MD355C2 - Procedeu de preparare a derivaţilor 1-benzil-3-oximetilindazolului sau a sărurilor lui cu baze farmaceutic acceptabile - Google Patents
Procedeu de preparare a derivaţilor 1-benzil-3-oximetilindazolului sau a sărurilor lui cu baze farmaceutic acceptabileInfo
- Publication number
- MD355C2 MD355C2 MD95-0055A MD950055A MD355C2 MD 355 C2 MD355 C2 MD 355C2 MD 950055 A MD950055 A MD 950055A MD 355 C2 MD355 C2 MD 355C2
- Authority
- MD
- Moldova
- Prior art keywords
- pharmaceutically acceptable
- formula
- acceptable bases
- oximethylindazole
- benzyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 1-benzylindazole-3-yl Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prezenta invenţie se referă la eterii 1-benzil-3-oximetil-indazolului cu formula I:A - CH2 -O - CRR1 -COORIII \tab I,în care A reprezintă 1-benzilindazol-3-il, R şi R1 pot fi identici sau diferiţi şi reprezintă C1-C2-alchil, RIII reprezintă H, sau sărurile lor cu baze farmaceutic acceptabile. Procedeul se caracterizează prin aceea că compusul cu formula IIa:în care Y reprezintă OH, este supus interacţiunii cu cetona cu formula RCOR1, în care R şi R1 au valorile indicate mai sus, şi cu cloroform în prezenţa hidroxidului metalului alcalin. În caz de necesitate se prepară sarea acidului cu formula I cu baze farmaceutic acceptabile. Reacţia se efectuează la temperatura de fierbere a amestecului reactant şi timpul de reacţie de la 30 minute până la 12 ore. Compuşii preparaţi prin metoda descrisă posedă activitate analgezică.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8947620A IT1230441B (it) | 1989-02-07 | 1989-02-07 | Eteri della serie dell'indazolo |
| SU904743128A RU2066318C1 (ru) | 1989-02-07 | 1990-02-06 | Производные 1-бензил-3-оксиметилиндазола или их соли с фармацевтически приемлемыми основаниями и промежуточные вещества для их получения |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD355B1 MD355B1 (ro) | 1995-12-31 |
| MD355C2 true MD355C2 (ro) | 1996-04-30 |
Family
ID=26329209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0055A MD355C2 (ro) | 1989-02-07 | 1994-12-28 | Procedeu de preparare a derivaţilor 1-benzil-3-oximetilindazolului sau a sărurilor lui cu baze farmaceutic acceptabile |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD355C2 (ro) |
-
1994
- 1994-12-28 MD MD95-0055A patent/MD355C2/ro active IP Right Grant
Non-Patent Citations (1)
| Title |
|---|
| Вейганд-Хильгетаг. Методы эксперимента в органической химии, М., 1968, р.714. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD355B1 (ro) | 1995-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20100206 |