MD4282C1 - Использование полиоксометаллатных комплексов с центральными атомами селена в качестве соединений обладающих противоопухолевой активностью - Google Patents
Использование полиоксометаллатных комплексов с центральными атомами селена в качестве соединений обладающих противоопухолевой активностью Download PDFInfo
- Publication number
- MD4282C1 MD4282C1 MDA20130003A MD20130003A MD4282C1 MD 4282 C1 MD4282 C1 MD 4282C1 MD A20130003 A MDA20130003 A MD A20130003A MD 20130003 A MD20130003 A MD 20130003A MD 4282 C1 MD4282 C1 MD 4282C1
- Authority
- MD
- Moldova
- Prior art keywords
- central
- complexes
- antitumor activity
- compounds possessing
- selenium atoms
- Prior art date
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- 230000000259 anti-tumor effect Effects 0.000 title claims abstract description 15
- 150000001875 compounds Chemical class 0.000 title claims abstract description 6
- 125000003748 selenium group Chemical group *[Se]* 0.000 title claims abstract description 5
- 239000013460 polyoxometalate Substances 0.000 title description 4
- 239000003814 drug Substances 0.000 abstract description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- 239000013078 crystal Substances 0.000 description 7
- 239000011669 selenium Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 206010029260 Neuroblastoma Diseases 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000020477 pH reduction Effects 0.000 description 4
- XMVONEAAOPAGAO-UHFFFAOYSA-N sodium tungstate Chemical compound [Na+].[Na+].[O-][W]([O-])(=O)=O XMVONEAAOPAGAO-UHFFFAOYSA-N 0.000 description 4
- 239000010949 copper Substances 0.000 description 3
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 description 3
- 229910052711 selenium Inorganic materials 0.000 description 3
- 235000015921 sodium selenite Nutrition 0.000 description 3
- 239000011781 sodium selenite Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002438 mitochondrial effect Effects 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 description 2
- 229940091258 selenium supplement Drugs 0.000 description 2
- 229960001471 sodium selenite Drugs 0.000 description 2
- 238000007669 thermal treatment Methods 0.000 description 2
- ORVNOKIJWHQPFV-UHFFFAOYSA-N 2-(2,5-diphenyl-1h-tetrazol-1-ium-3-yl)-3,4-dimethyl-2h-1,3-thiazole;bromide Chemical compound [Br-].S1C=C(C)N(C)C1N1N(C=2C=CC=CC=2)[NH2+]C(C=2C=CC=CC=2)=N1 ORVNOKIJWHQPFV-UHFFFAOYSA-N 0.000 description 1
- 229910021592 Copper(II) chloride Inorganic materials 0.000 description 1
- 108020005199 Dehydrogenases Proteins 0.000 description 1
- 229910003597 H2SeO3 Inorganic materials 0.000 description 1
- OKIZCWYLBDKLSU-UHFFFAOYSA-M N,N,N-Trimethylmethanaminium chloride Chemical compound [Cl-].C[N+](C)(C)C OKIZCWYLBDKLSU-UHFFFAOYSA-M 0.000 description 1
- 229910003424 Na2SeO3 Inorganic materials 0.000 description 1
- 229910020350 Na2WO4 Inorganic materials 0.000 description 1
- 229910018162 SeO2 Inorganic materials 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000005492 condensed matter physics Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- SPVXKVOXSXTJOY-UHFFFAOYSA-N selane Chemical group [SeH2] SPVXKVOXSXTJOY-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- CMZUMMUJMWNLFH-UHFFFAOYSA-N sodium metavanadate Chemical compound [Na+].[O-][V](=O)=O CMZUMMUJMWNLFH-UHFFFAOYSA-N 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к медицине, а именно к использованию полиоксометаллатных комплексов в качестве соединений, обладающих противоопухолевой активностью.Согласно изобретению, заявляется использование полиоксометаллатных комплексов с центральными атомами селена формулы Na7[Cu3Na3(H2O)9(SeW9O33)2]·nH2O, где n = 11,5; 13; 23, в качестве соединений, обладающих противоопухолевой активностью.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20130003A MD4282C1 (ru) | 2012-12-11 | 2012-12-11 | Использование полиоксометаллатных комплексов с центральными атомами селена в качестве соединений обладающих противоопухолевой активностью |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20130003A MD4282C1 (ru) | 2012-12-11 | 2012-12-11 | Использование полиоксометаллатных комплексов с центральными атомами селена в качестве соединений обладающих противоопухолевой активностью |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4282B1 MD4282B1 (ru) | 2014-04-30 |
| MD4282C1 true MD4282C1 (ru) | 2014-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20130003A MD4282C1 (ru) | 2012-12-11 | 2012-12-11 | Использование полиоксометаллатных комплексов с центральными атомами селена в качестве соединений обладающих противоопухолевой активностью |
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| Country | Link |
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| MD (1) | MD4282C1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105859820A (zh) * | 2016-03-31 | 2016-08-17 | 中北大学 | 叶酸包裹去氢胆酸-多钼氧簇-芘杂化物及其制备方法 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62230619A (ja) * | 1986-03-31 | 1987-10-09 | Poritoronikusu:Kk | ヘテロポリ酸イオンのアルカリ塩 |
| JPH01249725A (ja) * | 1988-03-30 | 1989-10-05 | Terumo Corp | 抗腫瘍剤 |
| JPH0283328A (ja) * | 1988-09-20 | 1990-03-23 | Terumo Corp | 抗腫瘍剤 |
| JPH02204416A (ja) * | 1989-02-03 | 1990-08-14 | Terumo Corp | 抗腫瘍剤 |
| JPH02204415A (ja) * | 1989-02-03 | 1990-08-14 | Terumo Corp | 抗腫瘍剤 |
| CN1258506A (zh) * | 1998-12-29 | 2000-07-05 | 东北师范大学 | 九钨三钛硅酸盐用作抗肿瘤药物 |
| US6656509B1 (en) * | 1998-06-09 | 2003-12-02 | Biosyn Arzneimittel Gmbh | Combination of selenium-containing compounds with cytostatics |
| CN1523018A (zh) * | 2003-09-09 | 2004-08-25 | 东北师范大学 | 杂多酸5－氟尿嘧啶盐类抗肿瘤药物及其合成方法 |
| MD4014B1 (en) * | 2009-04-23 | 2010-02-26 | Tatiana Gutul | Polyoxometalate complexes with antitumor activity |
| US20100172822A1 (en) * | 2007-06-13 | 2010-07-08 | University Of Science And Technology Of China | Use of sodium selenosulfate for supplementing selenium and enhancing the therapeutic efficacy of chemotherapy agents, and a rapid process for preparing sodium selenosulfate |
-
2012
- 2012-12-11 MD MDA20130003A patent/MD4282C1/ru not_active IP Right Cessation
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62230619A (ja) * | 1986-03-31 | 1987-10-09 | Poritoronikusu:Kk | ヘテロポリ酸イオンのアルカリ塩 |
| JPH01249725A (ja) * | 1988-03-30 | 1989-10-05 | Terumo Corp | 抗腫瘍剤 |
| JPH0283328A (ja) * | 1988-09-20 | 1990-03-23 | Terumo Corp | 抗腫瘍剤 |
| JPH02204416A (ja) * | 1989-02-03 | 1990-08-14 | Terumo Corp | 抗腫瘍剤 |
| JPH02204415A (ja) * | 1989-02-03 | 1990-08-14 | Terumo Corp | 抗腫瘍剤 |
| US6656509B1 (en) * | 1998-06-09 | 2003-12-02 | Biosyn Arzneimittel Gmbh | Combination of selenium-containing compounds with cytostatics |
| CN1258506A (zh) * | 1998-12-29 | 2000-07-05 | 东北师范大学 | 九钨三钛硅酸盐用作抗肿瘤药物 |
| CN1523018A (zh) * | 2003-09-09 | 2004-08-25 | 东北师范大学 | 杂多酸5－氟尿嘧啶盐类抗肿瘤药物及其合成方法 |
| US20100172822A1 (en) * | 2007-06-13 | 2010-07-08 | University Of Science And Technology Of China | Use of sodium selenosulfate for supplementing selenium and enhancing the therapeutic efficacy of chemotherapy agents, and a rapid process for preparing sodium selenosulfate |
| MD4014B1 (en) * | 2009-04-23 | 2010-02-26 | Tatiana Gutul | Polyoxometalate complexes with antitumor activity |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105859820A (zh) * | 2016-03-31 | 2016-08-17 | 中北大学 | 叶酸包裹去氢胆酸-多钼氧簇-芘杂化物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| MD4282B1 (ru) | 2014-04-30 |
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