622A1 (en) 2009-03-12
RU2010105971A (ru) 2011-10-20
WO2009030735A1 (en) 2009-03-12
US20110033387A1 (en) 2011-02-10
EP2183591A1 (en) 2010-05-12
AU2008294727B2 (en) 2013-10-17
RU2487358C2 (ru) 2013-07-10
CN101796413A (zh) 2010-08-04
KR20100068244A (ko) 2010-06-22
AU2008294727A1 (en) 2009-03-12
CN101796413B (zh) 2014-08-20
JP2010537657A (ja) 2010-12-09

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