CN101675049A - 作为α7-神经元烟碱样乙酰胆碱受体(NNRS)的选择性调节剂的氨基甲基氮杂金刚烷衍生物及其用途 - Google Patents

作为α7-神经元烟碱样乙酰胆碱受体(NNRS)的选择性调节剂的氨基甲基氮杂金刚烷衍生物及其用途 Download PDF

Info

Publication number
CN101675049A
CN101675049A CN200880009484A CN200880009484A CN101675049A CN 101675049 A CN101675049 A CN 101675049A CN 200880009484 A CN200880009484 A CN 200880009484A CN 200880009484 A CN200880009484 A CN 200880009484A CN 101675049 A CN101675049 A CN 101675049A
Authority
CN
China
Prior art keywords
compound
compounds
prodrug
acceptable salt
acid amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880009484A
Other languages
English (en)
Chinese (zh)
Inventor
L·施
M·J·C·斯卡尼奥
W·H·邦内尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CN101675049A publication Critical patent/CN101675049A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880009484A 2007-03-23 2008-03-20 作为α7-神经元烟碱样乙酰胆碱受体(NNRS)的选择性调节剂的氨基甲基氮杂金刚烷衍生物及其用途 Pending CN101675049A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89675507P 2007-03-23 2007-03-23
US60/896,755 2007-03-23
PCT/US2008/057652 WO2008118747A1 (en) 2007-03-23 2008-03-20 Amimomethyl azaadamantane derivatives and use thereof as selective modulators of the alpha7- neuronal nicotinic acetylcholine receptor (nnrs)

Publications (1)

Publication Number Publication Date
CN101675049A true CN101675049A (zh) 2010-03-17

Family

ID=39620402

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880009484A Pending CN101675049A (zh) 2007-03-23 2008-03-20 作为α7-神经元烟碱样乙酰胆碱受体(NNRS)的选择性调节剂的氨基甲基氮杂金刚烷衍生物及其用途

Country Status (7)

Country Link
US (1) US8168791B2 (enExample)
EP (2) EP2129673B1 (enExample)
JP (1) JP5394940B2 (enExample)
CN (1) CN101675049A (enExample)
CA (1) CA2679885A1 (enExample)
MX (1) MX2009010173A (enExample)
WO (1) WO2008118747A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI1015043A2 (pt) * 2009-06-19 2019-07-09 Abbott Lab derivados de diazahomoadamantano e métodos de uso dos mesmos
US10183938B2 (en) 2014-12-16 2019-01-22 Axovant Sciences Gmbh Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors
JP2018516973A (ja) 2015-06-10 2018-06-28 フォーラム・ファーマシューティカルズ・インコーポレイテッドＦｏｒｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． α７−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物
EP3334740A4 (en) 2015-08-12 2019-02-06 Axovant Sciences GmbH GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ALPHA 7-NICOTINIC ACETYLCHOLINE RECEPTORS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8523211D0 (en) 1985-09-19 1985-10-23 Beecham Group Plc Compounds
US5260303A (en) 1991-03-07 1993-11-09 G. D. Searle & Co. Imidazopyridines as serotonergic 5-HT3 antagonists
US5280028A (en) 1992-06-24 1994-01-18 G. D. Searle & Co. Benzimidazole compounds
US5434151A (en) 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5840903A (en) 1992-07-27 1998-11-24 G. D. Searle & Co. 4-aminomethyl-1-azaadamantane derived benzamides
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
US5399562A (en) 1994-02-04 1995-03-21 G. D. Searle & Co. Indolones useful as serotonergic agents
US7897766B2 (en) 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use

Also Published As

Publication number Publication date
EP2129673B1 (en) 2013-11-06
CA2679885A1 (en) 2008-10-02
WO2008118747A1 (en) 2008-10-02
US8168791B2 (en) 2012-05-01
JP5394940B2 (ja) 2014-01-22
EP2505588B1 (en) 2013-11-13
JP2010522204A (ja) 2010-07-01
EP2505588A1 (en) 2012-10-03
MX2009010173A (es) 2009-10-12
EP2129673A1 (en) 2009-12-09
US20080262023A1 (en) 2008-10-23

Similar Documents

Publication Publication Date Title
US8163916B2 (en) Azaadamantane ester and carbamate derivatives and methods of use thereof
SG176921A1 (en) Diazahomoadamantane derivatives and methods of use thereof
EP2114943A1 (en) Spirocyclic azaadamantane derivatives and methods of use
CN101641357B (zh) 4-取代的氮杂金刚烷衍生物及其使用方法
WO2007038058A2 (en) Amino-aza-adamantane derivatives and methods of use
EP2129673B1 (en) Amimomethyl azaadamantane derivatives and use thereof as selective modulators of the alpha7- neuronal nicotinic acetylcholine receptor (nnrs)
EP2069346B1 (en) Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof
HK1135972B (en) 4-substituted azaadamantane derivatives and methods of use thereof
HK1131609B (en) Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: ABBVIE INC.

Free format text: FORMER OWNER: ABBOTT GMBH. + CO. KG

Effective date: 20130620

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20130620

Address after: Illinois State

Applicant after: Abbvie Inc.

Address before: Illinois State

Applicant before: Abbott GmbH. & Co. Kg

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20100317