MD4526C1 - Metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele periferic - Google Patents

Metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele periferic

Info

Publication number
MD4526C1
MD4526C1 MDA20140060A MD20140060A MD4526C1 MD 4526 C1 MD4526 C1 MD 4526C1 MD A20140060 A MDA20140060 A MD A20140060A MD 20140060 A MD20140060 A MD 20140060A MD 4526 C1 MD4526 C1 MD 4526C1
Authority
MD
Moldova
Prior art keywords
peripheral blood
embryo
mononuclear cells
blood mononuclear
vitro fertilization
Prior art date
Application number
MDA20140060A
Other languages
English (en)
Russian (ru)
Other versions
MD4526B1 (ro
MD20140060A2 (en
Inventor
Александер ФЕСКОВ
Ирина Фескова
Евгения Жилкова
Станислав Жилков
Original Assignee
Mezadata Medical Ip Holding Llp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mezadata Medical Ip Holding Llp filed Critical Mezadata Medical Ip Holding Llp
Publication of MD20140060A2 publication Critical patent/MD20140060A2/ro
Publication of MD4526B1 publication Critical patent/MD4526B1/ro
Publication of MD4526C1 publication Critical patent/MD4526C1/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46431—Contraceptive or sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/31—Pituitary sex hormones, e.g. follicle-stimulating hormone [FSH], luteinising hormone [LH]; Chorionic gonadotropins

Abstract

Invenţia se referă la medicină, în special la o metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele periferic.Conform invenţiei, embrionul se implantează în uterul pacientei la cel puţin două luni, preferenţial pe parcursul a 3…12 luni, după extragerea ovulelor de la pacientă, cu scopul de a reduce riscul respingerii embrionului de către sistemul autoimunitar al pacientei şi de a creşte probabilitatea şi rezultatul sarcinii, totodată, înainte de implantarea embrionului, este pregătit endometrul uterului prin introducerea în uter a celulelor mononucleare din sângele periferic (PBMCs). De asemenea, metoda este combinată cu tehnici de crioprezervare, pentru păstrarea ovocitelor sau a embrionilor obţinuţi prin fertilizarea in vitro a pacientei.
MDA20140060A 2011-11-23 2012-11-21 Metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele periferic MD4526C1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161629651P 2011-11-23 2011-11-23
US13/655,257 US10271876B2 (en) 2011-11-23 2012-10-18 Method of in vitro fertilization with delay of embryo transfer and use of peripheral blood mononuclear cells
PCT/US2012/066258 WO2013078312A1 (en) 2011-11-23 2012-11-21 Method of in vitro fertilization with delay of embryo transfer and use of peripheral blood mononuclear cells

Publications (3)

Publication Number Publication Date
MD20140060A2 MD20140060A2 (en) 2014-11-30
MD4526B1 MD4526B1 (ro) 2017-11-30
MD4526C1 true MD4526C1 (ro) 2018-09-30

Family

ID=48470292

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20140060A MD4526C1 (ro) 2011-11-23 2012-11-21 Metodă de fertilizare in vitro cu întârzierea transferului embrionar şi utilizarea celulelor mononucleare din sângele periferic

Country Status (14)

Country Link
US (3) US10271876B2 (ro)
EP (1) EP2782993A4 (ro)
KR (1) KR20140113917A (ro)
CN (2) CN104126004A (ro)
AU (2) AU2012340647A1 (ro)
BR (1) BR112014012533A2 (ro)
CA (2) CA2856860C (ro)
EA (1) EA038427B1 (ro)
IL (2) IL232784A0 (ro)
MD (1) MD4526C1 (ro)
MX (1) MX2014006234A (ro)
UA (1) UA143229U (ro)
WO (1) WO2013078312A1 (ro)
ZA (1) ZA201404498B (ro)

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EP3037101B1 (en) 2014-12-22 2019-03-06 Ferring B.V. Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies
CA3035055A1 (en) 2016-08-29 2018-03-08 Progena, Inc. Autologous somatic stem cell therapy, method of controllable preparation of therapeutic composition and procedure of adaptive treatment of ivf patient
CN110361534B (zh) * 2018-03-26 2023-11-03 山大生殖研发中心有限公司 评估胚胎和预测体外受精成功率的化学标记物和其应用
RU2714124C1 (ru) * 2019-06-24 2020-02-12 Галина Александровна Суханова Способ проведения экстракорпорального оплодотворения
JP2022553069A (ja) * 2019-10-25 2022-12-21 インテレクソン ゲゼルシャフト ミット ベシュレンクテル ハフツング ｉｎ ｖｉｔｒｏ受精におけるＨＬＡクラスＩ分子とさらなる医学的意義
US20230154608A1 (en) * 2021-11-17 2023-05-18 Optum, Inc. Machine learning techniques for predictive endometriosis-based prediction
KR102599957B1 (ko) 2022-11-16 2023-11-09 주식회사 코스모스웨일 보조생식술 성공률 향상을 위한 배아이식용 배양액 조성물 및 이의 제조 방법

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Also Published As

Publication number Publication date
EP2782993A1 (en) 2014-10-01
AU2018203649B2 (en) 2020-10-08
MD4526B1 (ro) 2017-11-30
WO2013078312A1 (en) 2013-05-30
MD20140060A2 (en) 2014-11-30
US20220039834A1 (en) 2022-02-10
AU2012340647A1 (en) 2014-06-19
IL276077A (en) 2020-08-31
EA201490996A1 (ru) 2015-02-27
CA3079719A1 (en) 2013-05-30
CA2856860A1 (en) 2013-05-30
CA2856860C (en) 2020-07-07
ZA201404498B (en) 2015-08-26
EP2782993A4 (en) 2015-04-15
US11957384B2 (en) 2024-04-16
US20190110813A1 (en) 2019-04-18
KR20140113917A (ko) 2014-09-25
CN110295143A (zh) 2019-10-01
IL232784A0 (en) 2014-07-31
UA143229U (uk) 2020-07-27
US20130172666A1 (en) 2013-07-04
US10271876B2 (en) 2019-04-30
CN104126004A (zh) 2014-10-29
MX2014006234A (es) 2015-02-10
US11185348B2 (en) 2021-11-30
BR112014012533A2 (pt) 2017-06-06
EA038427B1 (ru) 2021-08-27
AU2018203649A1 (en) 2018-06-07

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Legal Events

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FG4A Patent for invention issued