MD4482C1 - Process for conjugating alpha-glucans with streptomycin - Google Patents

Process for conjugating alpha-glucans with streptomycin

Info

Publication number
MD4482C1
MD4482C1 MDA20160149A MD20160149A MD4482C1 MD 4482 C1 MD4482 C1 MD 4482C1 MD A20160149 A MDA20160149 A MD A20160149A MD 20160149 A MD20160149 A MD 20160149A MD 4482 C1 MD4482 C1 MD 4482C1
Authority
MD
Moldova
Prior art keywords
solution
streptomycin
alpha
temperature
glucans
Prior art date
Application number
MDA20160149A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4482B1 (en
Inventor
Штефан РОБУ
Виорел ПРИСАКАРЬ
Альберт ИВАНЧИК
Георге ДУКА
Мария ГОНЦА
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20160149A priority Critical patent/MD4482C1/en
Publication of MD4482B1 publication Critical patent/MD4482B1/en
Publication of MD4482C1 publication Critical patent/MD4482C1/en

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  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The invention relates to the field of chemistry and medicine, in particular to processes for creating polymeric materials with antibiotic properties.Summary of the invention consists in that it provides a process for conjugating alpha-glucans with streptomycin, which comprises the preparation of a colloidal solution of starch or dextran (solution 1) and a solution of streptomycin in dimethylformamide (solution 2). After cooling solution 1 and keeping it at a temperature of 0…2°C is slowly added triethylamine, then ethyl chloroformate, after 15…30 minutes is slowly added solution 2, after 20…40 minutes the resulting mixture is brought to room temperature and maintained for 2…3 hours. The solution is evaporated to a concentration of 15…20%, the resulting conjugate is precipitated with hexane and again with diethyl ether, and then dried under vacuum at a temperature of up to 40°C. At the same time, triethylamine, ethyl chloroformate and streptomycin are taken in equimolar amounts, and with respect to alpha-glucan - in accordance with the desired degree of substitution in the glucose unit of the polymer chain.The technical result of the invention consists in that the proposed method makes it possible to obtain polymer materials without secondary reactions.
MDA20160149A 2016-12-23 2016-12-23 Process for conjugating alpha-glucans with streptomycin MD4482C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20160149A MD4482C1 (en) 2016-12-23 2016-12-23 Process for conjugating alpha-glucans with streptomycin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20160149A MD4482C1 (en) 2016-12-23 2016-12-23 Process for conjugating alpha-glucans with streptomycin

Publications (2)

Publication Number Publication Date
MD4482B1 MD4482B1 (en) 2017-05-31
MD4482C1 true MD4482C1 (en) 2017-12-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20160149A MD4482C1 (en) 2016-12-23 2016-12-23 Process for conjugating alpha-glucans with streptomycin

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MD (1) MD4482C1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990015628A1 (en) * 1989-06-14 1990-12-27 Cetus Corporation Polymer/antibiotic conjugate
US5068321A (en) * 1988-10-27 1991-11-26 Wolff Walsrode Aktiengesellschaft Carbonic acid esters of polysaccharides and a process for their production

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068321A (en) * 1988-10-27 1991-11-26 Wolff Walsrode Aktiengesellschaft Carbonic acid esters of polysaccharides and a process for their production
WO1990015628A1 (en) * 1989-06-14 1990-12-27 Cetus Corporation Polymer/antibiotic conjugate

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
Dhaneshwar S.S. et al. Dextran: A promising macromolecular drug carrier. Indian J. Pharm. Sci., 2006, 68(6): 705-714. DOI: 10.4103/0250-474X.31000. Regăsit în Internet la 2016.10.20, url: http://www.ijpsonline.com/articles/dextran-a-promising-macromolecular-drug-carrier.html aricolul integral *
Elschner Th. et al. Synthesis and aminolysis of polysaccharide carbonates. Cellulose (2013), 20(1), 339-353. DOI 10.1007/s10570-012-9819-9, published online: 6 November 2012. Regăsit în Internet la 2016.09.26, url: https://www.researchgate.net/publication/257546487_Synthesis_and_aminolysis_of_polysaccharide_carbonates articolul integral *
Heinze, Th. et al. Functional Polymers based on Dextran. Adv. Polym. Sci. (2006) 205: 199-201, DOI 10.1007/12_100 Published online 8 September 2006. Regăsit în Internet la 2016.10.19, url: https://www.researchgate.net/profile/Stephanie_Schubert2/publication/226787974_Functional_Polymers_Based_on_Dextran/links/53edb0c20cf26b9b7dc5f388.pdf chapter 4.2.2.; 6.1.3 *
Hofman V., Ringsdorf H., Seganova A., Waginev W.H. Makromol. Chem., 1979, V.180, Nr. 3, p.837-841 *
Ivancic Albert et al. The study of prolongation effect of some antituberculous polimeric drugs based on N-vinylpyrrolidinone and other. Simpozionul Internaţional PRIORITĂŢILE CHIMIEI PENTRU O DEZVOLTARE DURABILĂ, PRIOCHEM, 25-26 octombrie 2012, Bucureşti ROMÂNIA, pag 65. Regăsit în Internet la 2016.09.30, url: http://www.icechim.ro/priochem/2012_Program_simpozion.pdf Rezumatul lărgit *
Larsen Claus. Dextran prodrugs - structure and stability in relation to therapeutic activity. Advanced Drug Delivery Review, 3 (1989), 103-154. Regăsit în Internet la 2016.10.31, url: http://docslide.us/documents/dextran-prodrugs-structure-and-stability-in-relation-to-therapeutic-activity.html pag. 118, Table X; 133; references 124 and 267 *
Robu Ştefan et al. Studiul proprietăţilor mecanice ale unor copolimeri ternari grefaţi cu ampicilină. Studia Universitatis Moldaviae, 2014, nr.1 (71), pag. 161-165. Regăsit în Internet la 2016.10.18, url: http://studiamsu.eu/wp-content/uploads/28.-p.161-165.pdf *
Stebbins N.D. et al. Antibiotic-containing polymers for localized, sustained drug delivery. Adv. Drug Deliv. Rev. 2014 November 30; 77-87, published online 2014 April 18, doi: 10.1016/j.addr.2014.04.006. Regăsit în Internet la 2016.10.19, url: http://europepmc.org/articles/pmc4201908 documentul integral, în special Chapter 2.3 *

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Publication number Publication date
MD4482B1 (en) 2017-05-31

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees