MX2009013779A - Uso de agonistas de tlr y/o interferonas tipo 1 para aliviar la toxicidad de los regimenes terapeuticos de agonistas de tnf-r. - Google Patents

Uso de agonistas de tlr y/o interferonas tipo 1 para aliviar la toxicidad de los regimenes terapeuticos de agonistas de tnf-r.

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Publication number
MX2009013779A
MX2009013779A MX2009013779A MX2009013779A MX2009013779A MX 2009013779 A MX2009013779 A MX 2009013779A MX 2009013779 A MX2009013779 A MX 2009013779A MX 2009013779 A MX2009013779 A MX 2009013779A MX 2009013779 A MX2009013779 A MX 2009013779A
Authority
MX
Mexico
Prior art keywords
tnf
type
interferons
therapeutic regimens
tlr agonists
Prior art date
Application number
MX2009013779A
Other languages
English (en)
Inventor
Ross Kedl
Cory Ahonen
Randolph Noelle
Original Assignee
Immurx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immurx Inc filed Critical Immurx Inc
Publication of MX2009013779A publication Critical patent/MX2009013779A/es

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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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Abstract

Se proporcionan métodos de terapia mejorados (más seguros y más efectivos) usando agonistas de TNF-R, por ejemplo, agonistas de CD40. Estos métodos proporcionan la adición de una cantidad de una interferona tipo 1 y/o un agonista de TLR que es efectiva para prevenir o reducir la toxicidad (toxicidad del hígado) que de otra manera puede resultar en algunos pacientes del agonista de TNF-R que se utiliza como una monoterapia (sin la interferona tipo 1 y/o agonista de TLR).
MX2009013779A 2007-06-15 2008-06-16 Uso de agonistas de tlr y/o interferonas tipo 1 para aliviar la toxicidad de los regimenes terapeuticos de agonistas de tnf-r. MX2009013779A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94428807P 2007-06-15 2007-06-15
PCT/US2008/067088 WO2008157473A1 (en) 2007-06-15 2008-06-16 Use of tlr agonists and/or type 1 interferons to alleviate toxicity of tnf-r agonist therapeutic regimens

Publications (1)

Publication Number Publication Date
MX2009013779A true MX2009013779A (es) 2010-05-20

Family

ID=40156653

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Application Number Title Priority Date Filing Date
MX2009013779A MX2009013779A (es) 2007-06-15 2008-06-16 Uso de agonistas de tlr y/o interferonas tipo 1 para aliviar la toxicidad de los regimenes terapeuticos de agonistas de tnf-r.

Country Status (9)

Country Link
US (2) US20110182847A1 (es)
EP (1) EP2170931A4 (es)
JP (1) JP2010530005A (es)
KR (1) KR20100034010A (es)
CN (1) CN101778861A (es)
AU (1) AU2008265911B2 (es)
CA (1) CA2691089A1 (es)
MX (1) MX2009013779A (es)
WO (1) WO2008157473A1 (es)

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DK2663580T3 (en) 2011-01-10 2017-03-13 Ct Atlantic Ltd COMBINATION THERAPY INCLUDING TUMOR ASSOCIATED ANTI-BINDING ANTIBODIES
CN103476458B (zh) 2011-01-10 2017-02-15 克利夫兰生物实验室公司 Toll样受体激动剂治疗癌症的用途
EP2892353A4 (en) * 2012-09-10 2016-10-26 Yeda Res & Dev INDIVIDUALIZED IMMUNOMODULATION THERAPY FOR NEURODEGENERATIVE ILLNESSES, CNS LESIONS AND AGGREGATIVE DEMENTIA
MX2017001279A (es) 2014-07-30 2017-08-07 Cleveland Biolabs Inc Usos y composiciones de la flagelina.
ES2952717T3 (es) * 2014-10-14 2023-11-03 Novartis Ag Moléculas de anticuerpos contra PD-L1 y usos de las mismas
WO2016109002A2 (en) 2014-10-16 2016-07-07 Cleveland Biolabs, Inc. Methods and compositions for the treatment of radiation-related disorders
CA3061077A1 (en) * 2016-04-26 2017-11-02 Qu Biologics Inc. Therapeutically triggering an innate immune response in a target tissue
KR20230149857A (ko) 2016-07-07 2023-10-27 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 항체-애쥬번트 접합체
WO2018183930A1 (en) * 2017-03-30 2018-10-04 Carson Dennis A Methods for isolating, expanding and administering cancer specific cd8+ t cells
AR111651A1 (es) * 2017-04-28 2019-08-07 Novartis Ag Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
CA3130794A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2
IL303265A (en) * 2020-12-04 2023-07-01 Univ Antwerpen Combined immunotherapy of IL-15 and CD40 agonists in cancer treatment
CN113827586B (zh) * 2021-09-06 2022-07-26 武汉市金银潭医院(武汉市传染病医院) 盐酸去甲替林在制备抗肠道病毒药物中的应用

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JP2005519990A (ja) * 2001-10-12 2005-07-07 ユニバーシティ オブ アイオワ リサーチ ファウンデーション イミダゾキノリン化合物を用いて免疫応答を増強するための方法および産物
EP2572714A1 (en) * 2002-12-30 2013-03-27 3M Innovative Properties Company Immunostimulatory Combinations
AU2004246999B2 (en) * 2003-02-06 2010-06-10 Aduro Biotech, Inc., Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the listeria, and methods of use thereof
JP5097400B2 (ja) * 2003-09-03 2012-12-12 デンドリセラピューティクス、インク． 複合ワクチン
US7700728B2 (en) * 2005-03-24 2010-04-20 Schering Corporation Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors
JP2008543943A (ja) * 2005-06-20 2008-12-04 ペプゲン コーポレイション ヒトインターフェロンアルファ類似体とインターフェロンタウの低毒性長期循環性キメラ
JP5427027B2 (ja) * 2006-05-03 2014-02-26 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・コロラド，ア・ボディー・コーポレイト Ｃｄ４０アゴニスト抗体／ｉ型インターフェロン相乗性アジュバントの結合体、それを含む複合体、および細胞性免疫を強化する治療としてのその使用
EP2589654A1 (en) * 2006-05-03 2013-05-08 The Regents of the University of Colorado, a body corporate CD40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity

Also Published As

Publication number Publication date
EP2170931A4 (en) 2010-06-30
CN101778861A (zh) 2010-07-14
US20130302278A1 (en) 2013-11-14
US20110182847A1 (en) 2011-07-28
AU2008265911A1 (en) 2008-12-24
AU2008265911B2 (en) 2013-05-16
EP2170931A1 (en) 2010-04-07
KR20100034010A (ko) 2010-03-31
WO2008157473A1 (en) 2008-12-24
CA2691089A1 (en) 2008-12-24
JP2010530005A (ja) 2010-09-02

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