MD4526B1 - Metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele periferic - Google Patents
Metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele perifericInfo
- Publication number
- MD4526B1 MD4526B1 MDA20140060A MD20140060A MD4526B1 MD 4526 B1 MD4526 B1 MD 4526B1 MD A20140060 A MDA20140060 A MD A20140060A MD 20140060 A MD20140060 A MD 20140060A MD 4526 B1 MD4526 B1 MD 4526B1
- Authority
- MD
- Moldova
- Prior art keywords
- peripheral blood
- embryo
- mononuclear cells
- blood mononuclear
- vitro fertilization
- Prior art date
Links
- 210000001161 mammalian embryo Anatomy 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 title abstract 4
- 238000000338 in vitro Methods 0.000 title abstract 3
- 230000004720 fertilization Effects 0.000 title abstract 2
- 210000004291 uterus Anatomy 0.000 abstract 3
- 230000001363 autoimmune Effects 0.000 abstract 2
- 230000032692 embryo implantation Effects 0.000 abstract 2
- 238000005138 cryopreservation Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- 210000002257 embryonic structure Anatomy 0.000 abstract 1
- 210000004696 endometrium Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
- 230000035935 pregnancy Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46431—Contraceptive or sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/31—Pituitary sex hormones, e.g. follicle-stimulating hormone [FSH], luteinising hormone [LH]; Chorionic gonadotropins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Medical Informatics (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
Abstract
Invenţia se referă la medicină, în special la o metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele periferic.Conform invenţiei, embrionul se implantează în uterul pacientei la cel puţin două luni, preferenţial pe parcursul a 3…12 luni, după extragerea ovulelor de la pacientă, cu scopul de a reduce riscul respingerii embrionului de către sistemul autoimunitar al pacientei şi de a creşte probabilitatea şi rezultatul sarcinii, totodată, înainte de implantarea embrionului, este pregătit endometrul uterului prin introducerea în uter a celulelor mononucleare din sângele periferic (PBMCs). De asemenea, metoda este combinată cu tehnici de crioprezervare, pentru păstrarea ovocitelor sau a embrionilor obţinuţi prin fertilizarea in vitro a pacientei.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161629651P | 2011-11-23 | 2011-11-23 | |
US13/655,257 US10271876B2 (en) | 2011-11-23 | 2012-10-18 | Method of in vitro fertilization with delay of embryo transfer and use of peripheral blood mononuclear cells |
PCT/US2012/066258 WO2013078312A1 (en) | 2011-11-23 | 2012-11-21 | Method of in vitro fertilization with delay of embryo transfer and use of peripheral blood mononuclear cells |
Publications (3)
Publication Number | Publication Date |
---|---|
MD20140060A2 MD20140060A2 (en) | 2014-11-30 |
MD4526B1 true MD4526B1 (ro) | 2017-11-30 |
MD4526C1 MD4526C1 (ro) | 2018-09-30 |
Family
ID=48470292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20140060A MD4526C1 (ro) | 2011-11-23 | 2012-11-21 | Metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele periferic |
Country Status (14)
Country | Link |
---|---|
US (3) | US10271876B2 (ro) |
EP (1) | EP2782993A4 (ro) |
KR (1) | KR20140113917A (ro) |
CN (2) | CN110295143A (ro) |
AU (2) | AU2012340647A1 (ro) |
BR (1) | BR112014012533A2 (ro) |
CA (2) | CA2856860C (ro) |
EA (1) | EA038427B1 (ro) |
IL (2) | IL232784A0 (ro) |
MD (1) | MD4526C1 (ro) |
MX (1) | MX2014006234A (ro) |
UA (1) | UA143229U (ro) |
WO (1) | WO2013078312A1 (ro) |
ZA (1) | ZA201404498B (ro) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2714124C1 (ru) * | 2019-06-24 | 2020-02-12 | Галина Александровна Суханова | Способ проведения экстракорпорального оплодотворения |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3037101B1 (en) | 2014-12-22 | 2019-03-06 | Ferring B.V. | Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies |
CA3035055A1 (en) * | 2016-08-29 | 2018-03-08 | Progena, Inc. | Autologous somatic stem cell therapy, method of controllable preparation of therapeutic composition and procedure of adaptive treatment of ivf patient |
CN110361534B (zh) * | 2018-03-26 | 2023-11-03 | 山大生殖研发中心有限公司 | 评估胚胎和预测体外受精成功率的化学标记物和其应用 |
WO2021078680A1 (en) * | 2019-10-25 | 2021-04-29 | Intellexon Gmbh | Hla class i molecules in in vitro fertilization and further medical implications |
US20230154608A1 (en) * | 2021-11-17 | 2023-05-18 | Optum, Inc. | Machine learning techniques for predictive endometriosis-based prediction |
KR102599957B1 (ko) | 2022-11-16 | 2023-11-09 | 주식회사 코스모스웨일 | 보조생식술 성공률 향상을 위한 배아이식용 배양액 조성물 및 이의 제조 방법 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4725579A (en) * | 1985-02-21 | 1988-02-16 | Serono Laboratories, Inc. | Method of in vitro fertilization by a unique combination of gonadotropins |
WO1999005255A1 (en) * | 1997-07-23 | 1999-02-04 | Northeastern University | Methods for enhancing or reducing preimplantation embryo survival rates |
US6838235B2 (en) * | 1998-11-30 | 2005-01-04 | Vitrolife Group | Methods for in vitro fertilization |
US20050118363A1 (en) * | 2003-09-26 | 2005-06-02 | Fuji Photo Film Co., Ltd. | Heat transfer recording material |
WO2005121322A1 (en) * | 2004-06-11 | 2005-12-22 | Kiwi Ingenuity Limited | Enzymatic modification of cell-surface h antigen by glycosyltransferases |
US20060015961A1 (en) * | 2004-05-17 | 2006-01-19 | Tilly Jonathan L | Methods and compositions for producing germ cells from peripheral blood derived germline stem cells |
US7819796B2 (en) * | 2002-04-05 | 2010-10-26 | Kode Biotech Limited | Embryo modification and implantation |
US8183214B2 (en) * | 2005-09-21 | 2012-05-22 | Kode Biotech Limited | Cell surface coating with hyaluronic acid oligomer derivative |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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IL56342A (en) | 1978-12-29 | 1982-05-31 | Zer Tamar | Method and means for determining human chorionic gonadotropin in urine |
CA2045126A1 (en) | 1989-01-10 | 1990-07-11 | Nicholas M. Gough | Leukaemia inhibitory factor from livestock species and use thereof to enhance implantation and development of embryonic cells |
US6927034B2 (en) | 1998-02-03 | 2005-08-09 | The Trustees Of Columbia University In The City Of New York | Methods for detecting trophoblast malignancy by HCG assay |
AUPP421298A0 (en) | 1998-06-19 | 1998-07-09 | Fertilitescentrum Ab | Method and medium for in vitro culture of human embryos |
EP1231836A4 (en) * | 1999-11-17 | 2004-06-02 | Univ Rochester | EX VIVO HUMAN IMMUNE SYSTEM |
RS21004A (en) | 2001-09-12 | 2006-12-15 | Aplied Research Systems Ars Holding N.V. | Use of hcg in controlled ovarian hyperstimulation |
CA2529724A1 (en) | 2002-06-17 | 2003-12-24 | Kobenhavns Amts Sygehus, Herlev | In vitro fertilisation |
JP2006512060A (ja) | 2002-11-07 | 2006-04-13 | ザ ユニヴァーシティ オヴ シカゴ | ヒト幹細胞の材料および方法 |
JP3762975B2 (ja) | 2003-03-18 | 2006-04-05 | 学校法人慶應義塾 | 単球由来多能性細胞momc |
EP1695080A1 (en) | 2003-08-28 | 2006-08-30 | Coopersurgical, Inc. | Method for determining embryo quality |
CA2557673A1 (en) * | 2004-03-25 | 2005-10-13 | Community Hospitals Of Indiana, Inc. | Cryopreservation media |
US20050241013A1 (en) * | 2004-04-22 | 2005-10-27 | Geoffrey Sher | Unique use of sHLA-G obtained in soluble form from JEG-3 cell line, by purification by PCR, HPLC, or any other techniques, as well as in other forms, as an implantation promoting agent when added to embryo culture and/or to the media in which embryos are transferred to the uterus following in vitro fertilization |
WO2007008377A1 (en) * | 2005-07-06 | 2007-01-18 | University Of Tennessee Research Foundation | Oocytes derived from ovarian culture initially containing no oocytes |
GB0601746D0 (en) * | 2006-01-27 | 2006-03-08 | Novocellus Ltd | Cryopreservation method |
WO2008148105A1 (en) * | 2007-05-25 | 2008-12-04 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
US20100239539A1 (en) * | 2009-03-23 | 2010-09-23 | Sing George L | Methods for promoting differentiation and differentiation efficiency |
US9815124B1 (en) | 2016-03-22 | 2017-11-14 | Flamur Tulovic | Hole saw with threadably removable portion |
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2012
- 2012-10-18 US US13/655,257 patent/US10271876B2/en active Active
- 2012-11-21 WO PCT/US2012/066258 patent/WO2013078312A1/en active Application Filing
- 2012-11-21 CN CN201910061947.6A patent/CN110295143A/zh active Pending
- 2012-11-21 AU AU2012340647A patent/AU2012340647A1/en not_active Abandoned
- 2012-11-21 UA UAA201407100U patent/UA143229U/uk unknown
- 2012-11-21 EA EA201490996A patent/EA038427B1/ru unknown
- 2012-11-21 KR KR1020147017099A patent/KR20140113917A/ko not_active Application Discontinuation
- 2012-11-21 CA CA2856860A patent/CA2856860C/en active Active
- 2012-11-21 MD MDA20140060A patent/MD4526C1/ro active IP Right Grant
- 2012-11-21 MX MX2014006234A patent/MX2014006234A/es unknown
- 2012-11-21 CN CN201280067823.5A patent/CN104126004A/zh active Pending
- 2012-11-21 BR BR112014012533A patent/BR112014012533A2/pt not_active Application Discontinuation
- 2012-11-21 CA CA3079719A patent/CA3079719A1/en active Pending
- 2012-11-21 EP EP12851029.4A patent/EP2782993A4/en active Pending
-
2014
- 2014-05-25 IL IL232784A patent/IL232784A0/en unknown
- 2014-06-19 ZA ZA2014/04498A patent/ZA201404498B/en unknown
-
2018
- 2018-05-23 AU AU2018203649A patent/AU2018203649B2/en active Active
- 2018-10-15 US US16/160,436 patent/US11185348B2/en active Active
-
2020
- 2020-07-15 IL IL276077A patent/IL276077A/en unknown
-
2021
- 2021-10-26 US US17/510,653 patent/US11957384B2/en active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4725579A (en) * | 1985-02-21 | 1988-02-16 | Serono Laboratories, Inc. | Method of in vitro fertilization by a unique combination of gonadotropins |
WO1999005255A1 (en) * | 1997-07-23 | 1999-02-04 | Northeastern University | Methods for enhancing or reducing preimplantation embryo survival rates |
US6838235B2 (en) * | 1998-11-30 | 2005-01-04 | Vitrolife Group | Methods for in vitro fertilization |
US7819796B2 (en) * | 2002-04-05 | 2010-10-26 | Kode Biotech Limited | Embryo modification and implantation |
US20050118363A1 (en) * | 2003-09-26 | 2005-06-02 | Fuji Photo Film Co., Ltd. | Heat transfer recording material |
US20060015961A1 (en) * | 2004-05-17 | 2006-01-19 | Tilly Jonathan L | Methods and compositions for producing germ cells from peripheral blood derived germline stem cells |
WO2005121322A1 (en) * | 2004-06-11 | 2005-12-22 | Kiwi Ingenuity Limited | Enzymatic modification of cell-surface h antigen by glycosyltransferases |
US8183214B2 (en) * | 2005-09-21 | 2012-05-22 | Kode Biotech Limited | Cell surface coating with hyaluronic acid oligomer derivative |
Non-Patent Citations (1)
Title |
---|
Yoshioka et. al. Intrauterine administration of autologous peripherel blood mononuclear cellspromotes implantation rates in patients with repeated failure of IVF-embryo transfer. Human Reproduction. V.21, No.12, p. 3290-3294 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2714124C1 (ru) * | 2019-06-24 | 2020-02-12 | Галина Александровна Суханова | Способ проведения экстракорпорального оплодотворения |
Also Published As
Publication number | Publication date |
---|---|
EA038427B1 (ru) | 2021-08-27 |
KR20140113917A (ko) | 2014-09-25 |
AU2012340647A1 (en) | 2014-06-19 |
UA143229U (uk) | 2020-07-27 |
EP2782993A4 (en) | 2015-04-15 |
BR112014012533A2 (pt) | 2017-06-06 |
MX2014006234A (es) | 2015-02-10 |
EP2782993A1 (en) | 2014-10-01 |
US20220039834A1 (en) | 2022-02-10 |
CA2856860A1 (en) | 2013-05-30 |
US11957384B2 (en) | 2024-04-16 |
EA201490996A1 (ru) | 2015-02-27 |
AU2018203649A1 (en) | 2018-06-07 |
US20130172666A1 (en) | 2013-07-04 |
ZA201404498B (en) | 2015-08-26 |
MD20140060A2 (en) | 2014-11-30 |
CA2856860C (en) | 2020-07-07 |
AU2018203649B2 (en) | 2020-10-08 |
MD4526C1 (ro) | 2018-09-30 |
CN110295143A (zh) | 2019-10-01 |
US20190110813A1 (en) | 2019-04-18 |
CA3079719A1 (en) | 2013-05-30 |
US11185348B2 (en) | 2021-11-30 |
US10271876B2 (en) | 2019-04-30 |
WO2013078312A1 (en) | 2013-05-30 |
IL232784A0 (en) | 2014-07-31 |
CN104126004A (zh) | 2014-10-29 |
IL276077A (en) | 2020-08-31 |
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Legal Events
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FG4A | Patent for invention issued |