MD746Z - Method for disinfection of the root canal - Google Patents
Method for disinfection of the root canal Download PDFInfo
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- MD746Z MD746Z MDS20130128A MDS20130128A MD746Z MD 746 Z MD746 Z MD 746Z MD S20130128 A MDS20130128 A MD S20130128A MD S20130128 A MDS20130128 A MD S20130128A MD 746 Z MD746 Z MD 746Z
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- Moldova
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- root canal
- canal
- treatment
- disinfection
- irrigated
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- 210000004262 dental pulp cavity Anatomy 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims abstract description 16
- 238000004659 sterilization and disinfection Methods 0.000 title abstract description 6
- 210000003296 saliva Anatomy 0.000 claims abstract description 5
- 229950003937 tolonium Drugs 0.000 claims abstract description 5
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims abstract description 5
- 239000005708 Sodium hypochlorite Substances 0.000 claims abstract description 4
- 239000012153 distilled water Substances 0.000 claims abstract description 4
- 230000035515 penetration Effects 0.000 claims abstract description 4
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 230000000249 desinfective effect Effects 0.000 claims description 4
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 201000004328 Pulpitis Diseases 0.000 abstract description 9
- 206010037464 Pulpitis dental Diseases 0.000 abstract description 9
- 201000001245 periodontitis Diseases 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 2
- 239000003504 photosensitizing agent Substances 0.000 description 11
- 230000006378 damage Effects 0.000 description 7
- 244000005700 microbiome Species 0.000 description 6
- 208000004480 periapical periodontitis Diseases 0.000 description 6
- 239000011941 photocatalyst Substances 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 210000004053 periapical tissue Anatomy 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005713 exacerbation Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004261 periodontium Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 239000000899 Gutta-Percha Substances 0.000 description 1
- 206010033372 Pain and discomfort Diseases 0.000 description 1
- 240000000342 Palaquium gutta Species 0.000 description 1
- 241001180873 Saposhnikovia divaricata Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229960001506 brilliant green Drugs 0.000 description 1
- HXCILVUBKWANLN-UHFFFAOYSA-N brilliant green cation Chemical compound C1=CC(N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](CC)CC)C=C1 HXCILVUBKWANLN-UHFFFAOYSA-N 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 210000003074 dental pulp Anatomy 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 229920000588 gutta-percha Polymers 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 230000002165 photosensitisation Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000003144 traumatizing effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
Landscapes
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
Description
Invenţia se referă la medicină, şi anume la stomatologie şi poate fi aplicată pentru dezinfectarea canalului radicular în tratamentul pulpitei şi periodontitei apicale. The invention relates to medicine, namely to dentistry and can be applied for root canal disinfection in the treatment of pulpitis and apical periodontitis.
Este cunoscută metoda de distrugere a microorganismelor patogene şi condiţionat-patogene, care constă în prelucrarea zonei contaminate cu microorganisme concomitent cu un fotosensibilizator şi un fotocatalizator, compoziţia este menţinută o perioadă de timp necesară pentru a se lega în mod eficient cu celulele microbiene, apoi zona se supune iradierii optice cu lungimea de undă corespunzătoare absorbţiei maxime a fotosensibilizatorului şi fotocatalizatorului şi o densitate de putere pentru activarea compoziţiei. În calitate de fotosensibilizator este folosită soluţia apoasă de albastru de metilen în concentraţie de 0,00025… 0,0025% şi/sau verde de briliant în concentraţie de 0,00001…0,000125%, iar în calitate de fotocatalizator sunt folosite nanoparticule de dioxid de titan în concentraţie de 0,01…0,1%. Iradierea se efectuează cu lumină policromatică laser LED cu bandă largă, cu lungimea de undă de 390…440 nm sau de 600…670 nm cu puterea iradierii de 15…50 mW/cm2 şi expoziţia de 1…30 min [1]. The method of destruction of pathogenic and conditionally pathogenic microorganisms is known, which consists in processing the area contaminated with microorganisms simultaneously with a photosensitizer and a photocatalyst, the composition is maintained for a period of time necessary for effective binding to microbial cells, then the area is subjected to optical irradiation with a wavelength corresponding to the maximum absorption of the photosensitizer and photocatalyst and a power density for activating the composition. As a photosensitizer, an aqueous solution of methylene blue in a concentration of 0.00025… 0.0025% and/or brilliant green in a concentration of 0.00001… 0.000125% is used, and as a photocatalyst, titanium dioxide nanoparticles in a concentration of 0.01… 0.1% are used. Irradiation is performed with polychromatic broadband LED laser light, with a wavelength of 390…440 nm or 600…670 nm, with an irradiation power of 15…50 mW/cm2 and an exposure of 1…30 min [1].
Însă, această metodă, testată în condiţii in vitro, nu este eficientă în dezinfectarea canalului radicular în cadrul tratamentului pulpitei şi periodontitei apicale, deoarece din cauza concentraţiei insuficiente a substanţelor fotosensibilizante (chiar şi aplicate concomitent cu fotocatalizatorul) şi a puterei reduse a iradierii nu se asigură distrugerea totală a microorganismelor prezente în canalul radicular, fapt care ulterior poate provoca exacerbarea pulpitei sau a periodontitei apicale. În plus, fotosensibilizatorul aplicat în cavitatea orală în concentraţii reduse este dezactivat de salivă. However, this method, tested in vitro, is not effective in disinfecting the root canal in the treatment of pulpitis and apical periodontitis, because due to the insufficient concentration of photosensitizing substances (even applied simultaneously with the photocatalyst) and the low irradiation power, the complete destruction of microorganisms present in the root canal is not ensured, which can subsequently cause exacerbation of pulpitis or apical periodontitis. In addition, the photosensitizer applied to the oral cavity in low concentrations is deactivated by saliva.
Este, de asemenea, cunoscută metoda de pregătire a canalului radicular pentru obturare, care constă în dilatarea canalului, introducerea în canal a unui fotosensibilizator în concentraţie de 56 M pentru 5…6 min şi iradierea cu un fascicul laser LED cu puterea de 0,5…1,0 W şi lungimea de undă de 662 nm începând cu zona apicală, porţiunea mijlocie şi orificiile canalului radicular [2]. The method of preparing the root canal for obturation is also known, which consists of dilating the canal, introducing a photosensitizer in a concentration of 56 M into the canal for 5…6 min and irradiating it with an LED laser beam with a power of 0.5…1.0 W and a wavelength of 662 nm starting with the apical zone, the middle portion and the root canal orifices [2].
Însă, această metodă presupune iradierea cu un fascicul laser LED cu putere mică ce nu asigură distrugerea tuturor microorganismelor, în special din microcanalele laterale adiacente, fapt care poate cauza complicaţii. Metoda este dificilă în aplicare, necesită mult timp pentru realizare, din care cauză provoacă disconfortul pacientului în timpul tratamentului. However, this method involves irradiation with a low-power LED laser beam that does not ensure the destruction of all microorganisms, especially in the adjacent lateral microchannels, which can cause complications. The method is difficult to implement, requires a long time to perform, which is why it causes patient discomfort during treatment.
Problema pe care o rezolvă prezenta invenţie este elaborarea unei metode eficiente de dezinfectare a canalului radicular, majorarea efectului bactericid, prevenirea complicaţiilor, reducerea disconfortului pacientului în timpul tratamentului. The problem solved by the present invention is to develop an effective method for disinfecting the root canal, increasing the bactericidal effect, preventing complications, and reducing patient discomfort during treatment.
Esenţa invenţiei constă în aceea că se izolează canalul de pătrunderea salivei, se irigă cu soluţie de 3% de hipoclorit de sodiu, se usucă, apoi în el se aplică albastru de toluidină sub formă de gel cu concentraţia de 0,1 mg/ml, pe o perioadă de 1…2 min, ulterior se iradiază cu lumină LED cu lungimea de undă de 625…635 nm, puterea de 2…3 W, timp de 30…60 s, apoi canalul radicular se irigă cu apă distilată, se usucă şi se plombează. The essence of the invention consists in isolating the canal from saliva penetration, irrigating it with a 3% solution of sodium hypochlorite, drying it, then applying toluidine blue in the form of a gel with a concentration of 0.1 mg/ml, for a period of 1…2 min, then irradiating it with LED light with a wavelength of 625…635 nm, power of 2…3 W, for 30…60 s, then the root canal is irrigated with distilled water, dried and filled.
Metoda propusă asigură dezinfectarea eficientă a canalului radicular, fapt care stopează propagarea infecţiei odontogene în ţesuturile periapicale, previne apariţia complicaţiilor. The proposed method ensures effective disinfection of the root canal, which stops the spread of odontogenic infection in the periapical tissues and prevents the occurrence of complications.
Gelul de albastru de toluidină cu viscozitate redusă, utilizat în calitate de fotosensibilizator, se introduce cu uşurinţă şi pătrunde până în zona apicală, nu se prelinge din canalul radicular, este inofensiv pentru ţesuturile periapicale. Fotosensibilizatorul are capacitatea de a penetra rapid membrana celulară a microorganismelor, astfel perioada de timp necesară pentru a se lega în mod eficient cu celulele microbiene constituie maximum 1…2 min, fapt care permite reducerea duratei şedinţei de tratament. Iradierea cu lumină LED se efectuează cu lungimea de undă corespunzătoare absorbţiei maxime a fotosensibilizatorului (625…635 nm) şi o densitate de putere suficientă pentru activarea lui. În urma iradierii se declanşează reacţii fotochimice, având ca rezultat formarea de oxigen atomic şi radicali liberi care induc distrugerea microorganismelor amplasate nu numai în interiorul canalului radicular, dar şi a celor persistente în profunzimea reţelei de microcanale laterale adiacente. Puterea de 2,0…3,0 W a LED-ului asigură producerea unui efect bactericid momentan. Ghidul optic, având forma care repetă configuraţia canalului radicular, asigură propagarea luminii nu doar la vârf, dar şi pe întreaga lungime a lui, uniform la o distanţă de 5 mm de la suprafaţa ghidului şi iradierea efectivă a zonei apicale, fără a o trauma. Dispozitivul dat produce vibraţii ce majorează gradul de contactare a fotosensibilizatorului cu ghidul optic şi optimizează difuzia fotosensibilizatorului în microcanalul radicular, asigură înlăturarea mai rapidă a microorganismelor şi previne formarea bulelor de aer. The low-viscosity toluidine blue gel, used as a photosensitizer, is easily introduced and penetrates to the apical area, does not leak from the root canal, is harmless to periapical tissues. The photosensitizer has the ability to quickly penetrate the cell membrane of microorganisms, so the time required to effectively bind with microbial cells is a maximum of 1…2 min, which allows reducing the duration of the treatment session. Irradiation with LED light is performed with the wavelength corresponding to the maximum absorption of the photosensitizer (625…635 nm) and a power density sufficient for its activation. Following irradiation, photochemical reactions are triggered, resulting in the formation of atomic oxygen and free radicals that induce the destruction of microorganisms located not only inside the root canal, but also those persisting in the depth of the adjacent lateral microchannel network. The LED power of 2.0…3.0 W ensures the production of a momentary bactericidal effect. The optical guide, having a shape that repeats the configuration of the root canal, ensures the propagation of light not only at the apex, but also along its entire length, uniformly at a distance of 5 mm from the guide surface and effective irradiation of the apical zone, without traumatizing it. This device produces vibrations that increase the degree of contact of the photosensitizer with the optical guide and optimize the diffusion of the photosensitizer in the root microchannel, ensures faster removal of microorganisms and prevents the formation of air bubbles.
Zona efectului citotoxic al oxigenului singlet nu depăşeşte 0,02 µm, iar durata de acţiune în sistemele biologice este mai mică de 0,04 ms, prin urmare, este exclusă eventualitatea distrugerii ţesuturilor periapicale. The cytotoxic effect zone of singlet oxygen does not exceed 0.02 µm, and the duration of action in biological systems is less than 0.04 ms, therefore, the possibility of destruction of periapical tissues is excluded.
Prin urmare, eficacitatea înaltă a metodei propuse şi obţinerea efectului de dezinfectare rapidă a canalului radicular asigură prevenirea exacerbărilor şi a complicaţiilor pulpitelor şi periodontitelor apicale. Therefore, the high effectiveness of the proposed method and the achievement of the rapid disinfection effect of the root canal ensure the prevention of exacerbations and complications of pulpitis and apical periodontitis.
Metoda revendicată este simplă şi rapidă în realizare, nu provoacă lezarea ţesuturilor cavităţii orale, durere sau disconfort pacientului în timpul tratamentului. The claimed method is simple and quick to perform, does not cause damage to the tissues of the oral cavity, pain or discomfort to the patient during treatment.
Rezultatul tehnic constă în majorarea eficacităţii tratamentului pulpitelor şi periodontitelor apicale, majorarea efectului bactericid, prevenirea apariţiei complicaţiilor, reducerea duratei şedinţei curative, lipsa durerii şi a disconfortului pacientului în timpul tratamentului. The technical result consists in increasing the effectiveness of the treatment of pulpitis and apical periodontitis, increasing the bactericidal effect, preventing the occurrence of complications, reducing the duration of the curative session, and eliminating pain and discomfort for the patient during treatment.
Metoda de dezinfectare a canalelor radiculare se realizează în modul următor: se izolează canalul de pătrunderea salivei, se irigă cu soluţie de 3% de hipoclorit de sodiu, se usucă, apoi în el se aplică albastru de toluidină sub formă de gel cu concentraţia de 0,1 mg/ml, pe o perioadă de 1…2 min, ulterior se iradiază cu lumină LED cu lungimea de undă de 625…635 nm, puterea de 2…3 W, timp de 30…60 s, apoi canalul radicular se irigă cu apă distilată, se usucă şi se plombează. The method of disinfecting root canals is carried out as follows: the canal is isolated from saliva penetration, irrigated with a 3% solution of sodium hypochlorite, dried, then toluidine blue is applied in the form of a gel with a concentration of 0.1 mg/ml, for a period of 1…2 min, then irradiated with LED light with a wavelength of 625…635 nm, power of 2…3 W, for 30…60 s, then the root canal is irrigated with distilled water, dried and sealed.
În cazul priodontitei apicale se iradiază mucoasa cavităţii orale la nivelul proiecţiei apexului radicular. In the case of apical periodontitis, the oral cavity mucosa is irradiated at the level of the projection of the root apex.
Exemplul 1 Example 1
Pacientul C., 18 ani. Diagnosticul: pulpită cronică fibroasă în 2.6. Tratamentul pulpitei a fost efectuat după metoda descrisă. Canalul radicular a fost obturat, iar defectul coronar a fost restabilit cu material compozit nanohibrid. Pacientul a suportat bine şedinţa de tratament, fără a manifesta semne de disconfort în decursul ei. După 1 an de la efectuarea tratamentului, semne de inflamare, iritare a pulpei sau periodonţiului nu s-au depistat. Pe radiogramă nu se determină semne de resorbţie a ţesutului osos din zona periapicală. Patient C., 18 years old. Diagnosis: chronic fibrous pulpitis in 2.6. Pulpitis treatment was performed according to the described method. The root canal was obturated, and the coronal defect was restored with nanohybrid composite material. The patient tolerated the treatment session well, without showing signs of discomfort during it. After 1 year after the treatment, no signs of inflammation, irritation of the pulp or periodontium were detected. The radiograph did not show signs of bone tissue resorption in the periapical area.
Exemplul 2 Example 2
Pacienta M., 16 ani. Diagnosticul: periodontită granulantă în 4.6. Tratamentul periodontitei a fost efectuat după metoda descrisă. Canalul radicular a fost obturat cu siler şi gutapercă, iar defectul coronar a fost restabilit cu material compozit nanohibrid. Copilul a suportat bine şedinţa de tratament. După 8 luni de la efectuarea tratamentului, semne de inflamare, iritare a ţesuturilor nu s-au depistat. Semne de resorbţie a canalului radicular şi a ţesutului osos din zona periapicală nu s-au depistat. Patient M., 16 years old. Diagnosis: granulating periodontitis in 4.6. Periodontitis treatment was performed according to the described method. The root canal was obturated with siler and gutta-percha, and the coronal defect was restored with nanohybrid composite material. The child tolerated the treatment session well. After 8 months of treatment, signs of inflammation, tissue irritation were not detected. Signs of resorption of the root canal and bone tissue in the periapical area were not detected.
Metoda propusă a fost aplicată pentru tratamentul pulpitelor şi periodontitelor la 69 copii şi tineri în cadrul Catedrei Chirurgie O.M.F. Pediatrică, Pedodonţie şi Ortodonţie, USMF ”Nicolae Testemiţanu”. Rezultatele sunt pozitive: eficienţa dezinfectării canalelor radiculare depăşeşte de 6 ori rezultatele obţinute la lotul martor. Obturaţiile sunt prezente, fără semne de inflamare şi iritare a pulpei dentare şi a periodonţiului, precum şi fără distrucţie a ţesutului osos din zona periapicală şi furcaţiei. În perioada de observaţie de la 1 până la 2 ani, nu s-au înregistrat complicaţii şi efecte secundare. The proposed method was applied for the treatment of pulpitis and periodontitis in 69 children and young people within the Department of Pediatric O.M.F. Surgery, Pedodontics and Orthodontics, USMF "Nicolae Testemiţanu". The results are positive: the efficiency of root canal disinfection exceeds 6 times the results obtained in the control group. The fillings are present, without signs of inflammation and irritation of the dental pulp and periodontium, as well as without destruction of bone tissue in the periapical area and furcation. During the observation period from 1 to 2 years, no complications and side effects were recorded.
1. RU 2430756 C1 2011.10.10 1. RU 2430756 C1 2011.10.10
2. RU 2240847 C1 2004.11.27 2. RU 2240847 C1 2004.11.27
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|---|---|---|---|
| MDS20130128A MD746Z (en) | 2013-07-12 | 2013-07-12 | Method for disinfection of the root canal |
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| Application Number | Priority Date | Filing Date | Title |
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| MDS20130128A MD746Z (en) | 2013-07-12 | 2013-07-12 | Method for disinfection of the root canal |
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| MD746Y MD746Y (en) | 2014-03-31 |
| MD746Z true MD746Z (en) | 2014-10-31 |
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Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD916G2 (en) * | 1996-12-09 | 1998-12-31 | Институтул Национал Де Фармачие | Ungent for stomatologic deseases treatment |
| RU2240847C1 (en) * | 2003-08-18 | 2004-11-27 | Рисованная Ольга Николаевна | Method for preparing dental canals for filling |
| MD3904G2 (en) * | 2008-05-07 | 2009-12-31 | Валериу ФАЛА | Composition for biosoluble medicated film for treatment of parodentium affections and of lesions of tunica mucosa of mouth (variants) |
| MD3905G2 (en) * | 2008-05-07 | 2010-01-31 | Валериу ФАЛА | Remedy of durable action in the form of gel for treatment of parodentium affections (variants) |
| MD3938G2 (en) * | 2008-05-07 | 2010-02-28 | Валериу ФАЛА | Method for treating the migratory periodontitis |
| RU2430756C1 (en) * | 2010-03-31 | 2011-10-10 | Государственное образовательное учреждение высшего профессионального образования "Саратовский государственный университет им. Н.Г. Чернышевского" | Method for elimination of pathogenic and opportunistic microorganisms |
| MD424Z (en) * | 2010-09-06 | 2012-05-31 | Валериу ФАЛА | Method for treatment of periodontium diseases |
| MD569Z (en) * | 2011-03-29 | 2013-07-31 | Дорин ИСТРАТИ | Method of regenerating the roots of immature permanent teeth in children |
| MD582Z (en) * | 2012-07-09 | 2013-08-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Method for preventing the dental caries in children with intellectual disabilities |
| MD597Z (en) * | 2012-08-16 | 2013-09-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Method for treating the dental caries in children with intellectual disabilities |
-
2013
- 2013-07-12 MD MDS20130128A patent/MD746Z/en not_active IP Right Cessation
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD916G2 (en) * | 1996-12-09 | 1998-12-31 | Институтул Национал Де Фармачие | Ungent for stomatologic deseases treatment |
| RU2240847C1 (en) * | 2003-08-18 | 2004-11-27 | Рисованная Ольга Николаевна | Method for preparing dental canals for filling |
| MD3904G2 (en) * | 2008-05-07 | 2009-12-31 | Валериу ФАЛА | Composition for biosoluble medicated film for treatment of parodentium affections and of lesions of tunica mucosa of mouth (variants) |
| MD3905G2 (en) * | 2008-05-07 | 2010-01-31 | Валериу ФАЛА | Remedy of durable action in the form of gel for treatment of parodentium affections (variants) |
| MD3938G2 (en) * | 2008-05-07 | 2010-02-28 | Валериу ФАЛА | Method for treating the migratory periodontitis |
| RU2430756C1 (en) * | 2010-03-31 | 2011-10-10 | Государственное образовательное учреждение высшего профессионального образования "Саратовский государственный университет им. Н.Г. Чернышевского" | Method for elimination of pathogenic and opportunistic microorganisms |
| MD424Z (en) * | 2010-09-06 | 2012-05-31 | Валериу ФАЛА | Method for treatment of periodontium diseases |
| MD569Z (en) * | 2011-03-29 | 2013-07-31 | Дорин ИСТРАТИ | Method of regenerating the roots of immature permanent teeth in children |
| MD582Z (en) * | 2012-07-09 | 2013-08-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Method for preventing the dental caries in children with intellectual disabilities |
| MD597Z (en) * | 2012-08-16 | 2013-09-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Method for treating the dental caries in children with intellectual disabilities |
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| Publication number | Publication date |
|---|---|
| MD746Y (en) | 2014-03-31 |
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