MD675C2 - The cobalt's complexes with antimicrobic activity and process for manufacturing of them - Google Patents
The cobalt's complexes with antimicrobic activity and process for manufacturing of themInfo
- Publication number
- MD675C2 MD675C2 MD95-0179A MD950179A MD675C2 MD 675 C2 MD675 C2 MD 675C2 MD 950179 A MD950179 A MD 950179A MD 675 C2 MD675 C2 MD 675C2
- Authority
- MD
- Moldova
- Prior art keywords
- activity
- cobalt
- antimicrobic
- complexes
- manufacturing
- Prior art date
Links
- 230000003377 anti-microbal effect Effects 0.000 title abstract 3
- 150000001868 cobalt Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- NDSTUUPEXNCUNW-UHFFFAOYSA-N (5-nitrofuran-2-yl)methanol Chemical compound OCC1=CC=C([N+]([O-])=O)O1 NDSTUUPEXNCUNW-UHFFFAOYSA-N 0.000 abstract 1
- 229910021503 Cobalt(II) hydroxide Inorganic materials 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- ASKVAEGIVYSGNY-UHFFFAOYSA-L cobalt(ii) hydroxide Chemical compound [OH-].[OH-].[Co+2] ASKVAEGIVYSGNY-UHFFFAOYSA-L 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000007857 hydrazones Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to the chimic and pharmaceutical industry and is concerning to the preparation of substances possessing antimicrobic and antifungal activity.Composition of general formula,is preparated by the interaction of hot ethanolic solutions of cobalt hydroxide (2+), β-izatine hydrazone and 5-nitrofurfurol 3-or-4-picoline in molar relation 1:2:2:2 during 1,5 hours.Theese complexes show the bacteriostatic activity that is 16-40 times more than their structure analogue,used in medicine and 2,5-30,0 times more than their primary standards, the toxity is 11,3-11,8 times lower than that of the structural analogue. It is founded that cobalt complexes show antimicrobic activity in the concentration range of 0,03-12,5 mkg/ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD95-0179A MD675C2 (en) | 1995-03-06 | 1995-03-06 | The cobalt's complexes with antimicrobic activity and process for manufacturing of them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD95-0179A MD675C2 (en) | 1995-03-06 | 1995-03-06 | The cobalt's complexes with antimicrobic activity and process for manufacturing of them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD950179A MD950179A (en) | 1996-09-30 |
| MD675B2 MD675B2 (en) | 1997-02-28 |
| MD675C2 true MD675C2 (en) | 1998-02-28 |
Family
ID=19738639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0179A MD675C2 (en) | 1995-03-06 | 1995-03-06 | The cobalt's complexes with antimicrobic activity and process for manufacturing of them |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD675C2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1303G2 (en) * | 1998-11-24 | 2000-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Bis[N'-(2-oxy-1-naphtal)-5-nitro-2-furfurylidenhydrazonato]zinc, manifesting antimicrobian avtivity with respect to bacteria of the Staphylococcus and Streptococcus kind |
| MD3942C2 (en) * | 2009-01-22 | 2010-02-28 | Институт Химии Академии Наук Молдовы | Iron and cobalt complexes with 2-furoic acid possessing antituberculous properties |
-
1995
- 1995-03-06 MD MD95-0179A patent/MD675C2/en active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Л.Н.Алексеева. "Антибактериальные препараты-производные 5-нитрофурфурола". 1963 г., Рига, АН Латв. ССР. * |
| Хим-фарм. журн. т. 26, № 7-8, 1992 г., с. 40-42. Н.М.Самусь, В.И. Цапков и др. "Синтез и противомикробная активность координационных соединений d-элементов с 2-оксибензилметиленгидразоном 5-нитро-2-фуральдегида". * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1303G2 (en) * | 1998-11-24 | 2000-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Bis[N'-(2-oxy-1-naphtal)-5-nitro-2-furfurylidenhydrazonato]zinc, manifesting antimicrobian avtivity with respect to bacteria of the Staphylococcus and Streptococcus kind |
| MD3942C2 (en) * | 2009-01-22 | 2010-02-28 | Институт Химии Академии Наук Молдовы | Iron and cobalt complexes with 2-furoic acid possessing antituberculous properties |
Also Published As
| Publication number | Publication date |
|---|---|
| MD675B2 (en) | 1997-02-28 |
| MD950179A (en) | 1996-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20150306 |