MD4482C1 - Procedeu de conjugare a alfa-glucanilor cu streptomicină - Google Patents

Procedeu de conjugare a alfa-glucanilor cu streptomicină

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Publication number
MD4482C1
MD4482C1 MDA20160149A MD20160149A MD4482C1 MD 4482 C1 MD4482 C1 MD 4482C1 MD A20160149 A MDA20160149 A MD A20160149A MD 20160149 A MD20160149 A MD 20160149A MD 4482 C1 MD4482 C1 MD 4482C1
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MD
Moldova
Prior art keywords
solution
streptomycin
alpha
temperature
glucans
Prior art date
Application number
MDA20160149A
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English (en)
Russian (ru)
Other versions
MD4482B1 (ro
Inventor
Штефан РОБУ
Виорел ПРИСАКАРЬ
Альберт ИВАНЧИК
Георге ДУКА
Мария ГОНЦА
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20160149A priority Critical patent/MD4482C1/ro
Publication of MD4482B1 publication Critical patent/MD4482B1/ro
Publication of MD4482C1 publication Critical patent/MD4482C1/ro

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  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Invenţia se referă la domeniul chimiei şi medicinii, şi anume la procedee de obţinere a materialelor polimerice cu proprietăţi antibiotice.Esenţa invenţiei constă în faptul că se propune un procedeu de conjugare a alfa-glucanilor cu streptomicină, care include pregătirea unei soluţii coloidale de amidon sau dextran în dimetilformamidă (soluţia 1) şi a unei soluţii de streptomicină în dimetilformamidă (soluţia 2). După răcirea soluţiei 1 şi menţinerea ei la temperatura de 0…2°C se adaugă consecutiv şi lent trietilamină, apoi cloroformiat de etil, după 15…30 min se adaugă lent soluţia 2, se menţine amestecul obţinut timp de 20…40 min, apoi se aduce la temperatura camerei şi se menţine 2…3 ore. Soluţia se evaporă până la o concentraţie de 15…20%, conjugatul obţinut se sedimentează cu hexan, apoi se resedimentează cu eter dietilic, după care se usucă în vid la temperatura de până la 40°C. Totodată trietilamina, cloroformiatul de etil şi streptomicina se iau în cantităţi echimolare, iar în raport cu alfa-glucan ̶ corespunzător cu gradul de substituţie dorit într-o unitate glucidică din catena polimerului.Rezultatul tehnic al invenţiei constă în faptul că procedeul propus permite obţinerea unor materiale polimerice fără reacţii secundare.
MDA20160149A 2016-12-23 2016-12-23 Procedeu de conjugare a alfa-glucanilor cu streptomicină MD4482C1 (ro)

Priority Applications (1)

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MDA20160149A MD4482C1 (ro) 2016-12-23 2016-12-23 Procedeu de conjugare a alfa-glucanilor cu streptomicină

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Application Number Priority Date Filing Date Title
MDA20160149A MD4482C1 (ro) 2016-12-23 2016-12-23 Procedeu de conjugare a alfa-glucanilor cu streptomicină

Publications (2)

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MD4482B1 MD4482B1 (ro) 2017-05-31
MD4482C1 true MD4482C1 (ro) 2017-12-31

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MDA20160149A MD4482C1 (ro) 2016-12-23 2016-12-23 Procedeu de conjugare a alfa-glucanilor cu streptomicină

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015628A1 (en) * 1989-06-14 1990-12-27 Cetus Corporation Polymer/antibiotic conjugate
US5068321A (en) * 1988-10-27 1991-11-26 Wolff Walsrode Aktiengesellschaft Carbonic acid esters of polysaccharides and a process for their production

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068321A (en) * 1988-10-27 1991-11-26 Wolff Walsrode Aktiengesellschaft Carbonic acid esters of polysaccharides and a process for their production
WO1990015628A1 (en) * 1989-06-14 1990-12-27 Cetus Corporation Polymer/antibiotic conjugate

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Dhaneshwar S.S. et al. Dextran: A promising macromolecular drug carrier. Indian J. Pharm. Sci., 2006, 68(6): 705-714. DOI: 10.4103/0250-474X.31000. Regăsit în Internet la 2016.10.20, url: http://www.ijpsonline.com/articles/dextran-a-promising-macromolecular-drug-carrier.html aricolul integral *
Elschner Th. et al. Synthesis and aminolysis of polysaccharide carbonates. Cellulose (2013), 20(1), 339-353. DOI 10.1007/s10570-012-9819-9, published online: 6 November 2012. Regăsit în Internet la 2016.09.26, url: https://www.researchgate.net/publication/257546487_Synthesis_and_aminolysis_of_polysaccharide_carbonates articolul integral *
Heinze, Th. et al. Functional Polymers based on Dextran. Adv. Polym. Sci. (2006) 205: 199-201, DOI 10.1007/12_100 Published online 8 September 2006. Regăsit în Internet la 2016.10.19, url: https://www.researchgate.net/profile/Stephanie_Schubert2/publication/226787974_Functional_Polymers_Based_on_Dextran/links/53edb0c20cf26b9b7dc5f388.pdf chapter 4.2.2.; 6.1.3 *
Hofman V., Ringsdorf H., Seganova A., Waginev W.H. Makromol. Chem., 1979, V.180, Nr. 3, p.837-841 *
Ivancic Albert et al. The study of prolongation effect of some antituberculous polimeric drugs based on N-vinylpyrrolidinone and other. Simpozionul Internaţional PRIORITĂŢILE CHIMIEI PENTRU O DEZVOLTARE DURABILĂ, PRIOCHEM, 25-26 octombrie 2012, Bucureşti ROMÂNIA, pag 65. Regăsit în Internet la 2016.09.30, url: http://www.icechim.ro/priochem/2012_Program_simpozion.pdf Rezumatul lărgit *
Larsen Claus. Dextran prodrugs - structure and stability in relation to therapeutic activity. Advanced Drug Delivery Review, 3 (1989), 103-154. Regăsit în Internet la 2016.10.31, url: http://docslide.us/documents/dextran-prodrugs-structure-and-stability-in-relation-to-therapeutic-activity.html pag. 118, Table X; 133; references 124 and 267 *
Robu Ştefan et al. Studiul proprietăţilor mecanice ale unor copolimeri ternari grefaţi cu ampicilină. Studia Universitatis Moldaviae, 2014, nr.1 (71), pag. 161-165. Regăsit în Internet la 2016.10.18, url: http://studiamsu.eu/wp-content/uploads/28.-p.161-165.pdf *
Stebbins N.D. et al. Antibiotic-containing polymers for localized, sustained drug delivery. Adv. Drug Deliv. Rev. 2014 November 30; 77-87, published online 2014 April 18, doi: 10.1016/j.addr.2014.04.006. Regăsit în Internet la 2016.10.19, url: http://europepmc.org/articles/pmc4201908 documentul integral, în special Chapter 2.3 *

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