MD694F1 - Process for the production of the crystalline tylosine - Google Patents
Process for the production of the crystalline tylosineInfo
- Publication number
- MD694F1 MD694F1 MD94-0028A MD940028A MD694F1 MD 694 F1 MD694 F1 MD 694F1 MD 940028 A MD940028 A MD 940028A MD 694 F1 MD694 F1 MD 694F1
- Authority
- MD
- Moldova
- Prior art keywords
- tylosine
- demineralizated
- production
- filtrate
- sodium
- Prior art date
Links
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000000706 filtrate Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910021536 Zeolite Inorganic materials 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000000630 rising effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 229910000162 sodium phosphate Inorganic materials 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 239000010457 zeolite Substances 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention relates to biotechnology and is concerned to the production of the tylosine - the macrolidic antibiotics, applicable in agriculture.The summary of the proposed invention consists in the fact, that the culture - producer is grown in optimum conditions, the mycelium is separated, the filtrate of the culture liquid is demineralizated, the tylosine is sorptioned out of the demineralizated filtrate with the acid cationic exchanger into sodium (sodium zeolite softening process) - the hydrogenous form, the tylosine is eluted with the two - substituted sodium phosphate, the received eluate is alcalified up to pH 9,0-10,5, the precipitated crystals are separated, they are dissolved in the acid equimolar solution, the solution is demineralizated and is dried.The technical result of the invention consists in rising the separation efficiency of the tylosine with 70 - 85% up to 97% .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD94-0028A MD694F1 (en) | 1993-12-23 | 1993-12-23 | Process for the production of the crystalline tylosine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD94-0028A MD694F1 (en) | 1993-12-23 | 1993-12-23 | Process for the production of the crystalline tylosine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD940028A MD940028A (en) | 1995-06-30 |
| MD694F1 true MD694F1 (en) | 1997-03-31 |
Family
ID=19738523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0028A MD694F1 (en) | 1993-12-23 | 1993-12-23 | Process for the production of the crystalline tylosine |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD694F1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3178341A (en) * | 1960-06-27 | 1965-04-13 | Lilly Co Eli | Antibiotics tylosin and desmycosin and derivatives thereof |
| BG20697A1 (en) * | 1974-08-27 | 1975-12-20 | ||
| SU1699162A1 (en) * | 1988-12-22 | 1996-04-20 | Всесоюзный научно-исследовательский проектно-конструкторский институт прикладной биохимии | Method of tylosin isolation |
-
1993
- 1993-12-23 MD MD94-0028A patent/MD694F1/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3178341A (en) * | 1960-06-27 | 1965-04-13 | Lilly Co Eli | Antibiotics tylosin and desmycosin and derivatives thereof |
| BG20697A1 (en) * | 1974-08-27 | 1975-12-20 | ||
| SU1699162A1 (en) * | 1988-12-22 | 1996-04-20 | Всесоюзный научно-исследовательский проектно-конструкторский институт прикладной биохимии | Method of tylosin isolation |
Non-Patent Citations (1)
| Title |
|---|
| Сборник научных трудов ВНИИСЭНТИ Минмедпрома СССР, вып.1, 1991 г., М., А.В. Гарбузов, К.П. Грешных, Г.М. Эльбирт и др. "Препараты антибиотиков и витаминов для животноводства", с. 52. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD940028A (en) | 1995-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD3A | Lapsed patent or short term patent |