MD694F1 - Procedeu de obţinere a tilozinei cristaline - Google Patents
Procedeu de obţinere a tilozinei cristalineInfo
- Publication number
- MD694F1 MD694F1 MD94-0028A MD940028A MD694F1 MD 694 F1 MD694 F1 MD 694F1 MD 940028 A MD940028 A MD 940028A MD 694 F1 MD694 F1 MD 694F1
- Authority
- MD
- Moldova
- Prior art keywords
- tylosine
- demineralizated
- production
- filtrate
- sodium
- Prior art date
Links
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000000706 filtrate Substances 0.000 abstract 2
- 229910052708 sodium Inorganic materials 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 229910021536 Zeolite Inorganic materials 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000000630 rising effect Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 229910000162 sodium phosphate Inorganic materials 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical class [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 239000010457 zeolite Substances 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Invenţia se referă la biotehnologie şi anume la obţinerea tilozinei - un antibiotic macrolid, aplicat în agricultură.Esenţa invenţiei constă în aceea că cultura producătoare se cultivă în condiţii optime, se separă miceliul, filtratul lichidului se desalinizează, tilozina se absoarbe din filtratul desalinizat în mediul cationitului acid în formă de sodiu de hidrogen, se eluează cu soluţia de fosfat de sodiu disubstituit, eluatul obţinut se alcalinizează până la valorile pH-ului de 9,0-10,5, cristalele sedimentate se separă, se dizolvă într-o soluţie echimolară de acid, soluţia se desalinizează şi se usucă.Rezultatul tehnic al invenţiei constă în sporirea gradului de purificare a tilozinei de la 70-85% până la 97%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD94-0028A MD694F1 (ro) | 1993-12-23 | 1993-12-23 | Procedeu de obţinere a tilozinei cristaline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD94-0028A MD694F1 (ro) | 1993-12-23 | 1993-12-23 | Procedeu de obţinere a tilozinei cristaline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD940028A MD940028A (ro) | 1995-06-30 |
| MD694F1 true MD694F1 (ro) | 1997-03-31 |
Family
ID=19738523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0028A MD694F1 (ro) | 1993-12-23 | 1993-12-23 | Procedeu de obţinere a tilozinei cristaline |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD694F1 (ro) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3178341A (en) * | 1960-06-27 | 1965-04-13 | Lilly Co Eli | Antibiotics tylosin and desmycosin and derivatives thereof |
| BG20697A1 (ro) * | 1974-08-27 | 1975-12-20 | ||
| SU1699162A1 (ru) * | 1988-12-22 | 1996-04-20 | Всесоюзный научно-исследовательский проектно-конструкторский институт прикладной биохимии | Способ выделения тилозина |
-
1993
- 1993-12-23 MD MD94-0028A patent/MD694F1/ro not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3178341A (en) * | 1960-06-27 | 1965-04-13 | Lilly Co Eli | Antibiotics tylosin and desmycosin and derivatives thereof |
| BG20697A1 (ro) * | 1974-08-27 | 1975-12-20 | ||
| SU1699162A1 (ru) * | 1988-12-22 | 1996-04-20 | Всесоюзный научно-исследовательский проектно-конструкторский институт прикладной биохимии | Способ выделения тилозина |
Non-Patent Citations (1)
| Title |
|---|
| Сборник научных трудов ВНИИСЭНТИ Минмедпрома СССР, вып.1, 1991 г., М., А.В. Гарбузов, К.П. Грешных, Г.М. Эльбирт и др. "Препараты антибиотиков и витаминов для животноводства", с. 52. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD940028A (ro) | 1995-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD3A | Lapsed patent or short term patent |