MD4296C1 - Preparation from Tenebrio molitor larvae with antioxidant activity, process for its preparation and pharmaceutical product on its base - Google Patents
Preparation from Tenebrio molitor larvae with antioxidant activity, process for its preparation and pharmaceutical product on its baseInfo
- Publication number
- MD4296C1 MD4296C1 MDA20120131A MD20120131A MD4296C1 MD 4296 C1 MD4296 C1 MD 4296C1 MD A20120131 A MDA20120131 A MD A20120131A MD 20120131 A MD20120131 A MD 20120131A MD 4296 C1 MD4296 C1 MD 4296C1
- Authority
- MD
- Moldova
- Prior art keywords
- preparation
- tenebrio molitor
- larvae
- molitor larvae
- pharmaceutical product
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 7
- 241000254109 Tenebrio molitor Species 0.000 title abstract 5
- 230000003078 antioxidant effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- 229940127557 pharmaceutical product Drugs 0.000 title abstract 3
- 229940099259 vaseline Drugs 0.000 abstract 3
- 239000002028 Biomass Substances 0.000 abstract 2
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002481 ethanol extraction Methods 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 239000000399 hydroalcoholic extract Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 238000005502 peroxidation Methods 0.000 abstract 1
- 239000006215 rectal suppository Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 238000007738 vacuum evaporation Methods 0.000 abstract 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention relates to the pharmaceutical field, namely to a preparation from Tenebrio molitor larvae with antioxidant activity, a process for its preparation and a pharmaceutical product on its base.The preparation derived from the biomass of Tenebrio molitor larvae, according to the invention, comprises: lyophilized hydroalcoholic extract - 45…80% and vaseline oil - the rest, and manifests activity of inhibiting the peroxidation of lipoproteins IC50% of16 mg/ml and the nitroxide radical IC50% of20 mg/ml.The process for producing the preparation, according to the invention, consists in that Tenebrio molitor larvae are grown on an artificial nutrient medium, then are collected the last age larvae, are washed, disinfected with ultraviolet rays, frozen-thawed and homogenized. From the homogenized biomass is carried out the aqueous extraction for 60…90 min, followed by 70% ethanol extraction, the extracts are concentrated by vacuum evaporation, are combined, lyophilized and mixed with vaseline oil.The pharmaceutical product with antioxidant activity in the form of rectal suppositories comprises, per one suppository with the mass of 2 g: preparation derived from Tenebrio molitor larvae in vaseline oil - 0.25 g and semisynthetic glycerides - 1.75 g
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120131A MD4296C1 (en) | 2012-12-28 | 2012-12-28 | Preparation from Tenebrio molitor larvae with antioxidant activity, process for its preparation and pharmaceutical product on its base |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120131A MD4296C1 (en) | 2012-12-28 | 2012-12-28 | Preparation from Tenebrio molitor larvae with antioxidant activity, process for its preparation and pharmaceutical product on its base |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4296B1 MD4296B1 (en) | 2014-08-31 |
MD4296C1 true MD4296C1 (en) | 2015-03-31 |
Family
ID=51485227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20120131A MD4296C1 (en) | 2012-12-28 | 2012-12-28 | Preparation from Tenebrio molitor larvae with antioxidant activity, process for its preparation and pharmaceutical product on its base |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4296C1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD1004Z (en) * | 2015-04-10 | 2016-09-30 | Виталие ГИКАВЫЙ | Method for the treatment of infravesical obstruction caused by benign prostatic hyperplasia |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4713C1 (en) | 2018-07-19 | 2021-04-30 | Чеслав ЧУХРИЙ | Process for producing an active complex of Lymantria dispar larvae |
Citations (20)
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FR2672605A1 (en) * | 1991-02-11 | 1992-08-14 | Ferent Maurice | PROCESS FOR THE EXTRACTION OF A BIOLOGICAL SUBSTANCE FROM LEPIDOPTERA LARVAE AND SUBSTANCE OBTAINED. |
RU2038086C1 (en) * | 1991-03-26 | 1995-06-27 | Спиридонов Николай Алексеевич | Method for extracting biologically active product from wax moth larvae |
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MD2764F1 (en) * | 2004-07-28 | 2005-05-31 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Entomologic hepatoprotective preparation |
MD2788F1 (en) * | 2004-07-28 | 2005-06-30 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Entomologic anti-inflammatory and antioxidant preparation |
MD2789F1 (en) * | 2004-07-28 | 2005-06-30 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Entomologic antioxidant and immunomodulating preparation |
MD2787F1 (en) * | 2004-07-28 | 2005-06-30 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Entomologic hepatoprotective and immunomodulating preparation |
CN101120701A (en) * | 2007-08-06 | 2008-02-13 | 杨琳 | Method for preparing tenebrio molitorl edible oil |
CN101204230A (en) * | 2006-12-21 | 2008-06-25 | 陈德国 | Further processing for tenebrio molitor and uses thereof |
KR20080103509A (en) * | 2006-01-13 | 2008-11-27 | 주식회사유한양행 | A method of separating a peptidoglycan recognition protein from a hemolymph of tenebrio molitor larvae |
RO122332B1 (en) * | 2003-08-25 | 2009-04-30 | Mircea CIUHRII | Pharmaceutical composition as suppositories or ovules, for the treatment of hemorrhoids, prostatic adenoma and uterine fibroma and process for preparing the same |
KR20100032553A (en) * | 2008-09-18 | 2010-03-26 | 대한민국(농촌진흥청장) | A composition containing silkworm excreta extracts for treatment of atopic dermatitis |
CN101199315B (en) * | 2007-11-05 | 2011-08-31 | 陈跃辉 | Tenebrio molitor source biological feed additive and its preparation method |
CN102321147A (en) * | 2011-09-08 | 2012-01-18 | 金振喜 | Method for extracting tenebrio molitor protein of fiber for producing wig |
CN102422974A (en) * | 2011-10-28 | 2012-04-25 | 山东省农业科学院农产品研究所 | Method for preparing tenebrio molitor protein powder by enzymolysis |
CN102697013A (en) * | 2012-06-25 | 2012-10-03 | 天津春发生物科技集团有限公司 | Tenebrio molitor larva enzymatic hydrolysate and preparation method thereof |
CN102697020A (en) * | 2012-06-25 | 2012-10-03 | 天津春发生物科技集团有限公司 | Pork-flavored essence and preparation method thereof |
CN102726702A (en) * | 2012-06-25 | 2012-10-17 | 天津春发生物科技集团有限公司 | Chicken flavor essence and preparation method thereof |
CN102210407B (en) * | 2011-05-23 | 2013-06-05 | 华南农业大学 | Economic insect tenebrio molitor feed formula, preparation method and application thereof |
CN103262940A (en) * | 2013-06-14 | 2013-08-28 | 北京宇宙龙养生科技有限公司 | Tenebrio molitor compound protein product and preparation method thereof |
-
2012
- 2012-12-28 MD MDA20120131A patent/MD4296C1/en active IP Right Grant
Patent Citations (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2672605A1 (en) * | 1991-02-11 | 1992-08-14 | Ferent Maurice | PROCESS FOR THE EXTRACTION OF A BIOLOGICAL SUBSTANCE FROM LEPIDOPTERA LARVAE AND SUBSTANCE OBTAINED. |
RU2038086C1 (en) * | 1991-03-26 | 1995-06-27 | Спиридонов Николай Алексеевич | Method for extracting biologically active product from wax moth larvae |
JP2004155679A (en) * | 2002-11-05 | 2004-06-03 | Kadoriile Nishida:Kk | Preparation for external use |
RO122332B1 (en) * | 2003-08-25 | 2009-04-30 | Mircea CIUHRII | Pharmaceutical composition as suppositories or ovules, for the treatment of hemorrhoids, prostatic adenoma and uterine fibroma and process for preparing the same |
MD2764F1 (en) * | 2004-07-28 | 2005-05-31 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Entomologic hepatoprotective preparation |
MD2788F1 (en) * | 2004-07-28 | 2005-06-30 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Entomologic anti-inflammatory and antioxidant preparation |
MD2789F1 (en) * | 2004-07-28 | 2005-06-30 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Entomologic antioxidant and immunomodulating preparation |
MD2787F1 (en) * | 2004-07-28 | 2005-06-30 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Entomologic hepatoprotective and immunomodulating preparation |
MD2788G2 (en) * | 2004-07-28 | 2006-01-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Entomologic anti-inflammatory and antioxidant preparation |
KR20080103509A (en) * | 2006-01-13 | 2008-11-27 | 주식회사유한양행 | A method of separating a peptidoglycan recognition protein from a hemolymph of tenebrio molitor larvae |
CA2636194C (en) * | 2006-01-13 | 2013-07-23 | Yuhan Corporation | A method of separating a peptidoglycan recognition protein from a hemolymph of tenebrio molitor larvae |
CN101204230A (en) * | 2006-12-21 | 2008-06-25 | 陈德国 | Further processing for tenebrio molitor and uses thereof |
CN101120701A (en) * | 2007-08-06 | 2008-02-13 | 杨琳 | Method for preparing tenebrio molitorl edible oil |
CN101199315B (en) * | 2007-11-05 | 2011-08-31 | 陈跃辉 | Tenebrio molitor source biological feed additive and its preparation method |
KR20100032553A (en) * | 2008-09-18 | 2010-03-26 | 대한민국(농촌진흥청장) | A composition containing silkworm excreta extracts for treatment of atopic dermatitis |
CN102210407B (en) * | 2011-05-23 | 2013-06-05 | 华南农业大学 | Economic insect tenebrio molitor feed formula, preparation method and application thereof |
CN102321147A (en) * | 2011-09-08 | 2012-01-18 | 金振喜 | Method for extracting tenebrio molitor protein of fiber for producing wig |
CN102422974A (en) * | 2011-10-28 | 2012-04-25 | 山东省农业科学院农产品研究所 | Method for preparing tenebrio molitor protein powder by enzymolysis |
CN102697013A (en) * | 2012-06-25 | 2012-10-03 | 天津春发生物科技集团有限公司 | Tenebrio molitor larva enzymatic hydrolysate and preparation method thereof |
CN102697020A (en) * | 2012-06-25 | 2012-10-03 | 天津春发生物科技集团有限公司 | Pork-flavored essence and preparation method thereof |
CN102726702A (en) * | 2012-06-25 | 2012-10-17 | 天津春发生物科技集团有限公司 | Chicken flavor essence and preparation method thereof |
CN103262940A (en) * | 2013-06-14 | 2013-08-28 | 北京宇宙龙养生科技有限公司 | Tenebrio molitor compound protein product and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
Ciuhrii V. Biotehnologia obţinerii formei medicamentoase pentru tratarea hiperplaziei benigne de prostată. Teza de doctor în biologie, Chişinău, 2010, 129 p. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD1004Z (en) * | 2015-04-10 | 2016-09-30 | Виталие ГИКАВЫЙ | Method for the treatment of infravesical obstruction caused by benign prostatic hyperplasia |
Also Published As
Publication number | Publication date |
---|---|
MD4296B1 (en) | 2014-08-31 |
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Legal Events
Date | Code | Title | Description |
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FG4A | Patent for invention issued |