MX2008010934A - Sistema terapeutico transdermico que contiene escopolamina. - Google Patents
Sistema terapeutico transdermico que contiene escopolamina.Info
- Publication number
- MX2008010934A MX2008010934A MX2008010934A MX2008010934A MX2008010934A MX 2008010934 A MX2008010934 A MX 2008010934A MX 2008010934 A MX2008010934 A MX 2008010934A MX 2008010934 A MX2008010934 A MX 2008010934A MX 2008010934 A MX2008010934 A MX 2008010934A
- Authority
- MX
- Mexico
- Prior art keywords
- polymer matrix
- scopolamine
- polymer
- flexible
- weight
- Prior art date
Links
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 title abstract 3
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 title abstract 3
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 title abstract 3
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 title abstract 3
- 229960002646 scopolamine Drugs 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 6
- 239000011159 matrix material Substances 0.000 abstract 5
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- 229920002959 polymer blend Polymers 0.000 abstract 1
- 229920005573 silicon-containing polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Se describen sistemas flexibles finitos para la administración transdérmica de escopolamina que consiste de: (a) una matriz polimérica que contiene una mezcla de polímeros que contiene (i) un polímero no funcional a base de acrílico que constituye cuando menos aproximadamente 60% en peso del peso seco de la matriz polimérica, y (ii) un polímero de silicona protegido resistente a la amina que constituye no más de aproximadamente 30% en peso seco del peso seco de la matriz polimérica y (b) escopolamina solubilizada en la matriz polimérica en donde el sistema finito flexible está sustancialmente libre de acetato de vinilo y componentes molares. En algunas modalidades, la matriz polimérica también comprende un promotor no polar de la penetración. También se describen métodos para producir y usar esos sistemas finitos flexibles.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77725706P | 2006-02-27 | 2006-02-27 | |
PCT/US2007/004911 WO2007100757A2 (en) | 2006-02-27 | 2007-02-26 | Transdermal therapeutic system comprising scopolamine |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2008010934A true MX2008010934A (es) | 2008-10-30 |
Family
ID=38266708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008010934A MX2008010934A (es) | 2006-02-27 | 2007-02-26 | Sistema terapeutico transdermico que contiene escopolamina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US8715723B2 (es) |
EP (1) | EP1998756A2 (es) |
JP (1) | JP2009528357A (es) |
CN (1) | CN101431988A (es) |
AU (1) | AU2007221117A1 (es) |
CA (1) | CA2643037C (es) |
MX (1) | MX2008010934A (es) |
NO (1) | NO20084088L (es) |
RU (1) | RU2008138595A (es) |
WO (1) | WO2007100757A2 (es) |
ZA (1) | ZA200807408B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10758619B2 (en) * | 2010-11-15 | 2020-09-01 | The Ohio State University | Controlled release mucoadhesive systems |
US9717697B2 (en) | 2012-10-15 | 2017-08-01 | Noven Pharmaceuticals, Inc. | Compositions and methods for the transdermal delivery of methylphenidate |
AR094289A1 (es) | 2012-12-28 | 2015-07-22 | Noven Pharma | Sistemas de administracion transdermica de farmacos para levonorgestrel y etinil estradiol |
CA2896347A1 (en) | 2012-12-28 | 2014-07-03 | Noven Pharmaceuticals, Inc. | Multi-polymer compositions for transdermal drug delivery |
WO2014159582A1 (en) | 2013-03-14 | 2014-10-02 | Noven Pharmaceuticals, Inc | Amphetamine transdermal compositions with acrylic block copolymer |
AR095259A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
AR095260A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones de anfetaminas transdérmicas estables y métodos de fabricación |
CA2956596A1 (en) * | 2014-07-31 | 2016-02-04 | Noven Pharmaceuticals, Inc. | Silicone-containing acrylic polymers for transdermal drug delivery compositions |
JP6807848B2 (ja) | 2015-02-06 | 2021-01-06 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | 経皮薬物送達のための感圧粘着剤 |
US10406116B2 (en) | 2015-02-06 | 2019-09-10 | Noven Pharmaceuticals, Inc. | Pressure-sensitive adhesives for transdermal drug delivery |
EP3506889A1 (en) * | 2016-08-03 | 2019-07-10 | Noven Pharmaceuticals, INC. | Pressure-sensitive adhesives for transdermal drug delivery |
CN110809466A (zh) * | 2017-06-26 | 2020-02-18 | 罗曼治疗系统股份公司 | 含东莨菪碱和硅氧烷丙烯酸杂化聚合物的经皮治疗系统 |
DE102018118507A1 (de) * | 2018-07-31 | 2020-02-06 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Abgabe von Scopolamin ohne Membran |
US20220160697A1 (en) * | 2019-03-19 | 2022-05-26 | Nobelpharma Co., Ltd. | Pharmaceutical composition having excellent drug absorption into the living body and excellent chemical stability |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
US4031894A (en) | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5474783A (en) | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US4994267A (en) | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
WO1991014463A1 (en) | 1990-03-28 | 1991-10-03 | Noven Pharmaceuticals, Inc. | Method and device for the release of drugs to the skin |
US4814168A (en) | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
US5714162A (en) | 1994-09-16 | 1998-02-03 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Scopolamine patch |
US6024974A (en) * | 1995-01-06 | 2000-02-15 | Noven Pharmaceuticals, Inc. | Composition and methods for transdermal delivery of acid labile drugs |
US5601839A (en) | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
US6316022B1 (en) | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
DE19738643C2 (de) | 1997-09-04 | 2001-10-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung |
US6210705B1 (en) * | 1997-12-15 | 2001-04-03 | Noven Pharmaceuticals, Nc. | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
US20030170195A1 (en) | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
WO2000074661A2 (en) | 1999-06-05 | 2000-12-14 | Noven Pharmaceuticals, Inc. | Solubility enhancement of drugs in transdermal drug delivery systems and methods of use |
DE10033853A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
ES2410532T3 (es) | 2000-09-19 | 2013-07-02 | Henkel Ag & Co. Kgaa | Adhesivo de acrilo útil en sistemas de administración transdérmica de fármacos |
US20060078602A1 (en) | 2004-10-08 | 2006-04-13 | Noven Pharmaceuticals, Inc. | Device for transdermal administration of drugs including acrylic polymers |
JP4704764B2 (ja) * | 2005-02-03 | 2011-06-22 | 日東電工株式会社 | 爪貼付用粘着組成物および爪用貼付剤 |
-
2007
- 2007-02-26 MX MX2008010934A patent/MX2008010934A/es not_active Application Discontinuation
- 2007-02-26 AU AU2007221117A patent/AU2007221117A1/en not_active Abandoned
- 2007-02-26 RU RU2008138595/15A patent/RU2008138595A/ru not_active Application Discontinuation
- 2007-02-26 WO PCT/US2007/004911 patent/WO2007100757A2/en active Application Filing
- 2007-02-26 EP EP07751653A patent/EP1998756A2/en not_active Withdrawn
- 2007-02-26 JP JP2008557323A patent/JP2009528357A/ja active Pending
- 2007-02-26 CA CA2643037A patent/CA2643037C/en active Active
- 2007-02-26 CN CNA2007800152407A patent/CN101431988A/zh active Pending
- 2007-02-26 US US11/710,610 patent/US8715723B2/en active Active
-
2008
- 2008-01-01 ZA ZA200807408A patent/ZA200807408B/xx unknown
- 2008-09-25 NO NO20084088A patent/NO20084088L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ZA200807408B (en) | 2009-09-30 |
JP2009528357A (ja) | 2009-08-06 |
US8715723B2 (en) | 2014-05-06 |
NO20084088L (no) | 2008-11-19 |
CA2643037A1 (en) | 2007-09-07 |
CA2643037C (en) | 2014-08-05 |
EP1998756A2 (en) | 2008-12-10 |
WO2007100757A3 (en) | 2007-10-18 |
WO2007100757A2 (en) | 2007-09-07 |
CN101431988A (zh) | 2009-05-13 |
RU2008138595A (ru) | 2010-04-10 |
AU2007221117A1 (en) | 2007-09-07 |
US20070212410A1 (en) | 2007-09-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |