MX173854B - Procedimiento para la preparacion de nuevos derivados del acido glutamico y producto obtenido - Google Patents
Procedimiento para la preparacion de nuevos derivados del acido glutamico y producto obtenidoInfo
- Publication number
- MX173854B MX173854B MX010556A MX1055688A MX173854B MX 173854 B MX173854 B MX 173854B MX 010556 A MX010556 A MX 010556A MX 1055688 A MX1055688 A MX 1055688A MX 173854 B MX173854 B MX 173854B
- Authority
- MX
- Mexico
- Prior art keywords
- glutamic acid
- procedure
- preparation
- product obtained
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un procedimiento de preparación en todas sus formas isómeras o en formas de mezclas de isómeros de los derivados del ácido glutámico así como sus sales de adición con los ácidos minerales u orgánicos o con las bases, caracterizados porque los mismsos reponden a la fórmula general (I): en la cual el ácido glutámico tiene configuración D ó L, caracterizado porque se hace reaccionar un derivado del ácido glutámico de fórmula (II): con un derivado de fórmula (III) que puede presentarse en forma de isómeros separados o en forma de mezclas de isómeros: para obtener un producto de fórmulas, que se aisla y, si se desea, se salifica, o se somete si es necesario a una de las reacciones siguientes, en cualquier orden: a) si X' o Y' representa un radical COO-Alk3: descarboxilación b) desprotección de las funciones amino, c) desalquilación de las funciones hidroxilo, d) amidificación de las funciones amino libres por un amino ácido o un peptido constituído por 2, 3 ó 4 aminoácidos cuya función amino está protegida, y desprotección posterior de esta función amino, e) esterificación o salificación por una base de las funciones carboxi, f) salificación por ácido de las funciones amino.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8702547A FR2611721B1 (fr) | 1987-02-26 | 1987-02-26 | Nouveaux derives de l'acide glutamique, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX10556A MX10556A (es) | 1993-09-01 |
| MX173854B true MX173854B (es) | 1994-04-07 |
Family
ID=9348338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX010556A MX173854B (es) | 1987-02-26 | 1988-02-25 | Procedimiento para la preparacion de nuevos derivados del acido glutamico y producto obtenido |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5089476A (es) |
| EP (1) | EP0284461B1 (es) |
| JP (1) | JPH0617350B2 (es) |
| KR (1) | KR880009989A (es) |
| AT (1) | ATE64374T1 (es) |
| CA (1) | CA1310443C (es) |
| DE (1) | DE3863214D1 (es) |
| ES (1) | ES2029040T3 (es) |
| FR (1) | FR2611721B1 (es) |
| GR (1) | GR3002416T3 (es) |
| MX (1) | MX173854B (es) |
| PT (1) | PT86835B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2645858B1 (fr) * | 1989-04-18 | 1991-06-14 | Roussel Uclaf | Nouveaux derives insatures de l'acide 2,6-diamino heptanedioique, leur procede de preparation et leur application comme medicaments |
| FR2651777B1 (fr) * | 1989-09-12 | 1991-12-13 | Roussel Uclaf | Nouveaux derives dicarboxyliques renfermant un heterocycle azote ou oxygene, leur procede de preparation et leur application comme medicaments. |
| US8420144B2 (en) * | 2005-11-09 | 2013-04-16 | Ajinomoto Co., Inc. | Kokumi-imparting agent, method of using, and compositions containing same |
| WO2007055388A2 (en) * | 2005-11-09 | 2007-05-18 | Ajinomoto Co., Inc. | Calcium receptor activator |
| WO2007055393A1 (en) * | 2005-11-09 | 2007-05-18 | Ajinomoto Co., Inc. | Kokumi-imparting agent |
| NZ581627A (en) * | 2007-05-08 | 2012-07-27 | Ajinomoto Kk | Low fat food with a calcium receptor activating additive |
| JPWO2009107660A1 (ja) * | 2008-02-25 | 2011-07-07 | 味の素株式会社 | 糖尿病又は肥満病の予防又は治療剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4311640A (en) * | 1978-11-14 | 1982-01-19 | Fujisawa Pharmaceutical Co., Ltd. | Peptide, process for preparation thereof and use thereof |
| DK156252C (da) * | 1979-07-31 | 1989-12-18 | Fujisawa Pharmaceutical Co | Analogifremgangsmaade til fremstilling af di-, tri- eller tetrapeptidderivater eller salte deraf |
| FR2566410A1 (fr) * | 1984-06-20 | 1985-12-27 | Delalande Sa | Nouveaux derives de l'acide diaminopimelique, leur procede de preparation et leur application en therapeutique |
| US4730006A (en) * | 1986-01-27 | 1988-03-08 | Merrell Dow Pharmaceuticals Inc. | Derivatives of 2,6-diamino-3-haloheptanedioic acid |
-
1987
- 1987-02-26 FR FR8702547A patent/FR2611721B1/fr not_active Expired - Fee Related
-
1988
- 1988-02-25 MX MX010556A patent/MX173854B/es unknown
- 1988-02-25 CA CA000559820A patent/CA1310443C/fr not_active Expired - Fee Related
- 1988-02-25 PT PT86835A patent/PT86835B/pt not_active IP Right Cessation
- 1988-02-26 AT AT88400446T patent/ATE64374T1/de active
- 1988-02-26 KR KR1019880001985A patent/KR880009989A/ko not_active Application Discontinuation
- 1988-02-26 JP JP63042392A patent/JPH0617350B2/ja not_active Expired - Lifetime
- 1988-02-26 DE DE8888400446T patent/DE3863214D1/de not_active Expired - Fee Related
- 1988-02-26 EP EP88400446A patent/EP0284461B1/fr not_active Expired - Lifetime
- 1988-02-26 US US07/161,163 patent/US5089476A/en not_active Expired - Fee Related
- 1988-02-26 ES ES198888400446T patent/ES2029040T3/es not_active Expired - Lifetime
-
1991
- 1991-08-02 GR GR90401170T patent/GR3002416T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2029040T3 (es) | 1992-07-16 |
| FR2611721B1 (fr) | 1990-01-26 |
| EP0284461A1 (fr) | 1988-09-28 |
| JPS63233961A (ja) | 1988-09-29 |
| GR3002416T3 (en) | 1992-12-30 |
| KR880009989A (ko) | 1988-10-06 |
| EP0284461B1 (fr) | 1991-06-12 |
| JPH0617350B2 (ja) | 1994-03-09 |
| CA1310443C (fr) | 1992-11-17 |
| ATE64374T1 (de) | 1991-06-15 |
| PT86835A (pt) | 1988-03-01 |
| US5089476A (en) | 1992-02-18 |
| PT86835B (pt) | 1992-05-29 |
| DE3863214D1 (de) | 1991-07-18 |
| MX10556A (es) | 1993-09-01 |
| FR2611721A1 (fr) | 1988-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES505960A0 (es) | Un procedimiento para la obtencion de un derivado acilico sustituido del compuesto acido 1,2,3,4-tetrahidro-3-isoqui- nolein-carboxilico | |
| ES2040261T3 (es) | Procedimiento para preparar acidos 6-fluor-4-oxo-1,4-dihidroquinolina-3-carboxilicos sustituidos y acidos 9-fluor-3-metil-7-oxo-2,3-dihidro-7h-pirido(1,2,3-de)(1,4)benzoxazina-6-carboxilico sustituidos. | |
| GR3001889T3 (en) | Prodrug compounds, process for the preparation thereof and sustained release preparation comprising the same | |
| ES517637A0 (es) | Un procedimiento de preparacion de los acidos(oxo-4-4h-(1)-benzopiran-8-il)-alcanoicos. | |
| JPS57108073A (en) | N-substituted omega-(2-oxo-4-imidazoline- 1-yl)alkanoic acid compound | |
| ES510599A0 (es) | Procedimiento para la preparacion de acidos (2-oxo-3-tetrahidrotienilcarbamoil)-alquiltio aceticos. | |
| MX10556A (es) | Procedimiento para la preparacion de nuevos derivados del acido glutamico y producto obtenido. | |
| MX167455B (es) | Procedimiento para la preparacion de acidos oxoftalazinil aceticos | |
| HU902612D0 (en) | Process for the preparation of 4-phenylmethyl-1h-indole derivatives | |
| DE3789064D1 (de) | Verfahren zur Herstellung von in Stellung 3 durch eine halogenierte gesättigte Kette substituierten Cyclopropancarbonsäurederivaten. | |
| BR8802816A (pt) | Derivados do acido(2-ciano-9-oximinoacetil)-aminico,processo para sua preparacao,composicoes praguicidas,processos para combater pragas e para a preparacao de composicoes | |
| IT1157249B (it) | Procedimento per la sintesi di eteri di n-propanol-diammina | |
| BR8802815A (pt) | Derivados de(2-ciano-2-oximinoacetil)-aminoacidos processo para sua preparacao,composicoes praguicidas,processos para o combate a parasitas e para a preparacao de composicoes | |
| PT88926A (pt) | Processo para a preparacao de derivados do acido aminopimelico e de compostos farmaceuticos que o contem | |
| DE3469527D1 (en) | Nortropine derivative, process for its preparation and its use | |
| IN170286B (es) | ||
| DE59202229D1 (de) | Verfahren zur Herstellung substituierter Indole. | |
| IT1240322B (it) | Acidi 2-(2,4-diaril-ossazol-5-il)-alcancarbossilici,loro esteri e salimetodi per la loro preparazione e composizioni farmaceutiche che li contengono | |
| ES2095831T3 (es) | Acidos tetrahidro-4-fenilimino-3-tiofeno-aceticos. | |
| DE58909563D1 (de) | 3-Anilino-2-hydroxycarbonyl-4-thiophenessigsäuren |