MD4482C1 - Procedeu de conjugare a alfa-glucanilor cu streptomicină - Google Patents
Procedeu de conjugare a alfa-glucanilor cu streptomicinăInfo
- Publication number
- MD4482C1 MD4482C1 MDA20160149A MD20160149A MD4482C1 MD 4482 C1 MD4482 C1 MD 4482C1 MD A20160149 A MDA20160149 A MD A20160149A MD 20160149 A MD20160149 A MD 20160149A MD 4482 C1 MD4482 C1 MD 4482C1
- Authority
- MD
- Moldova
- Prior art keywords
- solution
- streptomycin
- alpha
- temperature
- glucans
- Prior art date
Links
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Invenţia se referă la domeniul chimiei şi medicinii, şi anume la procedee de obţinere a materialelor polimerice cu proprietăţi antibiotice.Esenţa invenţiei constă în faptul că se propune un procedeu de conjugare a alfa-glucanilor cu streptomicină, care include pregătirea unei soluţii coloidale de amidon sau dextran în dimetilformamidă (soluţia 1) şi a unei soluţii de streptomicină în dimetilformamidă (soluţia 2). După răcirea soluţiei 1 şi menţinerea ei la temperatura de 0…2°C se adaugă consecutiv şi lent trietilamină, apoi cloroformiat de etil, după 15…30 min se adaugă lent soluţia 2, se menţine amestecul obţinut timp de 20…40 min, apoi se aduce la temperatura camerei şi se menţine 2…3 ore. Soluţia se evaporă până la o concentraţie de 15…20%, conjugatul obţinut se sedimentează cu hexan, apoi se resedimentează cu eter dietilic, după care se usucă în vid la temperatura de până la 40°C. Totodată trietilamina, cloroformiatul de etil şi streptomicina se iau în cantităţi echimolare, iar în raport cu alfa-glucan ̶ corespunzător cu gradul de substituţie dorit într-o unitate glucidică din catena polimerului.Rezultatul tehnic al invenţiei constă în faptul că procedeul propus permite obţinerea unor materiale polimerice fără reacţii secundare.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160149A MD4482C1 (ro) | 2016-12-23 | 2016-12-23 | Procedeu de conjugare a alfa-glucanilor cu streptomicină |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160149A MD4482C1 (ro) | 2016-12-23 | 2016-12-23 | Procedeu de conjugare a alfa-glucanilor cu streptomicină |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4482B1 MD4482B1 (ro) | 2017-05-31 |
MD4482C1 true MD4482C1 (ro) | 2017-12-31 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160149A MD4482C1 (ro) | 2016-12-23 | 2016-12-23 | Procedeu de conjugare a alfa-glucanilor cu streptomicină |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4482C1 (ro) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015628A1 (en) * | 1989-06-14 | 1990-12-27 | Cetus Corporation | Polymer/antibiotic conjugate |
US5068321A (en) * | 1988-10-27 | 1991-11-26 | Wolff Walsrode Aktiengesellschaft | Carbonic acid esters of polysaccharides and a process for their production |
-
2016
- 2016-12-23 MD MDA20160149A patent/MD4482C1/ro not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5068321A (en) * | 1988-10-27 | 1991-11-26 | Wolff Walsrode Aktiengesellschaft | Carbonic acid esters of polysaccharides and a process for their production |
WO1990015628A1 (en) * | 1989-06-14 | 1990-12-27 | Cetus Corporation | Polymer/antibiotic conjugate |
Non-Patent Citations (8)
Title |
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Dhaneshwar S.S. et al. Dextran: A promising macromolecular drug carrier. Indian J. Pharm. Sci., 2006, 68(6): 705-714. DOI: 10.4103/0250-474X.31000. Regăsit în Internet la 2016.10.20, url: http://www.ijpsonline.com/articles/dextran-a-promising-macromolecular-drug-carrier.html aricolul integral * |
Elschner Th. et al. Synthesis and aminolysis of polysaccharide carbonates. Cellulose (2013), 20(1), 339-353. DOI 10.1007/s10570-012-9819-9, published online: 6 November 2012. Regăsit în Internet la 2016.09.26, url: https://www.researchgate.net/publication/257546487_Synthesis_and_aminolysis_of_polysaccharide_carbonates articolul integral * |
Heinze, Th. et al. Functional Polymers based on Dextran. Adv. Polym. Sci. (2006) 205: 199-201, DOI 10.1007/12_100 Published online 8 September 2006. Regăsit în Internet la 2016.10.19, url: https://www.researchgate.net/profile/Stephanie_Schubert2/publication/226787974_Functional_Polymers_Based_on_Dextran/links/53edb0c20cf26b9b7dc5f388.pdf chapter 4.2.2.; 6.1.3 * |
Hofman V., Ringsdorf H., Seganova A., Waginev W.H. Makromol. Chem., 1979, V.180, Nr. 3, p.837-841 * |
Ivancic Albert et al. The study of prolongation effect of some antituberculous polimeric drugs based on N-vinylpyrrolidinone and other. Simpozionul Internaţional PRIORITĂŢILE CHIMIEI PENTRU O DEZVOLTARE DURABILĂ, PRIOCHEM, 25-26 octombrie 2012, Bucureşti ROMÂNIA, pag 65. Regăsit în Internet la 2016.09.30, url: http://www.icechim.ro/priochem/2012_Program_simpozion.pdf Rezumatul lărgit * |
Larsen Claus. Dextran prodrugs - structure and stability in relation to therapeutic activity. Advanced Drug Delivery Review, 3 (1989), 103-154. Regăsit în Internet la 2016.10.31, url: http://docslide.us/documents/dextran-prodrugs-structure-and-stability-in-relation-to-therapeutic-activity.html pag. 118, Table X; 133; references 124 and 267 * |
Robu Ştefan et al. Studiul proprietăţilor mecanice ale unor copolimeri ternari grefaţi cu ampicilină. Studia Universitatis Moldaviae, 2014, nr.1 (71), pag. 161-165. Regăsit în Internet la 2016.10.18, url: http://studiamsu.eu/wp-content/uploads/28.-p.161-165.pdf * |
Stebbins N.D. et al. Antibiotic-containing polymers for localized, sustained drug delivery. Adv. Drug Deliv. Rev. 2014 November 30; 77-87, published online 2014 April 18, doi: 10.1016/j.addr.2014.04.006. Regăsit în Internet la 2016.10.19, url: http://europepmc.org/articles/pmc4201908 documentul integral, în special Chapter 2.3 * |
Also Published As
Publication number | Publication date |
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MD4482B1 (ro) | 2017-05-31 |
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KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |