MX2009002775A - Derivados de ciclopeptido de quimica click como agentes de formacion de imagen para integrinas. - Google Patents

Derivados de ciclopeptido de quimica click como agentes de formacion de imagen para integrinas.

Info

Publication number
MX2009002775A
MX2009002775A MX2009002775A MX2009002775A MX2009002775A MX 2009002775 A MX2009002775 A MX 2009002775A MX 2009002775 A MX2009002775 A MX 2009002775A MX 2009002775 A MX2009002775 A MX 2009002775A MX 2009002775 A MX2009002775 A MX 2009002775A
Authority
MX
Mexico
Prior art keywords
integrins
derived
imaging agents
click chemistry
cyclopeptide derivatives
Prior art date
Application number
MX2009002775A
Other languages
English (en)
Inventor
Joseph C Walsh
Hartmuth Kolb
Kai Chen
Qianwa Liang
Henry Padgett
Farhad Karimi
Original Assignee
Siemens Medical Solutions
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions filed Critical Siemens Medical Solutions
Publication of MX2009002775A publication Critical patent/MX2009002775A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente solicitud se dirige a polipéptidos cíclicos radiomarcados, composiciones farmacéuticas que comprenden polipéptidos cíclicos raiomarcados, y métodos para utilizar los polipéptidos cíclicos radiomarcados. Tales polipéptidos se pueden utilizar en estudios de formación de imagen, tal como Tomografía de Emisión Positrónica (PET) o Tomografía de Emisión Monofotónica (SPECT).
MX2009002775A 2006-09-15 2007-09-17 Derivados de ciclopeptido de quimica click como agentes de formacion de imagen para integrinas. MX2009002775A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84483706P 2006-09-15 2006-09-15
US96327207P 2007-08-03 2007-08-03
PCT/US2007/020175 WO2008033561A2 (en) 2006-09-15 2007-09-17 Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins

Publications (1)

Publication Number Publication Date
MX2009002775A true MX2009002775A (es) 2009-06-17

Family

ID=39027295

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002775A MX2009002775A (es) 2006-09-15 2007-09-17 Derivados de ciclopeptido de quimica click como agentes de formacion de imagen para integrinas.

Country Status (9)

Country Link
US (1) US7666392B2 (es)
EP (1) EP2061519B1 (es)
JP (1) JP5237283B2 (es)
KR (1) KR20090053863A (es)
AU (1) AU2007294685B2 (es)
CA (1) CA2663454C (es)
MX (1) MX2009002775A (es)
MY (1) MY150757A (es)
WO (1) WO2008033561A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7993626B2 (en) * 2007-01-11 2011-08-09 Immunomedics, Inc. Methods and compositions for F-18 labeling of proteins, peptides and other molecules
WO2008033557A2 (en) * 2006-09-15 2008-03-20 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclic peptidomimetics as integrin markers
US8889100B2 (en) 2007-01-11 2014-11-18 Immunomedics, Inc. Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
US8545809B2 (en) 2007-01-11 2013-10-01 Immunomedics, Inc. Methods and compositions for improved 18F labeling of proteins, peptides and other molecules
WO2008134761A2 (en) * 2007-04-30 2008-11-06 Intezyne Technologies, Inc. Modification of biological targeting groups for the treatment of cancer
WO2009018175A2 (en) * 2007-07-27 2009-02-05 Siemens Medical Solutions Usa, Inc. Cyclic azapeptides as integrin markers
US9005577B2 (en) 2008-04-30 2015-04-14 Siemens Medical Solutions Usa, Inc. Substrate based PET imaging agents
WO2009134382A2 (en) * 2008-04-30 2009-11-05 Siemens Medical Solutions Usa, Inc. Cyclopeptides containing rgd mimetics as imaging markers for integrins
EP2288388B1 (en) * 2008-05-30 2016-08-31 Siemens Medical Solutions USA, Inc. Achievement of high therapeutic index through molecular imaging guided targeted drug treatment
EP2400992B1 (en) * 2009-02-27 2015-07-22 Genentech, Inc. Methods and compositions for protein labelling
JP5789821B2 (ja) * 2009-12-04 2015-10-07 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． タンパク質、ペプチドおよび他の分子の改善されたｆ−１８標識化のための方法および組成物
KR101430422B1 (ko) 2010-04-08 2014-08-14 지멘스 메디컬 솔루션즈 유에스에이, 인크. 함수 유기 용매에서 18ｆ-표지된 트레이서의 합성
US10639608B2 (en) 2010-04-08 2020-05-05 Siemens Medical Solutions Usa, Inc. System, device and method for preparing tracers and transferring materials during radiosynthesis
CN101891889B (zh) * 2010-08-18 2012-05-23 中国科学院长春应用化学研究所 阳离子聚合物及其制备方法
CN102086266B (zh) * 2010-12-24 2013-04-10 华东理工大学 含聚肽不对称超支化两性聚电解质及其制备方法
US9023318B2 (en) * 2011-06-08 2015-05-05 Siemens Medical Solutions Usa, Inc. Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof
EP4183853B1 (en) * 2016-04-15 2024-10-02 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
CN111032678A (zh) 2017-06-26 2020-04-17 拜西克尔德有限公司 具有可检测部分的双环肽配体和其用途
CN118772242A (zh) 2017-08-04 2024-10-15 拜斯科技术开发有限公司 Cd137特异性的双环肽配体
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
US11584825B2 (en) 2018-12-14 2023-02-21 Beckman Coulter, Inc. Polymer dye modification and applications
TW202110485A (zh) 2019-07-30 2021-03-16 英商拜西可泰克斯有限公司 異質雙環肽複合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420344D0 (en) * 2004-09-14 2004-10-13 Amersham Plc Diagnostic compounds
EP1733742A1 (en) 2005-06-17 2006-12-20 Universiteit Utrecht Holding B.V. Dendrimers multivalently substituted with active groups

Also Published As

Publication number Publication date
JP5237283B2 (ja) 2013-07-17
JP2010503685A (ja) 2010-02-04
US7666392B2 (en) 2010-02-23
CA2663454C (en) 2015-04-21
WO2008033561A3 (en) 2008-05-08
CA2663454A1 (en) 2008-03-20
MY150757A (en) 2014-02-28
US20080170992A1 (en) 2008-07-17
AU2007294685A1 (en) 2008-03-20
WO2008033561A2 (en) 2008-03-20
EP2061519A2 (en) 2009-05-27
EP2061519B1 (en) 2016-03-30
AU2007294685B2 (en) 2012-06-07
KR20090053863A (ko) 2009-05-27

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