MD4316C1 - Utilizarea propionatului de 3-(2, 2, 2-trimetilhidraziniu) dihidrat pentru tratamentul gastropatiilor portale la pacienţii cu ciroză hepatică - Google Patents
Utilizarea propionatului de 3-(2, 2, 2-trimetilhidraziniu) dihidrat pentru tratamentul gastropatiilor portale la pacienţii cu ciroză hepatică Download PDFInfo
- Publication number
- MD4316C1 MD4316C1 MDA20130063A MD20130063A MD4316C1 MD 4316 C1 MD4316 C1 MD 4316C1 MD A20130063 A MDA20130063 A MD A20130063A MD 20130063 A MD20130063 A MD 20130063A MD 4316 C1 MD4316 C1 MD 4316C1
- Authority
- MD
- Moldova
- Prior art keywords
- patients
- liver cirrhosis
- trimethylhydrazinium
- gastropathies
- portal
- Prior art date
Links
- 208000019425 cirrhosis of liver Diseases 0.000 title claims abstract description 15
- 208000012895 Gastric disease Diseases 0.000 title claims abstract description 10
- JFWLFLLRLZSBRA-UHFFFAOYSA-N 3-[(trimethylazaniumyl)amino]propanoate;dihydrate Chemical compound O.O.C[N+](C)(C)NCCC([O-])=O JFWLFLLRLZSBRA-UHFFFAOYSA-N 0.000 title claims abstract description 5
- 208000018556 stomach disease Diseases 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 description 9
- 230000002496 gastric effect Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 208000000624 Esophageal and Gastric Varices Diseases 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 210000001156 gastric mucosa Anatomy 0.000 description 3
- 230000004089 microcirculation Effects 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 230000000926 neurological effect Effects 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- GZSOSUNBTXMUFQ-NJGQXECBSA-N 5,7,3'-Trihydroxy-4'-methoxyflavone 7-O-rutinoside Natural products O(C[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](Oc2cc(O)c3C(=O)C=C(c4cc(O)c(OC)cc4)Oc3c2)O1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 GZSOSUNBTXMUFQ-NJGQXECBSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010056091 Varices oesophageal Diseases 0.000 description 2
- 230000000767 anti-ulcer Effects 0.000 description 2
- GZSOSUNBTXMUFQ-YFAPSIMESA-N diosmin Chemical compound C1=C(O)C(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)O1 GZSOSUNBTXMUFQ-YFAPSIMESA-N 0.000 description 2
- 229960004352 diosmin Drugs 0.000 description 2
- IGBKNLGEMMEWKD-UHFFFAOYSA-N diosmin Natural products COc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 IGBKNLGEMMEWKD-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000024170 esophageal varices Diseases 0.000 description 2
- 201000010120 esophageal varix Diseases 0.000 description 2
- 208000007386 hepatic encephalopathy Diseases 0.000 description 2
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 201000002282 venous insufficiency Diseases 0.000 description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- 206010053155 Epigastric discomfort Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010017788 Gastric haemorrhage Diseases 0.000 description 1
- 108010017480 Hemosiderin Proteins 0.000 description 1
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 102100021904 Potassium-transporting ATPase alpha chain 1 Human genes 0.000 description 1
- 108010083204 Proton Pumps Proteins 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000009854 mucosal lesion Effects 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 208000007232 portal hypertension Diseases 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20130063A MD4316C1 (ro) | 2013-09-12 | 2013-09-12 | Utilizarea propionatului de 3-(2, 2, 2-trimetilhidraziniu) dihidrat pentru tratamentul gastropatiilor portale la pacienţii cu ciroză hepatică |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20130063A MD4316C1 (ro) | 2013-09-12 | 2013-09-12 | Utilizarea propionatului de 3-(2, 2, 2-trimetilhidraziniu) dihidrat pentru tratamentul gastropatiilor portale la pacienţii cu ciroză hepatică |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4316B1 MD4316B1 (mo) | 2015-01-31 |
| MD4316C1 true MD4316C1 (ro) | 2015-08-31 |
Family
ID=52440945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20130063A MD4316C1 (ro) | 2013-09-12 | 2013-09-12 | Utilizarea propionatului de 3-(2, 2, 2-trimetilhidraziniu) dihidrat pentru tratamentul gastropatiilor portale la pacienţii cu ciroză hepatică |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4316C1 (mo) |
-
2013
- 2013-09-12 MD MDA20130063A patent/MD4316C1/ro not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MD4316B1 (mo) | 2015-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |