MD4452C1 - Use of N-(2,4-dimethylphenyl)-2-(2-hydroxybenzylidene)-hydrazinecarbothioamide as a Candida albicans kind fungi proliferation inhibitor - Google Patents
Use of N-(2,4-dimethylphenyl)-2-(2-hydroxybenzylidene)-hydrazinecarbothioamide as a Candida albicans kind fungi proliferation inhibitorInfo
- Publication number
- MD4452C1 MD4452C1 MDA20160020A MD20160020A MD4452C1 MD 4452 C1 MD4452 C1 MD 4452C1 MD A20160020 A MDA20160020 A MD A20160020A MD 20160020 A MD20160020 A MD 20160020A MD 4452 C1 MD4452 C1 MD 4452C1
- Authority
- MD
- Moldova
- Prior art keywords
- candida albicans
- hydrazinecarbothioamide
- hydroxybenzylidene
- dimethylphenyl
- medicine
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to chemistry and medicine, namely to the use of a biologically active organic compound from the class of thiosemicarbazones, which exhibits a high bactericidal and bacteriostatic activity against Candida albicans, and may find application in medicine and veterinary medicine for the prophylaxis and treatment of mycoses.Summary of the invention consists in the use as a Candida albicans kind fungi proliferation inhibitor of N-(2,4-dimethylphenyl)-2-(2-hydroxybenzylidene)-hydrazinecarbothioamide of formula:At the same time, said thiosemicarbazone exhibits at the same time a bacteriostatic antimicrobial activity 2-fold higher compared to Staphylococcus aureus and 4…17 times higher compared to Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa as compared to the reference methyl N'-[(2-hydroxynaphthalene-1-yl)methylidene]-N-(prop-2-en-1-yl)-hydrazinecarbimidothioate compound.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160020A MD4452C1 (en) | 2016-02-29 | 2016-02-29 | Use of N-(2,4-dimethylphenyl)-2-(2-hydroxybenzylidene)-hydrazinecarbothioamide as a Candida albicans kind fungi proliferation inhibitor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160020A MD4452C1 (en) | 2016-02-29 | 2016-02-29 | Use of N-(2,4-dimethylphenyl)-2-(2-hydroxybenzylidene)-hydrazinecarbothioamide as a Candida albicans kind fungi proliferation inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4452B1 MD4452B1 (en) | 2016-12-31 |
MD4452C1 true MD4452C1 (en) | 2017-07-31 |
Family
ID=57680006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160020A MD4452C1 (en) | 2016-02-29 | 2016-02-29 | Use of N-(2,4-dimethylphenyl)-2-(2-hydroxybenzylidene)-hydrazinecarbothioamide as a Candida albicans kind fungi proliferation inhibitor |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4452C1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4112B1 (en) * | 2010-05-17 | 2011-05-31 | Univ De Stat Din Moldova | Coordinative compounds of copper with 4-(dimethylphenyl)-thiosemicarbazones of 2-formylpyridine |
MD4402B1 (en) * | 2015-09-04 | 2016-02-29 | Universitatea De Stat Din Moldova | Methyl-N'-[(2-hydroxynaphthalene-1-il)methylidene]-N-prop-2-en-1-ylhydrazonothioate, exhibiting antifungal activity against Candida albicans |
-
2016
- 2016-02-29 MD MDA20160020A patent/MD4452C1/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4112B1 (en) * | 2010-05-17 | 2011-05-31 | Univ De Stat Din Moldova | Coordinative compounds of copper with 4-(dimethylphenyl)-thiosemicarbazones of 2-formylpyridine |
MD4402B1 (en) * | 2015-09-04 | 2016-02-29 | Universitatea De Stat Din Moldova | Methyl-N'-[(2-hydroxynaphthalene-1-il)methylidene]-N-prop-2-en-1-ylhydrazonothioate, exhibiting antifungal activity against Candida albicans |
Non-Patent Citations (3)
Title |
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Gulea A., Sargun A., Barba N., Jalba A., Poirier D., Petrenko P., Chumakov Yu. Synthesis and antileukaemia activity of N-(2,4-dimethylphenyl)hydrazine carbothioamide and its azomethine derivatives // Buletinul AŞM. Ştiinţele vieţii, 2012, nr. 3(318), p. 59-66 pag. 63 * |
Shailey Shinkal, Shefali Arora et al. A review on potential biological activity of thiosemicarbazides. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 2013, vol. 2, issue 6, pag. 4661-4681. Regăsit în Internet la 2016.10.25, url: www.wjpps.com/download/article/1386003042.pdf pag. 4666-4668 * |
Siwek A. et al. Antifungal effect of Arylthiosemicarbazones against Candida species. Search for molecular basis of antifungal activity of thiosemicarbazide derivatives. J. Mol. Model (2012), 18:4159-4170. DOI: 10.1007/s00894-012-1420-5, published online: 26 April 2012. Regăsit în Internet la 2016.10.24, url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429777/pdf/894_2012_Article_1420.pdf documentul integral * |
Also Published As
Publication number | Publication date |
---|---|
MD4452B1 (en) | 2016-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |