MX2009010173A - Derivados de aminometil aza-adamantano y uso de los mismos como moduladores selectivos del receptor de acetilcolina nicotinico alfa-7 neuronal (nnrs). - Google Patents
Derivados de aminometil aza-adamantano y uso de los mismos como moduladores selectivos del receptor de acetilcolina nicotinico alfa-7 neuronal (nnrs).Info
- Publication number
- MX2009010173A MX2009010173A MX2009010173A MX2009010173A MX2009010173A MX 2009010173 A MX2009010173 A MX 2009010173A MX 2009010173 A MX2009010173 A MX 2009010173A MX 2009010173 A MX2009010173 A MX 2009010173A MX 2009010173 A MX2009010173 A MX 2009010173A
- Authority
- MX
- Mexico
- Prior art keywords
- acetylcholine receptor
- nicotinic acetylcholine
- amimomethyl
- nnrs
- alpha7
- Prior art date
Links
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title abstract 3
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title abstract 3
- WENISBCJPGSITQ-UHFFFAOYSA-N 1-azatricyclo[3.3.1.13,7]decane Chemical class C1C(C2)CC3CC1CN2C3 WENISBCJPGSITQ-UHFFFAOYSA-N 0.000 title 1
- 230000001537 neural effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000006735 deficit Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000026139 Memory disease Diseases 0.000 abstract 1
- -1 aminomethyl azaadamantane derivatives Chemical class 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89675507P | 2007-03-23 | 2007-03-23 | |
| PCT/US2008/057652 WO2008118747A1 (en) | 2007-03-23 | 2008-03-20 | Amimomethyl azaadamantane derivatives and use thereof as selective modulators of the alpha7- neuronal nicotinic acetylcholine receptor (nnrs) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009010173A true MX2009010173A (es) | 2009-10-12 |
Family
ID=39620402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009010173A MX2009010173A (es) | 2007-03-23 | 2008-03-20 | Derivados de aminometil aza-adamantano y uso de los mismos como moduladores selectivos del receptor de acetilcolina nicotinico alfa-7 neuronal (nnrs). |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8168791B2 (enExample) |
| EP (2) | EP2129673B1 (enExample) |
| JP (1) | JP5394940B2 (enExample) |
| CN (1) | CN101675049A (enExample) |
| CA (1) | CA2679885A1 (enExample) |
| MX (1) | MX2009010173A (enExample) |
| WO (1) | WO2008118747A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI1015043A2 (pt) * | 2009-06-19 | 2019-07-09 | Abbott Lab | derivados de diazahomoadamantano e métodos de uso dos mesmos |
| US10183938B2 (en) | 2014-12-16 | 2019-01-22 | Axovant Sciences Gmbh | Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors |
| JP2018516973A (ja) | 2015-06-10 | 2018-06-28 | フォーラム・ファーマシューティカルズ・インコーポレイテッドＦｏｒｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | α７−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物 |
| EP3334740A4 (en) | 2015-08-12 | 2019-02-06 | Axovant Sciences GmbH | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ALPHA 7-NICOTINIC ACETYLCHOLINE RECEPTORS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8523211D0 (en) | 1985-09-19 | 1985-10-23 | Beecham Group Plc | Compounds |
| US5260303A (en) | 1991-03-07 | 1993-11-09 | G. D. Searle & Co. | Imidazopyridines as serotonergic 5-HT3 antagonists |
| US5280028A (en) | 1992-06-24 | 1994-01-18 | G. D. Searle & Co. | Benzimidazole compounds |
| US5434151A (en) | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| US5840903A (en) | 1992-07-27 | 1998-11-24 | G. D. Searle & Co. | 4-aminomethyl-1-azaadamantane derived benzamides |
| JP3235913B2 (ja) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
| US5399562A (en) | 1994-02-04 | 1995-03-21 | G. D. Searle & Co. | Indolones useful as serotonergic agents |
| US7897766B2 (en) | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
-
2008
- 2008-03-20 MX MX2009010173A patent/MX2009010173A/es active IP Right Grant
- 2008-03-20 EP EP08799662.5A patent/EP2129673B1/en active Active
- 2008-03-20 WO PCT/US2008/057652 patent/WO2008118747A1/en not_active Ceased
- 2008-03-20 JP JP2009554740A patent/JP5394940B2/ja not_active Expired - Fee Related
- 2008-03-20 US US12/052,093 patent/US8168791B2/en not_active Expired - Fee Related
- 2008-03-20 EP EP12162114.8A patent/EP2505588B1/en active Active
- 2008-03-20 CN CN200880009484A patent/CN101675049A/zh active Pending
- 2008-03-20 CA CA002679885A patent/CA2679885A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2129673B1 (en) | 2013-11-06 |
| CA2679885A1 (en) | 2008-10-02 |
| CN101675049A (zh) | 2010-03-17 |
| WO2008118747A1 (en) | 2008-10-02 |
| US8168791B2 (en) | 2012-05-01 |
| JP5394940B2 (ja) | 2014-01-22 |
| EP2505588B1 (en) | 2013-11-13 |
| JP2010522204A (ja) | 2010-07-01 |
| EP2505588A1 (en) | 2012-10-03 |
| EP2129673A1 (en) | 2009-12-09 |
| US20080262023A1 (en) | 2008-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| GB | Transfer or rights |