MD355C2 - Method of obtaining 1-benzyl-3-oximethylindazole derivaties or their salts with pharmaceutically acceptable bases - Google Patents
Method of obtaining 1-benzyl-3-oximethylindazole derivaties or their salts with pharmaceutically acceptable basesInfo
- Publication number
- MD355C2 MD355C2 MD95-0055A MD950055A MD355C2 MD 355 C2 MD355 C2 MD 355C2 MD 950055 A MD950055 A MD 950055A MD 355 C2 MD355 C2 MD 355C2
- Authority
- MD
- Moldova
- Prior art keywords
- pharmaceutically acceptable
- formula
- acceptable bases
- oximethylindazole
- benzyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 1-benzylindazole-3-yl Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to simple 1-benzyl-3-oximethylindazole ethers with the formula I:A-CH2-OCRR1-COORIII Iwhere A represents 1-benzylindazole-3-yl, R or R1 may be similar or different and may represent CI-C2-alkyl, RIII represents H or their salts with pharmaceutically acceptable bases. The method is remarcable by the fact that the compounds with the formula II a:A-CH2-Ywhere Y represents OH, are submitted to the influence of ketone with the formula RCORI, where R and R1 have the above-mentioned meaning and chloroform in the presence of alkali metal hydroxide. In case of necesity they obtain acid salt with the formula I with pharmaceutically acceptable bases. The reaction is carried out at the boiling temperature of the reactive mixture and lasts from 30 minutes up to 12 hours. The compounds obtained by this method have an anesthetic activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8947620A IT1230441B (en) | 1989-02-07 | 1989-02-07 | ETHERS OF THE INDAZOLE SERIES |
| SU904743128A RU2066318C1 (en) | 1989-02-07 | 1990-02-06 | 1-benzyl-3-oxymethylindazole derivatives or salts thereof with pharmaceutically acceptable bases thereof, and intermediate compounds for preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD355B1 MD355B1 (en) | 1995-12-31 |
| MD355C2 true MD355C2 (en) | 1996-04-30 |
Family
ID=26329209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0055A MD355C2 (en) | 1989-02-07 | 1994-12-28 | Method of obtaining 1-benzyl-3-oximethylindazole derivaties or their salts with pharmaceutically acceptable bases |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD355C2 (en) |
-
1994
- 1994-12-28 MD MD95-0055A patent/MD355C2/en active IP Right Grant
Non-Patent Citations (1)
| Title |
|---|
| Вейганд-Хильгетаг. Методы эксперимента в органической химии, М., 1968, р.714. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD355B1 (en) | 1995-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20100206 |