MD675C2 - Complecşi ai cobaltului cu acţiune antimicrobiană şi procedeu de obţinere a lor - Google Patents
Complecşi ai cobaltului cu acţiune antimicrobiană şi procedeu de obţinere a lorInfo
- Publication number
- MD675C2 MD675C2 MD95-0179A MD950179A MD675C2 MD 675 C2 MD675 C2 MD 675C2 MD 950179 A MD950179 A MD 950179A MD 675 C2 MD675 C2 MD 675C2
- Authority
- MD
- Moldova
- Prior art keywords
- activity
- cobalt
- antimicrobic
- complexes
- manufacturing
- Prior art date
Links
- 230000003377 anti-microbal effect Effects 0.000 title abstract 3
- 150000001868 cobalt Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- NDSTUUPEXNCUNW-UHFFFAOYSA-N (5-nitrofuran-2-yl)methanol Chemical compound OCC1=CC=C([N+]([O-])=O)O1 NDSTUUPEXNCUNW-UHFFFAOYSA-N 0.000 abstract 1
- 229910021503 Cobalt(II) hydroxide Inorganic materials 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- ASKVAEGIVYSGNY-UHFFFAOYSA-L cobalt(ii) hydroxide Chemical compound [OH-].[OH-].[Co+2] ASKVAEGIVYSGNY-UHFFFAOYSA-L 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000007857 hydrazones Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Invenţia se referă la industria chimico-farmaceutică şi este destinată obţinerii substanţelor ce posedă acţiune antimicrobiană şi antimicotică.Compuşii cu formula generală:în care R1 este H, CH3, R2 este CH3, H, se obţin la interacţiunea timp de 1,5 ore a soluţiilor de etanoli fierbinţi hidroxid de cobalt (+2), b-hidrazonei isatinei, 5-nitrofurfurolului şi a 3- sau 4-picolinei, în raportul molar de 1:2:2:2.Aceşti complecşi posedă o activitate bacteriostatică de 16-40 de ori mai mare decât analogul lor structural care se aplică în medicina practică şi de 2,5-30,0 ori mai activi decât analogul cel mai apropiat, iar toxicitatea este mai mică de 11,3-11,8 ori în comparaţie cu analogul structural. S-a stabilit că complecşii de cobalt manifestă o acţiune antimicrobiană în diapazonul concentraţiilor de 0,03-12,5 µg/ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD95-0179A MD675C2 (ro) | 1995-03-06 | 1995-03-06 | Complecşi ai cobaltului cu acţiune antimicrobiană şi procedeu de obţinere a lor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD95-0179A MD675C2 (ro) | 1995-03-06 | 1995-03-06 | Complecşi ai cobaltului cu acţiune antimicrobiană şi procedeu de obţinere a lor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD950179A MD950179A (ro) | 1996-09-30 |
| MD675B2 MD675B2 (ro) | 1997-02-28 |
| MD675C2 true MD675C2 (ro) | 1998-02-28 |
Family
ID=19738639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0179A MD675C2 (ro) | 1995-03-06 | 1995-03-06 | Complecşi ai cobaltului cu acţiune antimicrobiană şi procedeu de obţinere a lor |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD675C2 (ro) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1303G2 (ro) * | 1998-11-24 | 2000-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Bis[N'-(2-oxi-1-naftal)-5-nitro-2-furfurilidenhidrazonato]zinc, care manifestă activitate antimicrobiană faţă de bacteriile din genul Staphylococcus şi Streptococcus |
| MD3942C2 (ro) * | 2009-01-22 | 2010-02-28 | Институт Химии Академии Наук Молдовы | Complecşi ai fierului şi cobaltului cu acidul furan-2-carboxilic cu proprietăţi antituberculoase |
-
1995
- 1995-03-06 MD MD95-0179A patent/MD675C2/ro active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Л.Н.Алексеева. "Антибактериальные препараты-производные 5-нитрофурфурола". 1963 г., Рига, АН Латв. ССР. * |
| Хим-фарм. журн. т. 26, № 7-8, 1992 г., с. 40-42. Н.М.Самусь, В.И. Цапков и др. "Синтез и противомикробная активность координационных соединений d-элементов с 2-оксибензилметиленгидразоном 5-нитро-2-фуральдегида". * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1303G2 (ro) * | 1998-11-24 | 2000-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Bis[N'-(2-oxi-1-naftal)-5-nitro-2-furfurilidenhidrazonato]zinc, care manifestă activitate antimicrobiană faţă de bacteriile din genul Staphylococcus şi Streptococcus |
| MD3942C2 (ro) * | 2009-01-22 | 2010-02-28 | Институт Химии Академии Наук Молдовы | Complecşi ai fierului şi cobaltului cu acidul furan-2-carboxilic cu proprietăţi antituberculoase |
Also Published As
| Publication number | Publication date |
|---|---|
| MD675B2 (ro) | 1997-02-28 |
| MD950179A (ro) | 1996-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20150306 |