MD4482C1 - Process for conjugating alpha-glucans with streptomycin - Google Patents
Process for conjugating alpha-glucans with streptomycinInfo
- Publication number
- MD4482C1 MD4482C1 MDA20160149A MD20160149A MD4482C1 MD 4482 C1 MD4482 C1 MD 4482C1 MD A20160149 A MDA20160149 A MD A20160149A MD 20160149 A MD20160149 A MD 20160149A MD 4482 C1 MD4482 C1 MD 4482C1
- Authority
- MD
- Moldova
- Prior art keywords
- solution
- streptomycin
- alpha
- temperature
- glucans
- Prior art date
Links
Abstract
The invention relates to the field of chemistry and medicine, in particular to processes for creating polymeric materials with antibiotic properties.Summary of the invention consists in that it provides a process for conjugating alpha-glucans with streptomycin, which comprises the preparation of a colloidal solution of starch or dextran (solution 1) and a solution of streptomycin in dimethylformamide (solution 2). After cooling solution 1 and keeping it at a temperature of 0…2°C is slowly added triethylamine, then ethyl chloroformate, after 15…30 minutes is slowly added solution 2, after 20…40 minutes the resulting mixture is brought to room temperature and maintained for 2…3 hours. The solution is evaporated to a concentration of 15…20%, the resulting conjugate is precipitated with hexane and again with diethyl ether, and then dried under vacuum at a temperature of up to 40°C. At the same time, triethylamine, ethyl chloroformate and streptomycin are taken in equimolar amounts, and with respect to alpha-glucan - in accordance with the desired degree of substitution in the glucose unit of the polymer chain.The technical result of the invention consists in that the proposed method makes it possible to obtain polymer materials without secondary reactions.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160149A MD4482C1 (en) | 2016-12-23 | 2016-12-23 | Process for conjugating alpha-glucans with streptomycin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160149A MD4482C1 (en) | 2016-12-23 | 2016-12-23 | Process for conjugating alpha-glucans with streptomycin |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4482B1 MD4482B1 (en) | 2017-05-31 |
MD4482C1 true MD4482C1 (en) | 2017-12-31 |
Family
ID=58850667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160149A MD4482C1 (en) | 2016-12-23 | 2016-12-23 | Process for conjugating alpha-glucans with streptomycin |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4482C1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015628A1 (en) * | 1989-06-14 | 1990-12-27 | Cetus Corporation | Polymer/antibiotic conjugate |
US5068321A (en) * | 1988-10-27 | 1991-11-26 | Wolff Walsrode Aktiengesellschaft | Carbonic acid esters of polysaccharides and a process for their production |
-
2016
- 2016-12-23 MD MDA20160149A patent/MD4482C1/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5068321A (en) * | 1988-10-27 | 1991-11-26 | Wolff Walsrode Aktiengesellschaft | Carbonic acid esters of polysaccharides and a process for their production |
WO1990015628A1 (en) * | 1989-06-14 | 1990-12-27 | Cetus Corporation | Polymer/antibiotic conjugate |
Non-Patent Citations (8)
Title |
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Dhaneshwar S.S. et al. Dextran: A promising macromolecular drug carrier. Indian J. Pharm. Sci., 2006, 68(6): 705-714. DOI: 10.4103/0250-474X.31000. Regăsit în Internet la 2016.10.20, url: http://www.ijpsonline.com/articles/dextran-a-promising-macromolecular-drug-carrier.html aricolul integral * |
Elschner Th. et al. Synthesis and aminolysis of polysaccharide carbonates. Cellulose (2013), 20(1), 339-353. DOI 10.1007/s10570-012-9819-9, published online: 6 November 2012. Regăsit în Internet la 2016.09.26, url: https://www.researchgate.net/publication/257546487_Synthesis_and_aminolysis_of_polysaccharide_carbonates articolul integral * |
Heinze, Th. et al. Functional Polymers based on Dextran. Adv. Polym. Sci. (2006) 205: 199-201, DOI 10.1007/12_100 Published online 8 September 2006. Regăsit în Internet la 2016.10.19, url: https://www.researchgate.net/profile/Stephanie_Schubert2/publication/226787974_Functional_Polymers_Based_on_Dextran/links/53edb0c20cf26b9b7dc5f388.pdf chapter 4.2.2.; 6.1.3 * |
Hofman V., Ringsdorf H., Seganova A., Waginev W.H. Makromol. Chem., 1979, V.180, Nr. 3, p.837-841 * |
Ivancic Albert et al. The study of prolongation effect of some antituberculous polimeric drugs based on N-vinylpyrrolidinone and other. Simpozionul Internaţional PRIORITĂŢILE CHIMIEI PENTRU O DEZVOLTARE DURABILĂ, PRIOCHEM, 25-26 octombrie 2012, Bucureşti ROMÂNIA, pag 65. Regăsit în Internet la 2016.09.30, url: http://www.icechim.ro/priochem/2012_Program_simpozion.pdf Rezumatul lărgit * |
Larsen Claus. Dextran prodrugs - structure and stability in relation to therapeutic activity. Advanced Drug Delivery Review, 3 (1989), 103-154. Regăsit în Internet la 2016.10.31, url: http://docslide.us/documents/dextran-prodrugs-structure-and-stability-in-relation-to-therapeutic-activity.html pag. 118, Table X; 133; references 124 and 267 * |
Robu Ştefan et al. Studiul proprietăţilor mecanice ale unor copolimeri ternari grefaţi cu ampicilină. Studia Universitatis Moldaviae, 2014, nr.1 (71), pag. 161-165. Regăsit în Internet la 2016.10.18, url: http://studiamsu.eu/wp-content/uploads/28.-p.161-165.pdf * |
Stebbins N.D. et al. Antibiotic-containing polymers for localized, sustained drug delivery. Adv. Drug Deliv. Rev. 2014 November 30; 77-87, published online 2014 April 18, doi: 10.1016/j.addr.2014.04.006. Regăsit în Internet la 2016.10.19, url: http://europepmc.org/articles/pmc4201908 documentul integral, în special Chapter 2.3 * |
Also Published As
Publication number | Publication date |
---|---|
MD4482B1 (en) | 2017-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |