MD838G2 - Biologically active agent having immunomodulating properties, method for its obtainig, pharmaceutical preparation based on it and method for normalization of human and animal organism physiological state - Google Patents

Biologically active agent having immunomodulating properties, method for its obtainig, pharmaceutical preparation based on it and method for normalization of human and animal organism physiological state

Info

Publication number
MD838G2
MD838G2 MD95-0376A MD950376A MD838G2 MD 838 G2 MD838 G2 MD 838G2 MD 950376 A MD950376 A MD 950376A MD 838 G2 MD838 G2 MD 838G2
Authority
MD
Moldova
Prior art keywords
animal tissue
baa
products
biologically active
base
Prior art date
Application number
MD95-0376A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD838F1 (en
Inventor
Alexandr Nicolaenco
Original Assignee
Alexandr Nicolaenco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SU5055549 external-priority patent/RU2041717C1/en
Application filed by Alexandr Nicolaenco filed Critical Alexandr Nicolaenco
Publication of MD838F1 publication Critical patent/MD838F1/en
Publication of MD838G2 publication Critical patent/MD838G2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The group of inventions relates to the chemic-pharmaceutical industry, particularly, to the biologically active agents (BAA) obtaining having immunomodulating effect for using in medicine and veterinary science with the aim to normalisate the human and animals physiological body state, particularly, for restabilation of the functional activity of tissues and organs.The biologically active agent (BAA) in accordance with the present invention includes the organic substances on the base of hydrolysis products of the disintegrated animal tissue, particularly, thermostable low-molecular cell membranes components (CMC) with antigeneous structure, modificated at the embriogenesis and/or proliferation, and/or cell differenciation, and/or pathology, and/or preceeding, and/or simultaneous regeneration, and/or tissue reparation.Method for BAA obtaining includs disintegration and homogenation of raw material from the animal tissue, from the cell membranes containing sediment, extracted from the homogenate, after resuspending are obtained CMC, as raw material there is used modified animal tissue, the homogenate of which is cleaned from the non-disintegrated tissue elements by filtration and/or centrifugation at the acceleration of 150-250 g during 10-15 min, and a sediment is extracted, which contains CM, and which is subjected to hydrolysis, the products of which are filtrated, and/or centrifuged at an acceleration 1500 g during 20-30 min with separation of supernatante hydrolisis products containing CMC as desired product.The preparation for normalisation of physiological state of human beings and animals comprises organic substances on the base of the disintegrated animal tissue hydrolysis products in the quantity of 0,001-85,0%, the rest is the filler.Method for normalisation of the physiological state of human beings and animals by injection in the body of the preparation including the organic substance on the base of desintegrated animal tissue hydrolisis products in quantity of 0,001-85,0% and 15,0-99,999% of filler.The technical result consists in increasing the BAA range and preparations on its base which have the wide application in veterinary and medicine for deseases treatment, the control of which is carried out by the organism immunity system.
MD95-0376A 1992-07-21 1993-03-20 Biologically active agent having immunomodulating properties, method for its obtainig, pharmaceutical preparation based on it and method for normalization of human and animal organism physiological state MD838G2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SU5055549 RU2041717C1 (en) 1992-07-21 1992-07-21 Biologically active remedy, method for its producing, preparation containing the mentioned remedy and its application method
UA93030289A UA2163C2 (en) 1992-07-21 1992-12-17 Biologically MEANS THAT HAS immunomodulating property, the way it is received, preparations based on it NORMALIZATION AND METHOD physiological state of the human body and animals in diseases generated MAINLY functional insufficiency of organs and tissues, using such preparation
PCT/UA1993/000004 WO1994002105A1 (en) 1992-07-21 1993-07-20 Biologically active agent having immunomodulating properties, method for its obtaining and pharmaceutical preparation based on it

Publications (2)

Publication Number Publication Date
MD838F1 MD838F1 (en) 1997-09-30
MD838G2 true MD838G2 (en) 1998-09-30

Family

ID=26666276

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0376A MD838G2 (en) 1992-07-21 1993-03-20 Biologically active agent having immunomodulating properties, method for its obtainig, pharmaceutical preparation based on it and method for normalization of human and animal organism physiological state

Country Status (10)

Country Link
EP (1) EP0673653B1 (en)
AT (1) ATE361754T1 (en)
AU (1) AU4767793A (en)
BG (1) BG61679B1 (en)
CA (1) CA2149121A1 (en)
DE (1) DE69334138T2 (en)
HU (1) HUT72838A (en)
MD (1) MD838G2 (en)
PL (1) PL173302B1 (en)
WO (1) WO1994002105A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024105193A1 (en) 2022-11-17 2024-05-23 Koptyug Andrey V Novel compounds and methods

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413912A1 (en) * 1978-01-10 1979-08-03 Bontemps Raymond Frozen biogenic foetal material in normal saline - for regeneration and re-organisation of cells
SU904707A1 (en) * 1979-06-25 1982-02-15 Ленинградский Ветеринарный Институт Agent for increasing young stock organism resistancy and method of producing it
EP0106285A2 (en) * 1982-10-08 1984-04-25 Otsuka Pharmaceutical Co., Ltd. Glycosidic linkage related antigen, process for producing the same and anticancer agent containing the same as effective component
US4455302A (en) * 1973-10-24 1984-06-19 Robertson Harry J Medical protein hydrolysate, process of making the same and processes of utilizing the protein hydrolysate to aid in healing traumatized areas
EP0157427A2 (en) * 1984-04-06 1985-10-09 Otsuka Pharmaceutical Co., Ltd. Process for preparing glycosidic linkage related antigen
SU1412596A3 (en) * 1981-10-01 1988-07-23 Оцука Фармасьютикал Ко.,Лтд (Фирма) Method of producing lymphocytes cyto-toxic to cancer cells, and method of producing glyco-bound substance
EP0318030A1 (en) * 1987-11-26 1989-05-31 Otsuka Pharmaceutical Co., Ltd. Glycoprotein, preparation method, pharmaceutical compositions comprising it and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164388A (en) * 1966-06-14 1969-09-17 Shionogi & Co Crystalline Sulfur-Containing Glycolipid and the Production Thereof.
JPS5221570B2 (en) * 1973-08-30 1977-06-11
US4169139A (en) * 1974-10-07 1979-09-25 Arthur Karler Glyco/proteinaceous materials derivable from beef liver and other tissues useful for the treatment of toxic and allergic conditions
DE2530350C3 (en) * 1975-07-08 1978-10-26 Standard Elektrik Lorenz Ag, 7000 Stuttgart Feed circuit for televisions
FR2451193A1 (en) * 1979-03-13 1980-10-10 Brunel Henri Total embryonic complex for treatment of cancer - and as anti-reject agent in organic grafts and transplants, comprises a colloidal suspension of embryo
WO1981001367A1 (en) * 1979-11-22 1981-05-28 Cell Eng Ag A water soluble fraction capable of controlling the immune reactions of a host against allogeneic cells or tissue,the pharmaceutical compositions containing said fraction and a process for preparing the latter
JPS5933223A (en) * 1982-08-20 1984-02-23 Koken Kk Agent for suppressing proliferation of malignant tumor cell of man

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455302A (en) * 1973-10-24 1984-06-19 Robertson Harry J Medical protein hydrolysate, process of making the same and processes of utilizing the protein hydrolysate to aid in healing traumatized areas
FR2413912A1 (en) * 1978-01-10 1979-08-03 Bontemps Raymond Frozen biogenic foetal material in normal saline - for regeneration and re-organisation of cells
SU904707A1 (en) * 1979-06-25 1982-02-15 Ленинградский Ветеринарный Институт Agent for increasing young stock organism resistancy and method of producing it
SU1412596A3 (en) * 1981-10-01 1988-07-23 Оцука Фармасьютикал Ко.,Лтд (Фирма) Method of producing lymphocytes cyto-toxic to cancer cells, and method of producing glyco-bound substance
EP0106285A2 (en) * 1982-10-08 1984-04-25 Otsuka Pharmaceutical Co., Ltd. Glycosidic linkage related antigen, process for producing the same and anticancer agent containing the same as effective component
EP0157427A2 (en) * 1984-04-06 1985-10-09 Otsuka Pharmaceutical Co., Ltd. Process for preparing glycosidic linkage related antigen
EP0318030A1 (en) * 1987-11-26 1989-05-31 Otsuka Pharmaceutical Co., Ltd. Glycoprotein, preparation method, pharmaceutical compositions comprising it and use

Also Published As

Publication number Publication date
EP0673653A4 (en) 1996-07-03
ATE361754T1 (en) 2007-06-15
CA2149121A1 (en) 1994-02-03
BG99445A (en) 1996-03-29
HUT72838A (en) 1996-05-28
AU4767793A (en) 1994-02-14
WO1994002105A1 (en) 1994-02-03
PL173302B1 (en) 1998-02-27
BG61679B1 (en) 1998-03-31
EP0673653B1 (en) 2007-05-09
DE69334138T2 (en) 2008-01-10
HU9500409D0 (en) 1995-04-28
DE69334138D1 (en) 2007-06-21
EP0673653A1 (en) 1995-09-27
PL308536A1 (en) 1995-08-21
MD838F1 (en) 1997-09-30

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20130320