MD654Z - Метод прогнозирования течения злокачественной меланомы II и III стадии - Google Patents
Метод прогнозирования течения злокачественной меланомы II и III стадииInfo
- Publication number
- MD654Z MD654Z MDS20120167A MDS20120167A MD654Z MD 654 Z MD654 Z MD 654Z MD S20120167 A MDS20120167 A MD S20120167A MD S20120167 A MDS20120167 A MD S20120167A MD 654 Z MD654 Z MD 654Z
- Authority
- MD
- Moldova
- Prior art keywords
- level
- malignant melanoma
- tct
- cells
- evolution
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 33
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 title claims abstract description 21
- 201000001441 melanoma Diseases 0.000 title claims abstract description 20
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 13
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
- 230000002349 favourable effect Effects 0.000 claims abstract description 10
- 208000025865 Ulcer Diseases 0.000 claims abstract description 7
- 230000009545 invasion Effects 0.000 claims abstract description 7
- 238000011282 treatment Methods 0.000 claims abstract description 7
- 210000004027 cell Anatomy 0.000 claims description 9
- 230000036269 ulceration Effects 0.000 claims description 6
- 208000007256 Nevus Diseases 0.000 claims description 2
- 210000002919 epithelial cell Anatomy 0.000 claims description 2
- 206010024217 lentigo Diseases 0.000 claims description 2
- 210000002752 melanocyte Anatomy 0.000 claims description 2
- 101150061263 tct-1 gene Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000005352 clarification Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 description 6
- 238000003745 diagnosis Methods 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 3
- 238000012937 correction Methods 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010061818 Disease progression Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000030381 cutaneous melanoma Diseases 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000013277 forecasting method Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Изобретение относится к медицине, в частности к онкологии и может быть использовано для прогнозирования течения злокачественной меланомы II и III стадии.Согласно изобретению, заявленный метод включает клиническое и параклиническое обследование, где определяют следующие параметры: уточнение стадии болезни (ST), наличие образования язвы (U), клеточный тип опухоли (TCT), уровень инвазии по Кларку (NI), толщину опухоли по Бреслову (GT); примененный метод лечения (MT) и пол пациента (SP), затем вычисляют дискриминантную функцию (F) по формуле:F= -6,345 + 1,386 × ST + 4,768 × MT - 2,596 × SP - 3,384 × U + 0,806 × TCT + 1,780 × NI - 1,136 × GT.В случае, когда F < 0 прогнозируют благоприятное течение злокачественной меланомы, а когда F > 0 - неблагоприятное течение.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDS20120167A MD654Z (ru) | 2012-11-20 | 2012-11-20 | Метод прогнозирования течения злокачественной меланомы II и III стадии |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDS20120167A MD654Z (ru) | 2012-11-20 | 2012-11-20 | Метод прогнозирования течения злокачественной меланомы II и III стадии |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD654Y MD654Y (en) | 2013-07-31 |
| MD654Z true MD654Z (ru) | 2014-02-28 |
Family
ID=48875337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDS20120167A MD654Z (ru) | 2012-11-20 | 2012-11-20 | Метод прогнозирования течения злокачественной меланомы II и III стадии |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD654Z (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD726Z (ru) * | 2013-07-23 | 2014-08-31 | Адриан КИШКА | Метод прогнозирования течения желудочных предраковых состояний у мужчин |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD239Z (ru) * | 2010-02-15 | 2011-02-28 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Метод прогнозирования клинического развития рака молочной железы I стадии |
-
2012
- 2012-11-20 MD MDS20120167A patent/MD654Z/ru not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD239Z (ru) * | 2010-02-15 | 2011-02-28 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Метод прогнозирования клинического развития рака молочной железы I стадии |
Non-Patent Citations (2)
| Title |
|---|
| Balch C. M., Buzaid A. C., Soong S. J., et al. Final version of the American Joint Committee on Cancer stagind system for cutaneous melanoma. J. Clin. Oncol., 2001, vol. 19, p. 3635-3648 * |
| Montanara S., Luaschi A., Fideli P. et al. Malignat melanoma: analysis of survey, Ann. Oncol., 2005, 15(2S), p. 81-83 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD654Y (en) | 2013-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG9Y | Short term patent issued | ||
| KA4Y | Short-term patent lapsed due to non-payment of fees (with right of restoration) | ||
| MM4Y | Short-term patent definitely lapsed due to non-payment of fees |