MX2009010967A - Un metodo para la preparacion de mirtazapina. - Google Patents
Un metodo para la preparacion de mirtazapina.Info
- Publication number
- MX2009010967A MX2009010967A MX2009010967A MX2009010967A MX2009010967A MX 2009010967 A MX2009010967 A MX 2009010967A MX 2009010967 A MX2009010967 A MX 2009010967A MX 2009010967 A MX2009010967 A MX 2009010967A MX 2009010967 A MX2009010967 A MX 2009010967A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- mirtazapine
- formula
- preparation
- enantiomeric excess
- Prior art date
Links
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001785 mirtazapine Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 2
- -1 carboxylic acid compound Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07105985 | 2007-04-11 | ||
| PCT/EP2008/054316 WO2008125578A2 (en) | 2007-04-11 | 2008-04-10 | A method for the preparation of mirtazapine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009010967A true MX2009010967A (es) | 2009-12-15 |
Family
ID=38474342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009010967A MX2009010967A (es) | 2007-04-11 | 2008-04-10 | Un metodo para la preparacion de mirtazapina. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2146993B1 (OSRAM) |
| JP (1) | JP5635905B2 (OSRAM) |
| CN (1) | CN101679431B (OSRAM) |
| AR (1) | AR066005A1 (OSRAM) |
| CA (1) | CA2684021A1 (OSRAM) |
| MX (1) | MX2009010967A (OSRAM) |
| WO (1) | WO2008125578A2 (OSRAM) |
| ZA (1) | ZA200907537B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG191831A1 (en) * | 2011-03-31 | 2013-08-30 | Kaneka Corp | Process for preparing cyclic amine compounds |
| HRP20211040T1 (hr) | 2015-02-27 | 2021-10-01 | Dechra Limited | Poticanje apetita, upravljanje gubitkom težine, i liječenje anoreksije kod pasa i mačaka |
| CN121204204A (zh) * | 2025-11-27 | 2025-12-26 | 山东静远药业有限公司 | 一种苯磺酸米洛巴林关键中间体的对映体杂质的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) * | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| BR9815098A (pt) | 1997-11-14 | 2000-10-10 | Akzo Nobel Nv | Uso de mirtazapina ou de um seu sal farmaceuticamente aceitável, e, processo para o tratamento de apnéias do sono em um aninal. |
| KR20020019902A (ko) | 1999-04-19 | 2002-03-13 | 추후보정 | 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법 |
| AU6476300A (en) | 1999-09-30 | 2001-05-10 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a piperazine derivative |
| AU6474200A (en) | 1999-12-13 | 2001-06-18 | Sumika Fine Chemicals Co., Ltd. | Process for the preparation of a pyridinemethanol compound |
| EP1658850A1 (en) | 2000-02-11 | 2006-05-24 | Akzo Nobel N.V. | The use of mirtazapine for the treatment of sleep disorders |
| WO2003024918A1 (es) | 2001-09-14 | 2003-03-27 | Medichem S.A. | Compuestos intermedios para la preparación de mirtazapina y sus procedimientos de obtención |
| US6806283B2 (en) * | 2002-05-06 | 2004-10-19 | Virginia Commonwealth University | Selective serotonin receptor antagonists and therapeutic applications thereof |
| UA83666C2 (ru) * | 2003-07-10 | 2008-08-11 | Н.В. Органон | Способ получения энантиомерно чистого миртазапина |
| PL1651658T5 (pl) * | 2003-08-01 | 2020-11-30 | Mitsubishi Tanabe Pharma Corporation | Nowe związki o działaniu inhibitującym transporter zależny od sodu |
| JP2007284358A (ja) | 2006-04-13 | 2007-11-01 | Sumitomo Chemical Co Ltd | 光学活性なピペラジン化合物の製造方法 |
| TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
-
2008
- 2008-04-10 MX MX2009010967A patent/MX2009010967A/es not_active Application Discontinuation
- 2008-04-10 EP EP08736038.4A patent/EP2146993B1/en active Active
- 2008-04-10 AR ARP080101475 patent/AR066005A1/es unknown
- 2008-04-10 WO PCT/EP2008/054316 patent/WO2008125578A2/en not_active Ceased
- 2008-04-10 CA CA002684021A patent/CA2684021A1/en not_active Abandoned
- 2008-04-10 CN CN200880016144.9A patent/CN101679431B/zh active Active
- 2008-04-10 JP JP2010502504A patent/JP5635905B2/ja active Active
-
2009
- 2009-10-27 ZA ZA200907537A patent/ZA200907537B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2684021A1 (en) | 2008-10-23 |
| CN101679431B (zh) | 2013-08-14 |
| EP2146993B1 (en) | 2015-08-05 |
| WO2008125578A2 (en) | 2008-10-23 |
| JP5635905B2 (ja) | 2014-12-03 |
| EP2146993A2 (en) | 2010-01-27 |
| JP2010523620A (ja) | 2010-07-15 |
| WO2008125578A3 (en) | 2008-12-24 |
| AR066005A1 (es) | 2009-07-15 |
| CN101679431A (zh) | 2010-03-24 |
| ZA200907537B (en) | 2010-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: MERCK SHARP & DOHME B.V. |
|
| GB | Transfer or rights |
Owner name: MERCK SHARP & DOHME B.V. |
|
| FA | Abandonment or withdrawal |