MX2009009189A - Sintasa de acido graso en la enfermedad de higado. - Google Patents

Sintasa de acido graso en la enfermedad de higado.

Info

Publication number
MX2009009189A
MX2009009189A MX2009009189A MX2009009189A MX2009009189A MX 2009009189 A MX2009009189 A MX 2009009189A MX 2009009189 A MX2009009189 A MX 2009009189A MX 2009009189 A MX2009009189 A MX 2009009189A MX 2009009189 A MX2009009189 A MX 2009009189A
Authority
MX
Mexico
Prior art keywords
fatty acid
acid synthase
liver disease
expression
fas
Prior art date
Application number
MX2009009189A
Other languages
English (en)
Inventor
Susan M Medghalchi
Francis P Kuhajda
Original Assignee
Fasgen Diagnostics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fasgen Diagnostics Llc filed Critical Fasgen Diagnostics Llc
Publication of MX2009009189A publication Critical patent/MX2009009189A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91045—Acyltransferases (2.3)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se divulgan métodos y composiciones para detectar la expresión de sintasa de ácido graso (FAS) elevada en el hígado de un sujeto. La detección puede ser de la expresión en las células del hígado per se o en un fluido corporal de un sujeto. También se divulgan métodos para identificar la presencia o ausencia de enfermedad o patología del hígado en relación a la FAS elevada. Los métodos divulgados se pueden practicar con varias composiciones que comprenden reactivos para detectar la expresión de FAS como es descrito en la presente.
MX2009009189A 2007-02-27 2008-02-27 Sintasa de acido graso en la enfermedad de higado. MX2009009189A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89192807P 2007-02-27 2007-02-27
PCT/US2008/055198 WO2008106563A2 (en) 2007-02-27 2008-02-27 Fatty acid synthase in liver disease

Publications (1)

Publication Number Publication Date
MX2009009189A true MX2009009189A (es) 2009-11-05

Family

ID=39639486

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009189A MX2009009189A (es) 2007-02-27 2008-02-27 Sintasa de acido graso en la enfermedad de higado.

Country Status (8)

Country Link
US (1) US20090162870A1 (es)
EP (1) EP2132565A2 (es)
JP (1) JP2010519561A (es)
KR (1) KR20100014652A (es)
CN (1) CN101720434A (es)
CA (1) CA2679325A1 (es)
MX (1) MX2009009189A (es)
WO (1) WO2008106563A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010118324A2 (en) 2009-04-09 2010-10-14 Nuclea Biotechnologies, LLC Antibodies against fatty acid synthase
KR101138460B1 (ko) 2009-10-12 2012-04-26 한국생명공학연구원 항-ｆａｓｎ 자가면역 항체를 포함하는 간암 진단 마커 및 이의 항원을 포함하는 간암 진단용 조성물
WO2011140296A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (en) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
CA2849100A1 (en) * 2011-09-22 2013-03-28 Expression Pathology, Inc. Srm/mrm assay for the fatty acid synthase protein
WO2017189613A1 (en) * 2016-04-25 2017-11-02 Forma Therapeutics, Inc. Methods of using fasn inhibitors
US11169145B2 (en) * 2017-05-01 2021-11-09 Washington University Methods of detection and treatment for cardiovascular disease and foot wounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5759837A (en) * 1989-01-17 1998-06-02 John Hopkins University Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
US8247188B2 (en) * 2005-08-17 2012-08-21 Fasgen Diagnostics, Llc FAS binding antibodies
US20090163474A1 (en) * 2007-10-19 2009-06-25 Wyeth FXR Agonists for the Treatment of Nonalcoholic Fatty Liver and Cholesterol Gallstone Diseases

Also Published As

Publication number Publication date
US20090162870A1 (en) 2009-06-25
KR20100014652A (ko) 2010-02-10
WO2008106563A2 (en) 2008-09-04
CA2679325A1 (en) 2008-09-04
JP2010519561A (ja) 2010-06-03
WO2008106563A3 (en) 2008-11-06
EP2132565A2 (en) 2009-12-16
CN101720434A (zh) 2010-06-02

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